Xiaohan Li
@xlichem.bsky.social
Postdoc in Miller lab @UoDundeeLifeSciences.
Previous: #MSCAFellow @MRC_LMB; PhD @YaleChem; CCME @PKU1898
IDP/IDRs, membrane traffic, protein dynamics, evolution.
https://scholar.google.com/citations?user=-kHbQqwAAAAJ&hl=en
Previous: #MSCAFellow @MRC_LMB; PhD @YaleChem; CCME @PKU1898
IDP/IDRs, membrane traffic, protein dynamics, evolution.
https://scholar.google.com/citations?user=-kHbQqwAAAAJ&hl=en
Reposted by Xiaohan Li
Exciting opportunity for a #postdoc to join @suyangzhang.bsky.social’s group in the LMB Structural Studies Division to investigate co-transcriptional splicing using cryo-EM and biochemistry.
Read more: www.nature.com/naturecareer...
Apply by 11 FEB
#PostdocJobs #ScienceJobs
Read more: www.nature.com/naturecareer...
Apply by 11 FEB
#PostdocJobs #ScienceJobs
January 27, 2026 at 9:40 AM
Exciting opportunity for a #postdoc to join @suyangzhang.bsky.social’s group in the LMB Structural Studies Division to investigate co-transcriptional splicing using cryo-EM and biochemistry.
Read more: www.nature.com/naturecareer...
Apply by 11 FEB
#PostdocJobs #ScienceJobs
Read more: www.nature.com/naturecareer...
Apply by 11 FEB
#PostdocJobs #ScienceJobs
Reposted by Xiaohan Li
Why do mated songbirds sing beautifully coordinated duets? My Ph.D. work showed that duets are cooperative signals that pairs use to defend their shared territory. This visual summary is based on Logue & Gammon 2004 Animal Behaviour 68: 521-531 and Logue 2005 Cognition, Brain, Behavior 9:497-510.
January 12, 2026 at 4:17 PM
Why do mated songbirds sing beautifully coordinated duets? My Ph.D. work showed that duets are cooperative signals that pairs use to defend their shared territory. This visual summary is based on Logue & Gammon 2004 Animal Behaviour 68: 521-531 and Logue 2005 Cognition, Brain, Behavior 9:497-510.
Reposted by Xiaohan Li
Physicists' perspective on the future direction of condensates in Cell Biology.
arxiv.org/abs/2601.03677
arxiv.org/abs/2601.03677
Roadmap for Condensates in Cell Biology
Biomolecular condensates govern essential cellular processes yet elude description by traditional equilibrium models. This roadmap, distilled from structured discussions at a workshop and reflecting t...
arxiv.org
January 8, 2026 at 8:35 AM
Physicists' perspective on the future direction of condensates in Cell Biology.
arxiv.org/abs/2601.03677
arxiv.org/abs/2601.03677
Really don’t understand why loads of people are advocating delegation of paper reading and reference searching to AI, and even paper-writing using AI. It’s like volunteering to be left out of the discovery process and intellectual works, happily living as a slave to the “transformers”.
December 26, 2025 at 3:42 AM
Really don’t understand why loads of people are advocating delegation of paper reading and reference searching to AI, and even paper-writing using AI. It’s like volunteering to be left out of the discovery process and intellectual works, happily living as a slave to the “transformers”.
Reposted by Xiaohan Li
Experimental structures provide valuable hypotheses and accelerate but do not replace evolutionary and statistical analyses of protein sequences
AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination
www.nature.com/articles/s41...
www.nature.com/articles/s41...
AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination - Nature Methods
An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...
www.nature.com
December 15, 2025 at 9:38 AM
Experimental structures provide valuable hypotheses and accelerate but do not replace evolutionary and statistical analyses of protein sequences
Very exciting project! Trafficking, IDRs, and structural biology!
My excellent collaborator, Giulia Zanetti, is advertising for a post-doc to work on our shared MRC grant. Please consider applying to this great lab with a supportive mentor to do some exciting structural biology.
www.ucl.ac.uk/work-at-ucl/...
www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
December 11, 2025 at 4:04 PM
Very exciting project! Trafficking, IDRs, and structural biology!
Reposted by Xiaohan Li
Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752 - Medical Research Council
Location: Cambridge. Vacancy: Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752. Closing Date: 04/01/2026, 23:55
mrc.tal.net
December 10, 2025 at 2:28 PM
Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Reposted by Xiaohan Li
Our review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB
We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics
With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...
We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics
With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...
December 9, 2025 at 10:13 PM
Our review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB
We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics
With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...
We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics
With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...
Reposted by Xiaohan Li
I found a tiny octopus on the tide pool🐙✨️
Small as it is, it’s every bit an octopus ... and absolutely adorable!!
It even shoots ink🫧 ͛.*
Small as it is, it’s every bit an octopus ... and absolutely adorable!!
It even shoots ink🫧 ͛.*
December 8, 2025 at 12:41 PM
I found a tiny octopus on the tide pool🐙✨️
Small as it is, it’s every bit an octopus ... and absolutely adorable!!
It even shoots ink🫧 ͛.*
Small as it is, it’s every bit an octopus ... and absolutely adorable!!
It even shoots ink🫧 ͛.*
Reposted by Xiaohan Li
I agree. I think protein folding is evidence that one can form specific structures that are thermodynamically driven by non-specific, dynamic interactions, with additional contributions to specificity from h-bonds etc (that probably contribute less to the "driving" force).
December 4, 2025 at 7:38 AM
I agree. I think protein folding is evidence that one can form specific structures that are thermodynamically driven by non-specific, dynamic interactions, with additional contributions to specificity from h-bonds etc (that probably contribute less to the "driving" force).
Reposted by Xiaohan Li
The structure of most folded proteins are stabilised by the hydrophobic effect which in some sense is quite fuzzy. And the hydrophobic cores of proteins can be quite dynamic.
December 3, 2025 at 9:50 PM
The structure of most folded proteins are stabilised by the hydrophobic effect which in some sense is quite fuzzy. And the hydrophobic cores of proteins can be quite dynamic.
Reposted by Xiaohan Li
Now published in @cp-cellsystems.bsky.social - we look at the chemical features that make proteins tolerant to dehydration, and the functions these proteins fill. 🏜️🚱 tinyurl.com/bsfy56yt
Protein surface chemistry encodes an adaptive tolerance to desiccation
Desiccated cells lose over 85% of their water content and experience widespread biomolecular
dysfunction. Romero-Pérez et al. show that the yeast proteome contains a subset of
proteins that are desicc...
tinyurl.com
December 1, 2025 at 11:49 AM
Now published in @cp-cellsystems.bsky.social - we look at the chemical features that make proteins tolerant to dehydration, and the functions these proteins fill. 🏜️🚱 tinyurl.com/bsfy56yt
Reposted by Xiaohan Li
yep, this is very concerning.
Some have already tried to raise the alarm in 2022, and since then, the “quality” of AI-generated images has only improved...
www.cell.com/patterns/ful...
Some have already tried to raise the alarm in 2022, and since then, the “quality” of AI-generated images has only improved...
www.cell.com/patterns/ful...
November 21, 2025 at 5:39 PM
yep, this is very concerning.
Some have already tried to raise the alarm in 2022, and since then, the “quality” of AI-generated images has only improved...
www.cell.com/patterns/ful...
Some have already tried to raise the alarm in 2022, and since then, the “quality” of AI-generated images has only improved...
www.cell.com/patterns/ful...
Reposted by Xiaohan Li
Language models cannot reliably distinguish belief from knowledge and fact #AI
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Language models cannot reliably distinguish belief from knowledge and fact - Nature Machine Intelligence
Suzgun et al. find that current large language models cannot reliably distinguish between belief, knowledge and fact, raising concerns for their use in healthcare, law and journalism, where such disti...
www.nature.com
November 4, 2025 at 10:13 AM
Language models cannot reliably distinguish belief from knowledge and fact #AI
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Reposted by Xiaohan Li
If you’re into protein evolution, molecular innovation, or just good scientific detective work — we hope you enjoy reading this story as much as we loved uncovering it.
Link: www.nature.com/articles/s41...
Happy Halloween 👻🌿
Link: www.nature.com/articles/s41...
Happy Halloween 👻🌿
Electrostatic changes enabled the diversification of an exocyst subunit via protein complex escape - Nature Plants
The evolutionary diversification of an exocyst subunit was enabled by electrostatic shifts leading to its dissociation from the ancestral complex.
www.nature.com
October 31, 2025 at 10:19 AM
If you’re into protein evolution, molecular innovation, or just good scientific detective work — we hope you enjoy reading this story as much as we loved uncovering it.
Link: www.nature.com/articles/s41...
Happy Halloween 👻🌿
Link: www.nature.com/articles/s41...
Happy Halloween 👻🌿
Reposted by Xiaohan Li
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
October 20, 2025 at 11:26 AM
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
If you are interested in membrane trafficking and IDPRs, please join us!
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - MCDB - UOD2016
Closing date: Thursday 6 November 2025, 23:59
www.dundee.ac.uk
October 16, 2025 at 6:35 PM
If you are interested in membrane trafficking and IDPRs, please join us!
Reposted by Xiaohan Li
Best practices & tools in R & Python for statistical processing and visualization of #Lipidomics & #Metabolomics data
Data imputation/normalization
Batch correction
Data visualization
Statistical models
Instrumental handbook, adoptable for other omics
#NatComms 2025
www.nature.com/articles/s41...
Data imputation/normalization
Batch correction
Data visualization
Statistical models
Instrumental handbook, adoptable for other omics
#NatComms 2025
www.nature.com/articles/s41...
October 6, 2025 at 11:43 AM
Best practices & tools in R & Python for statistical processing and visualization of #Lipidomics & #Metabolomics data
Data imputation/normalization
Batch correction
Data visualization
Statistical models
Instrumental handbook, adoptable for other omics
#NatComms 2025
www.nature.com/articles/s41...
Data imputation/normalization
Batch correction
Data visualization
Statistical models
Instrumental handbook, adoptable for other omics
#NatComms 2025
www.nature.com/articles/s41...
Reposted by Xiaohan Li
🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
2026 Intrinsically Disordered Proteins Conference GRC
The 2026 Gordon Research Conference on Intrinsically Disordered Proteins will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.
grc.org
October 2, 2025 at 3:21 PM
🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
Reposted by Xiaohan Li
Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
October 1, 2025 at 4:30 PM
Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Reposted by Xiaohan Li
I'm hiring for a PhD position at Malmö University, Sweden!
The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.
More details and application form: tinyurl.com/4zm92365
Please feel free to share!
@vetenskapsradet.bsky.social | @mau.se
The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.
More details and application form: tinyurl.com/4zm92365
Please feel free to share!
@vetenskapsradet.bsky.social | @mau.se
October 2, 2025 at 7:46 AM
I'm hiring for a PhD position at Malmö University, Sweden!
The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.
More details and application form: tinyurl.com/4zm92365
Please feel free to share!
@vetenskapsradet.bsky.social | @mau.se
The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.
More details and application form: tinyurl.com/4zm92365
Please feel free to share!
@vetenskapsradet.bsky.social | @mau.se
Reposted by Xiaohan Li
The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
September 16, 2025 at 7:43 AM
The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
Is it just my feeling that the Bluesky community has suddenly grown dynamic and “real” (i.e, much less boring political statements to dilute interesting people and stuff on my timeline) in the past 3 months… oh Yay!
i.in
September 16, 2025 at 6:24 AM
Is it just my feeling that the Bluesky community has suddenly grown dynamic and “real” (i.e, much less boring political statements to dilute interesting people and stuff on my timeline) in the past 3 months… oh Yay!
I wish 7-11 can come to the UK as well. So tired of “meal deals” when you don’t have time to cook… I mean, it is indeed a deal, but not really a meal…
If you are of a certain age, you might remember the "I'll have what she's having" scene in "When Harry Met Sally."
The Japanese parent company of 7-Eleven is betting billions of dollars that it can expand its business in the U.S. by making its convenience stores more like the food meccas they are in Japan. www.nytimes.com/2025/09/09/b...
September 16, 2025 at 6:21 AM
I wish 7-11 can come to the UK as well. So tired of “meal deals” when you don’t have time to cook… I mean, it is indeed a deal, but not really a meal…
Reposted by Xiaohan Li
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
September 15, 2025 at 5:26 PM
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!