Rakyan Lab
@rakyanlab.bsky.social
Blizard Institute, QMUL, London. Working on inter-individual genetic and epigenetic variation of mammalian ribosomal DNA.
Reposted by Rakyan Lab
Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity
Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity
Lamb et al. show that the circadian clock rhythmically remodels ribosome composition in Neurospora crassa. Clock-regulated incorporation of the ribosomal protein eL31 is required for rhythmic translation and translation fidelity, linking temporal ribosome remodeling to daily changes in proteome diversity.
dlvr.it
November 8, 2025 at 8:50 PM
Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity
Reposted by Rakyan Lab
AI tells you what you want to hear, statisticians usually tell you what you don't want to hear
The advances we've made in statistics, experimental study design, and causal inference over the past century are remarkably useful for understanding our world. But there is never been a push to make people use them like we are seeing with generative AI. Perhaps take a moment to consider why.
November 7, 2025 at 9:13 AM
AI tells you what you want to hear, statisticians usually tell you what you don't want to hear
Oooh, very interesting!
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer
Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...
rdcu.be
November 7, 2025 at 8:29 AM
Oooh, very interesting!
Beautiful work.
Excited to share my first PhD student’s @biorxivpreprint.bsky.social!
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!
Check it out!
www.biorxiv.org/content/10.1...
November 1, 2025 at 7:41 AM
Beautiful work.
Reposted by Rakyan Lab
Even chimpanzees think rationally and weigh the evidence when making a choice ;-)
@science.org
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
Chimpanzees rationally revise their beliefs
The selective revision of beliefs in light of new evidence has been considered one of the hallmarks of human-level rationality. However, tests of this ability in other species are lacking. We examined...
www.science.org
October 31, 2025 at 1:52 AM
Even chimpanzees think rationally and weigh the evidence when making a choice ;-)
@science.org
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
Reposted by Rakyan Lab
We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle
Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
October 29, 2025 at 7:59 AM
We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle
Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
Reposted by Rakyan Lab
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London
www.kcl.ac.uk
September 25, 2025 at 5:01 PM
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Good collab with @droch.bsky.social so travel to CPH involved as well
www.kcl.ac.uk/jobs/126245-...
Reposted by Rakyan Lab
🚨Second position available in the lab.
Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell.
Please spread the word!
kcl-mrcdtp.com/project/the-...
Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell.
Please spread the word!
kcl-mrcdtp.com/project/the-...
The brain-muscle epigenetic interplay in neuromuscular disease - MRC DTP
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease marked by progressive motor neuron loss. Emerging evidence suggests a critical, previously underappreciated role for skeletal muscle in ALS onset and progression, highlighting pathological and molecular interplay between brain and muscle. However, systematic, high-resolution molecular analyses across these tissues remain scarce. This project will use advanced […]
kcl-mrcdtp.com
September 25, 2025 at 7:27 PM
🚨Second position available in the lab.
Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell.
Please spread the word!
kcl-mrcdtp.com/project/the-...
Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell.
Please spread the word!
kcl-mrcdtp.com/project/the-...
Reposted by Rakyan Lab
Unlocking the regulatory code of RNA: launching the Human RNome Project. #RNA #RNAregulation #RNomeProject #GenomeBiology 🧪🧬 🖥️
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
October 26, 2025 at 8:05 PM
Unlocking the regulatory code of RNA: launching the Human RNome Project. #RNA #RNAregulation #RNomeProject #GenomeBiology 🧪🧬 🖥️
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
Interesting! The evolutionary angle in particular is very nice.
Now online! Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing modifications to support ribosome function at extreme temperatures.
dlvr.it
October 24, 2025 at 9:50 AM
Interesting! The evolutionary angle in particular is very nice.
I did my PhD with Emma over 20 years ago (😊). Many congratulations to all of this years winners! 👏
Congratulations to the winners of the 2025 AEpiA Emma Whitelaw Publication Award!
🧬 1st place: @shellainasci.bsky.social
🧬 2nd place: @victoriasugrue.bsky.social
🧬 3rd place: @dairegannon.bsky.social
This award recognises outstanding publications by ECRs in the field of epigenetics.
🧬 1st place: @shellainasci.bsky.social
🧬 2nd place: @victoriasugrue.bsky.social
🧬 3rd place: @dairegannon.bsky.social
This award recognises outstanding publications by ECRs in the field of epigenetics.
October 20, 2025 at 8:28 AM
I did my PhD with Emma over 20 years ago (😊). Many congratulations to all of this years winners! 👏
Going through immigration doesn’t always put a smile on one’s face. But sometimes it does-
Immigration officer (Delhi): so you’re a scientist?
Me: Yes.
IO: You know about Mendel‘s laws?
Me: (a bit surprised..) Yes!
IO: Beautiful experiment using peas.
Me: Indeed!
IO: Enjoy your visit.
Immigration officer (Delhi): so you’re a scientist?
Me: Yes.
IO: You know about Mendel‘s laws?
Me: (a bit surprised..) Yes!
IO: Beautiful experiment using peas.
Me: Indeed!
IO: Enjoy your visit.
October 9, 2025 at 8:35 PM
Going through immigration doesn’t always put a smile on one’s face. But sometimes it does-
Immigration officer (Delhi): so you’re a scientist?
Me: Yes.
IO: You know about Mendel‘s laws?
Me: (a bit surprised..) Yes!
IO: Beautiful experiment using peas.
Me: Indeed!
IO: Enjoy your visit.
Immigration officer (Delhi): so you’re a scientist?
Me: Yes.
IO: You know about Mendel‘s laws?
Me: (a bit surprised..) Yes!
IO: Beautiful experiment using peas.
Me: Indeed!
IO: Enjoy your visit.
Well done!
Thrilled to share that the lab has been awarded a @wellcometrust.bsky.social Discovery Award to keep exploring the evolution of 6-methyladenine #6mA in Eukaryotes. We'll open postdoc (3️⃣) and tech (1️⃣) positions to start in 2026, please share with candidates or reach out if you’d like to join us.
October 8, 2025 at 12:26 PM
Well done!
Reposted by Rakyan Lab
The first 1 million prime numbers vizualized in 2D according to their prime factors (Umap)
Source: johnhw.github.io/uma...
Source: johnhw.github.io/uma...
September 25, 2025 at 8:05 AM
The first 1 million prime numbers vizualized in 2D according to their prime factors (Umap)
Source: johnhw.github.io/uma...
Source: johnhw.github.io/uma...
Reposted by Rakyan Lab
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
How Stowers Scientists Found the DNA Site Where Robertsonian Chromosomes Fuse
YouTube video by Stowers Institute for Medical Research
youtu.be
September 24, 2025 at 6:48 PM
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
Reposted by Rakyan Lab
Useful reminder from Peter Kellner on the problems we refuse to acknowledge are getting better, and the politics of hopelessness that this breeds
open.substack.com/pub/kellnerp...
open.substack.com/pub/kellnerp...
September 23, 2025 at 6:29 AM
Useful reminder from Peter Kellner on the problems we refuse to acknowledge are getting better, and the politics of hopelessness that this breeds
open.substack.com/pub/kellnerp...
open.substack.com/pub/kellnerp...
Reposted by Rakyan Lab
Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]
A complete diploid human genome benchmark for personalized genomics
Human genome resequencing typically involves mapping reads to a reference genome to call variants; however, this approach suffers from both technical and reference biases, leaving many duplicated and ...
www.biorxiv.org
September 22, 2025 at 5:01 PM
Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]
🤯
Brent Chapman can see again after doctors pulled out one of his teeth, flattened it, drilled a hole in it, placed a lens inside and implanted the tooth in one of his eyes. on.nbcboston.com/mRI06Sh
Man, 34, is no longer blind after tooth is implanted in eye in 'crazy' surgery
Tooth-in-eye surgery sounds like science fiction, but it can help people with severely damaged corneas see again. A patient and his doctors describe what it's like.
on.nbcboston.com
September 14, 2025 at 12:16 PM
🤯
Reposted by Rakyan Lab
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
www.nature.com
September 10, 2025 at 3:21 PM
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...