Bogdan Pasaniuc
@bpasaniuc.bsky.social
Computational and statistical genetics. Excited about all things science. Professor of genetics at UPenn. Views my own.
https://www.med.upenn.edu/bogdan-group/
https://www.med.upenn.edu/bogdan-group/
Pinned
Two more weeks to go! Inclusive Genomics to Promote Health Excellence Symposium at @upenn.edu @penngenetics.bsky.social @pennmedcso.bsky.social!
Excited to host such an amazing lineup of speakers! Registration is free but required; see www.med.upenn.edu/ccb/
Excited to host such an amazing lineup of speakers! Registration is free but required; see www.med.upenn.edu/ccb/
Reposted by Bogdan Pasaniuc
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
Exposure accumulation drives age-dependent disease architectures and polygenic risk scores
Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...
www.medrxiv.org
September 2, 2025 at 11:08 PM
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
Reposted by Bogdan Pasaniuc
I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:
What we talk about when we talk about risk
How embryo selection exploits our flawed intuitions about risk
open.substack.com
August 10, 2025 at 7:08 PM
I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:
Reposted by Bogdan Pasaniuc
📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
July 25, 2025 at 7:24 AM
📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
Reposted by Bogdan Pasaniuc
It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium offering reassurances about the uses of behavioural polygenic scores to one of their lead authors marketing embryo selection for IQ
August 2, 2025 at 2:15 AM
It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium offering reassurances about the uses of behavioural polygenic scores to one of their lead authors marketing embryo selection for IQ
Reposted by Bogdan Pasaniuc
A few thoughts on Herasight, the new embryo selection company. First, their whitepaper (drive.google.com/file/d/1EpFi...) implies that competitors like Nucleus have been marketing and selling grossly erroneous risk estimates. This is shocking if true! 🧵
August 2, 2025 at 2:38 PM
A few thoughts on Herasight, the new embryo selection company. First, their whitepaper (drive.google.com/file/d/1EpFi...) implies that competitors like Nucleus have been marketing and selling grossly erroneous risk estimates. This is shocking if true! 🧵
Reposted by Bogdan Pasaniuc
📣 We are recruiting! Please share!!
Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺
We have two roles available 👇
🧵 1/4
Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺
We have two roles available 👇
🧵 1/4
July 31, 2025 at 4:12 PM
📣 We are recruiting! Please share!!
Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺
We have two roles available 👇
🧵 1/4
Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺
We have two roles available 👇
🧵 1/4
Reposted by Bogdan Pasaniuc
We have multiple postdoc positions available in my group at NYU. Join us if you're interested in complex trait genetics and biology. More information about the lab on our website: mostafavilab.org
Home | Mostafavi Lab
mostafavilab.org
June 1, 2024 at 1:43 PM
We have multiple postdoc positions available in my group at NYU. Join us if you're interested in complex trait genetics and biology. More information about the lab on our website: mostafavilab.org
Reposted by Bogdan Pasaniuc
We have 2-3 group leader positions opening @fimm-uh.bsky.social !!
We are looking for outstanding candidates in human genetics and precision medicine.
This time we have a focus on population health data science. E.g. AI for EHR/health data
Generous starting package 💰
shorturl.at/FAk6n
We are looking for outstanding candidates in human genetics and precision medicine.
This time we have a focus on population health data science. E.g. AI for EHR/health data
Generous starting package 💰
shorturl.at/FAk6n
FIMM-EMBL Group Leaders in Molecular Medicine
FIMM-EMBL Group Leaders in Molecular Medicine
jobs.helsinki.fi
June 1, 2025 at 3:38 PM
We have 2-3 group leader positions opening @fimm-uh.bsky.social !!
We are looking for outstanding candidates in human genetics and precision medicine.
This time we have a focus on population health data science. E.g. AI for EHR/health data
Generous starting package 💰
shorturl.at/FAk6n
We are looking for outstanding candidates in human genetics and precision medicine.
This time we have a focus on population health data science. E.g. AI for EHR/health data
Generous starting package 💰
shorturl.at/FAk6n
Reposted by Bogdan Pasaniuc
Super excited to see this out. What started as some math in a grant in 2020, to a student deciding to take this on in 2022, to published in 2025.
These things can take time and patience is key!
These things can take time and patience is key!
📢OUT TODAY @natgenet.nature.com
📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.
By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.
By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk - Nature Genetics
SuShiE is a multiancestry fine-mapping method for molecular quantitative trait loci that leverages linkage disequilibrium heterogeneity to improve resolution, infer cross-ancestry effect size correlat...
www.nature.com
July 21, 2025 at 6:54 PM
Super excited to see this out. What started as some math in a grant in 2020, to a student deciding to take this on in 2022, to published in 2025.
These things can take time and patience is key!
These things can take time and patience is key!
Reposted by Bogdan Pasaniuc
📢OUT TODAY @natgenet.nature.com
📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.
By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.
By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk - Nature Genetics
SuShiE is a multiancestry fine-mapping method for molecular quantitative trait loci that leverages linkage disequilibrium heterogeneity to improve resolution, infer cross-ancestry effect size correlat...
www.nature.com
July 21, 2025 at 1:56 PM
📢OUT TODAY @natgenet.nature.com
📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.
By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.
By @zeyunlu.bsky.social, @nmancuso.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Reposted by Bogdan Pasaniuc
Super excited to share our new phenome-wide comparison of polygenic and proteomic risk scores in 40,000 people. We find proteins generally outpredict genetics for disease incidence, but polygenic prediction remains important in heritable diseases. medrxiv.org/content/10.1101/2025.07.10.25331242v1
July 15, 2025 at 1:32 AM
Super excited to share our new phenome-wide comparison of polygenic and proteomic risk scores in 40,000 people. We find proteins generally outpredict genetics for disease incidence, but polygenic prediction remains important in heritable diseases. medrxiv.org/content/10.1101/2025.07.10.25331242v1
Reposted by Bogdan Pasaniuc
Our new AJHG paper is online. We develop a new TWAS tool that uses local-ancestry information to improve power of gene mapping in admixed samples. Lead author Taylor Head (now at MD Anderson) did a phenomenal job spearheading this work!
🚨New method!
📄CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data
🧑🤝🧑 @epsteinstatgen.bsky.social @yjingj.bsky.social & co
📄CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data
🧑🤝🧑 @epsteinstatgen.bsky.social @yjingj.bsky.social & co
CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data
CADET is a transcriptome-wide association test for admixed cohorts that leverages
local ancestry information to improve detection of trait-influencing genes. CADET
outperformed existing methods using ...
www.cell.com
June 23, 2025 at 12:33 PM
Our new AJHG paper is online. We develop a new TWAS tool that uses local-ancestry information to improve power of gene mapping in admixed samples. Lead author Taylor Head (now at MD Anderson) did a phenomenal job spearheading this work!
Reposted by Bogdan Pasaniuc
📣New from @bpasaniuc.bsky.social & co
📄Exploring #depression treatment response by using #polygenic risk scoring across diverse populations
📄Exploring #depression treatment response by using #polygenic risk scoring across diverse populations
Exploring depression treatment response by using polygenic risk scoring across diverse populations
Ancestrally diverse biobanks where medication, disease, and genetics are linked provide
an opportunity to understand treatment response to major depressive disorder (MDD).
We developed polygenic risk ...
www.cell.com
June 30, 2025 at 3:48 PM
📣New from @bpasaniuc.bsky.social & co
📄Exploring #depression treatment response by using #polygenic risk scoring across diverse populations
📄Exploring #depression treatment response by using #polygenic risk scoring across diverse populations
Reposted by Bogdan Pasaniuc
Rivian just reported Q1 2025 earnings:
- Second straight quarter of gross profit
- R2 still on track for early 2026
- Hands-free driving rolling out
- $1B from VW coming in June
- Deliveries revised to 40k–46k for 2025
Full details: riviantrackr.com/news/rivian-...
- Second straight quarter of gross profit
- R2 still on track for early 2026
- Hands-free driving rolling out
- $1B from VW coming in June
- Deliveries revised to 40k–46k for 2025
Full details: riviantrackr.com/news/rivian-...
May 6, 2025 at 8:58 PM
Rivian just reported Q1 2025 earnings:
- Second straight quarter of gross profit
- R2 still on track for early 2026
- Hands-free driving rolling out
- $1B from VW coming in June
- Deliveries revised to 40k–46k for 2025
Full details: riviantrackr.com/news/rivian-...
- Second straight quarter of gross profit
- R2 still on track for early 2026
- Hands-free driving rolling out
- $1B from VW coming in June
- Deliveries revised to 40k–46k for 2025
Full details: riviantrackr.com/news/rivian-...
Two more weeks to go! Inclusive Genomics to Promote Health Excellence Symposium at @upenn.edu @penngenetics.bsky.social @pennmedcso.bsky.social!
Excited to host such an amazing lineup of speakers! Registration is free but required; see www.med.upenn.edu/ccb/
Excited to host such an amazing lineup of speakers! Registration is free but required; see www.med.upenn.edu/ccb/
May 2, 2025 at 12:54 PM
Two more weeks to go! Inclusive Genomics to Promote Health Excellence Symposium at @upenn.edu @penngenetics.bsky.social @pennmedcso.bsky.social!
Excited to host such an amazing lineup of speakers! Registration is free but required; see www.med.upenn.edu/ccb/
Excited to host such an amazing lineup of speakers! Registration is free but required; see www.med.upenn.edu/ccb/
Looking forward to presenting at the Cell Symposia: Precision genomics for human health in San Diego, September 11–13, 2025. For a chance to present your research at this event, submit an abstract before May 30 here: www.cell-symposia.com/precision-ge... #CSPrecisionGen25
See you in San Diego!
See you in San Diego!
Home – Cell Symposia: Precision genomics in human health
Cell Symposia: Precision genomics in human health
www.cell-symposia.com
May 2, 2025 at 12:56 AM
Looking forward to presenting at the Cell Symposia: Precision genomics for human health in San Diego, September 11–13, 2025. For a chance to present your research at this event, submit an abstract before May 30 here: www.cell-symposia.com/precision-ge... #CSPrecisionGen25
See you in San Diego!
See you in San Diego!
Reposted by Bogdan Pasaniuc
I wrote about how we must stand and fight against the threat of eugenics.
Fueled by white nationalism and scientific racism, these beliefs are factually wrong and ethically abhorrent.
This fight includes supporting efforts to diversify our workforce & science. To stop now would be a deep betrayal.
Fueled by white nationalism and scientific racism, these beliefs are factually wrong and ethically abhorrent.
This fight includes supporting efforts to diversify our workforce & science. To stop now would be a deep betrayal.
Eugenics is on the rise again: human geneticists must take a stand
Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics.
www.nature.com
April 24, 2025 at 12:44 PM
I wrote about how we must stand and fight against the threat of eugenics.
Fueled by white nationalism and scientific racism, these beliefs are factually wrong and ethically abhorrent.
This fight includes supporting efforts to diversify our workforce & science. To stop now would be a deep betrayal.
Fueled by white nationalism and scientific racism, these beliefs are factually wrong and ethically abhorrent.
This fight includes supporting efforts to diversify our workforce & science. To stop now would be a deep betrayal.
Reposted by Bogdan Pasaniuc
🚨 New paper 🚨
Do known genetic factors for obesity and type 2 diabetes affect weight loss from GLP1-RA (Ozempic) or bariatric surgery?
🔍 10,960 people, 9 biobanks, 6 countries
🧬 Minimal genetic impact on GLP1-RA response
📉 Modest effect after surgery
www.nature.com/articles/s41...
Do known genetic factors for obesity and type 2 diabetes affect weight loss from GLP1-RA (Ozempic) or bariatric surgery?
🔍 10,960 people, 9 biobanks, 6 countries
🧬 Minimal genetic impact on GLP1-RA response
📉 Modest effect after surgery
www.nature.com/articles/s41...
Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery - Nature Medicine
The authors found, after analyzing 10,960 individuals from 9 multiancestry biobanks across 6 countries, that genetic factors previously associated with BMI have limited impact on GLP-1 receptor agonis...
www.nature.com
April 18, 2025 at 1:32 PM
🚨 New paper 🚨
Do known genetic factors for obesity and type 2 diabetes affect weight loss from GLP1-RA (Ozempic) or bariatric surgery?
🔍 10,960 people, 9 biobanks, 6 countries
🧬 Minimal genetic impact on GLP1-RA response
📉 Modest effect after surgery
www.nature.com/articles/s41...
Do known genetic factors for obesity and type 2 diabetes affect weight loss from GLP1-RA (Ozempic) or bariatric surgery?
🔍 10,960 people, 9 biobanks, 6 countries
🧬 Minimal genetic impact on GLP1-RA response
📉 Modest effect after surgery
www.nature.com/articles/s41...
Reposted by Bogdan Pasaniuc
Incredible GRC Genetics and Genomics conference line-up this year in Portland, Maine (www.grc.org/human-geneti...). With conference-maxxing sessions that run to 9:30pm!
Submission deadline is June 8th, conference July 6-11th.
Submission deadline is June 8th, conference July 6-11th.
April 19, 2025 at 12:49 AM
Incredible GRC Genetics and Genomics conference line-up this year in Portland, Maine (www.grc.org/human-geneti...). With conference-maxxing sessions that run to 9:30pm!
Submission deadline is June 8th, conference July 6-11th.
Submission deadline is June 8th, conference July 6-11th.
Reposted by Bogdan Pasaniuc
Excited to see this published: rdcu.be/egHer
Common- and rare-variant genetic analyses of heart failure in >2 million individuals
🔘 Dozens of new common variant loci
🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes
🔘 A PRS modifies penetrance of TTNtv
Common- and rare-variant genetic analyses of heart failure in >2 million individuals
🔘 Dozens of new common variant loci
🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes
🔘 A PRS modifies penetrance of TTNtv
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum
Nature Genetics - Common-variant and rare-variant association analyses combining datasets from multiple populations yield insights into the genetic architecture of all-cause heart failure across...
rdcu.be
April 8, 2025 at 11:44 AM
Excited to see this published: rdcu.be/egHer
Common- and rare-variant genetic analyses of heart failure in >2 million individuals
🔘 Dozens of new common variant loci
🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes
🔘 A PRS modifies penetrance of TTNtv
Common- and rare-variant genetic analyses of heart failure in >2 million individuals
🔘 Dozens of new common variant loci
🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes
🔘 A PRS modifies penetrance of TTNtv
Reposted by Bogdan Pasaniuc
“Investments in science and public health are essential for the future of rural southern states like Mississippi.”
Read about my perspectives as a Mississippian and scientist in my recent OpEd : digital.meridianstar.com/The-Meridian...
Read about my perspectives as a Mississippian and scientist in my recent OpEd : digital.meridianstar.com/The-Meridian...
April 10, 2025 at 5:37 PM
“Investments in science and public health are essential for the future of rural southern states like Mississippi.”
Read about my perspectives as a Mississippian and scientist in my recent OpEd : digital.meridianstar.com/The-Meridian...
Read about my perspectives as a Mississippian and scientist in my recent OpEd : digital.meridianstar.com/The-Meridian...
Reposted by Bogdan Pasaniuc
This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something.
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....
April 9, 2025 at 9:09 PM
This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something.
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....
Reposted by Bogdan Pasaniuc
WHAMM identified as key kidney disease risk gene ft. @DhanunjayMukhi, Lakshmi Kolligundla, @TomohitoD, @andradesilvamag, @ksusztak.bsky.social (@PennKidney/ @penngenetics.bsky.social), @Hongbo919Liu (@UR_Med) & Matthew Palmer (@pennpathlabmed.bsky.social) www.cell.com/cell-reports...
April 4, 2025 at 6:05 PM
WHAMM identified as key kidney disease risk gene ft. @DhanunjayMukhi, Lakshmi Kolligundla, @TomohitoD, @andradesilvamag, @ksusztak.bsky.social (@PennKidney/ @penngenetics.bsky.social), @Hongbo919Liu (@UR_Med) & Matthew Palmer (@pennpathlabmed.bsky.social) www.cell.com/cell-reports...
Reposted by Bogdan Pasaniuc
The New York Times recently had an article on IVF and embryo selection which I think buries a few important ledes about these products ...
Opinion | Should Human Life Be Optimized?
Advances in genetic testing and artificial intelligence are changing what’s possible for those undergoing I.V.F. Are we ready for the future of fertility?
www.nytimes.com
April 3, 2025 at 5:29 PM
The New York Times recently had an article on IVF and embryo selection which I think buries a few important ledes about these products ...
Reposted by Bogdan Pasaniuc
I'm delighted to be part of this symposium, put on by University of Pennsylvania Perelman School of Medicine, and led by @bpasaniuc.bsky.social and @sarahtishkoff.bsky.social. See you in a few weeks! upenn.co1.qualtrics.com/jfe/form/SV_...
April 3, 2025 at 2:48 PM
I'm delighted to be part of this symposium, put on by University of Pennsylvania Perelman School of Medicine, and led by @bpasaniuc.bsky.social and @sarahtishkoff.bsky.social. See you in a few weeks! upenn.co1.qualtrics.com/jfe/form/SV_...