Robert Seaborne
@robertseaborne.bsky.social
Lecturer at King’s College London. Co-affiliate positions at The University of Copenhagen and The Blizard Institute London
Recruiting a comp PDRA for the lab 🚨
Working on multiple projects using integrated multi omics in bulk & single cell level
Passion for data, coding, bioinformatics & keen to lead our labs comp workflow
12 months in first instance but extendable for further 19 months
my.corehr.com/pls/coreport...
Working on multiple projects using integrated multi omics in bulk & single cell level
Passion for data, coding, bioinformatics & keen to lead our labs comp workflow
12 months in first instance but extendable for further 19 months
my.corehr.com/pls/coreport...
my.corehr.com
November 10, 2025 at 5:23 PM
Recruiting a comp PDRA for the lab 🚨
Working on multiple projects using integrated multi omics in bulk & single cell level
Passion for data, coding, bioinformatics & keen to lead our labs comp workflow
12 months in first instance but extendable for further 19 months
my.corehr.com/pls/coreport...
Working on multiple projects using integrated multi omics in bulk & single cell level
Passion for data, coding, bioinformatics & keen to lead our labs comp workflow
12 months in first instance but extendable for further 19 months
my.corehr.com/pls/coreport...
We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle
Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
October 29, 2025 at 7:59 AM
We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle
Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
Little under a week left to apply for this position to come and lead some cool experiments in muscle biology in London!
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London
www.kcl.ac.uk
October 6, 2025 at 11:54 AM
Little under a week left to apply for this position to come and lead some cool experiments in muscle biology in London!
Reposted by Robert Seaborne
We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere
14 postdoctoral fellowships to the BRIDGE – Translational Excellence Programme
employment.ku.dk
September 29, 2025 at 11:11 AM
We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere
🚨Second position available in the lab.
Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell.
Please spread the word!
kcl-mrcdtp.com/project/the-...
Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell.
Please spread the word!
kcl-mrcdtp.com/project/the-...
The brain-muscle epigenetic interplay in neuromuscular disease - MRC DTP
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease marked by progressive motor neuron loss. Emerging evidence suggests a critical, previously underappreciated role for skeletal muscle in ALS onset and progression, highlighting pathological and molecular interplay between brain and muscle. However, systematic, high-resolution molecular analyses across these tissues remain scarce. This project will use advanced […]
kcl-mrcdtp.com
September 25, 2025 at 7:27 PM
🚨Second position available in the lab.
Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell.
Please spread the word!
kcl-mrcdtp.com/project/the-...
Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell.
Please spread the word!
kcl-mrcdtp.com/project/the-...
Reposted by Robert Seaborne
Postdoc opportunity in muscle cell biology! You would not only be involved in an ambitious project but would also help develop cutting edge methods! Highly recommended! @robertseaborne.bsky.social
Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London
www.kcl.ac.uk
September 25, 2025 at 3:31 PM
Postdoc opportunity in muscle cell biology! You would not only be involved in an ambitious project but would also help develop cutting edge methods! Highly recommended! @robertseaborne.bsky.social
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London
www.kcl.ac.uk
September 25, 2025 at 5:01 PM
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Very happy to have been awarded a NIRG from the MRC. Stay tuned for some exciting (I think, but being biased) postdoc positions within our lab!
Congratulations to Dr Robert Seaborne @kingscollegelondon.bsky.social who has been awarded a New Investigator Grant from the Medical Research Council (MRC), which will support his work on understanding the role of skeletal muscle in motor neurone disease.
Read more ➡️ www.kcl.ac.uk/news/dr-robe...
Read more ➡️ www.kcl.ac.uk/news/dr-robe...
August 13, 2025 at 3:05 PM
Very happy to have been awarded a NIRG from the MRC. Stay tuned for some exciting (I think, but being biased) postdoc positions within our lab!
Reposted by Robert Seaborne
Congratulations to Dr Robert Seaborne @kingscollegelondon.bsky.social who has been awarded a New Investigator Grant from the Medical Research Council (MRC), which will support his work on understanding the role of skeletal muscle in motor neurone disease.
Read more ➡️ www.kcl.ac.uk/news/dr-robe...
Read more ➡️ www.kcl.ac.uk/news/dr-robe...
August 13, 2025 at 2:31 PM
Congratulations to Dr Robert Seaborne @kingscollegelondon.bsky.social who has been awarded a New Investigator Grant from the Medical Research Council (MRC), which will support his work on understanding the role of skeletal muscle in motor neurone disease.
Read more ➡️ www.kcl.ac.uk/news/dr-robe...
Read more ➡️ www.kcl.ac.uk/news/dr-robe...
Kings Prize Fellowship is now open, awarding funds for 18-24 months to an outstanding postdoc.
If keen to come to KCL and work on molecular dynamics of single myofibers in healthy/diseased contexts, drop me a message!
www.kcl.ac.uk/assets/resea...
If keen to come to KCL and work on molecular dynamics of single myofibers in healthy/diseased contexts, drop me a message!
www.kcl.ac.uk/assets/resea...
www.kcl.ac.uk
July 17, 2025 at 1:33 PM
Kings Prize Fellowship is now open, awarding funds for 18-24 months to an outstanding postdoc.
If keen to come to KCL and work on molecular dynamics of single myofibers in healthy/diseased contexts, drop me a message!
www.kcl.ac.uk/assets/resea...
If keen to come to KCL and work on molecular dynamics of single myofibers in healthy/diseased contexts, drop me a message!
www.kcl.ac.uk/assets/resea...
Fantastic opportunity for an ECR to establish their own group!
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
June 25, 2025 at 7:15 PM
Fantastic opportunity for an ECR to establish their own group!
Reposted by Robert Seaborne
Save the date! On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility news.ki.se/ki-to-recruit-junior-researchers-with-a-focus-on-excellence
KI to recruit junior researchers with a focus on excellence
On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility. As one of Europe’s leading medical universities, KI offe...
news.ki.se
June 18, 2025 at 4:51 PM
Save the date! On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility news.ki.se/ki-to-recruit-junior-researchers-with-a-focus-on-excellence
Epigenetic effects of paternal environmental exposures and experiences on offspring phenotypes
www.sciencedirect.com/science/arti....
www.sciencedirect.com/science/arti....
Epigenetic effects of paternal environmental exposures and experiences on offspring phenotypes
Recent decades have revealed increasing evidence for epigenetic inheritance through paternal environmental exposures and experiences, affecting offspr…
www.sciencedirect.com
June 5, 2025 at 11:56 AM
Epigenetic effects of paternal environmental exposures and experiences on offspring phenotypes
www.sciencedirect.com/science/arti....
www.sciencedirect.com/science/arti....
A pleasure to play a very small part in a very large story (and just as big collaboration). From @nireynon.bsky.social team.
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration
www.cell.com/cell-reports...
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration
www.cell.com/cell-reports...
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration
Jacques et al. conducted a thorough meta-analysis integrating multi-omics data from
over 1,000 participants to identify distinctive molecular signatures in human skeletal
muscle adaptation to various ...
www.cell.com
May 30, 2025 at 6:31 AM
A pleasure to play a very small part in a very large story (and just as big collaboration). From @nireynon.bsky.social team.
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration
www.cell.com/cell-reports...
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration
www.cell.com/cell-reports...
A wonderful time celebrating a fair few years of quality science!
A few brain cells, papers, grants, experiments and beers developed, created and shared amongst these lads over the years!
A few brain cells, papers, grants, experiments and beers developed, created and shared amongst these lads over the years!
May 24, 2025 at 1:56 PM
A wonderful time celebrating a fair few years of quality science!
A few brain cells, papers, grants, experiments and beers developed, created and shared amongst these lads over the years!
A few brain cells, papers, grants, experiments and beers developed, created and shared amongst these lads over the years!
Wow!
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM
www.nejm.org/doi/full/10....
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM
www.nejm.org/doi/full/10....
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM
Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...
www.nejm.org
May 16, 2025 at 2:42 PM
Wow!
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM
www.nejm.org/doi/full/10....
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM
www.nejm.org/doi/full/10....
Reposted by Robert Seaborne
Nice!
New paper from the lab! Want to know if there is a difference in ribosome collisions between your samples? We show that you can detect this in the rRNA reads in your ribosome profiling data.
academic.oup.com/nargab/artic...
academic.oup.com/nargab/artic...
Detecting ribosome collisions with differential rRNA fragment analysis in ribosome profiling data
Abstract. It has become clear in recent years that ribosomes regularly stall during translation. Such translation impairment has many causes, including exp
academic.oup.com
May 8, 2025 at 12:46 PM
Nice!
Reposted by Robert Seaborne
Another beautiful collaboration 🔬💪 Proof-of-principle of getting both functional and proteomics data from a single myofiber - even from our tiny nemaline myopathy ones! Thanks for all the fun times in the lab @robertseaborne.bsky.social
Integrated single-cell functional-proteomic profiling reveals a shift in myofibre specificity in human nemaline myopathy: A proof-of-principle study
Another collab between the labs @droch.bsky.social @adeshmukh.bsky.social
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Another collab between the labs @droch.bsky.social @adeshmukh.bsky.social
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Integrated single‐cell functional‐proteomic profiling reveals a shift in myofibre specificity in human nemaline myopathy: A proof‐of‐principle study
Abstract figure legend SMPFO uniquely develops data relating to the biophysical state of the sarcomeric protein, alongside global proteome profiling, on a single myofibre basis. Using this approach w...
physoc.onlinelibrary.wiley.com
May 6, 2025 at 6:04 PM
Another beautiful collaboration 🔬💪 Proof-of-principle of getting both functional and proteomics data from a single myofiber - even from our tiny nemaline myopathy ones! Thanks for all the fun times in the lab @robertseaborne.bsky.social
Reposted by Robert Seaborne
Excited to share another great collaborative effort — we successfully combined single muscle fiber proteomics with functional assays in the same fiber! This integrated approach allows a direct link between molecular composition and functional performance at the single cell/fiber level.
Integrated single-cell functional-proteomic profiling reveals a shift in myofibre specificity in human nemaline myopathy: A proof-of-principle study
Another collab between the labs @droch.bsky.social @adeshmukh.bsky.social
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Another collab between the labs @droch.bsky.social @adeshmukh.bsky.social
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Integrated single‐cell functional‐proteomic profiling reveals a shift in myofibre specificity in human nemaline myopathy: A proof‐of‐principle study
Abstract figure legend SMPFO uniquely develops data relating to the biophysical state of the sarcomeric protein, alongside global proteome profiling, on a single myofibre basis. Using this approach w...
physoc.onlinelibrary.wiley.com
May 6, 2025 at 5:47 AM
Excited to share another great collaborative effort — we successfully combined single muscle fiber proteomics with functional assays in the same fiber! This integrated approach allows a direct link between molecular composition and functional performance at the single cell/fiber level.
Integrated single-cell functional-proteomic profiling reveals a shift in myofibre specificity in human nemaline myopathy: A proof-of-principle study
Another collab between the labs @droch.bsky.social @adeshmukh.bsky.social
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Another collab between the labs @droch.bsky.social @adeshmukh.bsky.social
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Integrated single‐cell functional‐proteomic profiling reveals a shift in myofibre specificity in human nemaline myopathy: A proof‐of‐principle study
Abstract figure legend SMPFO uniquely develops data relating to the biophysical state of the sarcomeric protein, alongside global proteome profiling, on a single myofibre basis. Using this approach w...
physoc.onlinelibrary.wiley.com
May 5, 2025 at 9:01 AM
Integrated single-cell functional-proteomic profiling reveals a shift in myofibre specificity in human nemaline myopathy: A proof-of-principle study
Another collab between the labs @droch.bsky.social @adeshmukh.bsky.social
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Another collab between the labs @droch.bsky.social @adeshmukh.bsky.social
physoc.onlinelibrary.wiley.com/doi/10.1113/...
New collaborative paper from @droch.bsky.social group, combining SkM biopsy, single fascicle and single myofiber biophysical and molecular experiments in T2DM
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia
Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...
link.springer.com
April 30, 2025 at 6:56 AM
New collaborative paper from @droch.bsky.social group, combining SkM biopsy, single fascicle and single myofiber biophysical and molecular experiments in T2DM
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Robert Seaborne
Our new very collaborative paper showing that muscle myosin has a reduced energy demand in diabetes. Big impact on weight control in our mind!!! Thank you to everyone involved and funders @lundbeckfonden.bsky.social @novo-nordisk.bsky.social @ucph.bsky.social @myoblue.bsky.social #diabetes
Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia
Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...
link.springer.com
April 29, 2025 at 3:56 AM
Our new very collaborative paper showing that muscle myosin has a reduced energy demand in diabetes. Big impact on weight control in our mind!!! Thank you to everyone involved and funders @lundbeckfonden.bsky.social @novo-nordisk.bsky.social @ucph.bsky.social @myoblue.bsky.social #diabetes
Big thanks to @acmedsci.bsky.social for the 2 year grant that will fund a programme of work on skeletal muscle ageing. Looking forward to getting stuck into it!
#Springboard25
acmedsci.ac.uk/more/news/sp...
#Springboard25
acmedsci.ac.uk/more/news/sp...
Groundbreaking health research gets £7.6m boost as Academy funds emerging scientific leaders
acmedsci.ac.uk
April 7, 2025 at 9:38 AM
Big thanks to @acmedsci.bsky.social for the 2 year grant that will fund a programme of work on skeletal muscle ageing. Looking forward to getting stuck into it!
#Springboard25
acmedsci.ac.uk/more/news/sp...
#Springboard25
acmedsci.ac.uk/more/news/sp...
