Mill_lab
@cilialab.bsky.social
Group at MRC HGU using genetics, cell biology and lots of imaging to unlock the mysteries of mammalian #cilia. #cilia. #centrioles #cytoskeleton #RareDisease www.cilialab.co.uk
Reposted by Mill_lab
I guess it never gets old...bc we love #CellMigration
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
November 14, 2025 at 8:38 PM
I guess it never gets old...bc we love #CellMigration
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
Reposted by Mill_lab
Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems - Nature Communications
Proximity labeling allows proteomic mapping of subcellular structures. Here, Sroka et al. develop in situ APEX activation (iAPEX) to overcome limitations of labeling specificity and H2O2 toxicity, app...
www.nature.com
November 14, 2025 at 8:07 PM
Thrilled to share "in situ APEX activation" (iAPEX), a proximity labeling technology for subcellular #proteomics applied to primary #cilia. iAPEX uses an enzymatic cascade, in which a D-amino acid oxidase locally produces H2O2 to activate ascorbate peroxidase.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mill_lab
Rudolfo Karl, Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social and colleagues discover that renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 14, 2025 at 2:14 PM
Rudolfo Karl, Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social and colleagues discover that renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
Just heading home from our @mrcmousenetwork.bsky.social MRC NMGN Science Meeting 2025 in York where our Congenital Anomalies Cluster shared updates on our clinical VUS & phenotyping pipelines at the podium! Great discussions! #FunctionalGenomics #RareDisease #CongenitalAnomalies
November 14, 2025 at 6:40 PM
Just heading home from our @mrcmousenetwork.bsky.social MRC NMGN Science Meeting 2025 in York where our Congenital Anomalies Cluster shared updates on our clinical VUS & phenotyping pipelines at the podium! Great discussions! #FunctionalGenomics #RareDisease #CongenitalAnomalies
Reposted by Mill_lab
Correct guidance link: grants.nih.gov/grants/guide...
NOT-OD-26-005: Interim Guidance on Reopening of NIH Extramural Activities
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Interim Guidance on Reopening of NIH Extramural Activities NOT-OD-26-005. NIH
grants.nih.gov
November 14, 2025 at 5:24 PM
Correct guidance link: grants.nih.gov/grants/guide...
Reposted by Mill_lab
Updated guidance about study sections and due dates during the shut down. (Given the number of emails about issues with submission/letters of rec I had, this will help with those). grants.nih.gov/grants/guide...
NOT-OD-26-004: Information for the NIH Extramural Community During the Lapse of Federal Government Funding
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Information for the NIH Extramural Community During the Lapse of Federal Government Funding NOT-OD-26-004. NIH
grants.nih.gov
November 14, 2025 at 5:16 PM
Updated guidance about study sections and due dates during the shut down. (Given the number of emails about issues with submission/letters of rec I had, this will help with those). grants.nih.gov/grants/guide...
Reposted by Mill_lab
While trying to steer clear of the ‘best organelle’ debate, we’re delighted to highlight #JCSciliaSI, guest edited by @cilialab.bsky.social & @lottepedersen.bsky.social.
And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!
And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!
JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - FocalPlane
JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - News
focalplane.biologists.com
November 13, 2025 at 11:26 AM
While trying to steer clear of the ‘best organelle’ debate, we’re delighted to highlight #JCSciliaSI, guest edited by @cilialab.bsky.social & @lottepedersen.bsky.social.
And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!
And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!
Reposted by Mill_lab
The Next Gen Pregnancy Initiative is now accepting applications. Up to $500,000 over 4 years to support bold research into pregnancy duration, fetal growth, and pregnancy complications. Deadline: Dec 4, 2025.
Apply now buff.ly/rNhJKMW #bwfrepro
Apply now buff.ly/rNhJKMW #bwfrepro
Next Gen Pregnancy Initiative - Burroughs Wellcome Fund
by
buff.ly
October 7, 2025 at 9:33 AM
The Next Gen Pregnancy Initiative is now accepting applications. Up to $500,000 over 4 years to support bold research into pregnancy duration, fetal growth, and pregnancy complications. Deadline: Dec 4, 2025.
Apply now buff.ly/rNhJKMW #bwfrepro
Apply now buff.ly/rNhJKMW #bwfrepro
Reposted by Mill_lab
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
openrxiv.org
November 6, 2025 at 2:32 PM
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Reposted by Mill_lab
Laurence Wilson and Martin Bees use high-speed 3D holographic imaging to capture the flagellar beat of single algal cells, revealing changes in the ‘handedness’ of the flagellar shapes at different points in their cycle.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 6, 2025 at 9:05 AM
Laurence Wilson and Martin Bees use high-speed 3D holographic imaging to capture the flagellar beat of single algal cells, revealing changes in the ‘handedness’ of the flagellar shapes at different points in their cycle.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
Reposted by Mill_lab
The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor.
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
November 5, 2025 at 5:48 PM
The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor.
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
Reposted by Mill_lab
👉Do not miss talks by our coordinator Sophie Saunier and by John Sayer at #KidneyWk 2025 in Houston, TX, the meeting of the @asnkidney.bsky.social - 📅Thursday Nov 6th, 2pm, Room310A - 💊Leading Edge of Therapeutic Development in Cystic Kidney Disease session #NPH #ciliopathies @hkd-l.bsky.social
November 5, 2025 at 7:05 PM
👉Do not miss talks by our coordinator Sophie Saunier and by John Sayer at #KidneyWk 2025 in Houston, TX, the meeting of the @asnkidney.bsky.social - 📅Thursday Nov 6th, 2pm, Room310A - 💊Leading Edge of Therapeutic Development in Cystic Kidney Disease session #NPH #ciliopathies @hkd-l.bsky.social
Reposted by Mill_lab
So excited that our paper is now out with @jcellsci.bsky.social and a special thank you to the editors for featuring our work! Check out below! 🐸🔬
@natmosqueda.bsky.social, @psutton54.bsky.social and @brownlee.bsky.social @stonybrooku.bsky.social discover that importin α plays a regulatory role in ciliogenesis and cilia length with implications for Xenopus nephrogenesis.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 4, 2025 at 5:06 PM
So excited that our paper is now out with @jcellsci.bsky.social and a special thank you to the editors for featuring our work! Check out below! 🐸🔬
Reposted by Mill_lab
Amanda Smith, Lawrence Ostrowski and colleagues find that lipid nanoparticle-encapsulated Dnai1 mRNA rescues ciliary activity in primary ciliary dyskinesia mouse cell models.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 5, 2025 at 10:23 AM
Amanda Smith, Lawrence Ostrowski and colleagues find that lipid nanoparticle-encapsulated Dnai1 mRNA rescues ciliary activity in primary ciliary dyskinesia mouse cell models.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
Reposted by Mill_lab
I am excited to share our preprint on the use of machine learning to identify abnormal cilia function. I am proud of Nicholas Hadas, a talented PhD candidate, for his hard work in compiling the code and preparing this manuscript.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Machine Learning Analysis of Cilia-Driven Particle Transport Distinguishes Primary Ciliary Dyskinesia Cilia from Normal Cilia
Rational. Primary ciliary dyskinesia (PCD) is a genetic condition that results in dysmotile cilia and abnormal mucociliary clearance. Despite advances in understanding the pathogenesis of PCD, diagnos...
www.biorxiv.org
November 4, 2025 at 2:09 PM
I am excited to share our preprint on the use of machine learning to identify abnormal cilia function. I am proud of Nicholas Hadas, a talented PhD candidate, for his hard work in compiling the code and preparing this manuscript.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mill_lab
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
November 3, 2025 at 7:33 PM
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
Reposted by Mill_lab
We are thrilled to see this out in @jcellsci.bsky.social an in the special issue on Cilia. Cfap298 - which we call Kurly - is the mutant that keeps on giving us surprises! In this paper, a mutation generated by CRISPR, that deletes two aa and changes a third, specifically affects cilia motility.
Marvin Cortez, Cullen Young, Rebecca Burdine @rburdine1.bsky.social and colleagues identify a conserved domain in Cfap298 that governs left–right symmetry breaking in vertebrates.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 3, 2025 at 6:33 PM
We are thrilled to see this out in @jcellsci.bsky.social an in the special issue on Cilia. Cfap298 - which we call Kurly - is the mutant that keeps on giving us surprises! In this paper, a mutation generated by CRISPR, that deletes two aa and changes a third, specifically affects cilia motility.
Reposted by Mill_lab
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.
journals.biologists.com
November 3, 2025 at 5:32 PM
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Reposted by Mill_lab
Thrilled to share that this work has been accepted for publication @currentbiology.bsky.social 🥳
Special shoutout to the editorial team – the process was incredibly smooth and productive. Read more here:
www.sciencedirect.com/science/arti...
Special shoutout to the editorial team – the process was incredibly smooth and productive. Read more here:
www.sciencedirect.com/science/arti...
November 3, 2025 at 3:56 AM
Thrilled to share that this work has been accepted for publication @currentbiology.bsky.social 🥳
Special shoutout to the editorial team – the process was incredibly smooth and productive. Read more here:
www.sciencedirect.com/science/arti...
Special shoutout to the editorial team – the process was incredibly smooth and productive. Read more here:
www.sciencedirect.com/science/arti...
Reposted by Mill_lab
🚨 EXCLUSIVE: Lifesaving treatments for the millions of Britons who suffer from rare diseases could be approved years earlier under ambitious plans by the UK medicines watchdog: www.thetimes.com/article/0653...
New drugs to be approved faster so patients don’t wait years
The medicines watchdog is changing how it oversees research of 7,000 rare diseases, which collectively affect about one in 17 Britons
www.thetimes.com
November 2, 2025 at 8:58 AM
🚨 EXCLUSIVE: Lifesaving treatments for the millions of Britons who suffer from rare diseases could be approved years earlier under ambitious plans by the UK medicines watchdog: www.thetimes.com/article/0653...
Reposted by Mill_lab
Get out your calendars! The motors are out of quarantine and we plan to assemble in person on 8th May 2026 at University of Warwick Campus for a fun day on motors and the filaments they walk along. Livestream is planned too. More details on registration, travel bursaries etc. will be revealed soon.
October 30, 2025 at 2:18 PM
Get out your calendars! The motors are out of quarantine and we plan to assemble in person on 8th May 2026 at University of Warwick Campus for a fun day on motors and the filaments they walk along. Livestream is planned too. More details on registration, travel bursaries etc. will be revealed soon.
Everything you wanted to know about #cilia & #signaling in one big beautiful poster format from field thought leaders @wachtenlab.bsky.social & @sorentc.bsky.social- from our just live @jcellsci.bsky.social Special Issue… 🤩🤩🤩
I’m excited to share this collaborative work with Prof. Dagmar Wachten (@wachtenlab.bsky.social), providing an accessible overview of primary cilia signalling and recent advances in cellular signaling in health and disease. Many thanks to Dagmar for a fantastic collaboration! doi.org/10.1242/jcs....
Primary cilia signalling at a glance
Summary: We explore the primary cilium as a master regulator of cellular communication that integrates diverse signalling pathways to guide development and maintain homeostasis. Its dysfunction trigge...
doi.org
October 30, 2025 at 1:11 PM
Everything you wanted to know about #cilia & #signaling in one big beautiful poster format from field thought leaders @wachtenlab.bsky.social & @sorentc.bsky.social- from our just live @jcellsci.bsky.social Special Issue… 🤩🤩🤩
Reposted by Mill_lab
Well reported story on the PBS News Hour about science cuts and the ongoing and potential brain drain.
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
Top researchers consider leaving U.S. amid funding cuts: 'The science world is ending'
YouTube video by PBS NewsHour
www.youtube.com
October 30, 2025 at 11:36 AM
Well reported story on the PBS News Hour about science cuts and the ongoing and potential brain drain.
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
Reposted by Mill_lab
Really excited to see this out in the open: www.life-science-alliance.org/content/9/1/...! @isabellavoelkl.bsky.social explored and compared different in vitro developmental model systems to study ciliogenesis.
In vitro approaches to study centriole and cilium function in early mouse embryogenesis
Although centrioles and primary cilia play an essential role in early mammalian development, their specific function during the interval between their initial formation and the subsequent arrest of em...
www.life-science-alliance.org
October 30, 2025 at 9:17 AM
Really excited to see this out in the open: www.life-science-alliance.org/content/9/1/...! @isabellavoelkl.bsky.social explored and compared different in vitro developmental model systems to study ciliogenesis.
Reposted by Mill_lab
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
October 29, 2025 at 5:11 PM
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...