Alvin Wei Tian Ng
@alvinwtng.bsky.social
Computational Biologist in Singapore. Nocturnal baker and maker of caffeinated beverages.
Excited to see this thought provoking piece of work now published. So much more to learn about mutagenesis in healthy tissue.
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 9, 2025 at 11:51 PM
Excited to see this thought provoking piece of work now published. So much more to learn about mutagenesis in healthy tissue.
Reposted by Alvin Wei Tian Ng
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
October 8, 2025 at 8:49 AM
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Reposted by Alvin Wei Tian Ng
Rest in peace Jane Goodall, a true giant among scientists. Your breakthroughs into the secret lives of chimpanzees viewed through an anthropomorphic lens – without yet knowing that science had forbidden it – changed science forever, and with it how we see ourselves.
October 1, 2025 at 8:44 PM
Rest in peace Jane Goodall, a true giant among scientists. Your breakthroughs into the secret lives of chimpanzees viewed through an anthropomorphic lens – without yet knowing that science had forbidden it – changed science forever, and with it how we see ourselves.
Elegant work to unveil the etiology behind the ubiquitous SBS5 mutational signature. Glad to be in the audience to see this work presented and I have already put it on my reading list.
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature
Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...
www.biorxiv.org
September 3, 2025 at 12:32 PM
Elegant work to unveil the etiology behind the ubiquitous SBS5 mutational signature. Glad to be in the audience to see this work presented and I have already put it on my reading list.
Reposted by Alvin Wei Tian Ng
We are all somatic mutation mosaics.
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...
The Somatic Mosaicism across Human Tissues Network - Nature
The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.
nature.com
July 2, 2025 at 4:21 PM
We are all somatic mutation mosaics.
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...
Reposted by Alvin Wei Tian Ng
If you don’t have time to take a walk, then you don’t have time to do science. Charles Darwin would take two walks every day on his "thinking path", not as a break from science, but as a crucial part of it.
June 30, 2025 at 8:20 AM
If you don’t have time to take a walk, then you don’t have time to do science. Charles Darwin would take two walks every day on his "thinking path", not as a break from science, but as a crucial part of it.
Excited for the talks on the amazing biology of ecDNA! Interested in ecDNA in esophageal cancers and long read sequencing? Always happy to chat!
#CancerGrandChallenges #CGCecDNA
#CancerGrandChallenges #CGCecDNA
June 11, 2025 at 8:45 AM
Excited for the talks on the amazing biology of ecDNA! Interested in ecDNA in esophageal cancers and long read sequencing? Always happy to chat!
#CancerGrandChallenges #CGCecDNA
#CancerGrandChallenges #CGCecDNA
Attending BRCA Symposium 2025 and enjoying a master class from Ralph Scilly on HRD. I will also start calling SBS3 bland from now on.
May 7, 2025 at 7:28 PM
Attending BRCA Symposium 2025 and enjoying a master class from Ralph Scilly on HRD. I will also start calling SBS3 bland from now on.
Reposted by Alvin Wei Tian Ng
“If left unchallenged, a rising wave of white nationalism in many parts of the globe could threaten the progress that has been made in science — and broader society — towards a more equitable world,” writes Genevieve Wojcik in a Comment article for Nature. 🧬 🧪
Eugenics is on the rise again: human geneticists must take a stand
Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics.
go.nature.com
April 26, 2025 at 10:37 PM
“If left unchallenged, a rising wave of white nationalism in many parts of the globe could threaten the progress that has been made in science — and broader society — towards a more equitable world,” writes Genevieve Wojcik in a Comment article for Nature. 🧬 🧪
Reposted by Alvin Wei Tian Ng
Yes! - we are hiring @yale.edu - links below...
I'm biased, but I loved it, great talk!! Don't forget @s-j-aitken.bsky.social is hiring! She's a great scientist and person- you couldn't find a better PI.
April 26, 2025 at 12:26 AM
Yes! - we are hiring @yale.edu - links below...
Highlights of day 1 of #MITS : @steverozen.bsky.social on Aristolochic Acids their effects on carcinogeneis
, @nlbigas.bsky.social on driver mutations in small clones in the bladder. Sir Mike Stratton on signatures stem of the colorectum @mollyprz.bsky.social elegantly solving the etiology of a Sig
, @nlbigas.bsky.social on driver mutations in small clones in the bladder. Sir Mike Stratton on signatures stem of the colorectum @mollyprz.bsky.social elegantly solving the etiology of a Sig
April 24, 2025 at 1:17 PM
Highlights of day 1 of #MITS : @steverozen.bsky.social on Aristolochic Acids their effects on carcinogeneis
, @nlbigas.bsky.social on driver mutations in small clones in the bladder. Sir Mike Stratton on signatures stem of the colorectum @mollyprz.bsky.social elegantly solving the etiology of a Sig
, @nlbigas.bsky.social on driver mutations in small clones in the bladder. Sir Mike Stratton on signatures stem of the colorectum @mollyprz.bsky.social elegantly solving the etiology of a Sig
A wonderful reminder that my time spent comparing all the ecDNAs in organoids from the @RFitzgerald_lab added new insight to how we can use tumour organoids as a model to study ecDNA.
The future of tumor organoids in precision therapy: Trends in Cancer www.cell.com/trends/cance...
The future of tumor organoids in precision therapy: Trends in Cancer www.cell.com/trends/cance...
The future of tumor organoids in precision therapy
Tumoroids are cultures of patient-derived tumor cells, which are grown in 3D in the
presence of an extracellular matrix extract and specific growth factors. Tumoroids
can be generated from adult as we...
www.cell.com
April 9, 2025 at 2:43 PM
A wonderful reminder that my time spent comparing all the ecDNAs in organoids from the @RFitzgerald_lab added new insight to how we can use tumour organoids as a model to study ecDNA.
The future of tumor organoids in precision therapy: Trends in Cancer www.cell.com/trends/cance...
The future of tumor organoids in precision therapy: Trends in Cancer www.cell.com/trends/cance...
Reposted by Alvin Wei Tian Ng
And so it begins. I have been working in genomics / sequencing for more than 30 years but today is a particularly exciting day as I begin training on using the @nanopore MK1D sequencer which we will be using soon for student projects (and other things) at @ucdavis.bsky.social
Setting up my new @nanoporetech.com MK1D sequencer - can’t wait to get trained on it and then use it
March 19, 2025 at 2:47 PM
And so it begins. I have been working in genomics / sequencing for more than 30 years but today is a particularly exciting day as I begin training on using the @nanopore MK1D sequencer which we will be using soon for student projects (and other things) at @ucdavis.bsky.social
The first Singapore Long-Reads Symposium was a success! A massive thanks to the speakers: Keynote Heng Li, Ken Sung @jonathangoeke.bsky.social , @msikic.bsky.social & industrial partners @nanoporetech.com , @pacbio.bsky.social , @awscloud.bsky.social MGI_Technology Next Level Genomics & NovogeneAIT
March 17, 2025 at 2:32 AM
The first Singapore Long-Reads Symposium was a success! A massive thanks to the speakers: Keynote Heng Li, Ken Sung @jonathangoeke.bsky.social , @msikic.bsky.social & industrial partners @nanoporetech.com , @pacbio.bsky.social , @awscloud.bsky.social MGI_Technology Next Level Genomics & NovogeneAIT
I'm happy to announce that my project to use @nanoporetech.com sequencing to study Early Onset Colorectal Cancer has been funded!
#lkcmedicine #lkcmedicine #acsi | Alvin Ng | 27 comments
I'm happy to announce that I have been awarded the NMRC Open Fund - Young Individual Research Grant (OF-YIRG) for the project: Unveiling Risk Factors of Early-Onset Colorectal Cancers through…
www.linkedin.com
February 25, 2025 at 6:09 AM
I'm happy to announce that my project to use @nanoporetech.com sequencing to study Early Onset Colorectal Cancer has been funded!
Reposted by Alvin Wei Tian Ng
Our 2024 Wrapped! 🧪
- £173m awarded to our Cambridge Institute, @cruk-ci.bsky.social
- £58.7m to train clinician scientists
- 120,000+ people being recruited for the capsule sponge screening trial
- 3 cancer prevention vaccine projects
Read more about our progress this year 👇 cruk.ink/4iLz3ws
- £173m awarded to our Cambridge Institute, @cruk-ci.bsky.social
- £58.7m to train clinician scientists
- 120,000+ people being recruited for the capsule sponge screening trial
- 3 cancer prevention vaccine projects
Read more about our progress this year 👇 cruk.ink/4iLz3ws
Getting ahead of cancer: our 2024 research highlights - Cancer Research UK - Cancer News
To end the year, we want to highlight some of our biggest stories of 2024, including big advances in prevention, diagnosis, and treatment.
cruk.ink
December 19, 2024 at 10:01 AM
Our 2024 Wrapped! 🧪
- £173m awarded to our Cambridge Institute, @cruk-ci.bsky.social
- £58.7m to train clinician scientists
- 120,000+ people being recruited for the capsule sponge screening trial
- 3 cancer prevention vaccine projects
Read more about our progress this year 👇 cruk.ink/4iLz3ws
- £173m awarded to our Cambridge Institute, @cruk-ci.bsky.social
- £58.7m to train clinician scientists
- 120,000+ people being recruited for the capsule sponge screening trial
- 3 cancer prevention vaccine projects
Read more about our progress this year 👇 cruk.ink/4iLz3ws
Reposted by Alvin Wei Tian Ng
SPECIAL ISSUE! This month Genome Research publishes a diverse collection of research and review articles in a special issue highlighting advances in long-read sequencing applications in biology and medicine. Full issue links here: tinyurl.com/Genome-Res-3....
November 20, 2024 at 3:09 PM
SPECIAL ISSUE! This month Genome Research publishes a diverse collection of research and review articles in a special issue highlighting advances in long-read sequencing applications in biology and medicine. Full issue links here: tinyurl.com/Genome-Res-3....