Tony Ng
@aykcng.bsky.social
Clinical Lecturer in ICM studying immune dysregulation in critically ill humans | Molecular & synthetic biology enthusiast, genome engineering amateur | CRISPR | 🏳️🌈🏳️⚧️⚧️ Ally | 🇵🇹🇨🇦 | Incremental activism changes the world |
Reposted by Tony Ng
The molecule that gives caraway seeds their flavor is the mirror image of the molecule that gives spearmint its flavor.
August 10, 2025 at 2:15 AM
The molecule that gives caraway seeds their flavor is the mirror image of the molecule that gives spearmint its flavor.
Reposted by Tony Ng
Vancomycin-resistant 𝙀𝙣𝙩𝙚𝙧𝙤𝙘𝙤𝙘𝙘𝙪𝙨 𝙛𝙖𝙚𝙘𝙞𝙪𝙢 (VRE) thrives in the antibiotic-perturbed gut
VRE gobbles up enriched sugars and amino acids, and loss of short-chain fatty acids (acetate, propionate, butyrate) eliminates natural growth brakes
Therapeutic angle: Prebiotic SCFA mixtures block VRE growth!
VRE gobbles up enriched sugars and amino acids, and loss of short-chain fatty acids (acetate, propionate, butyrate) eliminates natural growth brakes
Therapeutic angle: Prebiotic SCFA mixtures block VRE growth!
Vancomycin-resistant enterococci utilise antibiotic-enriched nutrients for intestinal colonisation - Nature Communications
Here, the authors show that vancomycin-resistant enterococci grow in the antibiotic-treated gut microbiome by utilising enriched nutrients in the presence of reduced concentrations of inhibitory micro...
www.nature.com
July 11, 2025 at 1:08 PM
Vancomycin-resistant 𝙀𝙣𝙩𝙚𝙧𝙤𝙘𝙤𝙘𝙘𝙪𝙨 𝙛𝙖𝙚𝙘𝙞𝙪𝙢 (VRE) thrives in the antibiotic-perturbed gut
VRE gobbles up enriched sugars and amino acids, and loss of short-chain fatty acids (acetate, propionate, butyrate) eliminates natural growth brakes
Therapeutic angle: Prebiotic SCFA mixtures block VRE growth!
VRE gobbles up enriched sugars and amino acids, and loss of short-chain fatty acids (acetate, propionate, butyrate) eliminates natural growth brakes
Therapeutic angle: Prebiotic SCFA mixtures block VRE growth!
Reposted by Tony Ng
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 2, 2025 at 4:17 PM
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Reposted by Tony Ng
The #Rosshart Lab goes wild again! Ever wondered whether using #Wildlings in our research would change the outcome of our results? 🤔💡 #immunosky @fau.de
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype - Nature Communications
Here, the authors apply a standardized system, called TXsystem, to transplant wild mouse gut microbiota into SPF mice, developing “TXwildlings” mice that stably retain natural microbiota and human-lik...
www.nature.com
June 15, 2025 at 6:17 PM
The #Rosshart Lab goes wild again! Ever wondered whether using #Wildlings in our research would change the outcome of our results? 🤔💡 #immunosky @fau.de
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Tony Ng
Almost all Nobel Prizes are awarded for work that is exploratory, or absolutely basic science with no obvious commercial or medical benefit.
You cannot predict where advancements come from, so you have to invest in science and scientists.
Targeted (corporate) science investment will never do this.
You cannot predict where advancements come from, so you have to invest in science and scientists.
Targeted (corporate) science investment will never do this.
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...
www.richmondscientific.com/how-a-discov...
How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific
A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.
www.richmondscientific.com
June 8, 2025 at 10:26 PM
Almost all Nobel Prizes are awarded for work that is exploratory, or absolutely basic science with no obvious commercial or medical benefit.
You cannot predict where advancements come from, so you have to invest in science and scientists.
Targeted (corporate) science investment will never do this.
You cannot predict where advancements come from, so you have to invest in science and scientists.
Targeted (corporate) science investment will never do this.
Reposted by Tony Ng
Reposted by Tony Ng
The Intensive Care Society is deeply concerned by the Supreme Court’s recent decision regarding the naming of doctors involved in court of protection proceedings.
Read our full statement below👇
bit.ly/supremecourtrulingstatement
Read our full statement below👇
bit.ly/supremecourtrulingstatement
April 18, 2025 at 7:54 PM
The Intensive Care Society is deeply concerned by the Supreme Court’s recent decision regarding the naming of doctors involved in court of protection proceedings.
Read our full statement below👇
bit.ly/supremecourtrulingstatement
Read our full statement below👇
bit.ly/supremecourtrulingstatement
Reposted by Tony Ng
Don’t shame people for not immediately reading all the books they buy. Some books aren’t made to be ready right away, okay? Some books need time to mature. Some books need to cure for a while. Some books are prosciutto, and don’t you forget it.
April 16, 2025 at 2:30 PM
Don’t shame people for not immediately reading all the books they buy. Some books aren’t made to be ready right away, okay? Some books need time to mature. Some books need to cure for a while. Some books are prosciutto, and don’t you forget it.
Reposted by Tony Ng
🟠Sarampo pode “estragar” sistema imunológico por meses, alertam médicos.
www.metropoles.com/saude/saramp...
www.metropoles.com/saude/saramp...
Sarampo pode "estragar" sistema imunológico por meses
A infecção pelo sarampo leva à redução na imunidade que torna o paciente mais suscetível a outras doenças virais e bacterianas
www.metropoles.com
April 6, 2025 at 1:09 PM
🟠Sarampo pode “estragar” sistema imunológico por meses, alertam médicos.
www.metropoles.com/saude/saramp...
www.metropoles.com/saude/saramp...
Reposted by Tony Ng
Flexible-tip bougie vs stylet for tracheal intubation with a hyperangulated videolaryngoscope in critical care - which would you choose?
#AnSky #ICUSky #AirwaySky #MedSky
doi.org/10.1111/anae...
#AnSky #ICUSky #AirwaySky #MedSky
doi.org/10.1111/anae...
April 7, 2025 at 8:06 AM
Flexible-tip bougie vs stylet for tracheal intubation with a hyperangulated videolaryngoscope in critical care - which would you choose?
#AnSky #ICUSky #AirwaySky #MedSky
doi.org/10.1111/anae...
#AnSky #ICUSky #AirwaySky #MedSky
doi.org/10.1111/anae...
Reposted by Tony Ng
Today in @naturecomms.bsky.social we show the #FutileCreatineCycle plays a key role in #thermogenesis, independent of UCP1. We also challenge the belief that brown adipocytes lack enough ATP synthase for thermogenesis. Congrats to Jakub Bunk! @mcgillgci.bsky.social
Full paper: rdcu.be/egoV7
Full paper: rdcu.be/egoV7
The Futile Creatine Cycle powers UCP1-independent thermogenesis in classical BAT
Nature Communications - Thermogenesis by brown adipose tissue has long been thought to be solely controlled by uncoupling protein 1 (UCP1). Here, the authors show that energy expenditure in brown...
rdcu.be
April 4, 2025 at 3:04 PM
Today in @naturecomms.bsky.social we show the #FutileCreatineCycle plays a key role in #thermogenesis, independent of UCP1. We also challenge the belief that brown adipocytes lack enough ATP synthase for thermogenesis. Congrats to Jakub Bunk! @mcgillgci.bsky.social
Full paper: rdcu.be/egoV7
Full paper: rdcu.be/egoV7
Reposted by Tony Ng
editors note: the patient got dropped off in the ICU on rocket fuel quadruple pressors with a pH 6.5 and frequent pushes of bicarb, calcium, and methylene blue to keep the MAP >50
April 3, 2025 at 9:34 PM
editors note: the patient got dropped off in the ICU on rocket fuel quadruple pressors with a pH 6.5 and frequent pushes of bicarb, calcium, and methylene blue to keep the MAP >50
Reposted by Tony Ng
How did sun bear get that sunny chest patch? Still a mystery. But scientists recently discovered that a 1 base change in the gene TYRP1 can turn black bears brown. #2025MMM www.cell.com/current-biol...
March 27, 2025 at 12:26 AM
How did sun bear get that sunny chest patch? Still a mystery. But scientists recently discovered that a 1 base change in the gene TYRP1 can turn black bears brown. #2025MMM www.cell.com/current-biol...
Reposted by Tony Ng
How did Coati get their stripes? Not yet known ... but we know how another Carnivore loses them! 3 mutations in gene TAQPEP changes a cat from tabby striped to blotchy #RIP #2025MMM www.science.org/doi/10.1126/...
March 27, 2025 at 12:12 AM
How did Coati get their stripes? Not yet known ... but we know how another Carnivore loses them! 3 mutations in gene TAQPEP changes a cat from tabby striped to blotchy #RIP #2025MMM www.science.org/doi/10.1126/...
Reposted by Tony Ng
So happy to see this story come together. Check it out! Kathleen Mills and many collaborators - GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus | Science Immunology www.science.org/doi/10.1126/...
GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus
During mold infection, epithelial-derived GM-CSF licenses neutrophil killing of fungal cells, leading to improved survival.
www.science.org
March 21, 2025 at 7:57 PM
So happy to see this story come together. Check it out! Kathleen Mills and many collaborators - GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus | Science Immunology www.science.org/doi/10.1126/...
Repellent to this proud Canadian. It is not what we want.
Fox News anchor, Jesse Watters finds it “personally offensive” that Canadians refuse to be annexed by the US: “That’s what everyone in the world wants—American citizenship.”
American Imperialism is on full show.
American Imperialism is on full show.
March 14, 2025 at 9:35 AM
Repellent to this proud Canadian. It is not what we want.
Reposted by Tony Ng
I enjoyed this very very much.
February 27, 2025 at 12:46 PM
I enjoyed this very very much.
Reposted by Tony Ng
100s of accounts - click follow all!
#Ansky #Anaesthesia #Anaesthetist #ICU #Intensivist #PHEM #HEMS
Anaesthesia & ICM Packs
1 go.bsky.app/4N4D7MW
2 go.bsky.app/QEgekcF
3 go.bsky.app/CaeuLtL
4 go.bsky.app/7gHUdmc
5 go.bsky.app/FXJxs91
PHEM 1. go.bsky.app/NWQRhE1
2. go.bsky.app/KhwJfCs
#Ansky #Anaesthesia #Anaesthetist #ICU #Intensivist #PHEM #HEMS
Anaesthesia & ICM Packs
1 go.bsky.app/4N4D7MW
2 go.bsky.app/QEgekcF
3 go.bsky.app/CaeuLtL
4 go.bsky.app/7gHUdmc
5 go.bsky.app/FXJxs91
PHEM 1. go.bsky.app/NWQRhE1
2. go.bsky.app/KhwJfCs
January 12, 2025 at 2:42 PM
100s of accounts - click follow all!
#Ansky #Anaesthesia #Anaesthetist #ICU #Intensivist #PHEM #HEMS
Anaesthesia & ICM Packs
1 go.bsky.app/4N4D7MW
2 go.bsky.app/QEgekcF
3 go.bsky.app/CaeuLtL
4 go.bsky.app/7gHUdmc
5 go.bsky.app/FXJxs91
PHEM 1. go.bsky.app/NWQRhE1
2. go.bsky.app/KhwJfCs
#Ansky #Anaesthesia #Anaesthetist #ICU #Intensivist #PHEM #HEMS
Anaesthesia & ICM Packs
1 go.bsky.app/4N4D7MW
2 go.bsky.app/QEgekcF
3 go.bsky.app/CaeuLtL
4 go.bsky.app/7gHUdmc
5 go.bsky.app/FXJxs91
PHEM 1. go.bsky.app/NWQRhE1
2. go.bsky.app/KhwJfCs
Reposted by Tony Ng
from “Parable of the Talents” by Octavia Butler
February 16, 2025 at 2:28 PM
from “Parable of the Talents” by Octavia Butler
Reposted by Tony Ng
Just got added to the @standupforscience.bsky.social organizing discord (let's go RI!). Wow the organizing team is incredible. These rallies are going to be amazing.
March 7 - mark your calendars for the national/state rallies!
March 7 - mark your calendars for the national/state rallies!
February 14, 2025 at 4:46 PM
Just got added to the @standupforscience.bsky.social organizing discord (let's go RI!). Wow the organizing team is incredible. These rallies are going to be amazing.
March 7 - mark your calendars for the national/state rallies!
March 7 - mark your calendars for the national/state rallies!
Reposted by Tony Ng
#MoleBioSky
Did you know that not all stop codons are the same? I did not!
Like all degenerate codons, cells and bacteria use three different stop codons: UAA, UGA, and UAG. The latter (UAG, the "Amber" codon) is least used in mammalian cells.
Here's why, and how it's changing molecular biology/1
Did you know that not all stop codons are the same? I did not!
Like all degenerate codons, cells and bacteria use three different stop codons: UAA, UGA, and UAG. The latter (UAG, the "Amber" codon) is least used in mammalian cells.
Here's why, and how it's changing molecular biology/1
January 31, 2025 at 7:36 AM
#MoleBioSky
Did you know that not all stop codons are the same? I did not!
Like all degenerate codons, cells and bacteria use three different stop codons: UAA, UGA, and UAG. The latter (UAG, the "Amber" codon) is least used in mammalian cells.
Here's why, and how it's changing molecular biology/1
Did you know that not all stop codons are the same? I did not!
Like all degenerate codons, cells and bacteria use three different stop codons: UAA, UGA, and UAG. The latter (UAG, the "Amber" codon) is least used in mammalian cells.
Here's why, and how it's changing molecular biology/1
As Intensivists, we see death more than we would like. Often, we are the ones who bring up dying with patients who have chronic diseases. It is a collective responsibility to recognise and dignify the end of natural life, and not to prolong suffering. This is an important read for all!
Similar findings in the U.K., with the recent NCEPOD report on End of Life Care www.ncepod.org.uk/2024eolc.html
January 27, 2025 at 1:39 PM
As Intensivists, we see death more than we would like. Often, we are the ones who bring up dying with patients who have chronic diseases. It is a collective responsibility to recognise and dignify the end of natural life, and not to prolong suffering. This is an important read for all!
Reposted by Tony Ng
The sequence of SARSCoV2 was made available on Jan 10 2020. Exactly 11 months later on Dec 11th 2020 the first EUA was issued for an mRNA COVID vaccine.
These vaccines saved over 20 million lives.
None of this would have been possible without NIH funding & dedicated scientists.
#ScienceMatters
These vaccines saved over 20 million lives.
None of this would have been possible without NIH funding & dedicated scientists.
#ScienceMatters
January 25, 2025 at 9:50 PM
The sequence of SARSCoV2 was made available on Jan 10 2020. Exactly 11 months later on Dec 11th 2020 the first EUA was issued for an mRNA COVID vaccine.
These vaccines saved over 20 million lives.
None of this would have been possible without NIH funding & dedicated scientists.
#ScienceMatters
These vaccines saved over 20 million lives.
None of this would have been possible without NIH funding & dedicated scientists.
#ScienceMatters