Andrea Ganna
@andganna.bsky.social
Associate Prof in health data science @HiLIFE_helsinki @FIMM_UH - MGH/Harvard - Playing with all kind of data - http://dsgelab.org
Reposted by Andrea Ganna
1/ 🚨New paper in Nature Genetics
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic associations with educational fields - Nature Genetics
Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personalit...
www.nature.com
November 4, 2025 at 10:23 AM
1/ 🚨New paper in Nature Genetics
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Happy to have contributed to this study!
Our personality and behaviors, as captured by genetic markers, also influence what we end up studying and, eventually, our professional careers
Our personality and behaviors, as captured by genetic markers, also influence what we end up studying and, eventually, our professional careers
1/ 🚨New paper in Nature Genetics
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic associations with educational fields - Nature Genetics
Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personalit...
www.nature.com
November 4, 2025 at 11:38 AM
Happy to have contributed to this study!
Our personality and behaviors, as captured by genetic markers, also influence what we end up studying and, eventually, our professional careers
Our personality and behaviors, as captured by genetic markers, also influence what we end up studying and, eventually, our professional careers
EU vice-president Virkkunen launches RAISE: resource for AI science in Europe. Not exactly clear what this entails. But i understand: more money, more networking.
November 3, 2025 at 2:36 PM
EU vice-president Virkkunen launches RAISE: resource for AI science in Europe. Not exactly clear what this entails. But i understand: more money, more networking.
Yoshua Bengio and the role of EU in AI development
November 3, 2025 at 1:57 PM
Yoshua Bengio and the role of EU in AI development
Reposted by Andrea Ganna
Are you in #Boston for #ASHG25?
Come by and check out my poster (#1023) today from 2:30–4:30 PM.
Would love to connect and discuss about it :)
Come by and check out my poster (#1023) today from 2:30–4:30 PM.
Would love to connect and discuss about it :)
🎉 New preprint out!
"Removing genetic effects on plasma proteins enhances their utility as disease biomarkers"
We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease
👉 doi.org/10.1101/2025...
"Removing genetic effects on plasma proteins enhances their utility as disease biomarkers"
We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease
👉 doi.org/10.1101/2025...
October 17, 2025 at 3:14 PM
🎉 New preprint out!
"Removing genetic effects on plasma proteins enhances their utility as disease biomarkers"
We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease
👉 doi.org/10.1101/2025...
"Removing genetic effects on plasma proteins enhances their utility as disease biomarkers"
We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease
👉 doi.org/10.1101/2025...
October 16, 2025 at 9:16 PM
🎉 New preprint out!
"Removing genetic effects on plasma proteins enhances their utility as disease biomarkers"
We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease
👉 doi.org/10.1101/2025...
"Removing genetic effects on plasma proteins enhances their utility as disease biomarkers"
We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease
👉 doi.org/10.1101/2025...
Reposted by Andrea Ganna
Very important paper for the geroscience hypothesis. Healthy aging is critical, even in the face of obvious disease states.
🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much.
Our new study in Nature Genetics including 9 disease and 7 biobanks shows:
• Susceptibility variants ≠ survival
• PRSs for onset weak at predicting progression
• Lifespan PRS predicts survival better
Our new study in Nature Genetics including 9 disease and 7 biobanks shows:
• Susceptibility variants ≠ survival
• PRSs for onset weak at predicting progression
• Lifespan PRS predicts survival better
October 6, 2025 at 9:55 AM
Very important paper for the geroscience hypothesis. Healthy aging is critical, even in the face of obvious disease states.
💥 New preprint & our first RCT! 💥
Does an extremely high or low BMI polygenic score influence weight loss after a diet intervention?
GENEROOS is a 6-month randomized diet vs. control trial testing if genetic predisposition to higher BMI affects weight loss in overweight adults
Does an extremely high or low BMI polygenic score influence weight loss after a diet intervention?
GENEROOS is a 6-month randomized diet vs. control trial testing if genetic predisposition to higher BMI affects weight loss in overweight adults
October 8, 2025 at 8:01 PM
💥 New preprint & our first RCT! 💥
Does an extremely high or low BMI polygenic score influence weight loss after a diet intervention?
GENEROOS is a 6-month randomized diet vs. control trial testing if genetic predisposition to higher BMI affects weight loss in overweight adults
Does an extremely high or low BMI polygenic score influence weight loss after a diet intervention?
GENEROOS is a 6-month randomized diet vs. control trial testing if genetic predisposition to higher BMI affects weight loss in overweight adults
Reposted by Andrea Ganna
A pretty comprehensive comparison of most actual #proteomics platforms:
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery
www.nature.com/articles/s42...
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery
www.nature.com/articles/s42...
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery - Communications Chemistry
Plasma proteome profiling has surged as a promising avenue for biomarker discovery, yet comprehensive platform comparisons remain scarce. Here, the authors evaluate eight proteomics platforms, revealing key differences and complementary strengths, providing crucial insights for researchers into coverage trade-offs and implicating biomarker discovery and clinical applications.
www.nature.com
October 1, 2025 at 6:13 AM
A pretty comprehensive comparison of most actual #proteomics platforms:
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery
www.nature.com/articles/s42...
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery
www.nature.com/articles/s42...
🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much.
Our new study in Nature Genetics including 9 disease and 7 biobanks shows:
• Susceptibility variants ≠ survival
• PRSs for onset weak at predicting progression
• Lifespan PRS predicts survival better
Our new study in Nature Genetics including 9 disease and 7 biobanks shows:
• Susceptibility variants ≠ survival
• PRSs for onset weak at predicting progression
• Lifespan PRS predicts survival better
September 30, 2025 at 12:50 PM
🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much.
Our new study in Nature Genetics including 9 disease and 7 biobanks shows:
• Susceptibility variants ≠ survival
• PRSs for onset weak at predicting progression
• Lifespan PRS predicts survival better
Our new study in Nature Genetics including 9 disease and 7 biobanks shows:
• Susceptibility variants ≠ survival
• PRSs for onset weak at predicting progression
• Lifespan PRS predicts survival better
“Towards modeling evolving longitudinal health trajectories with a transformer-based deep learning model”
in collaboration with Pekka Marttinen at @AaltoUniversity
www.sciencedirect.com/science/arti...
in collaboration with Pekka Marttinen at @AaltoUniversity
www.sciencedirect.com/science/arti...
Towards modeling evolving longitudinal health trajectories with a transformer-based deep learning model
Health registers provide valuable insights into individuals’ health trajectories. This study explores the use of deep learning to model and analyze th…
www.sciencedirect.com
September 23, 2025 at 12:05 PM
“Towards modeling evolving longitudinal health trajectories with a transformer-based deep learning model”
in collaboration with Pekka Marttinen at @AaltoUniversity
www.sciencedirect.com/science/arti...
in collaboration with Pekka Marttinen at @AaltoUniversity
www.sciencedirect.com/science/arti...
If you are interested in our pilot use of cross-EU health data ahead of the European Health Data Space implementation, check this out
pubmed.ncbi.nlm.nih.gov/40926479/
pubmed.ncbi.nlm.nih.gov/40926479/
User journeys in cross-European secondary use of health data: insights ahead of the European Health Data Space - PubMed
The European Health Data Space (EHDS) regulation aims to facilitate cross-border sharing of health data across Europe. However, practical challenges related to data access, interoperability, quality, ...
pubmed.ncbi.nlm.nih.gov
September 23, 2025 at 10:50 AM
If you are interested in our pilot use of cross-EU health data ahead of the European Health Data Space implementation, check this out
pubmed.ncbi.nlm.nih.gov/40926479/
pubmed.ncbi.nlm.nih.gov/40926479/
Reposted by Andrea Ganna
A project many years in the process, we’re pleased to present our work on multi-ancestry meta-analysis across a boatload of traits in the UK Biobank: www.nature.com/articles/s41...
Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects - Nature Genetics
Genome-wide analyses for 7,266 traits leveraging data from several genetic ancestry groups in UK Biobank identify new associations and enhance resources for interpreting risk variants across diverse p...
www.nature.com
September 18, 2025 at 5:25 PM
A project many years in the process, we’re pleased to present our work on multi-ancestry meta-analysis across a boatload of traits in the UK Biobank: www.nature.com/articles/s41...
Cool work from @ewanbirney.bsky.social Moritz Gerstung, Tom Fitzgerald about modeling health trajectories with generative AI!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Learning the natural history of human disease with generative transformers - Nature
Delphi-2M forecasts a person’s future health, covering more than 1,000 diseases, provides insights into co-morbidity dynamics and generates synthetic data for the training of AI models that have never...
www.nature.com
September 17, 2025 at 7:49 PM
Cool work from @ewanbirney.bsky.social Moritz Gerstung, Tom Fitzgerald about modeling health trajectories with generative AI!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Andrea Ganna
Some people call it a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
My love letter to social science genetics: communities.springernature.com/posts/a-love...
My love letter to social science genetics: communities.springernature.com/posts/a-love...
A Love Letter to Social Science Genetics
Some people call social science genetics a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
communities.springernature.com
September 8, 2025 at 5:55 AM
Some people call it a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences.
My love letter to social science genetics: communities.springernature.com/posts/a-love...
My love letter to social science genetics: communities.springernature.com/posts/a-love...
Check out @tuomohartonen.bsky.social blog post on our study, out today in Nature Genetics, comparing electronic health record-based risk scores with genetic polygenic scores, and how they work better together!
tuomohartonen.substack.com/p/medical-re...
tuomohartonen.substack.com/p/medical-re...
August 27, 2025 at 5:47 PM
Check out @tuomohartonen.bsky.social blog post on our study, out today in Nature Genetics, comparing electronic health record-based risk scores with genetic polygenic scores, and how they work better together!
tuomohartonen.substack.com/p/medical-re...
tuomohartonen.substack.com/p/medical-re...
Reposted by Andrea Ganna
Are electronic health records (EHR) more predictive of disease onset than polygenic scores? Can we transfer EHR-based prediction models between countries? Our study on these questions using 3 biobank-based studies with N>845K, is out in @natgenet.nature.com today:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cross-biobank generalizability and accuracy of electronic health record-based predictors compared to polygenic scores - Nature Genetics
Comparison of electronic health record-based phenotype risk scores (PheRS) and polygenic scores (PGS) across 13 common diseases and three biobank-based studies indicates that PheRS and PGS may provide...
www.nature.com
August 27, 2025 at 2:15 PM
Are electronic health records (EHR) more predictive of disease onset than polygenic scores? Can we transfer EHR-based prediction models between countries? Our study on these questions using 3 biobank-based studies with N>845K, is out in @natgenet.nature.com today:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Happy to see this online!
Having an extra sex chromosome really challenge the binary definition of sex based on XX and XY. So it is not only a medical, but also an important societal question.
Having an extra sex chromosome really challenge the binary definition of sex based on XX and XY. So it is not only a medical, but also an important societal question.
📣Online now!
📄 #PheWAS of male and female sex chromosome trisomies in 1.5 million participants of MVP, FinnGen, and UK Biobank
@finngen.bsky.social @ukbiobank.bsky.social
📄 #PheWAS of male and female sex chromosome trisomies in 1.5 million participants of MVP, FinnGen, and UK Biobank
@finngen.bsky.social @ukbiobank.bsky.social
Phenome-wide association study of male and female sex chromosome trisomies in 1.5 million participants of MVP, FinnGen, and UK Biobank
We examined disease associations for sex chromosome trisomies (SCTs) by performing
a phenome-wide association study in 2,769 individuals with SCT (47,XXY: 1,319; 47,XYY:
1,108; and 47,XXX: 342). Many ...
www.cell.com
August 22, 2025 at 8:59 AM
Happy to see this online!
Having an extra sex chromosome really challenge the binary definition of sex based on XX and XY. So it is not only a medical, but also an important societal question.
Having an extra sex chromosome really challenge the binary definition of sex based on XX and XY. So it is not only a medical, but also an important societal question.
Impressive paper by EPIC. They built a autoregressive transformer on 150M individuals and 115 billion
medical events.
Including: diagnoses, medications, lab values, procedure
Cons: model is not shared (and unlikely will be)
arxiv.org/pdf/2508.12104
medical events.
Including: diagnoses, medications, lab values, procedure
Cons: model is not shared (and unlikely will be)
arxiv.org/pdf/2508.12104
August 22, 2025 at 5:57 AM
Impressive paper by EPIC. They built a autoregressive transformer on 150M individuals and 115 billion
medical events.
Including: diagnoses, medications, lab values, procedure
Cons: model is not shared (and unlikely will be)
arxiv.org/pdf/2508.12104
medical events.
Including: diagnoses, medications, lab values, procedure
Cons: model is not shared (and unlikely will be)
arxiv.org/pdf/2508.12104
Monthly update - July 2025
Picks of the Month
healthdatascience.substack.com
August 7, 2025 at 7:24 AM
The iPSYCH study represents a unique example to understand the ethical and legal challenges of using existing samples/data for health research. A thread 🧵
www.science.org/content/arti...
www.science.org/content/arti...
Blood taken from Danish babies ended up in huge genetic study—without consent
The iPsych project, which investigates the genetics of psychiatric disorders, has sent 140,000 opt-out notices amid backlash
www.science.org
August 5, 2025 at 5:16 PM
The iPSYCH study represents a unique example to understand the ethical and legal challenges of using existing samples/data for health research. A thread 🧵
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Andrea Ganna
Dived into past, present & future of human genetics with brilliant students & mentors.Grateful for the chance to present my work on personalized sequence→expression prediction and discussions with @sashagusevposts.bsky.social @bpasaniuc.bsky.social @mashaals.bsky.social @tuuliel.bsky.social & others
Leena Peltonen School of Human Genetics in full-swing!
@gosiatrynka.bsky.social
@dgmacarthur.bsky.social
@bpasaniuc.bsky.social
@tuuliel.bsky.social
@hilarycmartin.bsky.social
@sashagusevposts.bsky.social
@zkutalik.bsky.social
@mashaals.bsky.social
@alemedinarivera.bsky.social
@gosiatrynka.bsky.social
@dgmacarthur.bsky.social
@bpasaniuc.bsky.social
@tuuliel.bsky.social
@hilarycmartin.bsky.social
@sashagusevposts.bsky.social
@zkutalik.bsky.social
@mashaals.bsky.social
@alemedinarivera.bsky.social
August 1, 2025 at 6:07 PM
Dived into past, present & future of human genetics with brilliant students & mentors.Grateful for the chance to present my work on personalized sequence→expression prediction and discussions with @sashagusevposts.bsky.social @bpasaniuc.bsky.social @mashaals.bsky.social @tuuliel.bsky.social & others
Reposted by Andrea Ganna
This was such a special event! So grateful that I could be part of it, learning about great science, making truly unique connections with amazing fellow students and tutors, and even learning how to punt 🛶 Huge thanks to everyone who helped bring this unique school back to life!
Leena Peltonen School of Human Genetics in full-swing!
@gosiatrynka.bsky.social
@dgmacarthur.bsky.social
@bpasaniuc.bsky.social
@tuuliel.bsky.social
@hilarycmartin.bsky.social
@sashagusevposts.bsky.social
@zkutalik.bsky.social
@mashaals.bsky.social
@alemedinarivera.bsky.social
@gosiatrynka.bsky.social
@dgmacarthur.bsky.social
@bpasaniuc.bsky.social
@tuuliel.bsky.social
@hilarycmartin.bsky.social
@sashagusevposts.bsky.social
@zkutalik.bsky.social
@mashaals.bsky.social
@alemedinarivera.bsky.social
July 31, 2025 at 4:13 PM
This was such a special event! So grateful that I could be part of it, learning about great science, making truly unique connections with amazing fellow students and tutors, and even learning how to punt 🛶 Huge thanks to everyone who helped bring this unique school back to life!
Reposted by Andrea Ganna
It was a pleasure to be part of this summer school. Students were amazing, it was a great experience getting the chance to discuss one on one without hierarchy for three days with them. They taught me so much.
Leena Peltonen School of Human Genetics in full-swing!
@gosiatrynka.bsky.social
@dgmacarthur.bsky.social
@bpasaniuc.bsky.social
@tuuliel.bsky.social
@hilarycmartin.bsky.social
@sashagusevposts.bsky.social
@zkutalik.bsky.social
@mashaals.bsky.social
@alemedinarivera.bsky.social
@gosiatrynka.bsky.social
@dgmacarthur.bsky.social
@bpasaniuc.bsky.social
@tuuliel.bsky.social
@hilarycmartin.bsky.social
@sashagusevposts.bsky.social
@zkutalik.bsky.social
@mashaals.bsky.social
@alemedinarivera.bsky.social
August 1, 2025 at 1:18 AM
It was a pleasure to be part of this summer school. Students were amazing, it was a great experience getting the chance to discuss one on one without hierarchy for three days with them. They taught me so much.