Alessandro Valente
@alessvalente.bsky.social
Brain developmental biologist 🧠🧬🔬.
Interested in how gene expression&metabolism shape brain heterogeneity. From Rome 🏛️🇮🇹, living in CH.
Interested in how gene expression&metabolism shape brain heterogeneity. From Rome 🏛️🇮🇹, living in CH.
Reposted by Alessandro Valente
Which human brain circuits are implicated in neurodevelopmental conditions? We bridged human genetics, spatial transcriptomics and neurodevelopment to discover the convergence of autism-associated genes in the developing human thalamus! www.biorxiv.org/content/10.1...
November 11, 2025 at 10:55 AM
Which human brain circuits are implicated in neurodevelopmental conditions? We bridged human genetics, spatial transcriptomics and neurodevelopment to discover the convergence of autism-associated genes in the developing human thalamus! www.biorxiv.org/content/10.1...
Reposted by Alessandro Valente
This is a massive undertaking by a courageous group of experimentalists and computational scientists. I am honored to have contributed to this. #lipidtime chenges time zone today
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 7:35 AM
This is a massive undertaking by a courageous group of experimentalists and computational scientists. I am honored to have contributed to this. #lipidtime chenges time zone today
Reposted by Alessandro Valente
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Alessandro Valente
uMAIA offers an analytical framework designed to enable construction of high-resolution metabolic atlases using mass spec imaging data. @gioelelamanno.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Unified mass imaging maps the lipidome of vertebrate development - Nature Methods
uMAIA is an analytical framework designed to enable the construction of metabolic atlases at high resolution using mass spectrometry imaging data.
www.nature.com
September 3, 2025 at 4:59 PM
uMAIA offers an analytical framework designed to enable construction of high-resolution metabolic atlases using mass spec imaging data. @gioelelamanno.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alessandro Valente
#Throwback 🧪
COMMENT | Subcellular quantitative imaging of metabolites at the organelle level
@siuzdak.bsky.social
COMMENT | Subcellular quantitative imaging of metabolites at the organelle level
@siuzdak.bsky.social
Subcellular quantitative imaging of metabolites at the organelle level - Nature Metabolism
Subcellular quantitative analysis has been a long-standing goal of mass spectrometry imaging, but was originally thought to be unattainable. However, recent advances have made organelle-level absolute quantification through mass spectrometry imaging a reality, thanks to the development of nano secondary ion mass spectrometry.
bit.ly
July 19, 2025 at 3:02 PM
#Throwback 🧪
COMMENT | Subcellular quantitative imaging of metabolites at the organelle level
@siuzdak.bsky.social
COMMENT | Subcellular quantitative imaging of metabolites at the organelle level
@siuzdak.bsky.social
Reposted by Alessandro Valente
@science.org Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation | Science www.science.org/doi/10.1126/...
@jbuenrostro.bsky.social @eboyden3.bsky.social + al @broadinstitute.org @harvard.edu
#ExIGS #Chromatin #Lamin #Progeria #Aging #ExpansionMicroscopy
@jbuenrostro.bsky.social @eboyden3.bsky.social + al @broadinstitute.org @harvard.edu
#ExIGS #Chromatin #Lamin #Progeria #Aging #ExpansionMicroscopy
Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation
Microscopy and genomics are used to characterize cell function, but approaches to connect the two types of information are lacking, particularly at subnuclear resolution. Here, we describe expansion i...
www.science.org
May 29, 2025 at 6:24 PM
@science.org Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation | Science www.science.org/doi/10.1126/...
@jbuenrostro.bsky.social @eboyden3.bsky.social + al @broadinstitute.org @harvard.edu
#ExIGS #Chromatin #Lamin #Progeria #Aging #ExpansionMicroscopy
@jbuenrostro.bsky.social @eboyden3.bsky.social + al @broadinstitute.org @harvard.edu
#ExIGS #Chromatin #Lamin #Progeria #Aging #ExpansionMicroscopy
Reposted by Alessandro Valente
A study in Nature Aging shows that the drug trametinib extends lifespan in mice and that co-treatment with the known geroprotector rapamycin additively extends lifespan and healthspan, reducing inflammation and tumor growth. go.nature.com/4jwjcBk 🧪
June 1, 2025 at 7:16 PM
A study in Nature Aging shows that the drug trametinib extends lifespan in mice and that co-treatment with the known geroprotector rapamycin additively extends lifespan and healthspan, reducing inflammation and tumor growth. go.nature.com/4jwjcBk 🧪
Reposted by Alessandro Valente
"Thinking time —the time needed to concentrate without interruptions has always been central to scholarly work. It is essential to designing experiments, compiling data, assessing results, reviewing literature and, of course, writing. Yet, [it] is often undervalued."
www.nature.com/articles/d41...
www.nature.com/articles/d41...
May 23, 2025 at 2:56 AM
"Thinking time —the time needed to concentrate without interruptions has always been central to scholarly work. It is essential to designing experiments, compiling data, assessing results, reviewing literature and, of course, writing. Yet, [it] is often undervalued."
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Alessandro Valente
New preprint alert 📣
#Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬
Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵
#Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬
Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵
Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolution
While cortical organoids have been used to model different facets of neurodevelopmental conditions and human brain evolution, cerebellar organoids have not yet featured so prominently in the same cont...
www.biorxiv.org
May 16, 2025 at 11:08 AM
New preprint alert 📣
#Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬
Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵
#Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬
Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵
Reposted by Alessandro Valente
Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolution https://www.biorxiv.org/content/10.1101/2025.05.14.653684v1
May 16, 2025 at 11:15 AM
Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolution https://www.biorxiv.org/content/10.1101/2025.05.14.653684v1
Reposted by Alessandro Valente
Dorsal view of a larval zebrafish brain. Credit to @clairewyart.bsky.social. #ZebrafishZunday 🧪
January 26, 2025 at 1:44 PM
Dorsal view of a larval zebrafish brain. Credit to @clairewyart.bsky.social. #ZebrafishZunday 🧪
Reposted by Alessandro Valente
Please welcome our official #mesoSPIM channel on this platform, @mesospim.bsky.social. Repost is appreciated!
January 20, 2025 at 10:22 AM
Please welcome our official #mesoSPIM channel on this platform, @mesospim.bsky.social. Repost is appreciated!
Reposted by Alessandro Valente
Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease. Nature Methods names spatial proteomics its Method of the Year. 🧪
Method of the Year 2024: spatial proteomics - Nature Methods
Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.
go.nature.com
December 12, 2024 at 4:23 PM
Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease. Nature Methods names spatial proteomics its Method of the Year. 🧪
Reposted by Alessandro Valente
The birth of fruit fly's central nervous system imaged with multicolor #adaptive #lightsheet microscopy. The microscope self-aligns to a signal that appears during imaging.
www.nature.com/articles/nbt...
www.nature.com/articles/nbt...
December 11, 2024 at 8:32 PM
The birth of fruit fly's central nervous system imaged with multicolor #adaptive #lightsheet microscopy. The microscope self-aligns to a signal that appears during imaging.
www.nature.com/articles/nbt...
www.nature.com/articles/nbt...