Brian Glancy
@brianglancylab.bsky.social
We study how muscles are built to sustain power with a focus on mitochondrial energy metabolism.
Reposted by Brian Glancy
If so, you might want to read our new preprint on @biorxivpreprint.bsky.social! We repeated this experiment (acute exercise in untrained and trained mice, analyzed at different time points, comparison of untrained and trained at rest) on the single nucleus level.
2/3
doi.org/10.1101/2025...
2/3
doi.org/10.1101/2025...
Muscle Fiber- and Cell Type-Specificity of Training Adaptation in Male Mice
Skeletal muscle possesses extraordinary plasticity of structure, metabolism, and function in response to repeated contractile activity. As a syncytium embedded within a complex microenvironment, muscl...
doi.org
November 14, 2025 at 2:34 PM
If so, you might want to read our new preprint on @biorxivpreprint.bsky.social! We repeated this experiment (acute exercise in untrained and trained mice, analyzed at different time points, comparison of untrained and trained at rest) on the single nucleus level.
2/3
doi.org/10.1101/2025...
2/3
doi.org/10.1101/2025...
Reposted by Brian Glancy
📰🧵📰 REGISTRATION ANNOUNCEMENT!! 💻🧵💻
1/ #IBEC2026 Conference dates are from June 1-3 in #RoanokeVA. Early registration will open January 1, 2026. Early registration/ eligibility for awards through March 1. Preliminary schedule available here: t.co/D2buRVHKGb
1/ #IBEC2026 Conference dates are from June 1-3 in #RoanokeVA. Early registration will open January 1, 2026. Early registration/ eligibility for awards through March 1. Preliminary schedule available here: t.co/D2buRVHKGb
https://fbri.vtc.vt.edu/research/research-centers/center-for-exercise-medicine-research/IBEC-2026/conference-schedule.html
t.co
November 3, 2025 at 4:34 PM
📰🧵📰 REGISTRATION ANNOUNCEMENT!! 💻🧵💻
1/ #IBEC2026 Conference dates are from June 1-3 in #RoanokeVA. Early registration will open January 1, 2026. Early registration/ eligibility for awards through March 1. Preliminary schedule available here: t.co/D2buRVHKGb
1/ #IBEC2026 Conference dates are from June 1-3 in #RoanokeVA. Early registration will open January 1, 2026. Early registration/ eligibility for awards through March 1. Preliminary schedule available here: t.co/D2buRVHKGb
Reposted by Brian Glancy
Some interesting data from postdoc Nate Serrano: “Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle” www.biorxiv.org/content/10.1...
Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle
Non-peripheral myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to the activity o...
www.biorxiv.org
October 12, 2025 at 11:50 AM
Some interesting data from postdoc Nate Serrano: “Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle” www.biorxiv.org/content/10.1...
Reposted by Brian Glancy
Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice)
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Paternal exercise confers endurance capacity to offspring through sperm microRNAs
Yin et al. show that paternal exercise improves offspring endurance capacity and metabolic
health via sperm microRNAs that reprogram gene expression in early embryos, revealing
how exercise benefits c...
www.cell.com
October 6, 2025 at 3:17 PM
Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice)
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Reposted by Brian Glancy
We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere
14 postdoctoral fellowships to the BRIDGE – Translational Excellence Programme
employment.ku.dk
September 29, 2025 at 11:11 AM
We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere
Reposted by Brian Glancy
Our new preprint!
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.
🧵 Thread below…
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.
🧵 Thread below…
Mitochondrial cristae density is increased following high-intensity interval training in patients with type 2 diabetes
Aims/hypothesis: Mitochondrial cristae architecture is a key determinant of oxidative capacity in skeletal muscle. While mitochondrial dysfunction is common in type 2 diabetes, it remains unclear whet...
www.biorxiv.org
September 30, 2025 at 2:00 PM
Our new preprint!
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.
🧵 Thread below…
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.
🧵 Thread below…
Reposted by Brian Glancy
Title: Professor in Exercise and Sport Science or Exercise Physiology
📍Place: @newcastle 🇦🇺
💰Salary: $222,734 plus 17% superannuation plus annual leave loading
📅Deadline: 12/10/25
ℹ For more details👇 www.livehire.com/careers/univ...
📍Place: @newcastle 🇦🇺
💰Salary: $222,734 plus 17% superannuation plus annual leave loading
📅Deadline: 12/10/25
ℹ For more details👇 www.livehire.com/careers/univ...
Professor in Exercise and Sport Science or Exercise Physiology - University of Newcastle
FullTimePermanent • Callaghan, NSW 2308 • Salary: $222,734 plus 17% superannuation plus annual leave loading Position: Full-time, Continuing Location: Callaghan Campus, Newcastle, NSW Australia About ...
www.livehire.com
September 26, 2025 at 4:12 AM
Title: Professor in Exercise and Sport Science or Exercise Physiology
📍Place: @newcastle 🇦🇺
💰Salary: $222,734 plus 17% superannuation plus annual leave loading
📅Deadline: 12/10/25
ℹ For more details👇 www.livehire.com/careers/univ...
📍Place: @newcastle 🇦🇺
💰Salary: $222,734 plus 17% superannuation plus annual leave loading
📅Deadline: 12/10/25
ℹ For more details👇 www.livehire.com/careers/univ...
Reposted by Brian Glancy
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London
www.kcl.ac.uk
September 25, 2025 at 5:01 PM
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Reposted by Brian Glancy
Kinesiology and Applied Physiology at UD is hiring a biomechanist! We invite applications for a tenure-track assistant professor position with a preferred research focus in musuloskeletal modeling.
careers.udel.edu/cw/en-us/job...
careers.udel.edu/cw/en-us/job...
University of Delaware - Details - Kinesiology and Applied Physiology, Tenure-Track Assistant Professor
careers.udel.edu
September 23, 2025 at 1:50 PM
Kinesiology and Applied Physiology at UD is hiring a biomechanist! We invite applications for a tenure-track assistant professor position with a preferred research focus in musuloskeletal modeling.
careers.udel.edu/cw/en-us/job...
careers.udel.edu/cw/en-us/job...
Reposted by Brian Glancy
Mechanical Loading Induces the Longitudinal Growth of Muscle Fibers via an mTORC1-Independent Mechanism https://www.biorxiv.org/content/10.1101/2025.09.19.676647v1
September 21, 2025 at 10:02 AM
Mechanical Loading Induces the Longitudinal Growth of Muscle Fibers via an mTORC1-Independent Mechanism https://www.biorxiv.org/content/10.1101/2025.09.19.676647v1
Reposted by Brian Glancy
One nice thing about working with muscles and myofibrils is that biophysicists love them, and so we collaborate with them. Here, Danielle Tokarz's group at @smuhalifax.bsky.social used polarization second-harmonic generation microscopy in single fibrils opg.optica.org/boe/fulltext...
opg.optica.org
September 18, 2025 at 3:27 PM
One nice thing about working with muscles and myofibrils is that biophysicists love them, and so we collaborate with them. Here, Danielle Tokarz's group at @smuhalifax.bsky.social used polarization second-harmonic generation microscopy in single fibrils opg.optica.org/boe/fulltext...
Reposted by Brian Glancy
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
www.nature.com
September 15, 2025 at 6:03 PM
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Reposted by Brian Glancy
We are hiring! The University of Illinois Urbana-Champaign Department of Cell and Developmental Biology is hiring a faculty member in the area of Aging, broadly defined. Come join us! Deadline is soon! www.nature.com/naturecareer...
Assistant or Associate Professor - Urbana, Illinois job with University of Illinois, School of Molecular and Cellular Biology | 12843703
Tenure-track Assistant or Associate Professor Department of Cell and Developmental Biology School of Molecular and Cellular Biology University of I...
www.nature.com
September 15, 2025 at 2:31 PM
We are hiring! The University of Illinois Urbana-Champaign Department of Cell and Developmental Biology is hiring a faculty member in the area of Aging, broadly defined. Come join us! Deadline is soon! www.nature.com/naturecareer...
Reposted by Brian Glancy
Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice. A fun collaboration! onlinelibrary.wiley.com/doi/10.1111/...
Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice
Resident stem cells from aged planaria and murine skeletal muscle possess some inherent abilities to mitigate signs of aging after tissue regeneration.
onlinelibrary.wiley.com
September 15, 2025 at 2:21 AM
Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice. A fun collaboration! onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Brian Glancy
My MCDB dept is accepting applications for a faculty position at the Assistant Professor level!
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
MCDB Opens Search for Faculty | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB)
MCDB welcomes applications at the Assistant Professor level from outstanding biological scientists in all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal le...
lsa.umich.edu
August 26, 2025 at 1:29 PM
My MCDB dept is accepting applications for a faculty position at the Assistant Professor level!
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
Reposted by Brian Glancy
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share!
@uofunuip.bsky.social
@uofunuip.bsky.social
Open Rank, Tenure Track Position – Metabolic Physiology - Salt Lake City, Utah job with University of Utah, Department of Nutrition & Integrative Physiology | 12844064
The Department of Nutrition and Integrated Physiology (NUIP) at the University of Utah seeks a Tenure Track faculty member at the rank of Assistant...
www.nature.com
August 27, 2025 at 11:05 PM
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share!
@uofunuip.bsky.social
@uofunuip.bsky.social
Reposted by Brian Glancy
Check out this cool preprint led by @ccstorytime.bsky.social with snRNAseq data on 60,000 nuclei from human muscle-tendon tissue 4 h after exercise
@myoblue.bsky.social
@myoblue.bsky.social
BSMB Autumn meeting Surrey talking about our latest work. Very proud of Team Tendon & collaborators for persevering with such a difficult tissue 👏
www.biorxiv.org/content/10.1...
@ismcopenhagen.bsky.social @steffendanielle.bsky.social @valerioizzi.bsky.social @abigailmackey1.bsky.social
www.biorxiv.org/content/10.1...
@ismcopenhagen.bsky.social @steffendanielle.bsky.social @valerioizzi.bsky.social @abigailmackey1.bsky.social
September 3, 2025 at 4:40 AM
Check out this cool preprint led by @ccstorytime.bsky.social with snRNAseq data on 60,000 nuclei from human muscle-tendon tissue 4 h after exercise
@myoblue.bsky.social
@myoblue.bsky.social
Reposted by Brian Glancy
I'm happy to share new work in collaboration with Elena Koslover's lab! First author Keaton developed a mathematical framework for diffusion of soluble material through mitochondrial networks. Then, Lewis lab PhD candidate Camryn used live cell imaging to parameterize... 1/3
August 29, 2025 at 2:33 PM
I'm happy to share new work in collaboration with Elena Koslover's lab! First author Keaton developed a mathematical framework for diffusion of soluble material through mitochondrial networks. Then, Lewis lab PhD candidate Camryn used live cell imaging to parameterize... 1/3
Reposted by Brian Glancy
Please repost!
We have an open rank, tenure-line faculty position in biomechanics in the School of Kinesiology at the University of Michigan Ann Arbor. At U-M we have great colleagues, exceptional resources, and biomechanics can be found all across the campus. #BiomechSky
We have an open rank, tenure-line faculty position in biomechanics in the School of Kinesiology at the University of Michigan Ann Arbor. At U-M we have great colleagues, exceptional resources, and biomechanics can be found all across the campus. #BiomechSky
Tenure-track Faculty Position in Biomechanics (Open Rank), University of Michigan, Ann Arbor, MI, USA -
Biomch-L
The School of Kinesiology (http://kines.umich.edu) at the University of Michigan invites applications and nominations for a tenure-track faculty position at the level of Assistant Professor, Associate...
biomch-l.isbweb.org
August 28, 2025 at 9:44 PM
Please repost!
We have an open rank, tenure-line faculty position in biomechanics in the School of Kinesiology at the University of Michigan Ann Arbor. At U-M we have great colleagues, exceptional resources, and biomechanics can be found all across the campus. #BiomechSky
We have an open rank, tenure-line faculty position in biomechanics in the School of Kinesiology at the University of Michigan Ann Arbor. At U-M we have great colleagues, exceptional resources, and biomechanics can be found all across the campus. #BiomechSky
Reposted by Brian Glancy
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.
Descriptions and links in the following two posts.
Descriptions and links in the following two posts.
August 28, 2025 at 8:47 PM
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.
Descriptions and links in the following two posts.
Descriptions and links in the following two posts.
Reposted by Brian Glancy
🚀New preprint w/ @roberto_amv: We used chemogenetics to precisely control mitochondrial H2O2 in skeletal muscle in vivo. This exposes a dose-dependent sequence: translation suppression → proteolysis → denervation-like → degeneration @tejensen23 www.biorxiv.org/content/10.1...
August 28, 2025 at 2:13 PM
🚀New preprint w/ @roberto_amv: We used chemogenetics to precisely control mitochondrial H2O2 in skeletal muscle in vivo. This exposes a dose-dependent sequence: translation suppression → proteolysis → denervation-like → degeneration @tejensen23 www.biorxiv.org/content/10.1...
Reposted by Brian Glancy
Our department is recruiting a new tenure track Assistant/Associate Professor. Come join the #1 physiology department in the country and some awesome colleagues doing high impact science and training the next generation of scientists
jobs.sciencecareers.org/job/674815/a...
jobs.sciencecareers.org/job/674815/a...
Assistant/Associate Professor - Tenure Track - Physiology - University of Michigan, Ann Arbor job with University of Michigan Department of Molecular & Integrative Physiology | 674815
Tenure track assistant/associate professor in the Department of Molecular & Integrative Physiology at the University of Michigan Medical School.
jobs.sciencecareers.org
August 28, 2025 at 3:35 PM
Our department is recruiting a new tenure track Assistant/Associate Professor. Come join the #1 physiology department in the country and some awesome colleagues doing high impact science and training the next generation of scientists
jobs.sciencecareers.org/job/674815/a...
jobs.sciencecareers.org/job/674815/a...
Reposted by Brian Glancy
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
August 28, 2025 at 6:34 AM
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
Reposted by Brian Glancy
I read the preprint. It's very beautiful work from Hadi Boukhatmi's group. They test how if at all #Drosophila can repair their #muscles.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Immune–tracheal intercellular signalling coordinates the muscle injury response in Drosophila
Effective tissue adaptation to damage requires precise coordination among diverse cell types. In skeletal muscle, injury-responsive cells play a pivotal role in repair, yet the molecular and cellular ...
www.biorxiv.org
August 27, 2025 at 5:41 PM
I read the preprint. It's very beautiful work from Hadi Boukhatmi's group. They test how if at all #Drosophila can repair their #muscles.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Brian Glancy
New preprint! N-acetylcarnosine treatment shows an astonishing efficacy to improve age-associated survival by 50% at 24 months of age in female mice. Organ functions preserved primarily in heart, vasculature, muscle & bone. A huge team work led by Edwin who is on the job market this year.
N-acetylcarnosine attenuates age-associated declines in multi-organ systems to improve survival
Histidine containing dipeptides (HCDs) such as N-acetylcarnosine are endogenous metabolites that are ergogenic and mitigate metabolic dysfunction. We previously demonstrated that short-term N-acetylca...
doi.org
August 22, 2025 at 4:15 PM
New preprint! N-acetylcarnosine treatment shows an astonishing efficacy to improve age-associated survival by 50% at 24 months of age in female mice. Organ functions preserved primarily in heart, vasculature, muscle & bone. A huge team work led by Edwin who is on the job market this year.