Jerry C
@xianglejerry.bsky.social
Doctoral researcher @LabLappalainen // Alumni @wumin-lab.bsky.social @YaleCellBio // #actin #cytoskeleton #oscillations
Pinned
Jerry C
@xianglejerry.bsky.social
· Dec 24
Hi everyone, because it's my first time winning any contest, I ain't gonna lose this wave of opportunity to talk about it 👀. I got tweeted, but I feel the need to publicize this here too. I won the @ascbiology.bsky.social ASCB 2024 Image Contest! Thanks for selecting my entry!
Realized this morning that my submission got selected for Yale's Beauty in Science 2025 exhibition! Seeing the live-assembly of filopodia projections by formin mDia3 in mast cells got me really stoked back then! #FluorescenceFriday
July 4, 2025 at 2:21 PM
Realized this morning that my submission got selected for Yale's Beauty in Science 2025 exhibition! Seeing the live-assembly of filopodia projections by formin mDia3 in mast cells got me really stoked back then! #FluorescenceFriday
Reposted by Jerry C
🧵5/6 — The Big Picture
EndoNB works on endogenous proteins. No rare antibodies. No overexpression.
It’s scalable and ready to explore the 1000+ surface proteins we’ve barely studied.
We’re done understanding vesicular trafficking by looking at a handful of model surface proteins.
EndoNB works on endogenous proteins. No rare antibodies. No overexpression.
It’s scalable and ready to explore the 1000+ surface proteins we’ve barely studied.
We’re done understanding vesicular trafficking by looking at a handful of model surface proteins.
June 9, 2025 at 3:05 PM
🧵5/6 — The Big Picture
EndoNB works on endogenous proteins. No rare antibodies. No overexpression.
It’s scalable and ready to explore the 1000+ surface proteins we’ve barely studied.
We’re done understanding vesicular trafficking by looking at a handful of model surface proteins.
EndoNB works on endogenous proteins. No rare antibodies. No overexpression.
It’s scalable and ready to explore the 1000+ surface proteins we’ve barely studied.
We’re done understanding vesicular trafficking by looking at a handful of model surface proteins.
Reposted by Jerry C
🧵1/6 — Preprint Alert!
I am super proud to present the latest work of our lab. Earthlings and those just visiting, I introduce you…. EndoNB: A better, smarter and versatile way to study the dynamics of cell surface proteins. 🧪
www.biorxiv.org/content/10.1...
I am super proud to present the latest work of our lab. Earthlings and those just visiting, I introduce you…. EndoNB: A better, smarter and versatile way to study the dynamics of cell surface proteins. 🧪
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 9, 2025 at 2:56 PM
🧵1/6 — Preprint Alert!
I am super proud to present the latest work of our lab. Earthlings and those just visiting, I introduce you…. EndoNB: A better, smarter and versatile way to study the dynamics of cell surface proteins. 🧪
www.biorxiv.org/content/10.1...
I am super proud to present the latest work of our lab. Earthlings and those just visiting, I introduce you…. EndoNB: A better, smarter and versatile way to study the dynamics of cell surface proteins. 🧪
www.biorxiv.org/content/10.1...
Reposted by Jerry C
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Interphase cell morphology defines the mode, symmetry, and outcome of mitosis
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
www.science.org
May 6, 2025 at 8:39 PM
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Reposted by Jerry C
We show that under low ahesion conditions Tensin 1 forms endogenous condensates to store inactive adhesion components. These can be released upon stress-mediated Tensin 1 phosphorylation to regulate adhesion dynamics.
May 9, 2025 at 2:26 PM
We show that under low ahesion conditions Tensin 1 forms endogenous condensates to store inactive adhesion components. These can be released upon stress-mediated Tensin 1 phosphorylation to regulate adhesion dynamics.
Reposted by Jerry C
Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
Adhesion-derived condensates control component availability to regulate adhesion dynamics
Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...
www.biorxiv.org
May 9, 2025 at 2:23 PM
Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
Reposted by Jerry C
New preprint alert!📣 @midibu.bsky.social and team take a deep dive into Tensin1 liquid-liquid phase separation (LLPS) and the mechanisms of how it regulates adhesion dynamics!
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social
Adhesion-derived condensates control component availability to regulate adhesion dynamics
Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...
www.biorxiv.org
May 10, 2025 at 7:37 AM
New preprint alert!📣 @midibu.bsky.social and team take a deep dive into Tensin1 liquid-liquid phase separation (LLPS) and the mechanisms of how it regulates adhesion dynamics!
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social
Reposted by Jerry C
Unlike eggs & mitotic cells, in adherent interphasic cells the centrosome is NOT positioned by a balance of forces along #microtubules, but by cell shape organization around the #centrosome: rupress.org/jcb/article/...
@lblanchoin.bsky.social
@manuelthery.bsky.social
@gelinmatthieu.bsky.social
@lblanchoin.bsky.social
@manuelthery.bsky.social
@gelinmatthieu.bsky.social
April 17, 2025 at 4:28 PM
Unlike eggs & mitotic cells, in adherent interphasic cells the centrosome is NOT positioned by a balance of forces along #microtubules, but by cell shape organization around the #centrosome: rupress.org/jcb/article/...
@lblanchoin.bsky.social
@manuelthery.bsky.social
@gelinmatthieu.bsky.social
@lblanchoin.bsky.social
@manuelthery.bsky.social
@gelinmatthieu.bsky.social
Reposted by Jerry C
Progress on the quest for a red mStayGold!
Just out: mScarlet3-S2, a new photostable red FP derived from mScarlet3: www.researchsquare.com/article/rs-5...
Just out: mScarlet3-S2, a new photostable red FP derived from mScarlet3: www.researchsquare.com/article/rs-5...
December 25, 2024 at 8:45 AM
Progress on the quest for a red mStayGold!
Just out: mScarlet3-S2, a new photostable red FP derived from mScarlet3: www.researchsquare.com/article/rs-5...
Just out: mScarlet3-S2, a new photostable red FP derived from mScarlet3: www.researchsquare.com/article/rs-5...
Reposted by Jerry C
Incredible 4Pi and pan-expansion imaging of the Golgi 👇
March 29, 2025 at 4:03 PM
Incredible 4Pi and pan-expansion imaging of the Golgi 👇
Thanks for selecting my entry. This is one of my favorite movies captured. I’m very flattered 🙂
Check out the stunning movie by @xianglejerry.bsky.social from @wumin-lab.bsky.social, the winner of the 2024 ASCB Video Contest! Traveling waves of FBP17-EGFP at the cortex of immune mast cells #ASCB2024 @ascbiology.bsky.social
December 27, 2024 at 8:07 PM
Thanks for selecting my entry. This is one of my favorite movies captured. I’m very flattered 🙂
Hi everyone, because it's my first time winning any contest, I ain't gonna lose this wave of opportunity to talk about it 👀. I got tweeted, but I feel the need to publicize this here too. I won the @ascbiology.bsky.social ASCB 2024 Image Contest! Thanks for selecting my entry!
December 24, 2024 at 9:26 PM
Hi everyone, because it's my first time winning any contest, I ain't gonna lose this wave of opportunity to talk about it 👀. I got tweeted, but I feel the need to publicize this here too. I won the @ascbiology.bsky.social ASCB 2024 Image Contest! Thanks for selecting my entry!
It was a humbling experience being able to talk to people about our works at the ASCB. I’m flattered that I had plenty audience for me to keep going without break for ~6 h straight and going overtime! Thanks, everyone 🥹 #CellBio2024 @ascbiology.bsky.social
December 20, 2024 at 7:44 PM
It was a humbling experience being able to talk to people about our works at the ASCB. I’m flattered that I had plenty audience for me to keep going without break for ~6 h straight and going overtime! Thanks, everyone 🥹 #CellBio2024 @ascbiology.bsky.social
#FluorescenceFriday An old video of a cute mast cell (RBL-2H3) exhibiting cortical waves of active Cdc42 after getting treated with cytochalasin-D overnight. Sorry not sorry to kill #actin hehe. #TIRF 4 s per frame acquisition, 8 fps, 32× real time.
December 6, 2024 at 7:06 PM
#FluorescenceFriday An old video of a cute mast cell (RBL-2H3) exhibiting cortical waves of active Cdc42 after getting treated with cytochalasin-D overnight. Sorry not sorry to kill #actin hehe. #TIRF 4 s per frame acquisition, 8 fps, 32× real time.
Look at these distinct clusters exhibited by N-WASP and Arp2/3 ! Is branched #actin polymerization the sole driving force for nucleating cortical actin waves? Cross-talks within the actin network can be messy, so how can we study such complexities? #CellBio2024 @ascbiology.bsky.social
December 2, 2024 at 8:27 PM
Look at these distinct clusters exhibited by N-WASP and Arp2/3 ! Is branched #actin polymerization the sole driving force for nucleating cortical actin waves? Cross-talks within the actin network can be messy, so how can we study such complexities? #CellBio2024 @ascbiology.bsky.social
Reposted by Jerry C
Mix two motors of opposite polarity with microtubules and they will partition space !
Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns.
#morphogenesis
doi.org/10.1073/pnas...
(1/n)
Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns.
#morphogenesis
doi.org/10.1073/pnas...
(1/n)
November 27, 2024 at 1:42 PM
Mix two motors of opposite polarity with microtubules and they will partition space !
Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns.
#morphogenesis
doi.org/10.1073/pnas...
(1/n)
Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns.
#morphogenesis
doi.org/10.1073/pnas...
(1/n)
Reposted by Jerry C
Before I start posting about newer results on this platform, here is a video from our most recent paper -- www.nature.com/articles/s41...
November 22, 2024 at 4:44 AM
Before I start posting about newer results on this platform, here is a video from our most recent paper -- www.nature.com/articles/s41...
Reposted by Jerry C
If you're searching for the Mechanobiology community and starter pack, here it is:
Thought this would be a great opportunity to gather the #mechanobiology community. Please feel free to spread the word.
go.bsky.app/G5cQqYT
Thought this would be a great opportunity to gather the #mechanobiology community. Please feel free to spread the word.
go.bsky.app/G5cQqYT
November 12, 2024 at 12:46 PM
If you're searching for the Mechanobiology community and starter pack, here it is:
Thought this would be a great opportunity to gather the #mechanobiology community. Please feel free to spread the word.
go.bsky.app/G5cQqYT
Thought this would be a great opportunity to gather the #mechanobiology community. Please feel free to spread the word.
go.bsky.app/G5cQqYT
Reposted by Jerry C
here's the starter pack for cytoskeleton
go.bsky.app/TF83cpi
go.bsky.app/TF83cpi
November 11, 2024 at 3:03 PM
here's the starter pack for cytoskeleton
go.bsky.app/TF83cpi
go.bsky.app/TF83cpi
Reposted by Jerry C
Who needs immunofluorescence?
Focal adhesions (or cell feet as they were known then) were first observed in this 1975 paper by Abercombie and Dunn
doi.org/10.1016/0014...
This gem comes from the obituary of Graham Dunn published in J Cell Sci today.
doi.org/10.1242/jcs.... 🧪
Focal adhesions (or cell feet as they were known then) were first observed in this 1975 paper by Abercombie and Dunn
doi.org/10.1016/0014...
This gem comes from the obituary of Graham Dunn published in J Cell Sci today.
doi.org/10.1242/jcs.... 🧪
November 8, 2024 at 6:22 AM
Who needs immunofluorescence?
Focal adhesions (or cell feet as they were known then) were first observed in this 1975 paper by Abercombie and Dunn
doi.org/10.1016/0014...
This gem comes from the obituary of Graham Dunn published in J Cell Sci today.
doi.org/10.1242/jcs.... 🧪
Focal adhesions (or cell feet as they were known then) were first observed in this 1975 paper by Abercombie and Dunn
doi.org/10.1016/0014...
This gem comes from the obituary of Graham Dunn published in J Cell Sci today.
doi.org/10.1242/jcs.... 🧪
Reposted by Jerry C
I started a list of people working broadly on cell adhesion and cell migration. I likely missed many, please drop me a message if you want to be added
go.bsky.app/5Gzo7oZ
go.bsky.app/5Gzo7oZ
November 11, 2024 at 1:09 PM
I started a list of people working broadly on cell adhesion and cell migration. I likely missed many, please drop me a message if you want to be added
go.bsky.app/5Gzo7oZ
go.bsky.app/5Gzo7oZ