Adam Hoppe
@adhoppe.bsky.social
Macrophage cell biologist, microscopist, guitar player, adventurer and nice person.
Reposted by Adam Hoppe
1/I'm excited to share my review with CSHL exploring the concept of neighbouring cells as substrate to guide the collective migration of other cells. We tend to focus on cell-matrix interactions, but forget that within tissue, cell-cell interactions exist.
cshperspectives.cshlp.org/content/earl...
cshperspectives.cshlp.org/content/earl...
May 20, 2025 at 11:55 AM
1/I'm excited to share my review with CSHL exploring the concept of neighbouring cells as substrate to guide the collective migration of other cells. We tend to focus on cell-matrix interactions, but forget that within tissue, cell-cell interactions exist.
cshperspectives.cshlp.org/content/earl...
cshperspectives.cshlp.org/content/earl...
Reposted by Adam Hoppe
Our latest publication on #macrophages congrats Anna Mularski and @manondepierre.bsky.social @institutcochin.bsky.social @actin-paris-saclay.bsky.social Martial Balland @grenoblealpes.bsky.social
@cnrsbiologie.bsky.social cnrs physique @anr
@cnrsbiologie.bsky.social cnrs physique @anr
Comment les macrophages sont influencés par leur environnement ? 🧐
Une récente étude menée par @florenceniedergang.bsky.social révèle que leur interaction avec leur milieu joue un rôle clé dans leur activité immunitaire !
Une récente étude menée par @florenceniedergang.bsky.social révèle que leur interaction avec leur milieu joue un rôle clé dans leur activité immunitaire !
L’interaction entre les macrophages et leur milieu environnant affecte leur fonctionnement
Les macrophages sont des cellules du système immunitaire qui ingèrent et dégradent les microorganismes et les débris cellulaires selon un processus appe
buff.ly
March 28, 2025 at 6:44 PM
Our latest publication on #macrophages congrats Anna Mularski and @manondepierre.bsky.social @institutcochin.bsky.social @actin-paris-saclay.bsky.social Martial Balland @grenoblealpes.bsky.social
@cnrsbiologie.bsky.social cnrs physique @anr
@cnrsbiologie.bsky.social cnrs physique @anr
Reposted by Adam Hoppe
I knew there would be an effect! This has been one of the questions that I had for the longest time. Changing the mechanics of the substrate affects phagocytosis. Very interesting paper!
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
A crosstalk between adhesion and phagocytosis integrates macrophage functions into their microenvironment
Cell biology; Organizational aspects of cell biology; Specialized functions of cells;
Functional aspects of cell biology
www.cell.com
March 29, 2025 at 6:58 PM
I knew there would be an effect! This has been one of the questions that I had for the longest time. Changing the mechanics of the substrate affects phagocytosis. Very interesting paper!
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Reposted by Adam Hoppe
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
February 27, 2025 at 3:54 PM
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
Reposted by Adam Hoppe
Wu et al @sickkidsto.bsky.social show that Snx10 regulates PI(3,5)P2 accumulation on #lysosomes by controlling PI(3)P delivery. Deleting Snx10 inhibits ClC-7, thereby impairing (phago)lysosome resolution. This mechanism may account for Snx10-related #osteopetrosis. rupress.org/jcb/article/...
March 26, 2025 at 7:53 PM
Wu et al @sickkidsto.bsky.social show that Snx10 regulates PI(3,5)P2 accumulation on #lysosomes by controlling PI(3)P delivery. Deleting Snx10 inhibits ClC-7, thereby impairing (phago)lysosome resolution. This mechanism may account for Snx10-related #osteopetrosis. rupress.org/jcb/article/...
Reposted by Adam Hoppe
I have confirmation from several sources now that all T32s, many F30s and F31s, and most or all Center awards (P30, P50) have been terminated at Columbia.
This is quite damaging to research and to individuals.
This is pure terrorism and cannot be legal. But litigation will take time...
This is quite damaging to research and to individuals.
This is pure terrorism and cannot be legal. But litigation will take time...
March 11, 2025 at 2:30 PM
I have confirmation from several sources now that all T32s, many F30s and F31s, and most or all Center awards (P30, P50) have been terminated at Columbia.
This is quite damaging to research and to individuals.
This is pure terrorism and cannot be legal. But litigation will take time...
This is quite damaging to research and to individuals.
This is pure terrorism and cannot be legal. But litigation will take time...
Reposted by Adam Hoppe
ACTION ITEM
I was chatting with a young scientist who expressed concern re the multiplicity of ongoing issues
Over the course of our conversation, we arrived at the idea of a DASHBOARD where issues could be tracked
If anyone is interested in helping with this (ideally with expertise) please DM me
I was chatting with a young scientist who expressed concern re the multiplicity of ongoing issues
Over the course of our conversation, we arrived at the idea of a DASHBOARD where issues could be tracked
If anyone is interested in helping with this (ideally with expertise) please DM me
March 11, 2025 at 5:00 PM
ACTION ITEM
I was chatting with a young scientist who expressed concern re the multiplicity of ongoing issues
Over the course of our conversation, we arrived at the idea of a DASHBOARD where issues could be tracked
If anyone is interested in helping with this (ideally with expertise) please DM me
I was chatting with a young scientist who expressed concern re the multiplicity of ongoing issues
Over the course of our conversation, we arrived at the idea of a DASHBOARD where issues could be tracked
If anyone is interested in helping with this (ideally with expertise) please DM me
Reposted by Adam Hoppe
The 90-somethings who revolutionized how we think about strength training.
One simple exercise proved older adults can build and retain muscle – and caused a paradigm shift in science.
🧪👵🏼👴🏼🦵🏼
www.theguardian.com/wellness/202...
One simple exercise proved older adults can build and retain muscle – and caused a paradigm shift in science.
🧪👵🏼👴🏼🦵🏼
www.theguardian.com/wellness/202...
The ninetysomethings who revolutionized how we think about strength training
One simple exercise proved older adults can build and retain muscle – and caused a paradigm shift in science
www.theguardian.com
March 11, 2025 at 8:32 PM
The 90-somethings who revolutionized how we think about strength training.
One simple exercise proved older adults can build and retain muscle – and caused a paradigm shift in science.
🧪👵🏼👴🏼🦵🏼
www.theguardian.com/wellness/202...
One simple exercise proved older adults can build and retain muscle – and caused a paradigm shift in science.
🧪👵🏼👴🏼🦵🏼
www.theguardian.com/wellness/202...
Reposted by Adam Hoppe
Science, research & public health face unprecedented attacks in the U.S.
We stand with our American colleagues & support the Stand Up for Science call.
Join the global march tomorrow, incl. in Paris! 🧪✊
📍 March 7, 13:30 – Place Jussieu
🔗 More info: standupforscience.fr
#StandUpForScience
We stand with our American colleagues & support the Stand Up for Science call.
Join the global march tomorrow, incl. in Paris! 🧪✊
📍 March 7, 13:30 – Place Jussieu
🔗 More info: standupforscience.fr
#StandUpForScience
March 6, 2025 at 2:24 PM
Science, research & public health face unprecedented attacks in the U.S.
We stand with our American colleagues & support the Stand Up for Science call.
Join the global march tomorrow, incl. in Paris! 🧪✊
📍 March 7, 13:30 – Place Jussieu
🔗 More info: standupforscience.fr
#StandUpForScience
We stand with our American colleagues & support the Stand Up for Science call.
Join the global march tomorrow, incl. in Paris! 🧪✊
📍 March 7, 13:30 – Place Jussieu
🔗 More info: standupforscience.fr
#StandUpForScience
Reposted by Adam Hoppe
Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
February 27, 2025 at 8:13 PM
Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!
Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy
🧵1/N
Reposted by Adam Hoppe
"… it is the words and actions of all members of the scientific community … that form the collective voice of science …," writes @holdenthorp.bsky.social in a new #ScienceEditorial. scim.ag/4hR6ux0
February 24, 2025 at 7:08 PM
"… it is the words and actions of all members of the scientific community … that form the collective voice of science …," writes @holdenthorp.bsky.social in a new #ScienceEditorial. scim.ag/4hR6ux0
Reposted by Adam Hoppe
Economical Method to Construct a Prism-based TIRF Setup on an Existing Confocal Microscope to Perform smFRET Experiments by Dibyendu Kumar Sasmal and team: www.biorxiv.org/content/10.1...
February 25, 2025 at 11:12 AM
Economical Method to Construct a Prism-based TIRF Setup on an Existing Confocal Microscope to Perform smFRET Experiments by Dibyendu Kumar Sasmal and team: www.biorxiv.org/content/10.1...
Reposted by Adam Hoppe
EACR President-Elect @johannajoyce.bsky.social was recently interviewed by Nature Cancer about her impressive work on the tumour microenvironment and with the cancer research community:
www.nature.com/articles/s43...
www.nature.com/articles/s43...
February 25, 2025 at 9:43 AM
EACR President-Elect @johannajoyce.bsky.social was recently interviewed by Nature Cancer about her impressive work on the tumour microenvironment and with the cancer research community:
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Adam Hoppe
Migraine is more than a headache — a radical rethink offers hope to one billion people
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Migraine is more than a headache — a radical rethink offers hope to one billion people
Drugs that can prevent or relieve migraine attacks are only effective for some people. Research is starting to untangle the reasons why.
www.nature.com
February 18, 2025 at 6:30 PM
Migraine is more than a headache — a radical rethink offers hope to one billion people
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Adam Hoppe
Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters
The cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis and repair, immune reactivity, and pathologies driven b...
www.biorxiv.org
February 18, 2025 at 7:27 PM
Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Adam Hoppe
#WeekendRead. #LiveForever. Lantz, Thorp &co show @cp-immunity.bsky.social that in neonatal, not adult, macrophages efferocytosis following heart injury leads to the production of throboxane, that acts on cardiomyocytes promoting proliferation & repair. #ScienceSavesLives
Early-age efferocytosis directs macrophage arachidonic acid metabolism for tissue regeneration
Mechanisms that differentiate the capacity of newborn immune cells to orchestrate
tissue regeneration are inadequately understood. Lantz et al. discover that in response
to dying cells, neonatal macro...
www.cell.com
February 15, 2025 at 4:15 PM
#WeekendRead. #LiveForever. Lantz, Thorp &co show @cp-immunity.bsky.social that in neonatal, not adult, macrophages efferocytosis following heart injury leads to the production of throboxane, that acts on cardiomyocytes promoting proliferation & repair. #ScienceSavesLives
Reposted by Adam Hoppe
Wyatt Miller's thesis project is on bioRxiv! We describe the signaling cascade that allows the 'Don't Eat Me' signal CD47 to inhibit phagocytosis. www.biorxiv.org/content/10.1...
CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation
CD47 is expressed by viable cells to protect against phagocytosis. CD47 is recognized by SIRPα, an inhibitory receptor expressed by macrophages and other myeloid cells. Activated SIRPα recruits SHP-1 ...
www.biorxiv.org
February 12, 2025 at 6:42 PM
Wyatt Miller's thesis project is on bioRxiv! We describe the signaling cascade that allows the 'Don't Eat Me' signal CD47 to inhibit phagocytosis. www.biorxiv.org/content/10.1...
Reposted by Adam Hoppe
🔬 Are you eager to dive into the world of light microscopy & learn from top-notch microscopists about its essential techniques for life science applications? If that sounds exciting, don’t miss out on this free, in-depth iBiology series! 👉 www.ibiology.org/online-biolo...
November 16, 2024 at 5:19 PM
🔬 Are you eager to dive into the world of light microscopy & learn from top-notch microscopists about its essential techniques for life science applications? If that sounds exciting, don’t miss out on this free, in-depth iBiology series! 👉 www.ibiology.org/online-biolo...
Reposted by Adam Hoppe
go.bsky.app/JDAwbAJ Trying again with the actual link this time. Please tag yourself or others who study macropinocytosis, phagocytosis or efferocytosis, and I’ll add you to the pack!
November 24, 2024 at 3:59 AM
go.bsky.app/JDAwbAJ Trying again with the actual link this time. Please tag yourself or others who study macropinocytosis, phagocytosis or efferocytosis, and I’ll add you to the pack!
Reposted by Adam Hoppe
Since I've been here for a while… here are some useful features on Bluesky that you might not have discovered yet! 🧵
November 20, 2024 at 7:52 PM
Since I've been here for a while… here are some useful features on Bluesky that you might not have discovered yet! 🧵
Reposted by Adam Hoppe
New paper out of the Thiex Lab! The moral of the story is think twice before you use dextran to study macropinocytosis! 😅 www.molbiolcell.org/doi/full/10....
November 22, 2024 at 3:16 AM
New paper out of the Thiex Lab! The moral of the story is think twice before you use dextran to study macropinocytosis! 😅 www.molbiolcell.org/doi/full/10....