Michael Trakselis
@trakselis.bsky.social
#Traklab PI studying DNA replication and DNA repair mechanisms. Genome Instability @Baylor Director of Graduate Affairs Chemistry & Biochemistry #soccerdad
Pinned
Michael Trakselis
@trakselis.bsky.social
· Nov 13
With all the new activity here, its time to reintroduce the #Traklab at Baylor. We are a diverse group of scientists studying the molecular, structural, genetic, biological, and enzymatic mechanisms of DNA replication and repair processes. Would love to connect with y'all! #replication #repair 🧬
Reposted by Michael Trakselis
📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open)
🗓 May 30–31, 2026
✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators.
Please RT & share with your labs!
🔗 sites.google.com/view/kumc-mi...
🗓 May 30–31, 2026
✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators.
Please RT & share with your labs!
🔗 sites.google.com/view/kumc-mi...
February 3, 2026 at 8:41 PM
📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open)
🗓 May 30–31, 2026
✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators.
Please RT & share with your labs!
🔗 sites.google.com/view/kumc-mi...
🗓 May 30–31, 2026
✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators.
Please RT & share with your labs!
🔗 sites.google.com/view/kumc-mi...
Reposted by Michael Trakselis
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again.
www.nature.com/immersive/d4...
www.nature.com/immersive/d4...
January 20, 2026 at 10:53 PM
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again.
www.nature.com/immersive/d4...
www.nature.com/immersive/d4...
Reposted by Michael Trakselis
We are excited to host the first WOW Symposium for the 'Mutagenesis and Mechanistic Assessment" Special Interest Group @emgsus.bsky.social. Hosting Drs. Graham Walker (MIT), Mikhael Kashlev (NCI), and Julian Sale (MRC).
Please join us on March 6th at 11 am. Register at emgs-us.org/event/MolMec...
Please join us on March 6th at 11 am. Register at emgs-us.org/event/MolMec...
January 14, 2026 at 11:55 PM
We are excited to host the first WOW Symposium for the 'Mutagenesis and Mechanistic Assessment" Special Interest Group @emgsus.bsky.social. Hosting Drs. Graham Walker (MIT), Mikhael Kashlev (NCI), and Julian Sale (MRC).
Please join us on March 6th at 11 am. Register at emgs-us.org/event/MolMec...
Please join us on March 6th at 11 am. Register at emgs-us.org/event/MolMec...
Reposted by Michael Trakselis
Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version?
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
January 13, 2026 at 9:12 PM
Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version?
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
Reposted by Michael Trakselis
Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social
Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
www.eventsforce.net
January 5, 2026 at 4:52 PM
Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social
Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...
Watched Stranger Things S5E5 tonight with the fam. They was a pretty good representation of the DNA replication fork in Henry’s journal. No one else was impressed but me. 🧬
December 26, 2025 at 2:23 AM
Watched Stranger Things S5E5 tonight with the fam. They was a pretty good representation of the DNA replication fork in Henry’s journal. No one else was impressed but me. 🧬
Reposted by Michael Trakselis
Live thread of the NSF biology virtual office hour:
🧵
🧵
December 18, 2025 at 6:02 PM
Live thread of the NSF biology virtual office hour:
🧵
🧵
Reposted by Michael Trakselis
Horrifying news being confirmed about the state of NSF at the NSF IOS/BIO webinar
December 18, 2025 at 6:13 PM
Horrifying news being confirmed about the state of NSF at the NSF IOS/BIO webinar
Grads.. Start building your network now. It is so essential for life after graduation. www.nature.com/articles/d41...
I’ve earned my PhD — what now?
A chemist faces a classic early-career dilemma: what should they do next, and how do they start?
www.nature.com
December 18, 2025 at 2:22 PM
Grads.. Start building your network now. It is so essential for life after graduation. www.nature.com/articles/d41...
Reposted by Michael Trakselis
All the centers they’re cutting add up to less than $7 million in spending.
UNC athletics budget is $185.4 million for the 2025-26 fiscal year.
UNC athletics budget is $185.4 million for the 2025-26 fiscal year.
December 18, 2025 at 12:45 AM
All the centers they’re cutting add up to less than $7 million in spending.
UNC athletics budget is $185.4 million for the 2025-26 fiscal year.
UNC athletics budget is $185.4 million for the 2025-26 fiscal year.
Reposted by Michael Trakselis
Adam Luthman says: it depends. Some answers here: rdcu.be/eUVBj
Nonhomologous end-joining uses distinct mechanisms to repair each strand of a double strand break
Nature Communications - Breakage of both chromosomal DNA strands creates unique problems for DNA repair. Here, Luthman et al. show that for some broken ends, the two strand breaks are repaired in...
rdcu.be
December 16, 2025 at 5:36 PM
Adam Luthman says: it depends. Some answers here: rdcu.be/eUVBj
Make sure to gift something to you administrative staff that keeps the Department running all year long. For me, the best gift to give is Frangos! Originally from Chicago!
December 12, 2025 at 8:18 PM
Make sure to gift something to you administrative staff that keeps the Department running all year long. For me, the best gift to give is Frangos! Originally from Chicago!
Reposted by Michael Trakselis
I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...
PAR-26-121: Maximizing Investigators' Research Award (MIRA) (R35 - Clinical Trial Optional)
files.simpler.grants.gov
December 11, 2025 at 6:48 PM
I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...
Reposted by Michael Trakselis
Everyone shut thefuck up in that they discovered ribose and, for the first time in any extraterrestrialsample, glucose on Bennu.
This adds to earlier this yr 14 of the 20 amino acids thatlife on Earth uses to make proteinsand all five nucleobases that lifeon Earth uses
www.nasa.gov/missions/osi...
This adds to earlier this yr 14 of the 20 amino acids thatlife on Earth uses to make proteinsand all five nucleobases that lifeon Earth uses
www.nasa.gov/missions/osi...
Sugars, ‘Gum,’ Stardust Found in NASA's Asteroid Bennu Samples - NASA
The asteroid Bennu continues to provide new clues to scientists’ biggest questions about the formation of the early solar system and the origins of life. As
www.nasa.gov
December 2, 2025 at 5:35 PM
Everyone shut thefuck up in that they discovered ribose and, for the first time in any extraterrestrialsample, glucose on Bennu.
This adds to earlier this yr 14 of the 20 amino acids thatlife on Earth uses to make proteinsand all five nucleobases that lifeon Earth uses
www.nasa.gov/missions/osi...
This adds to earlier this yr 14 of the 20 amino acids thatlife on Earth uses to make proteinsand all five nucleobases that lifeon Earth uses
www.nasa.gov/missions/osi...
Reposted by Michael Trakselis
We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you.
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Postdoctoral Fellow - H Yardimci Lab
www.crick.ac.uk
November 25, 2025 at 11:55 AM
We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you.
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Reposted by Michael Trakselis
Happy to share our most recent work www.pnas.org/doi/10.1073/.... Here we describe how efficient DNA replication in E. coli is dependent on an interaction between SSB-ssDNA and the DNA polymerase (Pol III). Thanks to all the co-authors for their hard work!
Genome integrity relies on rapid recycling of DNA Pol III in bacteria | PNAS
DNA replication requires precise coordination between DNA unwinding and DNA synthesis.
In all domains of life, protein–protein interactions at the ...
www.pnas.org
November 20, 2025 at 4:54 PM
Happy to share our most recent work www.pnas.org/doi/10.1073/.... Here we describe how efficient DNA replication in E. coli is dependent on an interaction between SSB-ssDNA and the DNA polymerase (Pol III). Thanks to all the co-authors for their hard work!
Reposted by Michael Trakselis
Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 7, 2025 at 8:34 AM
Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇
Reposted by Michael Trakselis
POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
ANTONY LAB SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE
Edwin Antony Lab Website
www.antonylab.org
November 18, 2025 at 7:05 PM
POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
Wynton Marsalis and the Jazz at Lincoln Center Orchestra blew me away tonight. Thanks Baylor and A&S for sponsoring.
November 14, 2025 at 4:05 AM
Wynton Marsalis and the Jazz at Lincoln Center Orchestra blew me away tonight. Thanks Baylor and A&S for sponsoring.
Reposted by Michael Trakselis
Interested in inherited chromosomal instability syndromes and DNA repair? We are looking for an enthusiastic person to join the Stewart lab at the University of Birmingham as a senior technician. Please checkout the job advert: www.jobs.ac.uk/job/DPH515/senior-research-technician
Senior Research Technician at University of Birmingham
An academic position as a Senior Research Technician is being advertised on jobs.ac.uk. Click now to find more details and explore additional academic job opportunities.
www.jobs.ac.uk
November 6, 2025 at 8:34 AM
Interested in inherited chromosomal instability syndromes and DNA repair? We are looking for an enthusiastic person to join the Stewart lab at the University of Birmingham as a senior technician. Please checkout the job advert: www.jobs.ac.uk/job/DPH515/senior-research-technician
Reposted by Michael Trakselis
Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments
Homologous recombination (HR) deficiency upon Breast Cancer Gene 2 (BRCA2) loss arises from defects in the formation of RAD51 nucleoprotein filaments. We demonstrate that loss of the anti-recombinase ...
www.science.org
October 30, 2025 at 9:52 PM
Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Michael Trakselis
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 30, 2025 at 8:41 PM
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Michael Trakselis
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Human RPA is an essential telomerase processivity factor for maintaining telomeres
Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical ...
www.science.org
October 30, 2025 at 10:07 PM
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Happy to share a new publication on Mechanistic Coupling of Enzyme Activities at the Replisome in JBC. We #Traklab compare and contrast strategies used across organisms to coordinate the many enzymatic processes that occur during DNA replication. Hope it is helpful. doi.org/10.1016/j.jb...
October 24, 2025 at 6:12 PM
Happy to share a new publication on Mechanistic Coupling of Enzyme Activities at the Replisome in JBC. We #Traklab compare and contrast strategies used across organisms to coordinate the many enzymatic processes that occur during DNA replication. Hope it is helpful. doi.org/10.1016/j.jb...