Michael Levin
@mglevin.bsky.social
🫀Cardiologist @PennCardiology and @VAPhiladelphia
🧬Interested in human genetics of cardiovascular disease | #rstats enthusiast | mglev1n.github.io
🧬Interested in human genetics of cardiovascular disease | #rstats enthusiast | mglev1n.github.io
Pinned
Michael Levin
@mglevin.bsky.social
· Nov 16
Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates. #AHA24
https://ja.ma/3YTigyp
https://ja.ma/3YTigyp
🚨 Our work exploring polygenic risk scores for Coronary Heart Disease is now out in @JAMA_current and presented at #AHA24 by all-star #SarnoffCardio fellow Sarah Abramowitz!
Reposted by Michael Levin
New event at #AHA2025!
GPM Symposium Model Systems: Preclinical to Phase I Bridge
Nov 7 12:30-5:15
Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials
Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!
GPM Symposium Model Systems: Preclinical to Phase I Bridge
Nov 7 12:30-5:15
Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials
Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!
October 24, 2025 at 9:05 PM
New event at #AHA2025!
GPM Symposium Model Systems: Preclinical to Phase I Bridge
Nov 7 12:30-5:15
Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials
Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!
GPM Symposium Model Systems: Preclinical to Phase I Bridge
Nov 7 12:30-5:15
Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials
Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!
Reposted by Michael Levin
Amid the hype of using polygenic scores for embryo selection, some thoughts on their implementation potential in real-world settings (and problems) 👇
August 19, 2025 at 9:26 PM
Amid the hype of using polygenic scores for embryo selection, some thoughts on their implementation potential in real-world settings (and problems) 👇
Reposted by Michael Levin
Massive multi-ancestry GWAS resource for 1,167 clinical traits & diseases in 6 global biobanks (n=1,789,365)
👉29,139 locus-trait pairs
👉2,624 non-overlapping loci across the genome
👉associated with 6 traits each (median)
👉colocalization across traits for 72% of loci [1/3]
👉29,139 locus-trait pairs
👉2,624 non-overlapping loci across the genome
👉associated with 6 traits each (median)
👉colocalization across traits for 72% of loci [1/3]
April 24, 2025 at 7:57 PM
Massive multi-ancestry GWAS resource for 1,167 clinical traits & diseases in 6 global biobanks (n=1,789,365)
👉29,139 locus-trait pairs
👉2,624 non-overlapping loci across the genome
👉associated with 6 traits each (median)
👉colocalization across traits for 72% of loci [1/3]
👉29,139 locus-trait pairs
👉2,624 non-overlapping loci across the genome
👉associated with 6 traits each (median)
👉colocalization across traits for 72% of loci [1/3]
Reposted by Michael Levin
Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations!
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
April 23, 2025 at 11:35 AM
Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations!
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
Reposted by Michael Levin
ft. Cardone, Zhang, Noah, @sabramowitz.bsky.social, Sharma, DePaolo, Conery, Hoffman-Andrews, Judy, @noshreza.bsky.social, @5inghalp.bsky.social, Arany, Cappola, Day, Owens, @danrader.bsky.social @marylynritchie.bsky.social @bvoight28.bsky.social, Levin & Damrauer www.nature.com/articles/s41...
April 21, 2025 at 3:22 PM
ft. Cardone, Zhang, Noah, @sabramowitz.bsky.social, Sharma, DePaolo, Conery, Hoffman-Andrews, Judy, @noshreza.bsky.social, @5inghalp.bsky.social, Arany, Cappola, Day, Owens, @danrader.bsky.social @marylynritchie.bsky.social @bvoight28.bsky.social, Levin & Damrauer www.nature.com/articles/s41...
Reposted by Michael Levin
Thanks to @mglevin.bsky.social for sharing this new heart failure PRS from @naturegenet.bsky.social, 🔗: www.pgscatalog.org/score/PGS005.... This and more in the latest release, submit your scores at www.pgscatalog.org/submit!
April 17, 2025 at 10:28 AM
Thanks to @mglevin.bsky.social for sharing this new heart failure PRS from @naturegenet.bsky.social, 🔗: www.pgscatalog.org/score/PGS005.... This and more in the latest release, submit your scores at www.pgscatalog.org/submit!
Reposted by Michael Levin
105 new loci at #genome-wide significance linked to 5 distinct traits/diseases with shared #GeneticSusceptibility to #HeartFailure doi.org/10.1038/s415... @DavidSMLee @bvoight28.bsky.social @MarylynRitchie @damrauer #TranslationalScience
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum - Nature Genetics
Common-variant and rare-variant association analyses combining datasets from multiple populations yield insights into the genetic architecture of all-cause heart failure across the allele-frequency sp...
doi.org
April 11, 2025 at 12:45 PM
105 new loci at #genome-wide significance linked to 5 distinct traits/diseases with shared #GeneticSusceptibility to #HeartFailure doi.org/10.1038/s415... @DavidSMLee @bvoight28.bsky.social @MarylynRitchie @damrauer #TranslationalScience
Reposted by Michael Levin
Angiographic Burden of Coronary Atherosclerosis Contributes To Adverse ASCVD Outcomes Independent Of Traditional Risk Factors https://www.medrxiv.org/content/10.1101/2025.04.06.25325252v1
April 8, 2025 at 5:40 AM
Angiographic Burden of Coronary Atherosclerosis Contributes To Adverse ASCVD Outcomes Independent Of Traditional Risk Factors https://www.medrxiv.org/content/10.1101/2025.04.06.25325252v1
Excited to see this published: rdcu.be/egHer
Common- and rare-variant genetic analyses of heart failure in >2 million individuals
🔘 Dozens of new common variant loci
🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes
🔘 A PRS modifies penetrance of TTNtv
Common- and rare-variant genetic analyses of heart failure in >2 million individuals
🔘 Dozens of new common variant loci
🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes
🔘 A PRS modifies penetrance of TTNtv
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum
Nature Genetics - Common-variant and rare-variant association analyses combining datasets from multiple populations yield insights into the genetic architecture of all-cause heart failure across...
rdcu.be
April 8, 2025 at 11:44 AM
Excited to see this published: rdcu.be/egHer
Common- and rare-variant genetic analyses of heart failure in >2 million individuals
🔘 Dozens of new common variant loci
🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes
🔘 A PRS modifies penetrance of TTNtv
Common- and rare-variant genetic analyses of heart failure in >2 million individuals
🔘 Dozens of new common variant loci
🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes
🔘 A PRS modifies penetrance of TTNtv
Reposted by Michael Levin
Interested in calculating polygenic scores in the All Of Us workbench? Like those from @pgscatalog.bsky.social? Take a look at our new documentation for how to run pgsc_calc in the cloud environment: pgsc-calc.readthedocs.io/en/latest/ho.... Very much work-in-progress, optimisations incoming!
Running the PGS Catalog Calculator via the All of Us workbench — Polygenic Score (PGS) Catalog Calculator documentation
pgsc-calc.readthedocs.io
April 1, 2025 at 3:20 PM
Interested in calculating polygenic scores in the All Of Us workbench? Like those from @pgscatalog.bsky.social? Take a look at our new documentation for how to run pgsc_calc in the cloud environment: pgsc-calc.readthedocs.io/en/latest/ho.... Very much work-in-progress, optimisations incoming!
Reposted by Michael Levin
Effect of Disclosing a Polygenic Risk Score for Coronary Heart Disease on Adverse Cardiovascular Events www.ahajournals.org/doi/10.1161/...
March 31, 2025 at 11:18 AM
Effect of Disclosing a Polygenic Risk Score for Coronary Heart Disease on Adverse Cardiovascular Events www.ahajournals.org/doi/10.1161/...
Reposted by Michael Levin
CXCL12 drives natural variation in coronary artery anatomy across diverse populations @cellcellpress.bsky.social @tassimes.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
March 5, 2025 at 11:09 PM
CXCL12 drives natural variation in coronary artery anatomy across diverse populations @cellcellpress.bsky.social @tassimes.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Michael Levin
Q: How many genes should be tested for patients with hypertrophic cardiomyopathy? A: 29
Excited to share our latest: Re-Appraisal of HCM genes by our ClinGen Hereditary CVD Gene Curation Expert Panel out today in @jaccjournals.bsky.social
www.sciencedirect.com/science/arti...
Excited to share our latest: Re-Appraisal of HCM genes by our ClinGen Hereditary CVD Gene Curation Expert Panel out today in @jaccjournals.bsky.social
www.sciencedirect.com/science/arti...
Genes Associated With Hypertrophic Cardiomyopathy: A Reappraisal by the ClinGen Hereditary Cardiovascular Disease Gene Curation Expert Panel
Hypertrophic cardiomyopathy (HCM) is an inherited cardiac condition affecting ∼1 in 500 and exhibits marked genetic heterogeneity. Previously publishe…
www.sciencedirect.com
February 18, 2025 at 6:14 AM
Q: How many genes should be tested for patients with hypertrophic cardiomyopathy? A: 29
Excited to share our latest: Re-Appraisal of HCM genes by our ClinGen Hereditary CVD Gene Curation Expert Panel out today in @jaccjournals.bsky.social
www.sciencedirect.com/science/arti...
Excited to share our latest: Re-Appraisal of HCM genes by our ClinGen Hereditary CVD Gene Curation Expert Panel out today in @jaccjournals.bsky.social
www.sciencedirect.com/science/arti...
Reposted by Michael Levin
Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates.
https://ja.ma/3W8RykL
https://ja.ma/3W8RykL
January 11, 2025 at 7:00 PM
Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates.
https://ja.ma/3W8RykL
https://ja.ma/3W8RykL
Reposted by Michael Levin
🚀 Here are key takeaways from today's JAMA and JAMA Cardiology presentations a#AHA2424:
Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates. ž¡️ ja.ma/4fKewpK
November 16, 2024 at 10:00 PM
🚀 Here are key takeaways from today's JAMA and JAMA Cardiology presentations a#AHA2424:
Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates. ž¡️ ja.ma/4fKewpK
🚨 Our work exploring polygenic risk scores for Coronary Heart Disease is now out in @JAMA_current and presented at #AHA24 by all-star #SarnoffCardio fellow Sarah Abramowitz!
Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates. #AHA24
https://ja.ma/3YTigyp
https://ja.ma/3YTigyp
November 16, 2024 at 8:55 PM
🚨 Our work exploring polygenic risk scores for Coronary Heart Disease is now out in @JAMA_current and presented at #AHA24 by all-star #SarnoffCardio fellow Sarah Abramowitz!
Excited for these trainee presentations from the lab at
@ahascience.bsky.social #AHA24, spanning cardiovascular genomics and precision medicine. Come check out these talks, moderated posters, and posters to learn more about our work!
@ahascience.bsky.social #AHA24, spanning cardiovascular genomics and precision medicine. Come check out these talks, moderated posters, and posters to learn more about our work!
November 15, 2024 at 2:40 AM
Excited for these trainee presentations from the lab at
@ahascience.bsky.social #AHA24, spanning cardiovascular genomics and precision medicine. Come check out these talks, moderated posters, and posters to learn more about our work!
@ahascience.bsky.social #AHA24, spanning cardiovascular genomics and precision medicine. Come check out these talks, moderated posters, and posters to learn more about our work!