Two Fun facts: 1) I wanted to call this a "pinky-trigger" mechanism but the reviewers weren't having it. and 2) I designed the graphical abstract, so blame me. 🤫

Here, we show that specific arginine residues in the little finger domain of translesion DNA polymerases act to sense 8-oxoG bypass and then communicate to restrict subsequent incorporations downstream. This has kinetic implications for reducing mutagenesis after a TLS event.

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