Sebastiano Pasqualato
@spasqualato.bsky.social
Structural Biologist trying to make some good Science while providing support and services. Biophysics Unit manager at the National Facilities for Structural Biology, Human Technopole
Also, trying to have a fun life and a family!
Also, trying to have a fun life and a family!
Reposted by Sebastiano Pasqualato
Astounding words and performance. Take 2 mins to listen to it.
Sir Ian McKellen performing a monologue from Shakespeare’s Sir Thomas More on the Stephen Colbert show. Never have I heard this monologue performed with such a keen sense of prescience. Nor have I ever been in this exact historical moment.TY Sir Ian, for reaching us once again.
#Pinks #ProudBlue
#Pinks #ProudBlue
February 5, 2026 at 1:52 PM
Astounding words and performance. Take 2 mins to listen to it.
Reposted by Sebastiano Pasqualato
🔬 How do proteins know when and how to move? Our @francescryoem.bsky.social Group reveals how sortilin recognises thyroglobulin on its path to #thyroid hormone release via a short, flexible molecular “tag”.
Published in @natcomms.nature.com humantechnopole.it/en/news/how-... @iboniardi.bsky.social
Published in @natcomms.nature.com humantechnopole.it/en/news/how-... @iboniardi.bsky.social
How sortilin senses thyroglobulin along its pathway to thyroid hormone release - Human Technopole
Human Technopole researchers have identified the molecular mechanisms by which the membrane receptor sortilin binds thyroglobulin along its pathway to the release of thyroid hormones within the thyroi...
humantechnopole.it
February 3, 2026 at 11:36 AM
🔬 How do proteins know when and how to move? Our @francescryoem.bsky.social Group reveals how sortilin recognises thyroglobulin on its path to #thyroid hormone release via a short, flexible molecular “tag”.
Published in @natcomms.nature.com humantechnopole.it/en/news/how-... @iboniardi.bsky.social
Published in @natcomms.nature.com humantechnopole.it/en/news/how-... @iboniardi.bsky.social
Reposted by Sebastiano Pasqualato
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Multiscale structure of chromatin condensates explains phase separation and material properties
The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...
www.science.org
December 5, 2025 at 5:24 AM
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Reposted by Sebastiano Pasqualato
🧪An international study led by Prof. Roderick Lim has discovered that nuclear pore complexes—gateways in the nuclear membrane—are not rigid or gel-like as once thought. Instead, their interiors are constantly moving and rearranging. @unibas.ch @snsf.ch 👉
www.biozentrum.unibas.ch/news/detail/...
www.biozentrum.unibas.ch/news/detail/...
Shapeshifting gates guard the cell nucleus
An international study led by the University of Basel has discovered that nuclear pore complexes – tiny gateways in the nuclear membrane – are not rigid or gel-like as once thought. Their interiors ar...
www.biozentrum.unibas.ch
December 2, 2025 at 11:28 AM
🧪An international study led by Prof. Roderick Lim has discovered that nuclear pore complexes—gateways in the nuclear membrane—are not rigid or gel-like as once thought. Instead, their interiors are constantly moving and rearranging. @unibas.ch @snsf.ch 👉
www.biozentrum.unibas.ch/news/detail/...
www.biozentrum.unibas.ch/news/detail/...
Reposted by Sebastiano Pasqualato
This alternative view of “condensate” biogenesis is compatible with everything that LLPS claims for itself, including the apparent liquid-like behavior that people a bit ignorant of dynamics find so exciting. I explained this here
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
On the role of phase separation in the biogenesis of membraneless compartments | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
November 29, 2025 at 3:12 PM
This alternative view of “condensate” biogenesis is compatible with everything that LLPS claims for itself, including the apparent liquid-like behavior that people a bit ignorant of dynamics find so exciting. I explained this here
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Sebastiano Pasqualato
The things you find in your photo roll #2. For some reason, in August 2013 I took a picture of this charming letter from Max Perutz to Jim Watson, written shortly before Max died.
November 4, 2025 at 9:17 AM
The things you find in your photo roll #2. For some reason, in August 2013 I took a picture of this charming letter from Max Perutz to Jim Watson, written shortly before Max died.
Reposted by Sebastiano Pasqualato
Major modes of behavior within low-pLDDT regions were identified through a survey of human proteome predictions provided by the AlphaFold Protein Structure Database #AlphaFold2 #StructurePrediction #ConditionalFolding doi.org/10.1107/S205...
October 20, 2025 at 12:43 PM
Major modes of behavior within low-pLDDT regions were identified through a survey of human proteome predictions provided by the AlphaFold Protein Structure Database #AlphaFold2 #StructurePrediction #ConditionalFolding doi.org/10.1107/S205...
Reposted by Sebastiano Pasqualato
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
October 13, 2025 at 9:04 AM
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
Reposted by Sebastiano Pasqualato
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues
go.nature.com/3VNrH1s
go.nature.com/3VNrH1s
Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.
go.nature.com
October 6, 2025 at 10:52 AM
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues
go.nature.com/3VNrH1s
go.nature.com/3VNrH1s
Reposted by Sebastiano Pasqualato
Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
September 11, 2025 at 1:07 PM
Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
@gabrieleniola.bsky.social @ilpost.it vi segnalo questo errore in un vostro articolo. Nel film di Del Toro Waltz non è Pretorius, né uno scienziato che fa cose dopo la presunta morte del barone. Ciao e keep it up!
September 2, 2025 at 6:28 AM
@gabrieleniola.bsky.social @ilpost.it vi segnalo questo errore in un vostro articolo. Nel film di Del Toro Waltz non è Pretorius, né uno scienziato che fa cose dopo la presunta morte del barone. Ciao e keep it up!
Reposted by Sebastiano Pasqualato
Final days to get signed up for the Symposium on Structural Proteomics in Milan, 6-8 October! Registrations and abstract submissions for posters and talks still open until ❗this sunday August 31st!
@humantechnopole.bsky.social
Find out more at ssp2025.squarespace.com
@humantechnopole.bsky.social
Find out more at ssp2025.squarespace.com
August 27, 2025 at 7:38 AM
Final days to get signed up for the Symposium on Structural Proteomics in Milan, 6-8 October! Registrations and abstract submissions for posters and talks still open until ❗this sunday August 31st!
@humantechnopole.bsky.social
Find out more at ssp2025.squarespace.com
@humantechnopole.bsky.social
Find out more at ssp2025.squarespace.com
Reposted by Sebastiano Pasqualato
This ‘landmark’ study describes the structural mechanism of strand exchange by the RAD51 filament using cryogenic structural, biochemical, and single-molecule analyses.
buff.ly/Ieh84gj
buff.ly/Ieh84gj
August 26, 2025 at 10:02 AM
This ‘landmark’ study describes the structural mechanism of strand exchange by the RAD51 filament using cryogenic structural, biochemical, and single-molecule analyses.
buff.ly/Ieh84gj
buff.ly/Ieh84gj
Reposted by Sebastiano Pasqualato
Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 5, 2025 at 10:43 AM
Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sebastiano Pasqualato
🧬 We're excited to host the 13th Symposium on Structural #Proteomics at HT in Milan on 6–8 Oct 25! Join this international meeting with talks on protein structure and interactions by crosslinking MS, HDX-MS, native MS, chemoproteomics & more 👉 ssp2025.squarespace.com
▶️ @ssp2025.bsky.social
▶️ @ssp2025.bsky.social
July 24, 2025 at 12:32 PM
🧬 We're excited to host the 13th Symposium on Structural #Proteomics at HT in Milan on 6–8 Oct 25! Join this international meeting with talks on protein structure and interactions by crosslinking MS, HDX-MS, native MS, chemoproteomics & more 👉 ssp2025.squarespace.com
▶️ @ssp2025.bsky.social
▶️ @ssp2025.bsky.social
Reposted by Sebastiano Pasqualato
NEW from me at STAT:
We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out.
More @statnews.com:
www.statnews.com/2025/07/21/c...
🖥️🩺🧪🧬 #bioML
We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out.
More @statnews.com:
www.statnews.com/2025/07/21/c...
🖥️🩺🧪🧬 #bioML
AlphaFold developer Google DeepMind to fund CASP as NIH funding falls short
Protein structure prediction contest CASP gets temporary funding from Google DeepMind as NIH grant runs out.
www.statnews.com
July 21, 2025 at 4:40 PM
NEW from me at STAT:
We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out.
More @statnews.com:
www.statnews.com/2025/07/21/c...
🖥️🩺🧪🧬 #bioML
We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out.
More @statnews.com:
www.statnews.com/2025/07/21/c...
🖥️🩺🧪🧬 #bioML
Reposted by Sebastiano Pasqualato
Online Now: Condensin II activation by M18BP1 Online now:
Condensin II activation by M18BP1
Borsellini, Conti, Cutts, Harris, et al. identify an interaction between M18BP1 and condensin II that is essential for condensin II activity and chromatin localization. MCPH1 keeps the interphase genome uncondensed by competing with M18BP1. A phosphorylation-driven switch allows M18BP1 to trigger condensation at mitotic onset.
dlvr.it
July 3, 2025 at 10:57 PM
Online Now: Condensin II activation by M18BP1 Online now:
Reposted by Sebastiano Pasqualato
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
April 11, 2025 at 8:35 AM
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
Reposted by Sebastiano Pasqualato
🔴 Registrations are open! Join us at OPEN HT, a day dedicated to #lifesciences research, on the occasion of the 10th anniversary of the MIND district.
Register by 15 April 👉 humantechnopole.it/en/trainings...
The event will be held in Italian.
Register by 15 April 👉 humantechnopole.it/en/trainings...
The event will be held in Italian.
April 8, 2025 at 7:56 AM
🔴 Registrations are open! Join us at OPEN HT, a day dedicated to #lifesciences research, on the occasion of the 10th anniversary of the MIND district.
Register by 15 April 👉 humantechnopole.it/en/trainings...
The event will be held in Italian.
Register by 15 April 👉 humantechnopole.it/en/trainings...
The event will be held in Italian.
As always, excellent talk by Alessandro Borsellini from @alessandrovannini.bsky.social Lab, at @humantechnopole.bsky.social, showcasing his work at the 6th AIC-BMM meeting in Firenze! #associazioneitalianacristallografia sezione macromolecole biologiche
February 20, 2025 at 2:53 PM
As always, excellent talk by Alessandro Borsellini from @alessandrovannini.bsky.social Lab, at @humantechnopole.bsky.social, showcasing his work at the 6th AIC-BMM meeting in Firenze! #associazioneitalianacristallografia sezione macromolecole biologiche
The new Call for Access to services provided by the National Facilities of Human Technopole is online!
Check out our *new services*!
Fully funded access to services, including consumables, as well as complete access to HT and training (for services for which it is applicable)
Check out our *new services*!
Fully funded access to services, including consumables, as well as complete access to HT and training (for services for which it is applicable)
🚀 The first 2025 Call for Access for our National Facilities is now open! Researchers can apply for cutting-edge services in the fields of omics, imaging and data analysis. Submit your proposal by 31 May!
Apply here 👉 humantechnopole.it/en/national-...
Apply here 👉 humantechnopole.it/en/national-...
National Facilities - Human Technopole
humantechnopole.it
February 18, 2025 at 9:27 AM
The new Call for Access to services provided by the National Facilities of Human Technopole is online!
Check out our *new services*!
Fully funded access to services, including consumables, as well as complete access to HT and training (for services for which it is applicable)
Check out our *new services*!
Fully funded access to services, including consumables, as well as complete access to HT and training (for services for which it is applicable)
Reposted by Sebastiano Pasqualato
Great to have @martinpacesa.bsky.social as invited speaker to our weekly Structural Biology Colloquia. Such a solid, functional and impactful workflow 🤩. Thanks a lot for coming!
January 29, 2025 at 9:34 AM
Great to have @martinpacesa.bsky.social as invited speaker to our weekly Structural Biology Colloquia. Such a solid, functional and impactful workflow 🤩. Thanks a lot for coming!
Reposted by Sebastiano Pasqualato
A real milestone for the local community, today we celebrate the beginning of service provision by @humantechnopole.bsky.social National Facility for Structural Biology. Lucky to have a smiling @luigiscietti.bsky.social (in pic with our Gaetano D'Urso) from IEO as first user to the Cryo-EM Unit.
January 13, 2025 at 1:59 PM
A real milestone for the local community, today we celebrate the beginning of service provision by @humantechnopole.bsky.social National Facility for Structural Biology. Lucky to have a smiling @luigiscietti.bsky.social (in pic with our Gaetano D'Urso) from IEO as first user to the Cryo-EM Unit.
Reposted by Sebastiano Pasqualato
Excited to see the first batch of biomass safely delivered from our National Facility for Structural Biology @humantechnopole.bsky.social to Filippo Acconcia of Università Roma Tre. A big thank you to our stellar Biomass Unit, onward to more milestones!
January 15, 2025 at 3:24 PM
Excited to see the first batch of biomass safely delivered from our National Facility for Structural Biology @humantechnopole.bsky.social to Filippo Acconcia of Università Roma Tre. A big thank you to our stellar Biomass Unit, onward to more milestones!