Meghan Morrissey
@mmorrissey.bsky.social
Interested in how macrophages count and measure, and macrophage-cancer interactions. Assistant prof at UCSB https://morrisseylab.mcdb.ucsb.edu/
We have TWO papers out in @jcb.org this month! 🎉
First, @kirstin-rollins.bsky.social showed that macrophages nibble adherent target cells, like the ones found in solid tumors, instead of phagocytosing. Amazing movies from @sareenfiaz.bsky.social
doi.org/10.1083/jcb....
First, @kirstin-rollins.bsky.social showed that macrophages nibble adherent target cells, like the ones found in solid tumors, instead of phagocytosing. Amazing movies from @sareenfiaz.bsky.social
doi.org/10.1083/jcb....
October 17, 2025 at 5:07 PM
We have TWO papers out in @jcb.org this month! 🎉
First, @kirstin-rollins.bsky.social showed that macrophages nibble adherent target cells, like the ones found in solid tumors, instead of phagocytosing. Amazing movies from @sareenfiaz.bsky.social
doi.org/10.1083/jcb....
First, @kirstin-rollins.bsky.social showed that macrophages nibble adherent target cells, like the ones found in solid tumors, instead of phagocytosing. Amazing movies from @sareenfiaz.bsky.social
doi.org/10.1083/jcb....
Reposted by Meghan Morrissey
In @jcb.org, @mmorrissey.bsky.social lab demonstrate that the CD47 signaling pathway prevents #phagocytosis through dephosphorylation of the Rac GEF Vav. Cancer cells & synthetic targets w/ CD47 can still be phagocytosed less efficiently through a Rho-dependent mechanism rupress.org/jcb/article/...
October 16, 2025 at 5:45 PM
In @jcb.org, @mmorrissey.bsky.social lab demonstrate that the CD47 signaling pathway prevents #phagocytosis through dephosphorylation of the Rac GEF Vav. Cancer cells & synthetic targets w/ CD47 can still be phagocytosed less efficiently through a Rho-dependent mechanism rupress.org/jcb/article/...
Reposted by Meghan Morrissey
Miller, @mmorrissey.bsky.social et al. demonstrate that the CD47 signaling pathway prevents #phagocytosis through dephosphorylation of the Rac GEF Vav. Cancer cells & synthetic targets with CD47 can still be phagocytosed less efficiently through a Rho-dependent mechanism. rupress.org/jcb/article/...
October 16, 2025 at 6:15 PM
Miller, @mmorrissey.bsky.social et al. demonstrate that the CD47 signaling pathway prevents #phagocytosis through dephosphorylation of the Rac GEF Vav. Cancer cells & synthetic targets with CD47 can still be phagocytosed less efficiently through a Rho-dependent mechanism. rupress.org/jcb/article/...
Could not agree more 😁
Thrilled to see this out !! More cell biology of immune cells please!
Congrats to @mmorrissey.bsky.social and @kirstin-rollins.bsky.social 🥳
Congrats to @mmorrissey.bsky.social and @kirstin-rollins.bsky.social 🥳
Target cell adhesion limits macrophage #phagocytosis and promotes #trogocytosis, say @kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al.
@ucsantabarbara.bsky.social rupress.org/jcb/article/...
#Macrophages #Immunology
@ucsantabarbara.bsky.social rupress.org/jcb/article/...
#Macrophages #Immunology
October 10, 2025 at 4:35 PM
Could not agree more 😁
Reposted by Meghan Morrissey
@kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al show that #macrophages attack adherent cells using #trogocytosis instead of #phagocytosis. Reducing adhesion increased phagocytosis. Mitotic cells, which disassemble adhesions, are more vulnerable to phagocytosis rupress.org/jcb/article/...
October 3, 2025 at 5:34 PM
@kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al show that #macrophages attack adherent cells using #trogocytosis instead of #phagocytosis. Reducing adhesion increased phagocytosis. Mitotic cells, which disassemble adhesions, are more vulnerable to phagocytosis rupress.org/jcb/article/...
Reposted by Meghan Morrissey
#Macrophages are presumed to attack antibody-opsonized #cancer cells by #phagocytosis. In @jcb.org, @kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al find that macrophages attack adherent cells using #trogocytosis, or cell nibbling, instead of phagocytosis. rupress.org/jcb/article/...
October 3, 2025 at 6:39 PM
#Macrophages are presumed to attack antibody-opsonized #cancer cells by #phagocytosis. In @jcb.org, @kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al find that macrophages attack adherent cells using #trogocytosis, or cell nibbling, instead of phagocytosis. rupress.org/jcb/article/...
Reposted by Meghan Morrissey
Excited by phagocyte biology? Still making summer conference plans? The Phagocytes GRC has an amazing lineup of invited speakers and many opportunities for talks from submitted abstracts. Apply soon for full consideration! www.grc.org/phagocytes-c...
2025 Phagocytes Conference GRC
The 2025 Gordon Research Conference on Phagocytes will be held in Waterville Valley, New Hampshire. Apply today to reserve your spot.
www.grc.org
February 28, 2025 at 12:59 AM
Excited by phagocyte biology? Still making summer conference plans? The Phagocytes GRC has an amazing lineup of invited speakers and many opportunities for talks from submitted abstracts. Apply soon for full consideration! www.grc.org/phagocytes-c...
Wyatt Miller's thesis project is on bioRxiv! We describe the signaling cascade that allows the 'Don't Eat Me' signal CD47 to inhibit phagocytosis. www.biorxiv.org/content/10.1...
CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation
CD47 is expressed by viable cells to protect against phagocytosis. CD47 is recognized by SIRPα, an inhibitory receptor expressed by macrophages and other myeloid cells. Activated SIRPα recruits SHP-1 ...
www.biorxiv.org
February 12, 2025 at 6:42 PM
Wyatt Miller's thesis project is on bioRxiv! We describe the signaling cascade that allows the 'Don't Eat Me' signal CD47 to inhibit phagocytosis. www.biorxiv.org/content/10.1...
Excited to share @kirstin-rollins.bsky.social thesis project! 🥳Why do macrophages sometimes eat a whole cell, and sometimes just nibble off pieces? We found that if the target cell is stuck to a substrate or part of a 3D tissue, the macrophage nibbles instead of phagocytosing the whole cell.
Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis https://www.biorxiv.org/content/10.1101/2025.02.06.636906v1
February 10, 2025 at 5:56 PM
Excited to share @kirstin-rollins.bsky.social thesis project! 🥳Why do macrophages sometimes eat a whole cell, and sometimes just nibble off pieces? We found that if the target cell is stuck to a substrate or part of a 3D tissue, the macrophage nibbles instead of phagocytosing the whole cell.
Reposted by Meghan Morrissey
Trump & Musk are making massive cuts to the National Institutes of Health.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
February 8, 2025 at 11:16 PM
Trump & Musk are making massive cuts to the National Institutes of Health.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
Extremely grateful to Damon Runyon for this funding, especially with todays news on NIH grants. See a green macrophage nibbling on a pink cancer cell 👇
January 28, 2025 at 5:25 PM
Extremely grateful to Damon Runyon for this funding, especially with todays news on NIH grants. See a green macrophage nibbling on a pink cancer cell 👇
Reposted by Meghan Morrissey
@mmorrissey.bsky.social is investigating how immune cells known as macrophages might be induced to “nibble” cancer cells to death through a process called trogocytosis.
January 28, 2025 at 5:06 PM
@mmorrissey.bsky.social is investigating how immune cells known as macrophages might be induced to “nibble” cancer cells to death through a process called trogocytosis.
Reposted by Meghan Morrissey
Congratulations to the recipients of the 2025 Damon Runyon-Rachleff Innovation Award! Five exceptional scientists received initial grants, and three previous awardees were given Stage 2 support to continue their critical work. Read more: www.damonrunyon.org/news/entries...
Damon Runyon Cancer Research Foundation awards $3.2M to innovative early-career scientists
www.damonrunyon.org
January 28, 2025 at 5:06 PM
Congratulations to the recipients of the 2025 Damon Runyon-Rachleff Innovation Award! Five exceptional scientists received initial grants, and three previous awardees were given Stage 2 support to continue their critical work. Read more: www.damonrunyon.org/news/entries...
Reposted by Meghan Morrissey
@annalisebond.bsky.social and @mmorrissey.bsky.social @ucsantabarbara.bsky.social review the biochemical and biophysical mechanisms that macrophages use to tune phagocytic appetite.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
January 13, 2025 at 10:46 AM
@annalisebond.bsky.social and @mmorrissey.bsky.social @ucsantabarbara.bsky.social review the biochemical and biophysical mechanisms that macrophages use to tune phagocytic appetite.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Reposted by Meghan Morrissey
Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...
January 4, 2025 at 12:34 AM
Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...
Macrophages need to adjust their appetite based on whats happening around them... but how to make a macrophage hungrier? Annalise Bond assembled a list of biophysical and biochemical parameters that can tune phagocytosis. @jcellsci.bsky.social @biologists.bsky.social
doi.org/10.1242/jcs....
doi.org/10.1242/jcs....
Biochemical and biophysical mechanisms macrophages use to tune phagocytic appetite
Summary: Macrophages regulate their phagocytic appetite to rapidly clear pathogens and debris while minimizing damage to the surrounding tissue. We discuss the molecular toolkit for tuning macrophage ...
journals.biologists.com
January 3, 2025 at 4:42 PM
Macrophages need to adjust their appetite based on whats happening around them... but how to make a macrophage hungrier? Annalise Bond assembled a list of biophysical and biochemical parameters that can tune phagocytosis. @jcellsci.bsky.social @biologists.bsky.social
doi.org/10.1242/jcs....
doi.org/10.1242/jcs....
At #Ascb? Check our Wyatt Millers poster on CD47 today at 1:30 (b696) or his talk Monday at 5:30 p in the immune cell biology subgroup!
December 15, 2024 at 6:01 PM
At #Ascb? Check our Wyatt Millers poster on CD47 today at 1:30 (b696) or his talk Monday at 5:30 p in the immune cell biology subgroup!
Reposted by Meghan Morrissey
I'm excited to announce the EMBO Workshop on Immunobiophysics: from fundamental physics to understanding the immune response. April 27-May 2, 2025 in Les Houches, France (hybrid format). Registration/abstract details here: meetings.embo.org/event/25-imm...
Register by Monday December 2, 2024!
Register by Monday December 2, 2024!
Immunobiophysics: From fundamental physics to understanding the immune response
Immune cells respond in a coordinated way to protect us from pathogens like viruses and bacteria, and to maintain health by surveying for dysregulated cellular responses as occurs in diseases like ca…
meetings.embo.org
November 25, 2024 at 2:58 PM
I'm excited to announce the EMBO Workshop on Immunobiophysics: from fundamental physics to understanding the immune response. April 27-May 2, 2025 in Les Houches, France (hybrid format). Registration/abstract details here: meetings.embo.org/event/25-imm...
Register by Monday December 2, 2024!
Register by Monday December 2, 2024!
Reposted by Meghan Morrissey
go.bsky.app/JDAwbAJ Trying again with the actual link this time. Please tag yourself or others who study macropinocytosis, phagocytosis or efferocytosis, and I’ll add you to the pack!
November 24, 2024 at 3:59 AM
go.bsky.app/JDAwbAJ Trying again with the actual link this time. Please tag yourself or others who study macropinocytosis, phagocytosis or efferocytosis, and I’ll add you to the pack!
Such a great study showing that target biophysics govern the decision to trogocytose (nibble) vs phagocytose
Do you find yourself curious about the eating habits of macrophages? Check out our new preprint to discover the biophysical principles that guide macrophage behavior.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 6, 2024 at 6:38 PM
Such a great study showing that target biophysics govern the decision to trogocytose (nibble) vs phagocytose
Reposted by Meghan Morrissey
Do you find yourself curious about the eating habits of macrophages? Check out our new preprint to discover the biophysical principles that guide macrophage behavior.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 5, 2024 at 9:48 PM
Do you find yourself curious about the eating habits of macrophages? Check out our new preprint to discover the biophysical principles that guide macrophage behavior.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A light appetizer makes macrophages hungrier for their next meal. My lab's first grad student
@AnnaliseBond 's first paper is out now in
@dev_cell !!
authors.elsevier.com/sd/article/S...
@AnnaliseBond 's first paper is out now in
@dev_cell !!
authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
August 12, 2024 at 3:51 PM
A light appetizer makes macrophages hungrier for their next meal. My lab's first grad student
@AnnaliseBond 's first paper is out now in
@dev_cell !!
authors.elsevier.com/sd/article/S...
@AnnaliseBond 's first paper is out now in
@dev_cell !!
authors.elsevier.com/sd/article/S...
Interested in immune cell biology? Join us for ASCB #cellbio2024 in the subgroup organized by Minna Roh Johnson, Marcus Taylor and me! Just two weeks left to submit your abstract www.ascb.org/cellbio2024/...
Submit an Abstract-Cell Bio 2023
Submit an abstract for Cell Bio 2024-An American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO) Meeting.
www.ascb.org
July 23, 2024 at 4:07 PM
Interested in immune cell biology? Join us for ASCB #cellbio2024 in the subgroup organized by Minna Roh Johnson, Marcus Taylor and me! Just two weeks left to submit your abstract www.ascb.org/cellbio2024/...