@vdangioE3lab
@vdangioe3lab.bsky.social
The laboratory is investigating the role of ubiquitin system in cancer pathogenesis and response to treatment with ionising radiation.
Reposted by @vdangioE3lab
Induced proximity-based therapeutic modalities
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
Induced proximity-based therapeutic modalities - Nature Reviews Drug Discovery
Induced proximity modalities encompass monovalent and bifunctional agents, such as molecular glues and proteolysis-targeting chimeras, that induce an interaction between biomolecules to functionally m...
nature.com
November 4, 2025 at 4:12 PM
Induced proximity-based therapeutic modalities
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
Reposted by @vdangioE3lab
How can we find out what’s really going on inside cells when we’re generating so much complex data?
CORNETO is an open-source tool that uses machine learning to turn tangled omics datasets into clear maps of how genes, proteins, and signalling pathways interact.
www.ebi.ac.uk/about/news/r... 🧪
CORNETO is an open-source tool that uses machine learning to turn tangled omics datasets into clear maps of how genes, proteins, and signalling pathways interact.
www.ebi.ac.uk/about/news/r... 🧪
CORNETO: machine learning to decode complex omics data
New tool combines biological knowledge with machine learning to help researchers extract meaningful insights from complex omics data.
www.ebi.ac.uk
July 22, 2025 at 9:20 AM
How can we find out what’s really going on inside cells when we’re generating so much complex data?
CORNETO is an open-source tool that uses machine learning to turn tangled omics datasets into clear maps of how genes, proteins, and signalling pathways interact.
www.ebi.ac.uk/about/news/r... 🧪
CORNETO is an open-source tool that uses machine learning to turn tangled omics datasets into clear maps of how genes, proteins, and signalling pathways interact.
www.ebi.ac.uk/about/news/r... 🧪
Reposted by @vdangioE3lab
Research Saves Lives
At Hopkins, we just went live with an expansive website showing the extraordinary value of research, the impact of cuts to research, what's at stake, resources for our research community, etc.
Check it out: researchsaveslives.jhu.edu
At Hopkins, we just went live with an expansive website showing the extraordinary value of research, the impact of cuts to research, what's at stake, resources for our research community, etc.
Check it out: researchsaveslives.jhu.edu
June 2, 2025 at 9:24 PM
Research Saves Lives
At Hopkins, we just went live with an expansive website showing the extraordinary value of research, the impact of cuts to research, what's at stake, resources for our research community, etc.
Check it out: researchsaveslives.jhu.edu
At Hopkins, we just went live with an expansive website showing the extraordinary value of research, the impact of cuts to research, what's at stake, resources for our research community, etc.
Check it out: researchsaveslives.jhu.edu
Reposted by @vdangioE3lab
Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s!
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains - Nature Structural & Molecular Biology
Using biochemistry, chemical biology, and cryo-EM, Maiwald et al. elucidate how TRIP12 forms K29 linkages and K29/K48-linked branched ubiquitin chains, revealing a mechanism for polyubiquitylation sha...
www.nature.com
May 26, 2025 at 9:37 AM
Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s!
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
Reposted by @vdangioE3lab
On #InternationalOvarianCancerDay, we held a Shining a Light on Ovarian Cancer event where Professor Charlie Gourley, Dr Rob Hollis and Dr Sarah Taylor talked about how their research is driving personalised patient care & BBC journalist Christine Macleod shared her story of going through treatment.
May 9, 2025 at 9:09 AM
On #InternationalOvarianCancerDay, we held a Shining a Light on Ovarian Cancer event where Professor Charlie Gourley, Dr Rob Hollis and Dr Sarah Taylor talked about how their research is driving personalised patient care & BBC journalist Christine Macleod shared her story of going through treatment.
Reposted by @vdangioE3lab
🧬 New Research Alert! 🧬
"Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase"
www.biorxiv.org/content/10.1...
Our findings reveal that Fbxo42 main function is to control PP4 phosphatase.
Discussions are highly welcome!
#bioRxiv #Research #Science #ubiquitin
"Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase"
www.biorxiv.org/content/10.1...
Our findings reveal that Fbxo42 main function is to control PP4 phosphatase.
Discussions are highly welcome!
#bioRxiv #Research #Science #ubiquitin
Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase
F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin– F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of ...
www.biorxiv.org
May 7, 2025 at 12:38 PM
🧬 New Research Alert! 🧬
"Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase"
www.biorxiv.org/content/10.1...
Our findings reveal that Fbxo42 main function is to control PP4 phosphatase.
Discussions are highly welcome!
#bioRxiv #Research #Science #ubiquitin
"Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase"
www.biorxiv.org/content/10.1...
Our findings reveal that Fbxo42 main function is to control PP4 phosphatase.
Discussions are highly welcome!
#bioRxiv #Research #Science #ubiquitin
🧬 New Research Alert! 🧬
"Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase"
www.biorxiv.org/content/10.1...
Our findings reveal that Fbxo42 main function is to control PP4 phosphatase.
Discussions are highly welcome!
#bioRxiv #Research #Science #ubiquitin
"Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase"
www.biorxiv.org/content/10.1...
Our findings reveal that Fbxo42 main function is to control PP4 phosphatase.
Discussions are highly welcome!
#bioRxiv #Research #Science #ubiquitin
Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase
F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin– F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of ...
www.biorxiv.org
May 7, 2025 at 12:38 PM
🧬 New Research Alert! 🧬
"Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase"
www.biorxiv.org/content/10.1...
Our findings reveal that Fbxo42 main function is to control PP4 phosphatase.
Discussions are highly welcome!
#bioRxiv #Research #Science #ubiquitin
"Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase"
www.biorxiv.org/content/10.1...
Our findings reveal that Fbxo42 main function is to control PP4 phosphatase.
Discussions are highly welcome!
#bioRxiv #Research #Science #ubiquitin
Reposted by @vdangioE3lab
PAPER OUT!! 🥳🎉💃🏻🕺🏻💃🏻🕺🏻
A redefined InDel taxonomy provides insights into mutational signatures @NatureGenet
Brainchild of the amazing #GeneKoh
(Sir Jeffrey Cheah ECR)
Tweetorial below!! 👇
1/n
www.nature.com/articles/s41...
A redefined InDel taxonomy provides insights into mutational signatures @NatureGenet
Brainchild of the amazing #GeneKoh
(Sir Jeffrey Cheah ECR)
Tweetorial below!! 👇
1/n
www.nature.com/articles/s41...
A redefined InDel taxonomy provides insights into mutational signatures - Nature Genetics
This paper describes a framework for classifying small insertions and deletions from genomic data and applies it to a large dataset comprising seven tumor types. The analysis highlights new insertion ...
www.nature.com
April 10, 2025 at 4:48 PM
PAPER OUT!! 🥳🎉💃🏻🕺🏻💃🏻🕺🏻
A redefined InDel taxonomy provides insights into mutational signatures @NatureGenet
Brainchild of the amazing #GeneKoh
(Sir Jeffrey Cheah ECR)
Tweetorial below!! 👇
1/n
www.nature.com/articles/s41...
A redefined InDel taxonomy provides insights into mutational signatures @NatureGenet
Brainchild of the amazing #GeneKoh
(Sir Jeffrey Cheah ECR)
Tweetorial below!! 👇
1/n
www.nature.com/articles/s41...
Reposted by @vdangioE3lab
Stunning images from Francis Barr’s lab have won CRUK’s Research is Beautiful competition for February! 🌟 They capture microtubules connecting to chromosomes via kinetochores to create mitotic spindles. 🔬✨
news.cancerresearchuk.org/2025/03/13/l...
@oxfordbiochemistry.bsky.social
news.cancerresearchuk.org/2025/03/13/l...
@oxfordbiochemistry.bsky.social
Latest winner in our Research is Beautiful campaign - Cancer Research UK - Cancer News
Our Research is Beautiful campaign continues to inspire with some fantastic images, but there has to be a winner, and here’s February’s…
news.cancerresearchuk.org
March 20, 2025 at 10:24 AM
Stunning images from Francis Barr’s lab have won CRUK’s Research is Beautiful competition for February! 🌟 They capture microtubules connecting to chromosomes via kinetochores to create mitotic spindles. 🔬✨
news.cancerresearchuk.org/2025/03/13/l...
@oxfordbiochemistry.bsky.social
news.cancerresearchuk.org/2025/03/13/l...
@oxfordbiochemistry.bsky.social
Reposted by @vdangioE3lab
Huge thanks to our funders @wellcometrust.bsky.social who generously funded the project. Their long-term support for our lab has made this possible especially because the project started over a decade ago, throwing many surprises along the way!
Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.
rdcu.be/edRwF
rdcu.be/edRwF
March 17, 2025 at 9:03 PM
Huge thanks to our funders @wellcometrust.bsky.social who generously funded the project. Their long-term support for our lab has made this possible especially because the project started over a decade ago, throwing many surprises along the way!
Reposted by @vdangioE3lab
The irony of an article discussing the unpaid labor of scientists, published by a $4bn corporation reliant on the unpaid labor of scientists.
Meanwhile RJmedicine.org, a journal in which we offer $ honoraria to authors and reviewers, opened for submissions today
#academicSky #medSky #research
Meanwhile RJmedicine.org, a journal in which we offer $ honoraria to authors and reviewers, opened for submissions today
#academicSky #medSky #research
I spent two years organizing an international conference. How do I get compensated for my work?
It can be hard to say no to service requests in academia. Nature’s Careers team sought advice on how to ensure researchers don’t get stuck doing unpaid labour.
www.nature.com
March 18, 2025 at 12:58 AM
The irony of an article discussing the unpaid labor of scientists, published by a $4bn corporation reliant on the unpaid labor of scientists.
Meanwhile RJmedicine.org, a journal in which we offer $ honoraria to authors and reviewers, opened for submissions today
#academicSky #medSky #research
Meanwhile RJmedicine.org, a journal in which we offer $ honoraria to authors and reviewers, opened for submissions today
#academicSky #medSky #research
Reposted by @vdangioE3lab
Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.
rdcu.be/edRwF
rdcu.be/edRwF
March 17, 2025 at 8:58 PM
Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.
rdcu.be/edRwF
rdcu.be/edRwF
Reposted by @vdangioE3lab
Happy to post a new study on BioRxiv, where we show Integrated Stress Response activation as an off-target effect of multiple clinically evaluated WEE1 inhibitors. Team effort with the lab of Dan Durocher @durocher1.bsky.social and many others. www.biorxiv.org/content/10.1...
WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response
The WEE1 kinase negatively regulates CDK1/2 to control DNA replication and mitotic entry. Genetic factors that determine sensitivity to WEE1 inhibitors (WEE1i) are largely unknown. A genome-wide inser...
www.biorxiv.org
March 18, 2025 at 10:13 AM
Happy to post a new study on BioRxiv, where we show Integrated Stress Response activation as an off-target effect of multiple clinically evaluated WEE1 inhibitors. Team effort with the lab of Dan Durocher @durocher1.bsky.social and many others. www.biorxiv.org/content/10.1...
Reposted by @vdangioE3lab
Thanks to the many collaborators; the labs of Thijn Brummelkamp, Alexander van Oudenaarden, Steven de Jong, Frank Sicheri, Marvin Tanenbaum @marvintanenbaum.bsky.social @jervdberg.bsky.social @rinskjetjeerdsma.bsky.social @mauritsroorda.bsky.social @daaninthelab.bsky.social
March 18, 2025 at 10:13 AM
Thanks to the many collaborators; the labs of Thijn Brummelkamp, Alexander van Oudenaarden, Steven de Jong, Frank Sicheri, Marvin Tanenbaum @marvintanenbaum.bsky.social @jervdberg.bsky.social @rinskjetjeerdsma.bsky.social @mauritsroorda.bsky.social @daaninthelab.bsky.social
Reposted by @vdangioE3lab
Help 🚨 science Bluesky. We'd like an #GFP/#FluorescentProtein construct with an intron in the middle of the coding sequence for an experiment (not before the coding sequence). Does anyone know of anything that fits? We haven't turned up anything suitable from a quick search so far. Please repost 🙏
March 11, 2025 at 11:36 AM
Help 🚨 science Bluesky. We'd like an #GFP/#FluorescentProtein construct with an intron in the middle of the coding sequence for an experiment (not before the coding sequence). Does anyone know of anything that fits? We haven't turned up anything suitable from a quick search so far. Please repost 🙏
Reposted by @vdangioE3lab
Interesting idea: get the sick super-rich to pay for clinical trials
Alternative idea: get the super-rich to pay tax that allows democratically accountable governments to support clinical trials (and research and healthcare and....)
www.theguardian.com/news/2025/ma...
Alternative idea: get the super-rich to pay tax that allows democratically accountable governments to support clinical trials (and research and healthcare and....)
www.theguardian.com/news/2025/ma...
Many life-saving drugs fail for lack of funding. But there’s a solution: desperate rich people
Each year, hundreds of potentially world-changing treatments are discarded because scientists run out of cash. But where big pharma or altruists fear to tread, my friend and I have a solution. It’s re...
www.theguardian.com
March 11, 2025 at 8:30 AM
Interesting idea: get the sick super-rich to pay for clinical trials
Alternative idea: get the super-rich to pay tax that allows democratically accountable governments to support clinical trials (and research and healthcare and....)
www.theguardian.com/news/2025/ma...
Alternative idea: get the super-rich to pay tax that allows democratically accountable governments to support clinical trials (and research and healthcare and....)
www.theguardian.com/news/2025/ma...
Reposted by @vdangioE3lab
This is why UK gov needs to invest in PhD training & cut visa costs for scientists
Long term economic growth depends on skilled people
The UK should make the most of life sciences
Long term economic growth depends on skilled people
The UK should make the most of life sciences
UK life sciences ‘will need 145,000 new people within 10 years’.
Report warns of skills shortage in sector at heart of government plans to boost growth.
www.researchprofessionalnews.com/rr-news-uk-i...
Report warns of skills shortage in sector at heart of government plans to boost growth.
www.researchprofessionalnews.com/rr-news-uk-i...
UK life sciences ‘will need 145,000 new people within 10 years’ - Research Professional News
Report warns of skills shortage in sector at heart of government plans to boost growth
www.researchprofessionalnews.com
March 6, 2025 at 2:08 PM
This is why UK gov needs to invest in PhD training & cut visa costs for scientists
Long term economic growth depends on skilled people
The UK should make the most of life sciences
Long term economic growth depends on skilled people
The UK should make the most of life sciences
Reposted by @vdangioE3lab
I know there is not a lot of love for X on this platform but please think about Ivano's @ivanoamelio.bsky.social words
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Should scientists ditch the social-media platform X?
Letter to the Editor
www.nature.com
March 6, 2025 at 12:26 PM
I know there is not a lot of love for X on this platform but please think about Ivano's @ivanoamelio.bsky.social words
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by @vdangioE3lab
March is #OvarianCancerAwarenessMonth. IGC researchers are leading significant advancements in our understanding of the disease. Dr Robb Hollis has written about work being undertaken at the Nicola Murray Centre for Ovarian Cancer Research into uncommon types of ovarian cancer: edin.ac/4jBEcId
March 5, 2025 at 12:57 PM
March is #OvarianCancerAwarenessMonth. IGC researchers are leading significant advancements in our understanding of the disease. Dr Robb Hollis has written about work being undertaken at the Nicola Murray Centre for Ovarian Cancer Research into uncommon types of ovarian cancer: edin.ac/4jBEcId
Reposted by @vdangioE3lab
Review from our lab out today: "Roles for the 3D Genome In the cell cycle, DNA replication, and double strand break repair." Written by @scientistkate.bsky.social, with her co-supervisor @piptaberlay.bsky.social and collaborator Mat Jones. www.frontiersin.org/journals/cel...
March 4, 2025 at 10:05 PM
Review from our lab out today: "Roles for the 3D Genome In the cell cycle, DNA replication, and double strand break repair." Written by @scientistkate.bsky.social, with her co-supervisor @piptaberlay.bsky.social and collaborator Mat Jones. www.frontiersin.org/journals/cel...
Reposted by @vdangioE3lab
Happy that I got to handle and help publish this cool new work for @embojournal.org
And after many years of PARPi/(poly-ADP)ribose craze, exciting to see mono-ADP-ribosylation starting to reveal its secrets in so many ways now!
And after many years of PARPi/(poly-ADP)ribose craze, exciting to see mono-ADP-ribosylation starting to reveal its secrets in so many ways now!
I'm super excited to share our study in collaboration with @jnpruneda.bsky.social, published today in @embojournal.org! We show that PARPs are modified with a non-canonical ester-linked mono-ADP-ribosylated ubiquitin species for the first time in cells: www.embopress.org/doi/full/10....
Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose | The EMBO Journal
imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and
ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification
has remained ...
www.embopress.org
February 26, 2025 at 4:49 PM
Happy that I got to handle and help publish this cool new work for @embojournal.org
And after many years of PARPi/(poly-ADP)ribose craze, exciting to see mono-ADP-ribosylation starting to reveal its secrets in so many ways now!
And after many years of PARPi/(poly-ADP)ribose craze, exciting to see mono-ADP-ribosylation starting to reveal its secrets in so many ways now!
Reposted by @vdangioE3lab
📢 Don’t miss our next Cancer Biology and Medicine talk tomorrow!
The role of transcription factors in cancer
Prof Jason Carroll, @cruk-ci.bsky.social
Thurs 20 Feb, 9:30-10:30
WH lecture theatre, School of Clinical Medicine
All welcome @cambridge-scm.bsky.social
The role of transcription factors in cancer
Prof Jason Carroll, @cruk-ci.bsky.social
Thurs 20 Feb, 9:30-10:30
WH lecture theatre, School of Clinical Medicine
All welcome @cambridge-scm.bsky.social
February 19, 2025 at 10:00 AM
📢 Don’t miss our next Cancer Biology and Medicine talk tomorrow!
The role of transcription factors in cancer
Prof Jason Carroll, @cruk-ci.bsky.social
Thurs 20 Feb, 9:30-10:30
WH lecture theatre, School of Clinical Medicine
All welcome @cambridge-scm.bsky.social
The role of transcription factors in cancer
Prof Jason Carroll, @cruk-ci.bsky.social
Thurs 20 Feb, 9:30-10:30
WH lecture theatre, School of Clinical Medicine
All welcome @cambridge-scm.bsky.social
Reposted by @vdangioE3lab
Correlation Vs. Causation
February 18, 2025 at 4:46 PM
Correlation Vs. Causation
Reposted by @vdangioE3lab
Happy to share a @nature.com News and Views on the amazing discoveries by @brianliau.bsky.social & Ning Zheng labs on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Check it out. www.nature.com/articles/d41...
Molecular glue unexpectedly mimics the effect of cancer mutations
Protein structures could guide the design of molecular glue degraders.
www.nature.com
February 18, 2025 at 6:38 PM
Happy to share a @nature.com News and Views on the amazing discoveries by @brianliau.bsky.social & Ning Zheng labs on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Check it out. www.nature.com/articles/d41...
Reposted by @vdangioE3lab
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
February 12, 2025 at 4:20 PM
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5