Susanne Brenzinger
@subrenz.bsky.social
Specialist @ EMBL Microbial Automation & Culturomics Core Facility. Interested in bacterial stress response, cell physiology, antibiotics, phage defense... and whatever else piques my interest.
Reposted by Susanne Brenzinger
Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships. https://go.nature.com/49of3Mk 🧪
December 7, 2024 at 4:42 PM
Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships. https://go.nature.com/49of3Mk 🧪
Reposted by Susanne Brenzinger
I have an open Postdoc position in Molecular Systems Biology at ETH Zürich!
The project is about the conservation of transcription factors functions between strains of Pseudomonas aeruginosa 🧬🦠
More details and application at:
jobs.ethz.ch/job/view/JOP...
Please share!
The project is about the conservation of transcription factors functions between strains of Pseudomonas aeruginosa 🧬🦠
More details and application at:
jobs.ethz.ch/job/view/JOP...
Please share!
Postdoctoral Position in Molecular Systems Biology
jobs.ethz.ch
December 6, 2024 at 3:20 PM
I have an open Postdoc position in Molecular Systems Biology at ETH Zürich!
The project is about the conservation of transcription factors functions between strains of Pseudomonas aeruginosa 🧬🦠
More details and application at:
jobs.ethz.ch/job/view/JOP...
Please share!
The project is about the conservation of transcription factors functions between strains of Pseudomonas aeruginosa 🧬🦠
More details and application at:
jobs.ethz.ch/job/view/JOP...
Please share!
Reposted by Susanne Brenzinger
(1/3) Antibiotic resistance is costing human lives. 🦠
A study from EMBL's Typas group proposed a framework to identify antibiotic pairs that make bacteria resistant to one antibiotic but sensitive to other – this can help design new treatments and delay resistance. 🧬🧪
www.nature.com/articles/s41...
A study from EMBL's Typas group proposed a framework to identify antibiotic pairs that make bacteria resistant to one antibiotic but sensitive to other – this can help design new treatments and delay resistance. 🧬🧪
www.nature.com/articles/s41...
December 2, 2024 at 10:20 AM
(1/3) Antibiotic resistance is costing human lives. 🦠
A study from EMBL's Typas group proposed a framework to identify antibiotic pairs that make bacteria resistant to one antibiotic but sensitive to other – this can help design new treatments and delay resistance. 🧬🧪
www.nature.com/articles/s41...
A study from EMBL's Typas group proposed a framework to identify antibiotic pairs that make bacteria resistant to one antibiotic but sensitive to other – this can help design new treatments and delay resistance. 🧬🧪
www.nature.com/articles/s41...
Reposted by Susanne Brenzinger
a triangle 🔺
it’s a basic shape, but no bacteria is a triangle
a clothes hanger, a slice of pizza, a dorito—all triangles
just not bacteria
it’s a basic shape, but no bacteria is a triangle
a clothes hanger, a slice of pizza, a dorito—all triangles
just not bacteria
November 25, 2024 at 3:10 AM
a triangle 🔺
it’s a basic shape, but no bacteria is a triangle
a clothes hanger, a slice of pizza, a dorito—all triangles
just not bacteria
it’s a basic shape, but no bacteria is a triangle
a clothes hanger, a slice of pizza, a dorito—all triangles
just not bacteria
If there is one account worth following irrespective of your reasons for being on Bluesky, it is @auschwitzmemorial.bsky.social. A humbling and necessary constant reminder of the human abyss.
We are on @bsky.app.
Please consider following @auschwitzmemorial.bsky.social where every day we commemorate the victims & educate about the tragic human history of Auschwitz.
Repost please.
Please consider following @auschwitzmemorial.bsky.social where every day we commemorate the victims & educate about the tragic human history of Auschwitz.
Repost please.
November 20, 2024 at 10:28 PM
If there is one account worth following irrespective of your reasons for being on Bluesky, it is @auschwitzmemorial.bsky.social. A humbling and necessary constant reminder of the human abyss.
Reposted by Susanne Brenzinger
Trying to purify and sequence #phage for phage therapy?
Try #sphae a new approach to identify if your phage could be useful for treatment
#phagesky
Try #sphae a new approach to identify if your phage could be useful for treatment
#phagesky
Sphae: An automated toolkit for predicting phage therapy candidates from sequencing data https://www.biorxiv.org/content/10.1101/2024.11.18.624194v1
Sphae: An automated toolkit for predicting phage therapy candidates from sequencing data https://www.biorxiv.org/content/10.1101/2024.11.18.624194v1
Motivation: Phage therapy is a viable alternative for treating bacterial infections amidst the escal
www.biorxiv.org
November 19, 2024 at 3:09 AM
Reposted by Susanne Brenzinger
My first post on Blue Sky - moving over !
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
EMBL Jobs
We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.
www.embl.org
November 18, 2024 at 5:28 PM
My first post on Blue Sky - moving over !
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
Reposted by Susanne Brenzinger
To fill up my empty feed, my first post on #bluesky.
Earlier this year we showed how the DdmDE system from pandemic Vibrio cholerae defends against invading plasmids. A great collaboration between the labs of Martin Jinek (UZH) and @mblokesch.bsky.social (EPFL).
www.science.org/doi/10.1126/...
Earlier this year we showed how the DdmDE system from pandemic Vibrio cholerae defends against invading plasmids. A great collaboration between the labs of Martin Jinek (UZH) and @mblokesch.bsky.social (EPFL).
www.science.org/doi/10.1126/...
November 12, 2024 at 1:12 PM
To fill up my empty feed, my first post on #bluesky.
Earlier this year we showed how the DdmDE system from pandemic Vibrio cholerae defends against invading plasmids. A great collaboration between the labs of Martin Jinek (UZH) and @mblokesch.bsky.social (EPFL).
www.science.org/doi/10.1126/...
Earlier this year we showed how the DdmDE system from pandemic Vibrio cholerae defends against invading plasmids. A great collaboration between the labs of Martin Jinek (UZH) and @mblokesch.bsky.social (EPFL).
www.science.org/doi/10.1126/...
Reposted by Susanne Brenzinger
Woohoo, the Microbiology Department (this includes me) at the JLU Giessen is looking for a new colleague (W2 with tenure track to W3).
Look here: uni-giessen.de/karriere/ste...
(and yes, knowledge of the German language is required ...).
Come to Giessen! We have cookies.
Look here: uni-giessen.de/karriere/ste...
(and yes, knowledge of the German language is required ...).
Come to Giessen! We have cookies.
March 1, 2024 at 3:35 PM
Woohoo, the Microbiology Department (this includes me) at the JLU Giessen is looking for a new colleague (W2 with tenure track to W3).
Look here: uni-giessen.de/karriere/ste...
(and yes, knowledge of the German language is required ...).
Come to Giessen! We have cookies.
Look here: uni-giessen.de/karriere/ste...
(and yes, knowledge of the German language is required ...).
Come to Giessen! We have cookies.
Reposted by Susanne Brenzinger
A new class of immune signaling molecules generated by TIR domains: histidine conjugated to ADP-ribose
Check out our preprint: tinyurl.com/hisADP
A fantastic collaboration with the Tamulaitiene and Kranzusch labs
Check out our preprint: tinyurl.com/hisADP
A fantastic collaboration with the Tamulaitiene and Kranzusch labs
January 4, 2024 at 12:35 PM
A new class of immune signaling molecules generated by TIR domains: histidine conjugated to ADP-ribose
Check out our preprint: tinyurl.com/hisADP
A fantastic collaboration with the Tamulaitiene and Kranzusch labs
Check out our preprint: tinyurl.com/hisADP
A fantastic collaboration with the Tamulaitiene and Kranzusch labs
Can a phage defence system interfere with antibiotic action? 💊 Yes, it can! CBASS is triggered by antifolates and turns these mostly bacteriostatic drugs into bactericidal ones in bugs like V. cholerae. 🦠 www.nature.com/articles/s41564-023-01556-y Read full here: rdcu.be/du20r
The Vibrio cholerae CBASS phage defence system modulates resistance and killing by antifolate antibi...
High-throughput growth assays show that cyclic-oligonucleotide-based anti-phage signalling systems modulate Vibrio cholerae sensitivity to antifolates, and ultimately trigger cell lysis by these drugs...
www.nature.com
January 3, 2024 at 11:17 AM
Can a phage defence system interfere with antibiotic action? 💊 Yes, it can! CBASS is triggered by antifolates and turns these mostly bacteriostatic drugs into bactericidal ones in bugs like V. cholerae. 🦠 www.nature.com/articles/s41564-023-01556-y Read full here: rdcu.be/du20r
Reposted by Susanne Brenzinger
Thank you Tim Blower and Stineke van Houte for an awesome news and views!🎁🎁 #phagesky
Viruses wrap up bacterial defence systems
Bacteria use diverse defences against viral predators called bacteriophages. A method to identify antibacterial counter-defences in viral genomes has revealed striking modes of defence inhibition. Pre...
www.nature.com
December 19, 2023 at 3:06 PM
Thank you Tim Blower and Stineke van Houte for an awesome news and views!🎁🎁 #phagesky
Reposted by Susanne Brenzinger
Love this research highlight on our recent papers!🥊👊 @soreklab.bsky.social #phagesky
nature.com/articles/s41...
nature.com/articles/s41...
A never-ending defence fight - Nature Reviews Microbiology
Two recent studies provide mechanistic understanding of how bacteria employ the Gabija system for defence against phages, as well as how phages use anti-defence proteins to overcome bacterial immunity...
nature.com
December 13, 2023 at 4:44 PM
Love this research highlight on our recent papers!🥊👊 @soreklab.bsky.social #phagesky
nature.com/articles/s41...
nature.com/articles/s41...
Reposted by Susanne Brenzinger
Gift link to NYT article on an exciting breakthrough in treating extreme nausea in pregnant women (+ cancer patients). The female MD who conducted the breakthrough study (a) lost her pregnancy at 15 weeks gestation after suffering & (b) was told the problem was in her head.
Representation matters.
Representation matters.
Scientists Pinpoint Cause of Severe Morning Sickness
The discovery could lead to better treatments for severe nausea and vomiting during pregnancy.
www.nytimes.com
December 13, 2023 at 9:27 PM
Gift link to NYT article on an exciting breakthrough in treating extreme nausea in pregnant women (+ cancer patients). The female MD who conducted the breakthrough study (a) lost her pregnancy at 15 weeks gestation after suffering & (b) was told the problem was in her head.
Representation matters.
Representation matters.
Reposted by Susanne Brenzinger
PIRATES!!
Constructing phagemids? Nature's been there before. A free rolling-circle plamid hijacks an Inovirus to hitch a ride. Fantastic observation and work by Nicole and great collaborators, made possible by @SPP2330. doi: doi.org/10.1101/2023.1
Constructing phagemids? Nature's been there before. A free rolling-circle plamid hijacks an Inovirus to hitch a ride. Fantastic observation and work by Nicole and great collaborators, made possible by @SPP2330. doi: doi.org/10.1101/2023.1
November 29, 2023 at 9:37 AM
PIRATES!!
Constructing phagemids? Nature's been there before. A free rolling-circle plamid hijacks an Inovirus to hitch a ride. Fantastic observation and work by Nicole and great collaborators, made possible by @SPP2330. doi: doi.org/10.1101/2023.1
Constructing phagemids? Nature's been there before. A free rolling-circle plamid hijacks an Inovirus to hitch a ride. Fantastic observation and work by Nicole and great collaborators, made possible by @SPP2330. doi: doi.org/10.1101/2023.1
Reposted by Susanne Brenzinger
November 20, 2023 at 7:09 PM
If I'm already on it, another tool I use when encountering a hypothetical uncharacterized protein is CDVist by the Zhulin lab. Great to predict domains and easy to use. Inviting rabbit holes included. 😅 cdvist.joulinelab.org
October 8, 2023 at 5:24 PM
If I'm already on it, another tool I use when encountering a hypothetical uncharacterized protein is CDVist by the Zhulin lab. Great to predict domains and easy to use. Inviting rabbit holes included. 😅 cdvist.joulinelab.org
Reposted by Susanne Brenzinger
I started a #phage feed ... #phagesky
Add that hashtag to your posts to be included on the feed
Add that hashtag to your posts to be included on the feed
October 1, 2023 at 12:43 PM
I started a #phage feed ... #phagesky
Add that hashtag to your posts to be included on the feed
Add that hashtag to your posts to be included on the feed
One of the tools I find useful to get to know a new protein: PaperBLAST will find papers where your protein of interest has been described before. papers.genomics.lbl.gov/cgi-bin/litS...
PaperBLAST
papers.genomics.lbl.gov
October 6, 2023 at 6:59 PM
One of the tools I find useful to get to know a new protein: PaperBLAST will find papers where your protein of interest has been described before. papers.genomics.lbl.gov/cgi-bin/litS...
Reposted by Susanne Brenzinger
The scientific, economical, and regulatory roadblocks to #phage therapy - the example of Germany
www.mdpi.com/1999-4915/15...
www.mdpi.com/1999-4915/15...
October 3, 2023 at 10:01 AM
The scientific, economical, and regulatory roadblocks to #phage therapy - the example of Germany
www.mdpi.com/1999-4915/15...
www.mdpi.com/1999-4915/15...
Reposted by Susanne Brenzinger
Phage researchers, could you help out?
Reviewer asks us to refer to "phage typing as a standard tool for the differentiation of Bacilli". Can anyone point to specific literature applicable to all Bacilli? Or is it only for differentiating certain species from each other?
Reviewer asks us to refer to "phage typing as a standard tool for the differentiation of Bacilli". Can anyone point to specific literature applicable to all Bacilli? Or is it only for differentiating certain species from each other?
October 2, 2023 at 1:46 PM
Phage researchers, could you help out?
Reviewer asks us to refer to "phage typing as a standard tool for the differentiation of Bacilli". Can anyone point to specific literature applicable to all Bacilli? Or is it only for differentiating certain species from each other?
Reviewer asks us to refer to "phage typing as a standard tool for the differentiation of Bacilli". Can anyone point to specific literature applicable to all Bacilli? Or is it only for differentiating certain species from each other?
Reposted by Susanne Brenzinger
Reversible conjugation of a CBASS nucleotide cyclase regulates immune response to phage infection https://www.biorxiv.org/content/10.1101/2023.09.29.560134v1
Reversible conjugation of a CBASS nucleotide cyclase regulates immune response to phage infection https://www.biorxiv.org/content/10.1101/2023.09.29.560134v1
Antiviral defence systems build the prokaryotic immune system and their proper regulation is vital f
www.biorxiv.org
September 30, 2023 at 4:19 AM
Reversible conjugation of a CBASS nucleotide cyclase regulates immune response to phage infection https://www.biorxiv.org/content/10.1101/2023.09.29.560134v1
Reposted by Susanne Brenzinger
The strain on scientific publishing 📄:
We've got issues. Scientists overwhelmed, editors overworked, constant special issue invites, mass article retractions, journal delistings… JUST WHAT IS GOING ON!?
See: arxiv.org/abs/2309.15884
A 🧵1/n
#AcademicChatter #PublishOrPerish #PhDAdvice #PhDChat
We've got issues. Scientists overwhelmed, editors overworked, constant special issue invites, mass article retractions, journal delistings… JUST WHAT IS GOING ON!?
See: arxiv.org/abs/2309.15884
A 🧵1/n
#AcademicChatter #PublishOrPerish #PhDAdvice #PhDChat
September 29, 2023 at 7:50 AM
The strain on scientific publishing 📄:
We've got issues. Scientists overwhelmed, editors overworked, constant special issue invites, mass article retractions, journal delistings… JUST WHAT IS GOING ON!?
See: arxiv.org/abs/2309.15884
A 🧵1/n
#AcademicChatter #PublishOrPerish #PhDAdvice #PhDChat
We've got issues. Scientists overwhelmed, editors overworked, constant special issue invites, mass article retractions, journal delistings… JUST WHAT IS GOING ON!?
See: arxiv.org/abs/2309.15884
A 🧵1/n
#AcademicChatter #PublishOrPerish #PhDAdvice #PhDChat
I'm really looking forward to this meeting next week! It's been a great group of labs & projects and so many interesting presentations at the last meetings!
September 27, 2023 at 6:16 PM
I'm really looking forward to this meeting next week! It's been a great group of labs & projects and so many interesting presentations at the last meetings!
Reposted by Susanne Brenzinger
Can we limit infection by disarming pathogens rather than killing them? In this review we discuss the current state of play with this approach to tackle antibiotic resistance. www.nature.com/articles/s44...
September 23, 2023 at 9:06 AM
Can we limit infection by disarming pathogens rather than killing them? In this review we discuss the current state of play with this approach to tackle antibiotic resistance. www.nature.com/articles/s44...