Carlos Henriquez-Olguin
@musclebiology.bsky.social
Scientist interested in muscle biology, molecular metabolism, and exercise physiology. #myoblue
🚀New preprint w/ @roberto_amv: We used chemogenetics to precisely control mitochondrial H2O2 in skeletal muscle in vivo. This exposes a dose-dependent sequence: translation suppression → proteolysis → denervation-like → degeneration @tejensen23 www.biorxiv.org/content/10.1...
August 28, 2025 at 2:13 PM
🚀New preprint w/ @roberto_amv: We used chemogenetics to precisely control mitochondrial H2O2 in skeletal muscle in vivo. This exposes a dose-dependent sequence: translation suppression → proteolysis → denervation-like → degeneration @tejensen23 www.biorxiv.org/content/10.1...
Check out our latest paper challenging the long-standing belief that insulin elicits a transient H₂O₂ production. New insights into skeletal muscle redox signaling and insulin action 🤩
Our new paper in Redox Biol showing that insulin stimulation of skeletal muscle surprisingly does not detectably increase the ROS H2O2 using state-of-art methods in different models including humans, but in fact causes a selective reductive shift - enjoy
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Revisiting Insulin-Stimulated Hydrogen Peroxide Dynamics Reveals a Cytosolic Reductive Shift in Skeletal Muscle
The intracellular redox state is crucial for insulin responses in peripheral tissues. Despite the longstanding belief that insulin signaling increases…
www.sciencedirect.com
March 27, 2025 at 7:34 AM
Check out our latest paper challenging the long-standing belief that insulin elicits a transient H₂O₂ production. New insights into skeletal muscle redox signaling and insulin action 🤩
Reposted by Carlos Henriquez-Olguin
“Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison” by @robertoandresmv.bsky.social, @musclebiology.bsky.social, @elbenhardt.bsky.social et al. (sorry if I do not find all of the #bluesky handles).
www.sciencedirect.com/science/arti...
3/17
www.sciencedirect.com/science/arti...
3/17
Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison
Striated muscle cells, encompassing cardiac myocytes and skeletal muscle fibers, are fundamental to athletic performance, facilitating blood circulati…
www.sciencedirect.com
January 30, 2025 at 7:33 AM
“Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison” by @robertoandresmv.bsky.social, @musclebiology.bsky.social, @elbenhardt.bsky.social et al. (sorry if I do not find all of the #bluesky handles).
www.sciencedirect.com/science/arti...
3/17
www.sciencedirect.com/science/arti...
3/17
Reposted by Carlos Henriquez-Olguin
Free radicals and antioxidants: appealing to magic
Our short paper argues that molecules cannot be classified as good or evil. Limited evidence supporting the consumption of antioxidants or superfoods and such interventions risk disrupting fundamental redox processes.
www.cell.com/trends/endoc...
Our short paper argues that molecules cannot be classified as good or evil. Limited evidence supporting the consumption of antioxidants or superfoods and such interventions risk disrupting fundamental redox processes.
www.cell.com/trends/endoc...
Free radicals and antioxidants: appealing to magic
In biology, there are no good or evil molecules. There is limited or no evidence to
support the consumption of antioxidants or (super)foods rich in antioxidants, for
the intended purpose of an antioxi...
www.cell.com
November 25, 2024 at 9:43 AM
Free radicals and antioxidants: appealing to magic
Our short paper argues that molecules cannot be classified as good or evil. Limited evidence supporting the consumption of antioxidants or superfoods and such interventions risk disrupting fundamental redox processes.
www.cell.com/trends/endoc...
Our short paper argues that molecules cannot be classified as good or evil. Limited evidence supporting the consumption of antioxidants or superfoods and such interventions risk disrupting fundamental redox processes.
www.cell.com/trends/endoc...
