Sam Lambert
@iamslambert.bsky.social
🇨🇦 in 🇬🇧. Assistant Prof. studying polygenic scores & multimorbidity at University of Cambridge; co-lead @pgscatalog.bsky.social. Otherwise, probably talking about good films, bad tv, or wine.
Reposted by Sam Lambert
Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).
GitHub - PGScatalog/pgsc_calc: The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation
The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation - PGScatalog/pgsc_calc
github.com
November 11, 2025 at 5:43 PM
Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).
Reposted by Sam Lambert
Another month and lots of new & useful data added to www.PGSCatalog.org! Including new multi-ancestry insulin resistance scores, a score tailored for heart failure in East Asian individuals & more!
PGS Catalog - The Polygenic Score Catalog
The Polygenic Score (PGS) Catalog is an open database of
published PGS and the relevant metadata needed to apply and evaluate them correctly.
www.PGSCatalog.org
November 11, 2025 at 5:41 PM
Another month and lots of new & useful data added to www.PGSCatalog.org! Including new multi-ancestry insulin resistance scores, a score tailored for heart failure in East Asian individuals & more!
Reposted by Sam Lambert
🚨 Countdown to #ASHG25: Predicted Effector Gene standard is coming! 🚨 Join us and be part of the conversation!
📌 Poster Oct 16 | 2:30–4:30 | Poster Hall
🗓️ Session Oct 17 | 11:45–1:15 | Room 259A
Learn more: kpnashg2025.wordpress.com/pegs-workshop/
📌 Poster Oct 16 | 2:30–4:30 | Poster Hall
🗓️ Session Oct 17 | 11:45–1:15 | Room 259A
Learn more: kpnashg2025.wordpress.com/pegs-workshop/
PEGs Workshop
Friday, October 17th | 11:45AM – 1:15PM | Convention Center room 259A The meeting will open with an introduction (Noel Burtt), include a recap of the landscape analysis (Laura Harris), presentation…
kpnashg2025.wordpress.com
October 14, 2025 at 8:24 AM
🚨 Countdown to #ASHG25: Predicted Effector Gene standard is coming! 🚨 Join us and be part of the conversation!
📌 Poster Oct 16 | 2:30–4:30 | Poster Hall
🗓️ Session Oct 17 | 11:45–1:15 | Room 259A
Learn more: kpnashg2025.wordpress.com/pegs-workshop/
📌 Poster Oct 16 | 2:30–4:30 | Poster Hall
🗓️ Session Oct 17 | 11:45–1:15 | Room 259A
Learn more: kpnashg2025.wordpress.com/pegs-workshop/
Reposted by Sam Lambert
ICYMI 👉 Quantifying the fairness of polygenic risk scores: our modelling and analysis for CVD risk prediction www.medrxiv.org/content/10.1...
Overall PRS fairness levels similar to or better than traditional predictors (age, sex, BP, lipids)
h\t @iamslambert.bsky.social @clairecoffey.bsky.social
Overall PRS fairness levels similar to or better than traditional predictors (age, sex, BP, lipids)
h\t @iamslambert.bsky.social @clairecoffey.bsky.social
Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction
Background Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a critical...
www.medrxiv.org
October 5, 2025 at 2:46 PM
ICYMI 👉 Quantifying the fairness of polygenic risk scores: our modelling and analysis for CVD risk prediction www.medrxiv.org/content/10.1...
Overall PRS fairness levels similar to or better than traditional predictors (age, sex, BP, lipids)
h\t @iamslambert.bsky.social @clairecoffey.bsky.social
Overall PRS fairness levels similar to or better than traditional predictors (age, sex, BP, lipids)
h\t @iamslambert.bsky.social @clairecoffey.bsky.social
Reposted by Sam Lambert
Our new paper is out, in which we developed an approach to transform Polygenic Scores (PGSs) into disorder probabilities (i.e., the absolute lifetime disorder risk).
Below a thread 👇
open access link: rdcu.be/eIjvC
Below a thread 👇
open access link: rdcu.be/eIjvC
Estimating disorder probability based on polygenic prediction using the BPC approach
Nature Communications - Here the authors present a method to transform polygenic scores into disorder probabilities using only GWAS summary statistics, genotype data and a prior - no tuning sample...
rdcu.be
September 27, 2025 at 2:47 AM
Our new paper is out, in which we developed an approach to transform Polygenic Scores (PGSs) into disorder probabilities (i.e., the absolute lifetime disorder risk).
Below a thread 👇
open access link: rdcu.be/eIjvC
Below a thread 👇
open access link: rdcu.be/eIjvC
Reposted by Sam Lambert
Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...
Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction
Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a…
www.medrxiv.org
September 19, 2025 at 5:06 PM
Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...
Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...
Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction
Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a…
www.medrxiv.org
September 19, 2025 at 5:06 PM
Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...
Reposted by Sam Lambert
Awesome work by @clairecoffey.bsky.social @iamslambert.bsky.social @sritchie73.bsky.social Lisa Pennells and Angela Wood
September 19, 2025 at 3:31 PM
Awesome work by @clairecoffey.bsky.social @iamslambert.bsky.social @sritchie73.bsky.social Lisa Pennells and Angela Wood
Reposted by Sam Lambert
PRS are well know to have variable performance across ancestries, frequently with a European bias. We looked closely at fairness of PRS for CVD risk prediction, both with PRS on it's own and in an integrated risk score...
Our results were surprising... 👉 www.medrxiv.org/content/10.1...
Our results were surprising... 👉 www.medrxiv.org/content/10.1...
Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction
Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a critica...
www.medrxiv.org
September 19, 2025 at 3:29 PM
PRS are well know to have variable performance across ancestries, frequently with a European bias. We looked closely at fairness of PRS for CVD risk prediction, both with PRS on it's own and in an integrated risk score...
Our results were surprising... 👉 www.medrxiv.org/content/10.1...
Our results were surprising... 👉 www.medrxiv.org/content/10.1...
Reposted by Sam Lambert
🚨Exciting fully funded PhD opportunity!
Applications are open for a DTP iCase interdisciplinary PhD studentship in Public Health and Primary Care supervised by @eliasallara.bsky.social
Apply by 2 Dec 2025 👉 www.cam.ac.uk/jobs/dtp-ica...
Applications are open for a DTP iCase interdisciplinary PhD studentship in Public Health and Primary Care supervised by @eliasallara.bsky.social
Apply by 2 Dec 2025 👉 www.cam.ac.uk/jobs/dtp-ica...
September 19, 2025 at 12:16 PM
🚨Exciting fully funded PhD opportunity!
Applications are open for a DTP iCase interdisciplinary PhD studentship in Public Health and Primary Care supervised by @eliasallara.bsky.social
Apply by 2 Dec 2025 👉 www.cam.ac.uk/jobs/dtp-ica...
Applications are open for a DTP iCase interdisciplinary PhD studentship in Public Health and Primary Care supervised by @eliasallara.bsky.social
Apply by 2 Dec 2025 👉 www.cam.ac.uk/jobs/dtp-ica...
Reposted by Sam Lambert
Sept is approaching & I can already hear initial chats/enquiries for potential PhD studies happening!
If you're interested in a PhD, check out our department @cam.ac.uk www.phpc.cam.ac.uk/education-an...
We've a super interdisciplinary faculty spanning primary care, data science, epidemiology etc
If you're interested in a PhD, check out our department @cam.ac.uk www.phpc.cam.ac.uk/education-an...
We've a super interdisciplinary faculty spanning primary care, data science, epidemiology etc
Doctoral Training | Department of Public Health and Primary Care (PHPC)
Course Code – MDPU22 A doctorate from the University of Cambridge is primarily a research degree based on a research programme developed in conjunction with a supervisor.
www.phpc.cam.ac.uk
August 27, 2025 at 12:35 PM
Sept is approaching & I can already hear initial chats/enquiries for potential PhD studies happening!
If you're interested in a PhD, check out our department @cam.ac.uk www.phpc.cam.ac.uk/education-an...
We've a super interdisciplinary faculty spanning primary care, data science, epidemiology etc
If you're interested in a PhD, check out our department @cam.ac.uk www.phpc.cam.ac.uk/education-an...
We've a super interdisciplinary faculty spanning primary care, data science, epidemiology etc
Reposted by Sam Lambert
⏰ Last couple of days to apply to join my group @Cambridge as a postdoc and work on the environmental (un)sustainability of AI!
⏳ Closing September 16th.
✏️ Apply here: tinyurl.com/2ukkp8yx
Or learn more about what we do at www.lannelongue-group.org
Initial examples of research projects below 👇
⏳ Closing September 16th.
✏️ Apply here: tinyurl.com/2ukkp8yx
Or learn more about what we do at www.lannelongue-group.org
Initial examples of research projects below 👇
Research Associate*/Research Assistant in Sustainability of AI (Fixed Term)
An exciting opportunity has arisen for a talented researcher to join our team as part of the Green Algorithms Initiative, one of the leading academic teams in the field of sustainable computing. The
www.cam.ac.uk
September 15, 2025 at 8:50 AM
⏰ Last couple of days to apply to join my group @Cambridge as a postdoc and work on the environmental (un)sustainability of AI!
⏳ Closing September 16th.
✏️ Apply here: tinyurl.com/2ukkp8yx
Or learn more about what we do at www.lannelongue-group.org
Initial examples of research projects below 👇
⏳ Closing September 16th.
✏️ Apply here: tinyurl.com/2ukkp8yx
Or learn more about what we do at www.lannelongue-group.org
Initial examples of research projects below 👇
Reposted by Sam Lambert
ICYMI it's not a Max Planck directorship but still a great opportunity to join an exciting research environment down under 😁 bsky.app/profile/mike...
📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
August 3, 2025 at 6:18 PM
ICYMI it's not a Max Planck directorship but still a great opportunity to join an exciting research environment down under 😁 bsky.app/profile/mike...
Reposted by Sam Lambert
📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
July 25, 2025 at 7:24 AM
📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
Reposted by Sam Lambert
Is anyone aware of PhD students having access to #allofus data? We are being told it's impossible. Which seems... impractical... given that students do so much of the research in many places. Please reskeet even if you don't know the answer? Would really like to resolve this barrier for my student.
July 2, 2025 at 3:48 PM
Is anyone aware of PhD students having access to #allofus data? We are being told it's impossible. Which seems... impractical... given that students do so much of the research in many places. Please reskeet even if you don't know the answer? Would really like to resolve this barrier for my student.
Interested in methods for updating risk prediction models (time-to-event) with new features? Check out this new paper with Will Underwood & co introducing the CARE method, and an application where we augment SCORE2 with PGS & IMD: arxiv.org/abs/2506.23870.
July 1, 2025 at 8:31 PM
Interested in methods for updating risk prediction models (time-to-event) with new features? Check out this new paper with Will Underwood & co introducing the CARE method, and an application where we augment SCORE2 with PGS & IMD: arxiv.org/abs/2506.23870.
Reposted by Sam Lambert
We're working closely with our PredictDB colleagues to bring you an integrated resource for multi-omic predictors
We're happy to announce that PrediXcan GTExV8 expression predictors are now annotated and openly available via OmicsPred! www.omicspred.org
More info www.omicspred.org/publication/...
We're happy to announce that PrediXcan GTExV8 expression predictors are now annotated and openly available via OmicsPred! www.omicspred.org
More info www.omicspred.org/publication/...
OmicsPred is an atlas of genetic scores for prediction of multi-omics data.
www.omicspred.org
June 16, 2025 at 12:24 PM
We're working closely with our PredictDB colleagues to bring you an integrated resource for multi-omic predictors
We're happy to announce that PrediXcan GTExV8 expression predictors are now annotated and openly available via OmicsPred! www.omicspred.org
More info www.omicspred.org/publication/...
We're happy to announce that PrediXcan GTExV8 expression predictors are now annotated and openly available via OmicsPred! www.omicspred.org
More info www.omicspred.org/publication/...
Reposted by Sam Lambert
Super excited to see beginning integration of PredictDB into OmicsPred!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
June 16, 2025 at 10:33 AM
Super excited to see beginning integration of PredictDB into OmicsPred!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
Reposted by Sam Lambert
❓Has anyone looked at the overlap between MVP and All of Us? Big enough to worry about when training/testing PGS?
cc @sritchie73.bsky.social @iamslambert.bsky.social
cc @sritchie73.bsky.social @iamslambert.bsky.social
June 12, 2025 at 2:59 PM
❓Has anyone looked at the overlap between MVP and All of Us? Big enough to worry about when training/testing PGS?
cc @sritchie73.bsky.social @iamslambert.bsky.social
cc @sritchie73.bsky.social @iamslambert.bsky.social
Reposted by Sam Lambert
NB: The Polygenic Score Catalog has just lost its NIH funding. It was substantial. We are now on auxillary funding sources.
If anyone has a spare £1m plz DM
If anyone has a spare £1m plz DM
May 29, 2025 at 8:13 PM
NB: The Polygenic Score Catalog has just lost its NIH funding. It was substantial. We are now on auxillary funding sources.
If anyone has a spare £1m plz DM
If anyone has a spare £1m plz DM
Reposted by Sam Lambert
From a genomics & bioinformatics perspective, these new NIH policies will likely knock out the pillars of these research fields across the world. No joke. Reseachers everywhere should be aware and **non-US funders need to step up** to fill the big gaps that will appear in the coming months.
How are folks handling NIH’s no foreign subawards policy? Anyone working with big consortia (e.g. Human Protein Atlas, Sweden), this will become a massive problem—some orgs are the only source for rare reagents/proteins, and distribute them at cost. Curious the implications/plans for navigating.
May 3, 2025 at 3:55 PM
From a genomics & bioinformatics perspective, these new NIH policies will likely knock out the pillars of these research fields across the world. No joke. Reseachers everywhere should be aware and **non-US funders need to step up** to fill the big gaps that will appear in the coming months.
Lots of food for thought about circadian regulation during the #eshg2025 genetic epidemiology session today… 🤔 am I too sleep deprived to understand?
May 25, 2025 at 9:36 AM
Lots of food for thought about circadian regulation during the #eshg2025 genetic epidemiology session today… 🤔 am I too sleep deprived to understand?
@hasanga.bsky.social from @mikeinouye.bsky.social / @cambridgebaker.bsky.social @cambridge-ceu.bsky.social sharing new results for local-ancestry effects on CAD risk loci. #ESHG2025
May 24, 2025 at 9:38 AM
@hasanga.bsky.social from @mikeinouye.bsky.social / @cambridgebaker.bsky.social @cambridge-ceu.bsky.social sharing new results for local-ancestry effects on CAD risk loci. #ESHG2025
I meant #ESHG2025, oops!
Great fun sharing the @pgscatalog.bsky.social at the pre- #ESHG25 course on open-source genomics resources. Thanks to Juliana Cerqueira and Inga Prokopenko for the invite!
Looking forward to the rest of the conference!
Looking forward to the rest of the conference!
May 24, 2025 at 8:37 AM
I meant #ESHG2025, oops!
Great fun sharing the @pgscatalog.bsky.social at the pre- #ESHG25 course on open-source genomics resources. Thanks to Juliana Cerqueira and Inga Prokopenko for the invite!
Looking forward to the rest of the conference!
Looking forward to the rest of the conference!
May 23, 2025 at 4:45 PM
Great fun sharing the @pgscatalog.bsky.social at the pre- #ESHG25 course on open-source genomics resources. Thanks to Juliana Cerqueira and Inga Prokopenko for the invite!
Looking forward to the rest of the conference!
Looking forward to the rest of the conference!