Mill_lab
@cilialab.bsky.social
Group at MRC HGU using genetics, cell biology and lots of imaging to unlock the mysteries of mammalian #cilia. #cilia. #centrioles #cytoskeleton #RareDisease www.cilialab.co.uk
Just heading home from our @mrcmousenetwork.bsky.social MRC NMGN Science Meeting 2025 in York where our Congenital Anomalies Cluster shared updates on our clinical VUS & phenotyping pipelines at the podium! Great discussions! #FunctionalGenomics #RareDisease #CongenitalAnomalies
November 14, 2025 at 6:40 PM
Just heading home from our @mrcmousenetwork.bsky.social MRC NMGN Science Meeting 2025 in York where our Congenital Anomalies Cluster shared updates on our clinical VUS & phenotyping pipelines at the podium! Great discussions! #FunctionalGenomics #RareDisease #CongenitalAnomalies
With @jcellsci.bsky.social, we're 🥂 celebrating the Special Issue on Cilia & Flagella, guest edited by myself & @lottepedersen.bsky.social. We've handpicked 4 standout papers – research from our community, for our community – paired with 2 cutting-edge talks showcasing latest breakthroughs. /2
October 21, 2025 at 6:15 PM
With @jcellsci.bsky.social, we're 🥂 celebrating the Special Issue on Cilia & Flagella, guest edited by myself & @lottepedersen.bsky.social. We've handpicked 4 standout papers – research from our community, for our community – paired with 2 cutting-edge talks showcasing latest breakthroughs. /2
🎆 Join us for an unmissable finale to 2025! 🎆 We're thrilled to bring our #cilia & #centrosome community together 25/11/2025 15:00-17:45 GMT! Our 53rd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium schedule is live: www.eventbrite.co.uk/e/bscb-genso... /1
October 21, 2025 at 6:11 PM
🎆 Join us for an unmissable finale to 2025! 🎆 We're thrilled to bring our #cilia & #centrosome community together 25/11/2025 15:00-17:45 GMT! Our 53rd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium schedule is live: www.eventbrite.co.uk/e/bscb-genso... /1
This government's ambition? 50% of clinical decisions will be genomics-informed by 2035! 🧬 Harness the power of partnerships and openly share data. Patient voice MUST remain at the center. A coalition of the determined to shift not needles, but systems!
#RareDiseaseSummit2025 #RareDisease
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#RareDiseaseSummit2025 #RareDisease
/6
October 15, 2025 at 12:33 PM
This government's ambition? 50% of clinical decisions will be genomics-informed by 2035! 🧬 Harness the power of partnerships and openly share data. Patient voice MUST remain at the center. A coalition of the determined to shift not needles, but systems!
#RareDiseaseSummit2025 #RareDisease
/6
#RareDiseaseSummit2025 #RareDisease
/6
🏗️ Turn vision into action. Let's ensure our bold plans don't get buried in bureaucracy and printed in glossy documents...
💡 Despite the challenges, I left energized. Change feels possible—we're on the cusp of something transformative.
/5
💡 Despite the challenges, I left energized. Change feels possible—we're on the cusp of something transformative.
/5
October 15, 2025 at 12:33 PM
🏗️ Turn vision into action. Let's ensure our bold plans don't get buried in bureaucracy and printed in glossy documents...
💡 Despite the challenges, I left energized. Change feels possible—we're on the cusp of something transformative.
/5
💡 Despite the challenges, I left energized. Change feels possible—we're on the cusp of something transformative.
/5
🔨 Break down silos. We need to tackle data fragmentation to build a connected and resilient rare disease ecosystem.
🛣️ Revolutionary therapies need revolutionary regulatory routes. Who pays 💰 ? How do we create bespoke and novel paths to commercialization?
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🛣️ Revolutionary therapies need revolutionary regulatory routes. Who pays 💰 ? How do we create bespoke and novel paths to commercialization?
/4
October 15, 2025 at 12:33 PM
🔨 Break down silos. We need to tackle data fragmentation to build a connected and resilient rare disease ecosystem.
🛣️ Revolutionary therapies need revolutionary regulatory routes. Who pays 💰 ? How do we create bespoke and novel paths to commercialization?
/4
🛣️ Revolutionary therapies need revolutionary regulatory routes. Who pays 💰 ? How do we create bespoke and novel paths to commercialization?
/4
🫥 Make it routine. Genetic testing as standard as whole blood work in the NHS—& we need to tackle stigma around genetic disorders.
💪 "Nothing about us, without us." Patients must be active participants, not just subjects of our research. Their voices constantly challenge us to do better.
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💪 "Nothing about us, without us." Patients must be active participants, not just subjects of our research. Their voices constantly challenge us to do better.
/3
October 15, 2025 at 12:33 PM
🫥 Make it routine. Genetic testing as standard as whole blood work in the NHS—& we need to tackle stigma around genetic disorders.
💪 "Nothing about us, without us." Patients must be active participants, not just subjects of our research. Their voices constantly challenge us to do better.
/3
💪 "Nothing about us, without us." Patients must be active participants, not just subjects of our research. Their voices constantly challenge us to do better.
/3
⏳ The opportunity is NOW. The UK has huge potential to accelerate innovation and clinical trials if we "move fast and in different ways."
⚖️ Equity matters. How do we avoid a two-tiered system and ensure everyone has access to diagnosis & delivery?
/2
⚖️ Equity matters. How do we avoid a two-tiered system and ensure everyone has access to diagnosis & delivery?
/2
October 15, 2025 at 12:33 PM
⏳ The opportunity is NOW. The UK has huge potential to accelerate innovation and clinical trials if we "move fast and in different ways."
⚖️ Equity matters. How do we avoid a two-tiered system and ensure everyone has access to diagnosis & delivery?
/2
⚖️ Equity matters. How do we avoid a two-tiered system and ensure everyone has access to diagnosis & delivery?
/2
Organized by @alexionpharma.bsky.social & Harriet Holme PCD Research, this Rare Disease Summit: Transforming Diagnosis and Treatment yesterday @crick.ac.uk brought together diverse experts to tackle critical challenges: too few diagnosed, too slow, & too few therapies.
🔑 Key takeaways:
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🔑 Key takeaways:
/1
October 15, 2025 at 12:33 PM
Organized by @alexionpharma.bsky.social & Harriet Holme PCD Research, this Rare Disease Summit: Transforming Diagnosis and Treatment yesterday @crick.ac.uk brought together diverse experts to tackle critical challenges: too few diagnosed, too slow, & too few therapies.
🔑 Key takeaways:
/1
🔑 Key takeaways:
/1
Happy Canadian Thanksgiving to those who celebrate!! 20 years on I have finally managed to source key ingredients ahead of the American date… We are grateful for the people, the interactions & opportunities to move needles…
October 12, 2025 at 6:02 PM
Happy Canadian Thanksgiving to those who celebrate!! 20 years on I have finally managed to source key ingredients ahead of the American date… We are grateful for the people, the interactions & opportunities to move needles…
Incredibly powerful patient panel to counter narrative that PCD is mild- importance of advocacy for care for their own health in a system where PCD is under appreciated. Burden of airway clearance & toll of school, family & work. Trade-offs choice of nebs, commitments & health trade-offs. #OTM2025
August 20, 2025 at 7:57 PM
Incredibly powerful patient panel to counter narrative that PCD is mild- importance of advocacy for care for their own health in a system where PCD is under appreciated. Burden of airway clearance & toll of school, family & work. Trade-offs choice of nebs, commitments & health trade-offs. #OTM2025
PCD Foundation On The Move 2025 kicks off in Minneapolis. President Michele Manion welcomes an audience of 200! Exciting times ahead for #PrimaryCiliaryDyskinesia- registries, clinical trials and more! #OTM2025
August 20, 2025 at 5:23 PM
PCD Foundation On The Move 2025 kicks off in Minneapolis. President Michele Manion welcomes an audience of 200! Exciting times ahead for #PrimaryCiliaryDyskinesia- registries, clinical trials and more! #OTM2025
We wrap-up with our deep-dive panel discussion. #FanFavorite #UKCilia2025 /7
August 19, 2025 at 5:37 PM
We wrap-up with our deep-dive panel discussion. #FanFavorite #UKCilia2025 /7
We have a fabulous finish with @konjikusicmia.bsky.social (@reiterlab.bsky.social, UCSF) on #GPCRs, #signaling, and #hypogonadism in #BBS models across the hypothalamus-pituitary-gonad axes and its many ciliated cell types! #Ciliopathies? www.biorxiv.org/content/10.1... #UKCilia2025 /6
August 19, 2025 at 5:35 PM
We have a fabulous finish with @konjikusicmia.bsky.social (@reiterlab.bsky.social, UCSF) on #GPCRs, #signaling, and #hypogonadism in #BBS models across the hypothalamus-pituitary-gonad axes and its many ciliated cell types! #Ciliopathies? www.biorxiv.org/content/10.1... #UKCilia2025 /6
What do #DNADamageRepair, #CentrioleBiogenesis and #R-loops have in common- required for multiciliogenesis, where DNA damage scales with number of forming #centrioles! Masterclass talk Cayla Jewett (Pearson lab, Anschutz, UColorado). www.biorxiv.org/content/10.1... #UKCilia2025 /5
August 19, 2025 at 5:30 PM
What do #DNADamageRepair, #CentrioleBiogenesis and #R-loops have in common- required for multiciliogenesis, where DNA damage scales with number of forming #centrioles! Masterclass talk Cayla Jewett (Pearson lab, Anschutz, UColorado). www.biorxiv.org/content/10.1... #UKCilia2025 /5
CSF-flow and ependymal cilia in #MultipleSclerosis pathophysiology (ventricular enlargement & decreased flow) in human & mouse models of disease- intriguing talk by Maxime Bigotte (Stratton lab, McGill) from his recently pre-printed work www.biorxiv.org/content/10.1... #UKCilia2025 /4
August 19, 2025 at 5:23 PM
CSF-flow and ependymal cilia in #MultipleSclerosis pathophysiology (ventricular enlargement & decreased flow) in human & mouse models of disease- intriguing talk by Maxime Bigotte (Stratton lab, McGill) from his recently pre-printed work www.biorxiv.org/content/10.1... #UKCilia2025 /4
Soon to be #NewPI Yinwen Liang (Joyner lab, MSKCC) on informatics approach to find novel transcriptional regulators of #ciliogenesis- SP5 and SP8 specificity protein TFs drive expression of core ciliary machinery in primary & motile cilia! www.biorxiv.org/content/10.1... #UKCilia2025 /3
August 19, 2025 at 5:18 PM
Soon to be #NewPI Yinwen Liang (Joyner lab, MSKCC) on informatics approach to find novel transcriptional regulators of #ciliogenesis- SP5 and SP8 specificity protein TFs drive expression of core ciliary machinery in primary & motile cilia! www.biorxiv.org/content/10.1... #UKCilia2025 /3
Next new Dr Poulomi Das (Lechtreck lab UGA) marvels with mysterious mastigonemes in Chlamy and subcomplexes involved in targeting PKD2 channels to ciliary subdomains. 🧪 #UKCilia2025 /2
August 19, 2025 at 5:15 PM
Next new Dr Poulomi Das (Lechtreck lab UGA) marvels with mysterious mastigonemes in Chlamy and subcomplexes involved in targeting PKD2 channels to ciliary subdomains. 🧪 #UKCilia2025 /2
Our 52nd BSCB GenSoc UK Cilia and Centrosome e-symposium kicks off with a spectacular #super-resolution showcase on how RPGR variants affect #multiciliogenesis & cilia motility to cause #PCD or #IRDs via #actin dynamics! Zhen Liu wows- ICYMI: www.biorxiv.org/content/10.1... #UKCilia2025 /1
August 19, 2025 at 5:11 PM
Our 52nd BSCB GenSoc UK Cilia and Centrosome e-symposium kicks off with a spectacular #super-resolution showcase on how RPGR variants affect #multiciliogenesis & cilia motility to cause #PCD or #IRDs via #actin dynamics! Zhen Liu wows- ICYMI: www.biorxiv.org/content/10.1... #UKCilia2025 /1
Sometimes life just aligns…
August 2, 2025 at 6:45 PM
Sometimes life just aligns…
We have something for everyone- CSF flow & #neurodegeneration, ciliary trafficking of PKD2 complexes, cilia & #actin dynamics, #DNADamageResponse & multiciliation, cilia & pituitary development & transcriptional control of ciliogenesis... Great breaking science & rising talent to be showcased...🧪
July 29, 2025 at 10:17 AM
We have something for everyone- CSF flow & #neurodegeneration, ciliary trafficking of PKD2 complexes, cilia & #actin dynamics, #DNADamageResponse & multiciliation, cilia & pituitary development & transcriptional control of ciliogenesis... Great breaking science & rising talent to be showcased...🧪
Second a #SeniorResearchSpecialist position developing human iPSCs to incorporate the human genetic context into disease modelling for rare respiratory diseases. 🧪🧪Info here: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
📅 New deadline closes 14 July 2025 (11:59pm GMT) 📅 3/4
📅 New deadline closes 14 July 2025 (11:59pm GMT) 📅 3/4
July 7, 2025 at 2:53 PM
Second a #SeniorResearchSpecialist position developing human iPSCs to incorporate the human genetic context into disease modelling for rare respiratory diseases. 🧪🧪Info here: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
📅 New deadline closes 14 July 2025 (11:59pm GMT) 📅 3/4
📅 New deadline closes 14 July 2025 (11:59pm GMT) 📅 3/4
First a #PostDoc position responsible for developing #GenomeSurgery approaches to correct patient-modelled variants in cell-based and in vivo animal models. 🧪🧪 Info here: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
📅 New deadline closes 14 July 2025 (11:59pm GMT) 📅 2/4
📅 New deadline closes 14 July 2025 (11:59pm GMT) 📅 2/4
July 7, 2025 at 2:52 PM
First a #PostDoc position responsible for developing #GenomeSurgery approaches to correct patient-modelled variants in cell-based and in vivo animal models. 🧪🧪 Info here: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
📅 New deadline closes 14 July 2025 (11:59pm GMT) 📅 2/4
📅 New deadline closes 14 July 2025 (11:59pm GMT) 📅 2/4
📣 Cilia Lab is growing 📣 - we have 2️⃣ open positions at @uoe-igc.bsky.social @edinburgh-uni.bsky.social for talented and motivated researchers interested in disease modelling & genetic therapies which target #RareRespiratoryDiseases at their root cause. 🧪🧪#ciliopathies #PrimaryCiliaryDyskinesia 1/4
July 7, 2025 at 2:44 PM
📣 Cilia Lab is growing 📣 - we have 2️⃣ open positions at @uoe-igc.bsky.social @edinburgh-uni.bsky.social for talented and motivated researchers interested in disease modelling & genetic therapies which target #RareRespiratoryDiseases at their root cause. 🧪🧪#ciliopathies #PrimaryCiliaryDyskinesia 1/4
Happy Canada Day 🇨🇦 to those who celebrate- we did beignettes a la Tim Horton for breakfast, and big BBQ this evening after a bodysurfing session. #ElbowsOut identity worth fighting for…
July 1, 2025 at 7:43 PM
Happy Canada Day 🇨🇦 to those who celebrate- we did beignettes a la Tim Horton for breakfast, and big BBQ this evening after a bodysurfing session. #ElbowsOut identity worth fighting for…