Joachim Nielsen
@joachimnielsen.bsky.social
Associate Professor in Muscle Physiology and Metabolism. University of Southern Denmark.
Pinned
Mitochondrial cristae density is increased following high-intensity interval training in patients with type 2 diabetes
Aims/hypothesis: Mitochondrial cristae architecture is a key determinant of oxidative capacity in skeletal muscle. While mitochondrial dysfunction is common in type 2 diabetes, it remains unclear whet...
www.biorxiv.org
Our new preprint!
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.
🧵 Thread below…
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.
🧵 Thread below…
Reposted by Joachim Nielsen
First post on Blue Sky
New pre-print!
Does muscle remember disuse muscle wasting?
Our new study shows skeletal muscle retains a molecular memory of disuse!
Young muscle shows transcriptional resilience to repeated atrophy.
Aged muscle shows exaggerated susceptibility.
doi.org/10.1101/2025...
New pre-print!
Does muscle remember disuse muscle wasting?
Our new study shows skeletal muscle retains a molecular memory of disuse!
Young muscle shows transcriptional resilience to repeated atrophy.
Aged muscle shows exaggerated susceptibility.
doi.org/10.1101/2025...
October 31, 2025 at 4:34 PM
First post on Blue Sky
New pre-print!
Does muscle remember disuse muscle wasting?
Our new study shows skeletal muscle retains a molecular memory of disuse!
Young muscle shows transcriptional resilience to repeated atrophy.
Aged muscle shows exaggerated susceptibility.
doi.org/10.1101/2025...
New pre-print!
Does muscle remember disuse muscle wasting?
Our new study shows skeletal muscle retains a molecular memory of disuse!
Young muscle shows transcriptional resilience to repeated atrophy.
Aged muscle shows exaggerated susceptibility.
doi.org/10.1101/2025...
Reposted by Joachim Nielsen
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
openrxiv.org
November 6, 2025 at 2:32 PM
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Reposted by Joachim Nielsen
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
Reposted by Joachim Nielsen
Hopefully of interest to scientists and exercise practitioners with and interest in muscle mass and functional gains in human volunteers. doi.org/10.1113/JP28...
@jphysiol.bsky.social
@jphysiol.bsky.social
NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training-induced changes in muscle morphology, function and gene networks relative to placebo ingestion...
doi.org
October 27, 2025 at 2:10 PM
Hopefully of interest to scientists and exercise practitioners with and interest in muscle mass and functional gains in human volunteers. doi.org/10.1113/JP28...
@jphysiol.bsky.social
@jphysiol.bsky.social
Reposted by Joachim Nielsen
This article is a homecoming for me.
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
Principles of protein abundance regulation across single cells in a mammalian tissue
Protein synthesis and clearance are major regulatory steps of gene expression, but their in vivo regulatory roles across the cells comprising complex tissues remains unexplored. Here, we systematicall...
www.biorxiv.org
October 18, 2025 at 11:56 AM
This article is a homecoming for me.
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.
Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.
www.biorxiv.org/content/10.1...
Reposted by Joachim Nielsen
Is Human Energy Expenditure Constrained? I recently debated Herman Pontzer on this topic in Shenzhen, China.
My slides can be viewed here:
www.linkedin.com/posts/javier...
My slides can be viewed here:
www.linkedin.com/posts/javier...
RACMEM Debate: Is Human Energy Expenditure Constrained? | Javier Gonzalez
Is human energy expenditure constrained?
This hypothesis was proposed by Herman Pontzer, and has received widespread interest with coverage from mainstream media, podcasts, and even the RI Christmas ...
www.linkedin.com
October 19, 2025 at 12:13 PM
Is Human Energy Expenditure Constrained? I recently debated Herman Pontzer on this topic in Shenzhen, China.
My slides can be viewed here:
www.linkedin.com/posts/javier...
My slides can be viewed here:
www.linkedin.com/posts/javier...
Reposted by Joachim Nielsen
Manuscript now accepted! 🥳 @steffendanielle.bsky.social @valerioizzi.bsky.social @abigailmackey1.bsky.social @ismcopenhagen.bsky.social
Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit
Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit
October 15, 2025 at 3:59 PM
Manuscript now accepted! 🥳 @steffendanielle.bsky.social @valerioizzi.bsky.social @abigailmackey1.bsky.social @ismcopenhagen.bsky.social
Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit
Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit
The Expanding Clinical and Genetic Spectrum of Muscle Glycogen Storage Disease 0, (GSD0B) - Donoghue - 2025 - American Journal of Medical Genetics Part A - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
The Expanding Clinical and Genetic Spectrum of Muscle Glycogen Storage Disease 0, (GSD0B)
Glycogen storage disorders are a group of genetic disorders affecting glucose homeostasis in the body. Muscular glycogen stores are essential for liberating glucose for energy supply during bursts of...
onlinelibrary.wiley.com
October 12, 2025 at 7:09 PM
The Expanding Clinical and Genetic Spectrum of Muscle Glycogen Storage Disease 0, (GSD0B) - Donoghue - 2025 - American Journal of Medical Genetics Part A - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Joachim Nielsen
New #scisignal paper: Phosphorylation of RYR1 at Ser2902 decreases Ca2+ leak in skeletal muscle and susceptibility to malignant hyperthermia and heat stroke. #Myoblue tinyurl.com/bddss3j6
Phosphorylation of RYR1 at Ser2902 decreases Ca2+ leak in skeletal muscle and susceptibility to malignant hyperthermia and heat stroke
Reducing Ca2+ leak through mutant RYR1 prevents pathological heat production in skeletal muscle.
tinyurl.com
October 7, 2025 at 6:53 PM
New #scisignal paper: Phosphorylation of RYR1 at Ser2902 decreases Ca2+ leak in skeletal muscle and susceptibility to malignant hyperthermia and heat stroke. #Myoblue tinyurl.com/bddss3j6
Reposted by Joachim Nielsen
Excited to share that our paper on mitochondrial cardiolipin dynamics is published in @natcomms.nature.com today! We provide molecular explanations for unique aspects of mitochondrial morphology and the mechanisms underlying cardiolipin-related Barth Syndrome.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1 - Nature Communications
This study reveals how cardiolipin governs mitochondrial morphology by modulating the activity of human OPA1 and how its replacement by monolyso-cardiolipin, as observed in Barth syndrome, impacts mitochondrial membrane-shaping mechanisms.
www.nature.com
September 30, 2025 at 8:09 PM
Excited to share that our paper on mitochondrial cardiolipin dynamics is published in @natcomms.nature.com today! We provide molecular explanations for unique aspects of mitochondrial morphology and the mechanisms underlying cardiolipin-related Barth Syndrome.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our new preprint!
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.
🧵 Thread below…
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.
🧵 Thread below…
Mitochondrial cristae density is increased following high-intensity interval training in patients with type 2 diabetes
Aims/hypothesis: Mitochondrial cristae architecture is a key determinant of oxidative capacity in skeletal muscle. While mitochondrial dysfunction is common in type 2 diabetes, it remains unclear whet...
www.biorxiv.org
September 30, 2025 at 2:00 PM
Our new preprint!
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.
🧵 Thread below…
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.
🧵 Thread below…
Reposted by Joachim Nielsen
Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle
Objective: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical mod...
www.biorxiv.org
September 30, 2025 at 10:42 AM
Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Joachim Nielsen
Does biological sex impact the rate of intrinsic mitochondrial respiration in the presence of creatine in human skeletal muscle? Emily J. Ferguson (@queensuresearch.bsky.social) et al. investigate!
📜 buff.ly/46B6lzL
📜 buff.ly/46B6lzL
September 26, 2025 at 2:12 PM
Does biological sex impact the rate of intrinsic mitochondrial respiration in the presence of creatine in human skeletal muscle? Emily J. Ferguson (@queensuresearch.bsky.social) et al. investigate!
📜 buff.ly/46B6lzL
📜 buff.ly/46B6lzL
Reposted by Joachim Nielsen
Mechanical Loading Induces the Longitudinal Growth of Muscle Fibers via an mTORC1-Independent Mechanism https://www.biorxiv.org/content/10.1101/2025.09.19.676647v1
September 21, 2025 at 10:02 AM
Mechanical Loading Induces the Longitudinal Growth of Muscle Fibers via an mTORC1-Independent Mechanism https://www.biorxiv.org/content/10.1101/2025.09.19.676647v1
Divergent Changes in Peak Fat Oxidation and Fatmax Following 3-Day Dietary Interventions Are Related to Muscle Glycogen Availability in Men
by Tarry, Vestergaard, Petersen, Olsen, Ingersen, Connor, Pilegaard, Dela, Larsen, Shaw, and Helge
onlinelibrary.wiley.com/share/CDCGW2...
by Tarry, Vestergaard, Petersen, Olsen, Ingersen, Connor, Pilegaard, Dela, Larsen, Shaw, and Helge
onlinelibrary.wiley.com/share/CDCGW2...
Divergent Changes in Peak Fat Oxidation and Fatmax Following 3‐Day Dietary Interventions Are Related to Muscle Glycogen Availability in Men
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onlinelibrary.wiley.com
September 10, 2025 at 12:32 PM
Divergent Changes in Peak Fat Oxidation and Fatmax Following 3-Day Dietary Interventions Are Related to Muscle Glycogen Availability in Men
by Tarry, Vestergaard, Petersen, Olsen, Ingersen, Connor, Pilegaard, Dela, Larsen, Shaw, and Helge
onlinelibrary.wiley.com/share/CDCGW2...
by Tarry, Vestergaard, Petersen, Olsen, Ingersen, Connor, Pilegaard, Dela, Larsen, Shaw, and Helge
onlinelibrary.wiley.com/share/CDCGW2...
Reposted by Joachim Nielsen
Sarcopenia is accelerated loss of skeletal muscle mass and function commonly, but not exclusively, associated with advancing age. It is observed across many species including humans in whom it can lead to decline in physical function and mobility. https://www.nature.c...
September 6, 2025 at 6:37 AM
Sarcopenia is accelerated loss of skeletal muscle mass and function commonly, but not exclusively, associated with advancing age. It is observed across many species including humans in whom it can lead to decline in physical function and mobility. https://www.nature.c...
Reposted by Joachim Nielsen
Congrats to Steffen Raun, Lykke Sylow and Team for their new Redox Biology paper, "Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis", that included the CMR's Prof Paul Gregorevic
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis
Long-term exercise training elicits tremendous health benefits; however, the molecular understanding is incomplete and identifying therapeutic targets…
www.sciencedirect.com
August 30, 2025 at 5:58 AM
Congrats to Steffen Raun, Lykke Sylow and Team for their new Redox Biology paper, "Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis", that included the CMR's Prof Paul Gregorevic
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Joachim Nielsen
🚨 The last paper of my PhD is out in @MSSE
Regular Long Runs and Higher Training Volumes are Associated with Better Running Economy Durability in Performance Matched Well-Trained Male Runners
🙏🏻 Rich Blagrove & Jonathan Folland
Temporary free download.
🔗 journals.lww.com/acsm-msse/ab...
🧵 1/7
Regular Long Runs and Higher Training Volumes are Associated with Better Running Economy Durability in Performance Matched Well-Trained Male Runners
🙏🏻 Rich Blagrove & Jonathan Folland
Temporary free download.
🔗 journals.lww.com/acsm-msse/ab...
🧵 1/7
August 29, 2025 at 5:21 PM
🚨 The last paper of my PhD is out in @MSSE
Regular Long Runs and Higher Training Volumes are Associated with Better Running Economy Durability in Performance Matched Well-Trained Male Runners
🙏🏻 Rich Blagrove & Jonathan Folland
Temporary free download.
🔗 journals.lww.com/acsm-msse/ab...
🧵 1/7
Regular Long Runs and Higher Training Volumes are Associated with Better Running Economy Durability in Performance Matched Well-Trained Male Runners
🙏🏻 Rich Blagrove & Jonathan Folland
Temporary free download.
🔗 journals.lww.com/acsm-msse/ab...
🧵 1/7
Elegant study on glycogen using the one-legged exercise model:
Exercise- and diet-induced glycogen depletion impairs performance during one-legged constant-load, high-intensity exercise in humans
Thomassen, McKenna, Olmedillas, Wyckelsma, Bangsbo, Nordsborg
www.frontiersin.org/journals/phy...
Exercise- and diet-induced glycogen depletion impairs performance during one-legged constant-load, high-intensity exercise in humans
Thomassen, McKenna, Olmedillas, Wyckelsma, Bangsbo, Nordsborg
www.frontiersin.org/journals/phy...
August 24, 2025 at 8:47 AM
Elegant study on glycogen using the one-legged exercise model:
Exercise- and diet-induced glycogen depletion impairs performance during one-legged constant-load, high-intensity exercise in humans
Thomassen, McKenna, Olmedillas, Wyckelsma, Bangsbo, Nordsborg
www.frontiersin.org/journals/phy...
Exercise- and diet-induced glycogen depletion impairs performance during one-legged constant-load, high-intensity exercise in humans
Thomassen, McKenna, Olmedillas, Wyckelsma, Bangsbo, Nordsborg
www.frontiersin.org/journals/phy...
Reposted by Joachim Nielsen
Congratulations to Researcher @itsmedipsikha.bsky.social for being one of the recipients of the EFSD/Lilly Young Investigator Awards! We celebrated her achievement with some cakes and bubbles earlier 🥳 @easdnews.bsky.social @cbmr.science
www.europeandiabetesfoundation.org/recipients/e...
www.europeandiabetesfoundation.org/recipients/e...
August 21, 2025 at 2:28 PM
Congratulations to Researcher @itsmedipsikha.bsky.social for being one of the recipients of the EFSD/Lilly Young Investigator Awards! We celebrated her achievement with some cakes and bubbles earlier 🥳 @easdnews.bsky.social @cbmr.science
www.europeandiabetesfoundation.org/recipients/e...
www.europeandiabetesfoundation.org/recipients/e...
Join our PhD course in metabolism and EC coupling.
November 10-15. University of Southern Denmark.
Enrol here: www.sdu.dk/en/forskning...
November 10-15. University of Southern Denmark.
Enrol here: www.sdu.dk/en/forskning...
August 13, 2025 at 6:14 PM
Join our PhD course in metabolism and EC coupling.
November 10-15. University of Southern Denmark.
Enrol here: www.sdu.dk/en/forskning...
November 10-15. University of Southern Denmark.
Enrol here: www.sdu.dk/en/forskning...
Reposted by Joachim Nielsen
New paper!
Do ketone esters affect post-exercise recovery?
doi.org/10.1007/s003...
#ketones #exercise #sports #nutrition #recovery
Do ketone esters affect post-exercise recovery?
doi.org/10.1007/s003...
#ketones #exercise #sports #nutrition #recovery
August 12, 2025 at 5:26 PM
New paper!
Do ketone esters affect post-exercise recovery?
doi.org/10.1007/s003...
#ketones #exercise #sports #nutrition #recovery
Do ketone esters affect post-exercise recovery?
doi.org/10.1007/s003...
#ketones #exercise #sports #nutrition #recovery
Reposted by Joachim Nielsen
“Muscle memory theory: A critical evaluation” in @JPhysiol led by postdoc Nate Serrano physoc.onlinelibrary.wiley.com/doi/10.1113/...
Muscle memory theory: A critical evaluation
Click on the article title to read more.
physoc.onlinelibrary.wiley.com
August 6, 2025 at 6:35 PM
“Muscle memory theory: A critical evaluation” in @JPhysiol led by postdoc Nate Serrano physoc.onlinelibrary.wiley.com/doi/10.1113/...