Brendan Evano
@brendan-evano.bsky.social
Stem cell biology and engineering
Researcher @cnrsbiologie.bsky.social @pasteur.fr @TajbakhshLab.bsky.social
Researcher @cnrsbiologie.bsky.social @pasteur.fr @TajbakhshLab.bsky.social
Reposted by Brendan Evano
New #stemcellreports paper: Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells. #Myoblue tinyurl.com/yyjhn94p
Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells
In this manuscript, Sacco, Caputo, and colleagues demonstrate that modulation of the
JAK2/STAT3 signaling pathway during in vitro myogenic differentiation promotes expansion
of PAX7+ SMPCs in multiple...
tinyurl.com
October 30, 2025 at 4:07 PM
New #stemcellreports paper: Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells. #Myoblue tinyurl.com/yyjhn94p
Reposted by Brendan Evano
✨🔬 Get ready for groundbreaking #StemCell research!
Join us in Lyon, Nov 17–19, 2025, for the 7th #FSSCR Annual Meeting.
Connect with leading experts and be part of inspiring scientific exchanges 👇
👉 buff.ly/FRotkAi
@FSSCR_officiel
#FSSCR2025
Join us in Lyon, Nov 17–19, 2025, for the 7th #FSSCR Annual Meeting.
Connect with leading experts and be part of inspiring scientific exchanges 👇
👉 buff.ly/FRotkAi
@FSSCR_officiel
#FSSCR2025
October 30, 2025 at 10:17 AM
✨🔬 Get ready for groundbreaking #StemCell research!
Join us in Lyon, Nov 17–19, 2025, for the 7th #FSSCR Annual Meeting.
Connect with leading experts and be part of inspiring scientific exchanges 👇
👉 buff.ly/FRotkAi
@FSSCR_officiel
#FSSCR2025
Join us in Lyon, Nov 17–19, 2025, for the 7th #FSSCR Annual Meeting.
Connect with leading experts and be part of inspiring scientific exchanges 👇
👉 buff.ly/FRotkAi
@FSSCR_officiel
#FSSCR2025
Reposted by Brendan Evano
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Reposted by Brendan Evano
So proud of the exciting story from my PhD student Jakub Sumbal on contractile fibroblasts shaping branching morphogenesis!
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social
It just came out online, check it out here:
rdcu.be/eIIKD
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social
It just came out online, check it out here:
rdcu.be/eIIKD
Contractile fibroblasts form a transient niche for the branching mammary epithelium
Nature Communications - Fibroblasts represent a heterogenous cell population but how their differences reflect their plasticity and origin is not fully understood. Here, the authors map the origin...
rdcu.be
September 29, 2025 at 4:34 PM
So proud of the exciting story from my PhD student Jakub Sumbal on contractile fibroblasts shaping branching morphogenesis!
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social
It just came out online, check it out here:
rdcu.be/eIIKD
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social
It just came out online, check it out here:
rdcu.be/eIIKD
Reposted by Brendan Evano
Ventricle position can be remodeled after heart looping!
In a model of heterotaxy we uncovered a new asymmetric morphogenesis process during which the heart reorients its chambers.
So grateful to all the authors for their expertise and input during this long (but fun) ride 💪
Read more here ⬇️
In a model of heterotaxy we uncovered a new asymmetric morphogenesis process during which the heart reorients its chambers.
So grateful to all the authors for their expertise and input during this long (but fun) ride 💪
Read more here ⬇️
September 24, 2025 at 7:53 PM
Ventricle position can be remodeled after heart looping!
In a model of heterotaxy we uncovered a new asymmetric morphogenesis process during which the heart reorients its chambers.
So grateful to all the authors for their expertise and input during this long (but fun) ride 💪
Read more here ⬇️
In a model of heterotaxy we uncovered a new asymmetric morphogenesis process during which the heart reorients its chambers.
So grateful to all the authors for their expertise and input during this long (but fun) ride 💪
Read more here ⬇️
Reposted by Brendan Evano
New #stemcellreports paper: Unraveling the matrisome signatures of quiescent and activated muscle stem cells. #Myoblue tinyurl.com/ycyy3nw5
Unraveling the matrisome signatures of quiescent and activated muscle stem cells
The extracellular matrix (ECM) niche regulates skeletal muscle stem cell (MuSC) behavior.
Using transcriptomic data and 3D imaging, they show that quiescent MuSCs express unique
ECM markers, including...
tinyurl.com
September 11, 2025 at 6:02 PM
New #stemcellreports paper: Unraveling the matrisome signatures of quiescent and activated muscle stem cells. #Myoblue tinyurl.com/ycyy3nw5
Reposted by Brendan Evano
Save the date! The @pasteur.fr Pasteur course on image analysis is announced:
It will happen from the 1st of June to the 5th 2026.
This year there will be only one track: the Early Career Investigator track (beginners). 👇
It will happen from the 1st of June to the 5th 2026.
This year there will be only one track: the Early Career Investigator track (beginners). 👇
September 10, 2025 at 12:50 PM
Save the date! The @pasteur.fr Pasteur course on image analysis is announced:
It will happen from the 1st of June to the 5th 2026.
This year there will be only one track: the Early Career Investigator track (beginners). 👇
It will happen from the 1st of June to the 5th 2026.
This year there will be only one track: the Early Career Investigator track (beginners). 👇
Reposted by Brendan Evano
New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵
Flagellar gliding in choanoflagellates
Freire-Delgado and Brunet discover a new mode of cell motility in choanoflagellates,
the closest relatives of animals. Under mild confinement, choanoflagellate move over
surfaces without cell deformat...
www.cell.com
September 9, 2025 at 6:12 PM
New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵
Reposted by Brendan Evano
Tuesday, Sept. 16, seminar at noon by Bert Blaauw (Veneto Inst. of Molecular Medicine, Univ of Padova, Italy): Reduced ATP turnover during hibernation in relaxed skeletal muscle
institutcochin.fr/en/agenda/re...
@inserm.fr @cnrs-idf-villejuif.bsky.social @cnrsbiologie.bsky.social @upcite.bsky.social
institutcochin.fr/en/agenda/re...
@inserm.fr @cnrs-idf-villejuif.bsky.social @cnrsbiologie.bsky.social @upcite.bsky.social
Reduced ATP turnover during hibernation in relaxed skeletal muscle
Hibernating brown bears, due to a drastic reduction in metabolic rate, show only moderate muscle wasting. Here, we evaluate if ATPase activity of resting skeletal muscle myosin can contribute to this ...
institutcochin.fr
September 9, 2025 at 4:03 PM
Tuesday, Sept. 16, seminar at noon by Bert Blaauw (Veneto Inst. of Molecular Medicine, Univ of Padova, Italy): Reduced ATP turnover during hibernation in relaxed skeletal muscle
institutcochin.fr/en/agenda/re...
@inserm.fr @cnrs-idf-villejuif.bsky.social @cnrsbiologie.bsky.social @upcite.bsky.social
institutcochin.fr/en/agenda/re...
@inserm.fr @cnrs-idf-villejuif.bsky.social @cnrsbiologie.bsky.social @upcite.bsky.social
Reposted by Brendan Evano
Do not hesitate to register for Sept 18. Please repost this message.
Pleased to announce launching Institut Cochin Foundation, on Sept. 18 at 6 p.m., upon registration, either in the Rosalind Franklin room, 22 rue Méchain, Paris or via video conference: presentation of @institutcochin.bsky.social, meet researchers and call for donations-thanks for your support!
September 9, 2025 at 4:08 PM
Do not hesitate to register for Sept 18. Please repost this message.
Reposted by Brendan Evano
🔬 Don’t miss the 7th Annual FSSCR Meeting in Lyon!
✨ #StemCells research & future clinical applications.
📆 Register by 19 Oct 2025 for regular rates 👉
✨ #StemCells research & future clinical applications.
📆 Register by 19 Oct 2025 for regular rates 👉
FSSCR ANNUAL MEETING
French Society on Stem Cell Research (FSSCR)
buff.ly
September 3, 2025 at 12:30 PM
🔬 Don’t miss the 7th Annual FSSCR Meeting in Lyon!
✨ #StemCells research & future clinical applications.
📆 Register by 19 Oct 2025 for regular rates 👉
✨ #StemCells research & future clinical applications.
📆 Register by 19 Oct 2025 for regular rates 👉
Reposted by Brendan Evano
'The problem is that AAV-based therapies inevitably come with their own risks, and (in my opinion) these should be balanced by impressive efficacy data to make a convincing profile. Obviously this wasn’t present here, which sort of leaves everyone out there to soak up the risk part'
Sarepta, Sarepta
www.science.org
July 26, 2025 at 7:47 AM
'The problem is that AAV-based therapies inevitably come with their own risks, and (in my opinion) these should be balanced by impressive efficacy data to make a convincing profile. Obviously this wasn’t present here, which sort of leaves everyone out there to soak up the risk part'
Reposted by Brendan Evano
Rémi Mounier, Bénédicte Chazaud @benchazaud.bsky.social @inserm.fr at Université Claude Bernard Lyon and co-workers show that immune #aging impairs #muscle #regeneration via #macrophage-derived anti-oxidant selenoprotein P.
-> www.embopress.org/doi/full/10....
-> www.embopress.org/doi/full/10....
July 19, 2025 at 8:19 AM
Rémi Mounier, Bénédicte Chazaud @benchazaud.bsky.social @inserm.fr at Université Claude Bernard Lyon and co-workers show that immune #aging impairs #muscle #regeneration via #macrophage-derived anti-oxidant selenoprotein P.
-> www.embopress.org/doi/full/10....
-> www.embopress.org/doi/full/10....
Reposted by Brendan Evano
SARCOMERES divide! Mechanism how muscles grow while contracting - daughter sarcomeres appear everywhere. Seen live, registered on our cover. Pioneered by @clementrodier.bsky.social @friedrich-group.bsky.social Ian Estabrook @ibdm.bsky.social $ by @hfspo.bsky.social www.science.org/doi/10.1126/...
July 10, 2025 at 10:16 AM
SARCOMERES divide! Mechanism how muscles grow while contracting - daughter sarcomeres appear everywhere. Seen live, registered on our cover. Pioneered by @clementrodier.bsky.social @friedrich-group.bsky.social Ian Estabrook @ibdm.bsky.social $ by @hfspo.bsky.social www.science.org/doi/10.1126/...
Reposted by Brendan Evano
New #NatureMedicine paper: AAV mini-dystrophin gene therapy for Duchenne muscular dystrophy: a phase 1b trial. #DMD #Myoblue tinyurl.com/bdhwrkka
AAV mini-dystrophin gene therapy for Duchenne muscular dystrophy: a phase 1b trial - Nature Medicine
In the primary report of a phase 1b trial, adeno-associated virus gene therapy with fordadistrogene movaparvovec in patients with Duchenne muscular dystrophy was well tolerated in an ambulatory cohort...
tinyurl.com
June 29, 2025 at 12:40 PM
New #NatureMedicine paper: AAV mini-dystrophin gene therapy for Duchenne muscular dystrophy: a phase 1b trial. #DMD #Myoblue tinyurl.com/bdhwrkka
Reposted by Brendan Evano
Pluripotency, CRISPR/Cas9, organoid days. Lectures to bench. With a precious and passionate lecture by Michele De Luca
June 24, 2025 at 7:47 PM
Pluripotency, CRISPR/Cas9, organoid days. Lectures to bench. With a precious and passionate lecture by Michele De Luca
Reposted by Brendan Evano
Education… so important. Second day of the #ASCB course @institutpasteur with @LabTajbakhsh @zenlabpasteur @bgayraudmorel and a great group of interactive students. Once again with the irreplaceable trio: Laurence Daheron, Frank Yates, Michel Cohen-Tannoudji!
June 24, 2025 at 7:46 PM
Education… so important. Second day of the #ASCB course @institutpasteur with @LabTajbakhsh @zenlabpasteur @bgayraudmorel and a great group of interactive students. Once again with the irreplaceable trio: Laurence Daheron, Frank Yates, Michel Cohen-Tannoudji!
Reposted by Brendan Evano
Excited to share our review on Hallmark of Stem Cell Aging! With Tom Rando and Peggy Goodell @goodell-lab.bsky.social!!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Hallmarks of stem cell aging
As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are …
www.sciencedirect.com
June 25, 2025 at 3:31 AM
Excited to share our review on Hallmark of Stem Cell Aging! With Tom Rando and Peggy Goodell @goodell-lab.bsky.social!!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Brendan Evano
I am happy to announce with @hanli-pasteur.bsky.social that we'll organise a summer school titled "Senescence from Cell Cultures to Humans through Model Organisms" in Paris, Fr on June 23-24, 2025
Aimed at 2nd and 3rd year PhD student + postdocs
Submit your provisional project tinyurl.com/2uhfzxbp
Aimed at 2nd and 3rd year PhD student + postdocs
Submit your provisional project tinyurl.com/2uhfzxbp
February 27, 2025 at 3:40 PM
I am happy to announce with @hanli-pasteur.bsky.social that we'll organise a summer school titled "Senescence from Cell Cultures to Humans through Model Organisms" in Paris, Fr on June 23-24, 2025
Aimed at 2nd and 3rd year PhD student + postdocs
Submit your provisional project tinyurl.com/2uhfzxbp
Aimed at 2nd and 3rd year PhD student + postdocs
Submit your provisional project tinyurl.com/2uhfzxbp
Reposted by Brendan Evano
#DanioDigest (May 2025)
Community News:
Prof Caren Norden @nordenlab.bsky.social appointed Darwin Professor of Animal Embryology at PDN at the University of Cambridge.
Prof Elizabeth Chen @echenlab.bsky.social elected as President of @ascbiology.bsky.social for 2027. (1/38)
Community News:
Prof Caren Norden @nordenlab.bsky.social appointed Darwin Professor of Animal Embryology at PDN at the University of Cambridge.
Prof Elizabeth Chen @echenlab.bsky.social elected as President of @ascbiology.bsky.social for 2027. (1/38)
June 21, 2025 at 3:35 PM
#DanioDigest (May 2025)
Community News:
Prof Caren Norden @nordenlab.bsky.social appointed Darwin Professor of Animal Embryology at PDN at the University of Cambridge.
Prof Elizabeth Chen @echenlab.bsky.social elected as President of @ascbiology.bsky.social for 2027. (1/38)
Community News:
Prof Caren Norden @nordenlab.bsky.social appointed Darwin Professor of Animal Embryology at PDN at the University of Cambridge.
Prof Elizabeth Chen @echenlab.bsky.social elected as President of @ascbiology.bsky.social for 2027. (1/38)
Reposted by Brendan Evano
Our paper describing the creation of a nationwide core facility for bioimage analysis if out in @plos Computational Biology!
🎉✌️
journals.plos.org/ploscompbiol...
So happy about this paper and how the work turned out.
A small thread 👇
#bioimageanalysis #corefacility
🎉✌️
journals.plos.org/ploscompbiol...
So happy about this paper and how the work turned out.
A small thread 👇
#bioimageanalysis #corefacility
F-BIAS: Towards a distributed national core facility for bioimage analysis †
Author summary We describe our experience in creating a nationwide core facility offering services in bioimage analysis. This virtual facility federates existing resources scattered across the territo...
journals.plos.org
June 11, 2025 at 8:29 AM
Our paper describing the creation of a nationwide core facility for bioimage analysis if out in @plos Computational Biology!
🎉✌️
journals.plos.org/ploscompbiol...
So happy about this paper and how the work turned out.
A small thread 👇
#bioimageanalysis #corefacility
🎉✌️
journals.plos.org/ploscompbiol...
So happy about this paper and how the work turned out.
A small thread 👇
#bioimageanalysis #corefacility
Reposted by Brendan Evano
Do not miss this seminar today: institutcochin.fr/en/agenda/ta...
#Seminar on June 12 at noon by Justin Fallon (Brown University, Providence, US): Targeting neural and muscle #stem cells to promote adult hippocampal #neurogenesis and #muscle growth
institutcochin.fr/en/agenda/ta...
@inserm.fr @upcite.bsky.social @cnrs-idf-villejuif.bsky.social
institutcochin.fr/en/agenda/ta...
@inserm.fr @upcite.bsky.social @cnrs-idf-villejuif.bsky.social
Targeting neural and muscle stem cells to promote adult hippocampal neurogenesis and muscle growth
Adult stem cells offer an attractive target for treating a range of diseases and for extending healthspan. Neural and muscle stem (satellite) cells are generally quiescent, but can be activated to gen...
institutcochin.fr
June 11, 2025 at 7:25 AM
Do not miss this seminar today: institutcochin.fr/en/agenda/ta...
Reposted by Brendan Evano
New #NatureCancer paper: Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia. #Myoblue tinyurl.com/yhjx4sjt
Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia - Nature Cancer
Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia development during c...
tinyurl.com
May 26, 2025 at 4:46 PM
New #NatureCancer paper: Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia. #Myoblue tinyurl.com/yhjx4sjt
Reposted by Brendan Evano
Deadline Reminder June 1 for Early Registration / Abstract Submission: 6th Int'l Conference on #StemCells at the Kalimera Kriti Conference Center in #sissi #crete #Greece from Oct. 1-6, 2025 www.aegeanconferences.org/src/App/conf...
May 7, 2025 at 9:12 AM
Deadline Reminder June 1 for Early Registration / Abstract Submission: 6th Int'l Conference on #StemCells at the Kalimera Kriti Conference Center in #sissi #crete #Greece from Oct. 1-6, 2025 www.aegeanconferences.org/src/App/conf...
Reposted by Brendan Evano
We have a fantastic group of speakers from the Stem Cell field. Don't miss the discounted early registration deadline of June 1st. Available trainee travel awards will be selected based on abstracts submitted before the June 1st deadline.
Deadline Reminder June 1 for Early Registration / Abstract Submission: 6th Int'l Conference on #StemCells at the Kalimera Kriti Conference Center in #sissi #crete #Greece from Oct. 1-6, 2025 www.aegeanconferences.org/src/App/conf...
May 21, 2025 at 7:46 PM
We have a fantastic group of speakers from the Stem Cell field. Don't miss the discounted early registration deadline of June 1st. Available trainee travel awards will be selected based on abstracts submitted before the June 1st deadline.