Brendan Evano
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brendan-evano.bsky.social
Brendan Evano
@brendan-evano.bsky.social
Stem cell biology and engineering
Researcher @cnrsbiologie.bsky.social @pasteur.fr @TajbakhshLab.bsky.social
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April 7, 2025 at 7:16 AM
The differentiation of dystrophic stem cells relied on dual p38–PI3K signalling, an unrecognised synergy not seen in healthy cells which depended solely on p38.
March 14, 2025 at 3:23 PM
For mechanistic studies we developed an in vitro live imaging assay with isolated stem cells.
March 14, 2025 at 3:23 PM
Stem cell fate decisions were cell-autonomous, while their migration behaviour was largely determined by the healthy vs dystrophic muscle fibre niches.
March 14, 2025 at 3:23 PM
To explore the contribution of autonomous vs niche-driven cues, we set up a niche switching assay between healthy and dystrophic stem cells and muscle fibres.

(YFP-labelled dystrophic stem cell grafted to a healthy fibre here)
March 14, 2025 at 3:23 PM
Ex vivo dystrophic stem cells indeed showed altered migration and precocious differentiation, through imbalanced symmetric divisions.
March 14, 2025 at 3:23 PM
We developed an ex vivo live imaging assay with stem cells within their muscle fibre niche to recapitulate the in vivo phenotypes and allow for perturbation studies.
March 14, 2025 at 3:23 PM
Using in vivo live imaging, we showed that dystrophic stem cells have impaired migration kinetics and precocious differentiation.
March 14, 2025 at 3:23 PM