Vince Luca, PhD
@thelucalab.bsky.social
We use structure-guided engineering to design biologics & immunotherapies.
Associate Professor of Immunology,
Director - Center for Antibody & Protein Engineering (CAPE) @ Moffitt Cancer Center
www.thelucalab.org
Associate Professor of Immunology,
Director - Center for Antibody & Protein Engineering (CAPE) @ Moffitt Cancer Center
www.thelucalab.org
Reposted by Vince Luca, PhD
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 12, 2025 at 9:26 PM
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Reposted by Vince Luca, PhD
Biological Chemistry's position is still taking applications. UM is a great place to be a PI, I'd love to see a new membrane biology or lipids expert join our community.
This is open for new and established investigators.
This is open for new and established investigators.
Collaborative. Creative. Impactful. Come join us in Ann Arbor! For more information and application link see jobs.sciencecareers.org/job/675674/f...
November 11, 2025 at 3:33 PM
Biological Chemistry's position is still taking applications. UM is a great place to be a PI, I'd love to see a new membrane biology or lipids expert join our community.
This is open for new and established investigators.
This is open for new and established investigators.
designing a new timberwolves jersey after every win 🐺
record: 7-4
record: 7-4
November 11, 2025 at 1:07 PM
Reposted by Vince Luca, PhD
Computrs usd a rstrictd alphabt to dsign protins that fold & “mak sns.”
Design stable, folded proteins using only the 10 "ancient" amino acids.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 10, 2025 at 11:08 PM
Computrs usd a rstrictd alphabt to dsign protins that fold & “mak sns.”
Reposted by Vince Luca, PhD
Excited to share our new review on our current understanding of small cell lung cancer (SCLC) heterogeneity and plasticity, led by Gina Duronio in the lab: www.tandfonline.com/doi/full/10....
November 10, 2025 at 6:29 PM
Excited to share our new review on our current understanding of small cell lung cancer (SCLC) heterogeneity and plasticity, led by Gina Duronio in the lab: www.tandfonline.com/doi/full/10....
Reposted by Vince Luca, PhD
We are hiring an immunologist. This is a hard money position. We have a very robust research infrastructure. Rowan is rapidly growing, with 20,000+ undergrads, two med schools, and a vet school. Contact me for more details. jobs.rowan.edu/en-us/job/50...
Rowan HR - Details - Open-Rank Tenured/Tenure-Track Faculty, Immunology, Department of Biomedical Sciences (CMSRU)Job Postings | Human Resources | Rowan University
Rowan University is a Carnegie-classified national doctoral research institution dedicated to excellence in undergraduate and graduate education.
jobs.rowan.edu
November 7, 2025 at 4:46 PM
We are hiring an immunologist. This is a hard money position. We have a very robust research infrastructure. Rowan is rapidly growing, with 20,000+ undergrads, two med schools, and a vet school. Contact me for more details. jobs.rowan.edu/en-us/job/50...
Reposted by Vince Luca, PhD
Excited to share our latest work on a new cilia disassembly pathway and a link between this pathway and the neurological disorder focal cortical dysplasia: www.science.org/doi/10.1126/...
Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...
Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...
A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia
A gain-of-function screen uncovers a cilia disassembly pathway linked to genes somatically mutated in neurodevelopmental disease.
www.science.org
October 30, 2025 at 3:14 PM
Excited to share our latest work on a new cilia disassembly pathway and a link between this pathway and the neurological disorder focal cortical dysplasia: www.science.org/doi/10.1126/...
Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...
Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...
Reposted by Vince Luca, PhD
ATTN: Two faculty positions are available in my department (neuroscience) at the University of Minnesota. This is a general search with no topic focus. November 20th application deadline.
Apply here: hr.umn.edu/jobs/Find-Job
Assistant Prof job code: 364920
Associate/Full Prof job code: 364921
Apply here: hr.umn.edu/jobs/Find-Job
Assistant Prof job code: 364920
Associate/Full Prof job code: 364921
October 30, 2025 at 3:59 PM
ATTN: Two faculty positions are available in my department (neuroscience) at the University of Minnesota. This is a general search with no topic focus. November 20th application deadline.
Apply here: hr.umn.edu/jobs/Find-Job
Assistant Prof job code: 364920
Associate/Full Prof job code: 364921
Apply here: hr.umn.edu/jobs/Find-Job
Assistant Prof job code: 364920
Associate/Full Prof job code: 364921
Reposted by Vince Luca, PhD
This year’s Merck-Banyu Lectureship Award winner is Professor Koji Kubota from Hokkaido University. We are thrilled to welcome him to Stanford Chemistry on Thursday, October 23rd where he will give an exciting lecture on "Exploring Synthetic Mechanochemistry." chemistry.stanford.edu/events/merck...
October 21, 2025 at 4:59 PM
This year’s Merck-Banyu Lectureship Award winner is Professor Koji Kubota from Hokkaido University. We are thrilled to welcome him to Stanford Chemistry on Thursday, October 23rd where he will give an exciting lecture on "Exploring Synthetic Mechanochemistry." chemistry.stanford.edu/events/merck...
Reposted by Vince Luca, PhD
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
October 9, 2025 at 6:06 PM
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
Reposted by Vince Luca, PhD
If you’re around at the #NotchMeetingXIII poster session today, come by to check out Poster #9! 🧬✨
@anna_frontino will be there presenting our shared work on how Jagged1 variants shape liver vascular and biliary development.
Stop by to say hi and chat Notch!
@anna_frontino will be there presenting our shared work on how Jagged1 variants shape liver vascular and biliary development.
Stop by to say hi and chat Notch!
October 6, 2025 at 12:36 PM
If you’re around at the #NotchMeetingXIII poster session today, come by to check out Poster #9! 🧬✨
@anna_frontino will be there presenting our shared work on how Jagged1 variants shape liver vascular and biliary development.
Stop by to say hi and chat Notch!
@anna_frontino will be there presenting our shared work on how Jagged1 variants shape liver vascular and biliary development.
Stop by to say hi and chat Notch!
Reposted by Vince Luca, PhD
CAR T therapy has seen great effectiveness in liquid tumors, but little in solid tumors (e.g. ovarian cancer).
Here we developed hyper-migratory CAR TV cells to infiltrate en masse ovarian tumors. (Left: control CAR T cells; right CAR TV cells).
Read this here: www.biorxiv.org/content/10.1...
Here we developed hyper-migratory CAR TV cells to infiltrate en masse ovarian tumors. (Left: control CAR T cells; right CAR TV cells).
Read this here: www.biorxiv.org/content/10.1...
October 5, 2025 at 4:48 PM
CAR T therapy has seen great effectiveness in liquid tumors, but little in solid tumors (e.g. ovarian cancer).
Here we developed hyper-migratory CAR TV cells to infiltrate en masse ovarian tumors. (Left: control CAR T cells; right CAR TV cells).
Read this here: www.biorxiv.org/content/10.1...
Here we developed hyper-migratory CAR TV cells to infiltrate en masse ovarian tumors. (Left: control CAR T cells; right CAR TV cells).
Read this here: www.biorxiv.org/content/10.1...
Reposted by Vince Luca, PhD
I've been watching as NIGMS works their tails off to get R35 awards out the door before the end of the FY on 30 Sept. They all look great but this one really grabbed my attention.
It's about long "noncoding" (lnc) RNA's. Only, this one *does* encode peptides…
reporter.nih.gov/project-deta...
It's about long "noncoding" (lnc) RNA's. Only, this one *does* encode peptides…
reporter.nih.gov/project-deta...
RePORT ⟩ RePORTER
reporter.nih.gov
September 17, 2025 at 11:10 PM
I've been watching as NIGMS works their tails off to get R35 awards out the door before the end of the FY on 30 Sept. They all look great but this one really grabbed my attention.
It's about long "noncoding" (lnc) RNA's. Only, this one *does* encode peptides…
reporter.nih.gov/project-deta...
It's about long "noncoding" (lnc) RNA's. Only, this one *does* encode peptides…
reporter.nih.gov/project-deta...
Reposted by Vince Luca, PhD
Dear scientific community,
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
September 8, 2025 at 3:16 PM
Dear scientific community,
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
Reposted by Vince Luca, PhD
University efficiency drives may have opposite effect, study finds.
The administrative burden in Australian universities is most keenly felt by teaching and research staff, according to a study from the University of Melbourne’s faculty of education.
www.researchprofessionalnews.com/rr-news-aust...
The administrative burden in Australian universities is most keenly felt by teaching and research staff, according to a study from the University of Melbourne’s faculty of education.
www.researchprofessionalnews.com/rr-news-aust...
University efficiency drives may have opposite effect, study finds - Research Professional News
Teaching and research staff say reforms mean more red tape for them, Australian survey reports
www.researchprofessionalnews.com
August 26, 2025 at 1:28 PM
University efficiency drives may have opposite effect, study finds.
The administrative burden in Australian universities is most keenly felt by teaching and research staff, according to a study from the University of Melbourne’s faculty of education.
www.researchprofessionalnews.com/rr-news-aust...
The administrative burden in Australian universities is most keenly felt by teaching and research staff, according to a study from the University of Melbourne’s faculty of education.
www.researchprofessionalnews.com/rr-news-aust...
Bindcraft is awesome! If you haven’t already seen the preprint check out the final pub here. We’ve had nearly 100% success using it for the targets we’ve attempted.
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 27, 2025 at 4:46 PM
Bindcraft is awesome! If you haven’t already seen the preprint check out the final pub here. We’ve had nearly 100% success using it for the targets we’ve attempted.
Reposted by Vince Luca, PhD
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 27, 2025 at 4:14 PM
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vince Luca, PhD
Am I crazy or did we just have a convo about how we can't fund cancer research?
May 23, 2025 at 2:23 AM
Am I crazy or did we just have a convo about how we can't fund cancer research?
Reposted by Vince Luca, PhD
Donald Trump cut funding for cancer research by 31% in the first three months of his term.
This is an attack on every American family who has loved someone with cancer.
This is an attack on every American family who has loved someone with cancer.
May 16, 2025 at 9:05 PM
Donald Trump cut funding for cancer research by 31% in the first three months of his term.
This is an attack on every American family who has loved someone with cancer.
This is an attack on every American family who has loved someone with cancer.
Reposted by Vince Luca, PhD
My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑🎓 Please RT. It's a great place with world-class expertise in all sorts of biomedical & biological engineering topics like synthetic biology. It's also not in the USA. www.imperial.ac.uk/jobs/search-...
May 2, 2025 at 3:20 PM
My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑🎓 Please RT. It's a great place with world-class expertise in all sorts of biomedical & biological engineering topics like synthetic biology. It's also not in the USA. www.imperial.ac.uk/jobs/search-...
Reposted by Vince Luca, PhD
"I would not have dared to dream that metastatic melanoma would become a treatable disease in my lifetime. Yet here we are today, with 43% of people diagnosed with metastatic melanoma living 10 years or more, due to treatments that we broadly refer to as cancer immunotherapy." Barry P. Sleckman, UAB
The Senate Committee on Appropriations is holding a hearing on Biomedical Research: Keeping America’s Edge in Innovation on April 30 at 10:30am ET, chaired by Senator Susan Collins 🧪
www.appropriations.senate.gov/hearings/bio...
www.appropriations.senate.gov/hearings/bio...
Biomedical Research: Keeping America’s Edge in Innovation | United States Senate Committee on Appropriations
United States Senate Committee on Appropriations
www.appropriations.senate.gov
April 30, 2025 at 3:14 PM
"I would not have dared to dream that metastatic melanoma would become a treatable disease in my lifetime. Yet here we are today, with 43% of people diagnosed with metastatic melanoma living 10 years or more, due to treatments that we broadly refer to as cancer immunotherapy." Barry P. Sleckman, UAB
Reposted by Vince Luca, PhD
Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
April 21, 2025 at 7:21 PM
Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
Reposted by Vince Luca, PhD
Huge opportunity for postdocs gearing up for an academic job search, hosted by @stanford-chemh.bsky.social @berkeleymcb.bsky.social and UCSF!
Hello Community!
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
April 25, 2025 at 11:46 PM
Huge opportunity for postdocs gearing up for an academic job search, hosted by @stanford-chemh.bsky.social @berkeleymcb.bsky.social and UCSF!
Reposted by Vince Luca, PhD
Actually, flip the headline. It's really "How the Federal Government Became so Dependent on Universities."
These competitively awarded, peer reviewed research grants produce tremendous returns on investment. New tech, health, science that benefit all people & businesses in the USA & world.
These competitively awarded, peer reviewed research grants produce tremendous returns on investment. New tech, health, science that benefit all people & businesses in the USA & world.
April 19, 2025 at 1:13 PM
Actually, flip the headline. It's really "How the Federal Government Became so Dependent on Universities."
These competitively awarded, peer reviewed research grants produce tremendous returns on investment. New tech, health, science that benefit all people & businesses in the USA & world.
These competitively awarded, peer reviewed research grants produce tremendous returns on investment. New tech, health, science that benefit all people & businesses in the USA & world.