Sam Lambert
@iamslambert.bsky.social
🇨🇦 in 🇬🇧. Assistant Prof. studying polygenic scores & multimorbidity at University of Cambridge; co-lead @pgscatalog.bsky.social. Otherwise, probably talking about good films, bad tv, or wine.
Reposted by Sam Lambert
Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).
GitHub - PGScatalog/pgsc_calc: The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation
The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation - PGScatalog/pgsc_calc
github.com
November 11, 2025 at 5:43 PM
Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).
On a personal note, it's great to have the first preprint out from my first PhD student! bsky.app/profile/clai...
I passed my PhD viva! 🎉 Thank you to everyone who has been a part of this incredible journey, especially my supervisors @iamslambert.bsky.social, Angela Wood, and @mikeinouye.bsky.social 😄
September 19, 2025 at 5:08 PM
On a personal note, it's great to have the first preprint out from my first PhD student! bsky.app/profile/clai...
There's much more in the preprint - a great team effort from @clairecoffey.bsky.social @sritchie73.bsky.social, Lisa Pennells, Angela Wood & @mikeinouye.bsky.social all from @cambridge-ceu.bsky.social!
September 19, 2025 at 5:06 PM
There's much more in the preprint - a great team effort from @clairecoffey.bsky.social @sritchie73.bsky.social, Lisa Pennells, Angela Wood & @mikeinouye.bsky.social all from @cambridge-ceu.bsky.social!
Clinical statements (AHA, ESC) have suggested that PRS may be most useful as a risk-enhancing factor for those at intermediate risk. We used PRS to reclassify individuals at intermediate risk by QRISK3 and showed improved sensitivity and fairness benefits (particularly for age & sex).
September 19, 2025 at 5:06 PM
Clinical statements (AHA, ESC) have suggested that PRS may be most useful as a risk-enhancing factor for those at intermediate risk. We used PRS to reclassify individuals at intermediate risk by QRISK3 and showed improved sensitivity and fairness benefits (particularly for age & sex).
We evaluated PRS in two contexts, as a standalone risk predictor and as a risk-enhancing factor. Given the known performance differences across ancestries, we were surprised to find that the fairness of PRS predictions across ethnicities was equal to or lower other CVD risk factors when used alone.
September 19, 2025 at 5:06 PM
We evaluated PRS in two contexts, as a standalone risk predictor and as a risk-enhancing factor. Given the known performance differences across ancestries, we were surprised to find that the fairness of PRS predictions across ethnicities was equal to or lower other CVD risk factors when used alone.
Reposted by Sam Lambert
Awesome work by @clairecoffey.bsky.social @iamslambert.bsky.social @sritchie73.bsky.social Lisa Pennells and Angela Wood
September 19, 2025 at 3:31 PM
Awesome work by @clairecoffey.bsky.social @iamslambert.bsky.social @sritchie73.bsky.social Lisa Pennells and Angela Wood
Reposted by Sam Lambert
NB: The Polygenic Score Catalog has just lost its NIH funding. It was substantial. We are now on auxillary funding sources.
If anyone has a spare £1m plz DM
If anyone has a spare £1m plz DM
May 29, 2025 at 8:13 PM
NB: The Polygenic Score Catalog has just lost its NIH funding. It was substantial. We are now on auxillary funding sources.
If anyone has a spare £1m plz DM
If anyone has a spare £1m plz DM