Xiaohan Li
@xlichem.bsky.social
Postdoc in Miller lab @UoDundeeLifeSciences.
Previous: #MSCAFellow @MRC_LMB; PhD @YaleChem; CCME @PKU1898
IDP/IDRs, membrane traffic, protein dynamics, evolution.
https://scholar.google.com/citations?user=-kHbQqwAAAAJ&hl=en
Previous: #MSCAFellow @MRC_LMB; PhD @YaleChem; CCME @PKU1898
IDP/IDRs, membrane traffic, protein dynamics, evolution.
https://scholar.google.com/citations?user=-kHbQqwAAAAJ&hl=en
Reposted by Xiaohan Li
yep, this is very concerning.
Some have already tried to raise the alarm in 2022, and since then, the “quality” of AI-generated images has only improved...
www.cell.com/patterns/ful...
Some have already tried to raise the alarm in 2022, and since then, the “quality” of AI-generated images has only improved...
www.cell.com/patterns/ful...
November 21, 2025 at 5:39 PM
yep, this is very concerning.
Some have already tried to raise the alarm in 2022, and since then, the “quality” of AI-generated images has only improved...
www.cell.com/patterns/ful...
Some have already tried to raise the alarm in 2022, and since then, the “quality” of AI-generated images has only improved...
www.cell.com/patterns/ful...
Reposted by Xiaohan Li
Language models cannot reliably distinguish belief from knowledge and fact #AI
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Language models cannot reliably distinguish belief from knowledge and fact - Nature Machine Intelligence
Suzgun et al. find that current large language models cannot reliably distinguish between belief, knowledge and fact, raising concerns for their use in healthcare, law and journalism, where such disti...
www.nature.com
November 4, 2025 at 10:13 AM
Language models cannot reliably distinguish belief from knowledge and fact #AI
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.
www.nature.com/articles/s42...
Reposted by Xiaohan Li
If you’re into protein evolution, molecular innovation, or just good scientific detective work — we hope you enjoy reading this story as much as we loved uncovering it.
Link: www.nature.com/articles/s41...
Happy Halloween 👻🌿
Link: www.nature.com/articles/s41...
Happy Halloween 👻🌿
Electrostatic changes enabled the diversification of an exocyst subunit via protein complex escape - Nature Plants
The evolutionary diversification of an exocyst subunit was enabled by electrostatic shifts leading to its dissociation from the ancestral complex.
www.nature.com
October 31, 2025 at 10:19 AM
If you’re into protein evolution, molecular innovation, or just good scientific detective work — we hope you enjoy reading this story as much as we loved uncovering it.
Link: www.nature.com/articles/s41...
Happy Halloween 👻🌿
Link: www.nature.com/articles/s41...
Happy Halloween 👻🌿
Reposted by Xiaohan Li
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
October 20, 2025 at 11:26 AM
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
If you are interested in membrane trafficking and IDPRs, please join us!
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - MCDB - UOD2016
Closing date: Thursday 6 November 2025, 23:59
www.dundee.ac.uk
October 16, 2025 at 6:35 PM
If you are interested in membrane trafficking and IDPRs, please join us!
Reposted by Xiaohan Li
Best practices & tools in R & Python for statistical processing and visualization of #Lipidomics & #Metabolomics data
Data imputation/normalization
Batch correction
Data visualization
Statistical models
Instrumental handbook, adoptable for other omics
#NatComms 2025
www.nature.com/articles/s41...
Data imputation/normalization
Batch correction
Data visualization
Statistical models
Instrumental handbook, adoptable for other omics
#NatComms 2025
www.nature.com/articles/s41...
October 6, 2025 at 11:43 AM
Best practices & tools in R & Python for statistical processing and visualization of #Lipidomics & #Metabolomics data
Data imputation/normalization
Batch correction
Data visualization
Statistical models
Instrumental handbook, adoptable for other omics
#NatComms 2025
www.nature.com/articles/s41...
Data imputation/normalization
Batch correction
Data visualization
Statistical models
Instrumental handbook, adoptable for other omics
#NatComms 2025
www.nature.com/articles/s41...
Reposted by Xiaohan Li
🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
2026 Intrinsically Disordered Proteins Conference GRC
The 2026 Gordon Research Conference on Intrinsically Disordered Proteins will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.
grc.org
October 2, 2025 at 3:21 PM
🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
Reposted by Xiaohan Li
Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
October 1, 2025 at 4:30 PM
Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Reposted by Xiaohan Li
I'm hiring for a PhD position at Malmö University, Sweden!
The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.
More details and application form: tinyurl.com/4zm92365
Please feel free to share!
@vetenskapsradet.bsky.social | @mau.se
The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.
More details and application form: tinyurl.com/4zm92365
Please feel free to share!
@vetenskapsradet.bsky.social | @mau.se
October 2, 2025 at 7:46 AM
I'm hiring for a PhD position at Malmö University, Sweden!
The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.
More details and application form: tinyurl.com/4zm92365
Please feel free to share!
@vetenskapsradet.bsky.social | @mau.se
The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.
More details and application form: tinyurl.com/4zm92365
Please feel free to share!
@vetenskapsradet.bsky.social | @mau.se
Reposted by Xiaohan Li
The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
September 16, 2025 at 7:43 AM
The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
Is it just my feeling that the Bluesky community has suddenly grown dynamic and “real” (i.e, much less boring political statements to dilute interesting people and stuff on my timeline) in the past 3 months… oh Yay!
i.in
September 16, 2025 at 6:24 AM
Is it just my feeling that the Bluesky community has suddenly grown dynamic and “real” (i.e, much less boring political statements to dilute interesting people and stuff on my timeline) in the past 3 months… oh Yay!
I wish 7-11 can come to the UK as well. So tired of “meal deals” when you don’t have time to cook… I mean, it is indeed a deal, but not really a meal…
If you are of a certain age, you might remember the "I'll have what she's having" scene in "When Harry Met Sally."
The Japanese parent company of 7-Eleven is betting billions of dollars that it can expand its business in the U.S. by making its convenience stores more like the food meccas they are in Japan. www.nytimes.com/2025/09/09/b...
September 16, 2025 at 6:21 AM
I wish 7-11 can come to the UK as well. So tired of “meal deals” when you don’t have time to cook… I mean, it is indeed a deal, but not really a meal…
Reposted by Xiaohan Li
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
September 15, 2025 at 5:26 PM
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
Reposted by Xiaohan Li
This isn't how birding is supposed to work!
September 11, 2025 at 4:20 PM
This isn't how birding is supposed to work!
Reposted by Xiaohan Li
New #preprint from talented graduate student for a workflow we have been using for a while into a formal usage www.biorxiv.org/content/10.1...
Phyling: phylogenetic inference from annotated genomes
Phyling is a fast, scalable, and user-friendly tool supporting phylogenomic reconstruction of species phylogenies directly from protein-encoded genomic data. It identifies orthologous genes by searchi...
www.biorxiv.org
August 6, 2025 at 6:43 PM
New #preprint from talented graduate student for a workflow we have been using for a while into a formal usage www.biorxiv.org/content/10.1...
Reposted by Xiaohan Li
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
June 23, 2025 at 1:00 PM
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
🚨Interdisciplinary perspectives needed🚨
Have you worked across disciplines in research? We want to hear from you!
Take part in the Healthier Science through Collaboration (HxC) survey. Help shape better, more inclusive research environments.
app.onlinesurveys.jisc.ac.uk/s/edinburgh/...
Please RT.
Have you worked across disciplines in research? We want to hear from you!
Take part in the Healthier Science through Collaboration (HxC) survey. Help shape better, more inclusive research environments.
app.onlinesurveys.jisc.ac.uk/s/edinburgh/...
Please RT.
HxC Survey on Interdisciplinary Work
Online surveys is a powerful, easy to use tool for creating online surveys. Run by Jisc, online surveys is used by over 300 different organisations in the UK...
app.onlinesurveys.jisc.ac.uk
June 9, 2025 at 4:08 PM
🚨Interdisciplinary perspectives needed🚨
Have you worked across disciplines in research? We want to hear from you!
Take part in the Healthier Science through Collaboration (HxC) survey. Help shape better, more inclusive research environments.
app.onlinesurveys.jisc.ac.uk/s/edinburgh/...
Please RT.
Have you worked across disciplines in research? We want to hear from you!
Take part in the Healthier Science through Collaboration (HxC) survey. Help shape better, more inclusive research environments.
app.onlinesurveys.jisc.ac.uk/s/edinburgh/...
Please RT.
Reposted by Xiaohan Li
"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...
Rachel Thomas, PhD - Deep learning gets the glory, deep fact checking gets ignored
an AI researcher going back to school for immunology
rachel.fast.ai
June 4, 2025 at 3:53 PM
"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...
Join us for the first Scottish Cell Biology Meeting in Dundee! 🔥
Free registration and lots of opportunities for oral, poster presentations, and networking opportunities! #SCBM2025
Abstract submission until June 6th, general registration until July. All cell biologists are welcome!
Free registration and lots of opportunities for oral, poster presentations, and networking opportunities! #SCBM2025
Abstract submission until June 6th, general registration until July. All cell biologists are welcome!
May 30, 2025 at 9:08 AM
Join us for the first Scottish Cell Biology Meeting in Dundee! 🔥
Free registration and lots of opportunities for oral, poster presentations, and networking opportunities! #SCBM2025
Abstract submission until June 6th, general registration until July. All cell biologists are welcome!
Free registration and lots of opportunities for oral, poster presentations, and networking opportunities! #SCBM2025
Abstract submission until June 6th, general registration until July. All cell biologists are welcome!
Reposted by Xiaohan Li
How did life on Earth begin? 🌍🧬
New #LMBResearch from Phil Holliger’s group, including James Attwater (now @uclchemistry.bsky.social @uclnews.bsky.social) shows how pH-freeze-thaw cycles enables RNA self-replication, overcoming a key evolutionary hurdle.
Read more: www.ucl.ac.uk/news/2025/ma...
New #LMBResearch from Phil Holliger’s group, including James Attwater (now @uclchemistry.bsky.social @uclnews.bsky.social) shows how pH-freeze-thaw cycles enables RNA self-replication, overcoming a key evolutionary hurdle.
Read more: www.ucl.ac.uk/news/2025/ma...
Chemists recreate how RNA might have reproduced for first time
Chemists at UCL and the MRC Laboratory of Molecular Biology have demonstrated how RNA (ribonucleic acid) might have replicated itself on early Earth – a key process in the origin of life.
www.ucl.ac.uk
May 29, 2025 at 8:40 AM
How did life on Earth begin? 🌍🧬
New #LMBResearch from Phil Holliger’s group, including James Attwater (now @uclchemistry.bsky.social @uclnews.bsky.social) shows how pH-freeze-thaw cycles enables RNA self-replication, overcoming a key evolutionary hurdle.
Read more: www.ucl.ac.uk/news/2025/ma...
New #LMBResearch from Phil Holliger’s group, including James Attwater (now @uclchemistry.bsky.social @uclnews.bsky.social) shows how pH-freeze-thaw cycles enables RNA self-replication, overcoming a key evolutionary hurdle.
Read more: www.ucl.ac.uk/news/2025/ma...
Really great to see this out!
Now published! Big congrats to first author @gginell.bsky.social
We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
May 23, 2025 at 11:56 AM
Really great to see this out!
Reposted by Xiaohan Li
"De novo prediction of protein structural dynamics"
I'll be presenting an overview of the field tomorrow at a workshop. Link to a PDF copy of the presentation: delalamo.xyz/assets/post_...
I'll be presenting an overview of the field tomorrow at a workshop. Link to a PDF copy of the presentation: delalamo.xyz/assets/post_...
delalamo.xyz
April 27, 2025 at 2:16 PM
"De novo prediction of protein structural dynamics"
I'll be presenting an overview of the field tomorrow at a workshop. Link to a PDF copy of the presentation: delalamo.xyz/assets/post_...
I'll be presenting an overview of the field tomorrow at a workshop. Link to a PDF copy of the presentation: delalamo.xyz/assets/post_...
Reposted by Xiaohan Li
AlphaFold is amazing but gives you static structures 🧊
In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃
Code: github.com/KULL-Centre/...
Colab: github.com/matteo-cagia...
In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃
Code: github.com/KULL-Centre/...
Colab: github.com/matteo-cagia...
April 17, 2025 at 7:11 PM
AlphaFold is amazing but gives you static structures 🧊
In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃
Code: github.com/KULL-Centre/...
Colab: github.com/matteo-cagia...
In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃
Code: github.com/KULL-Centre/...
Colab: github.com/matteo-cagia...
Reposted by Xiaohan Li
Pleased to see Kevin's paper on the Retromer complex interaction with yeast Vps5 and Vps17 proteins now online!
Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer - Nature Communications
Retromer complex cooperates with Vps5 and Vps17 in yeast to traffic transmembrane proteins. Here, the authors present structural and functional studies that reveal the mechanism of Retromer and Vps5 i...
www.nature.com
April 16, 2025 at 1:59 AM
Pleased to see Kevin's paper on the Retromer complex interaction with yeast Vps5 and Vps17 proteins now online!
Reposted by Xiaohan Li
A great tribute to David Stevens, a terrific cell biologist and missed by so many of his friends and colleagues. As they say 'one of the good guys'. journals.biologists.com/jcs/article/...
Remembering David Stephens (1971–2024)
In the autumn of 2024, David Stephens, a prominent member of the UK cell biology community and a brilliant scientist, leader and mentor, passed away. With his pragmatism and natural authority, combine...
journals.biologists.com
April 7, 2025 at 4:44 PM
A great tribute to David Stevens, a terrific cell biologist and missed by so many of his friends and colleagues. As they say 'one of the good guys'. journals.biologists.com/jcs/article/...