C.M.Hammell@CSHL
@cmhammell.bsky.social
Professor at CSHL; interested in temporal cell fate specification during development... proud dad of 4 and married to the most fascinating woman in the world.
https://www.cshl.edu/research/faculty-staff/christopher-hammell/
https://www.cshl.edu/research/faculty-staff/christopher-hammell/
Reposted by C.M.Hammell@CSHL
our latest work summary: cohesin is preferentially loaded at/near active enhancers and loop extrudes in both directions, forming loops that create the dna contacts that appear as the newly defined "fountains" in hic maps pubmed.ncbi.nlm.nih.gov/40210441/
Cohesin organizes 3D DNA contacts surrounding active enhancers in C. elegans - PubMed
In mammals, cohesin and CTCF organize the 3D genome into topologically associating domains (TADs) to regulate communication between <i>cis</i>-regulatory elements. Many organisms, including <i>S. cere...
pubmed.ncbi.nlm.nih.gov
May 7, 2025 at 4:26 PM
our latest work summary: cohesin is preferentially loaded at/near active enhancers and loop extrudes in both directions, forming loops that create the dna contacts that appear as the newly defined "fountains" in hic maps pubmed.ncbi.nlm.nih.gov/40210441/
Ha. Idiots!
April 4, 2025 at 1:16 PM
Ha. Idiots!
Reposted by C.M.Hammell@CSHL
Reposted by C.M.Hammell@CSHL
Kickass worm-friend @rnareylab.bsky.social wrote a piece for @sciencehomecoming.bsky.social and you should read it and send it to your red-state friends and fam. Hurting research hurts all of us. #invertsolidarity 🧪 www.heraldbanner.com/opinion/colu...
Why federally funded science matters to Texas | Columns | heraldbanner.com
www.heraldbanner.com
February 23, 2025 at 11:57 PM
Kickass worm-friend @rnareylab.bsky.social wrote a piece for @sciencehomecoming.bsky.social and you should read it and send it to your red-state friends and fam. Hurting research hurts all of us. #invertsolidarity 🧪 www.heraldbanner.com/opinion/colu...
Reposted by C.M.Hammell@CSHL
Reposted by C.M.Hammell@CSHL
Reposted by C.M.Hammell@CSHL
The Postbaccalaureate Research Education Program at UMass Chan prepares students with a bachelor’s or master’s degree for doctoral study in the biomedical sciences through a yearlong, mentored research project. Apply by Feb. 28: direc.to/mqhT
#MolecularGenetics #CellBiology #PublicHealth
#MolecularGenetics #CellBiology #PublicHealth
February 17, 2025 at 8:05 PM
The Postbaccalaureate Research Education Program at UMass Chan prepares students with a bachelor’s or master’s degree for doctoral study in the biomedical sciences through a yearlong, mentored research project. Apply by Feb. 28: direc.to/mqhT
#MolecularGenetics #CellBiology #PublicHealth
#MolecularGenetics #CellBiology #PublicHealth
Reposted by C.M.Hammell@CSHL
What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX
https://www.biorxiv.org/content/10.1101/2025.02.14.638102v1?ct=
t.co
February 18, 2025 at 2:51 PM
What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX
Reposted by C.M.Hammell@CSHL
www.embopress.org/doi/epdf/10.....
Please check out Xuhang's exciting article in MSB!
Please check out Xuhang's exciting article in MSB!
Enhanced flux potential analysis links changes in enzyme expression to metabolic flux
www.embopress.org
February 18, 2025 at 11:40 AM
www.embopress.org/doi/epdf/10.....
Please check out Xuhang's exciting article in MSB!
Please check out Xuhang's exciting article in MSB!
Reposted by C.M.Hammell@CSHL
👇🏻👇🏻
Portuguese editorial cartoonist Zez Vaz reaches back to Tiananmen Square to call on American defiance.
February 15, 2025 at 7:26 PM
👇🏻👇🏻
Reposted by C.M.Hammell@CSHL
Your Action Is Needed!
Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy
www.ascb.org/science-poli...
Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy
www.ascb.org/science-poli...
February 5, 2025 at 3:39 PM
Your Action Is Needed!
Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy
www.ascb.org/science-poli...
Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy
www.ascb.org/science-poli...
Reposted by C.M.Hammell@CSHL
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Reposted by C.M.Hammell@CSHL
FBI Uncovers Al-Qaeda Plot To Just Sit Back And Enjoy Collapse Of United States
FBI Uncovers Al-Qaeda Plot To Just Sit Back And Enjoy Collapse Of United States
WASHINGTON—Putting the nation on alert against what it has described as a “highly credible terrorist threat,” the FBI announced today that it has uncovered a plot by members of al-Qaeda to sit back an...
theonion.com
February 5, 2025 at 6:31 PM
FBI Uncovers Al-Qaeda Plot To Just Sit Back And Enjoy Collapse Of United States
Very cool paper!!!
Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection:
rdcu.be/d8xLv (1/6)
rdcu.be/d8xLv (1/6)
Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing
Nature Biotechnology - Metabolites can be quantified using a combination of aptamers and DNA barcodes.
rdcu.be
February 4, 2025 at 6:48 PM
Very cool paper!!!
Indeed! Cool paper!
Cool new paper from my colleague and friend Andy Fraser.
Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection:
rdcu.be/d8xLv (1/6)
rdcu.be/d8xLv (1/6)
February 4, 2025 at 6:48 PM
Indeed! Cool paper!
Reposted by C.M.Hammell@CSHL
Itziar Pinilla-Macua, Sachin Surve and Alexander Sorkin find that that signalling through the EGFR-VAV2-Rac1 pathway persists in endosomes and is required for EGFR-driven cell migration.
#OpenAccess
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
January 28, 2025 at 4:12 PM
Itziar Pinilla-Macua, Sachin Surve and Alexander Sorkin find that that signalling through the EGFR-VAV2-Rac1 pathway persists in endosomes and is required for EGFR-driven cell migration.
#OpenAccess
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
#OpenAccess
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
All of these podcasts are fantastic. Try them out!
How did Cell, Nature & Science become the 3 hottest journals in biomedical research? You could call it 'The Curious Case of Benjamin Lewin’ & it's told in today's episode of the Night Science podcast with Keith Yamamoto (@kryamamoto.bsky.social ; starts at 15:00) @nightsciencepod.bsky.social ⬇️
January 28, 2025 at 2:59 AM
All of these podcasts are fantastic. Try them out!
Reposted by C.M.Hammell@CSHL
Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genetic coupling of enhancer activity and connectivity in gene expression control - Nature Communications
Here, the authors study the effects of expression quantitative trait loci on enhancer activity and promoter contacts in primary monocytes isolated from male individuals, suggesting an inherent genetic...
www.nature.com
January 27, 2025 at 2:49 PM
Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
“Dr Phil joins Chicago immigration raid…” ….headline says it all.
Dr Phil joins Chicago immigration raid as border czar says more arrests coming
TV personality embeds in one of several raids in US cities in what Tom Homan says are only ‘beginning stages’
www.theguardian.com
January 27, 2025 at 8:24 PM
“Dr Phil joins Chicago immigration raid…” ….headline says it all.
Great meeting! Register now!
🧪 If you are a network (or network-curious!) biologist, please consider attending the upcoming CSHL Network Biology Meeting. Details + abstract deadline below!
FYI 🔔The abstract deadline for #cshlnetworks is coming up - Jan. 27th! Register to submit your abstract here:
bit.ly/40cIfSl
@fritzroth.bsky.social @jsvanleeuwen.bsky.social @pedrobeltrao.bsky.social
bit.ly/40cIfSl
@fritzroth.bsky.social @jsvanleeuwen.bsky.social @pedrobeltrao.bsky.social
January 15, 2025 at 12:50 AM
Great meeting! Register now!
Reposted by C.M.Hammell@CSHL
Spotlight: Edward Courvan and Roy Parker @colorado.edu discuss new work from Escayola, Zhang, @karlaneugebauer.bsky.social and colleagues (https://buff.ly/4fPlwBt) that carefully profiles Cajal Body components and finds an unexpected role for 60S ribosomal proteins. https://buff.ly/40rjnaD
January 9, 2025 at 8:50 PM
Spotlight: Edward Courvan and Roy Parker @colorado.edu discuss new work from Escayola, Zhang, @karlaneugebauer.bsky.social and colleagues (https://buff.ly/4fPlwBt) that carefully profiles Cajal Body components and finds an unexpected role for 60S ribosomal proteins. https://buff.ly/40rjnaD
Reposted by C.M.Hammell@CSHL
It's still true that no philosopher has had a bigger impact on science than Popper, who argued that we should make risky and bold predictions to test our ideas. Do the killer experiment, he would say; the one that has a chance to kill your hypothesis.
January 10, 2025 at 2:41 AM
It's still true that no philosopher has had a bigger impact on science than Popper, who argued that we should make risky and bold predictions to test our ideas. Do the killer experiment, he would say; the one that has a chance to kill your hypothesis.
