Rui Ponte Costa
@somnirons.bsky.social
Computational neuroscientist bringing machine and neural learning closer together [Oxford NeuroAI] @ox.ac.uk @oxforddpag.bsky.social 🇵🇹🇪🇺🇬🇧🌳
neuralml.github.io
www.medsci.ox.ac.uk/neuroai
neuralml.github.io
www.medsci.ox.ac.uk/neuroai
Pinned
Hippocampus supports multi-task reinforcement learning under partial observability - Nature Communications
Neural mechanisms underlying reinforcement learning in naturalistic environments are not fully understood. Here authors show that reinforcement learning (RL) agents with hippocampal-like recurrence, u...
www.nature.com
How does the brain find its way in realistic environments? 🧠 Using deep RL and neural data, we show that hippocampal-like networks support navigation, learning, and generalisation in partially observable environments—mirroring real animal behaviour. Now out:
www.nature.com/articles/s41...
#neuroAI
www.nature.com/articles/s41...
#neuroAI
Reposted by Rui Ponte Costa
Just published my review of neuroscience in 2025, on The Spike.
The 10th of these, would you believe?
This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more
Enjoy!
medium.com/the-spike/20...
The 10th of these, would you believe?
This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more
Enjoy!
medium.com/the-spike/20...
2025: A Review of the Year in Neuroscience
Enlightening the brain
medium.com
December 30, 2025 at 3:52 PM
Just published my review of neuroscience in 2025, on The Spike.
The 10th of these, would you believe?
This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more
Enjoy!
medium.com/the-spike/20...
The 10th of these, would you believe?
This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more
Enjoy!
medium.com/the-spike/20...
Reposted by Rui Ponte Costa
Curious to hear from anyone who attended this workshop nenckiopenlab.org/why/
It explored questions like:
What motivates – and demotivates us – in our research?
How our overt motivations – ones that we speak about in public, in grant writing or science communication – relate to the real ones?
It explored questions like:
What motivates – and demotivates us – in our research?
How our overt motivations – ones that we speak about in public, in grant writing or science communication – relate to the real ones?
December 28, 2025 at 1:20 AM
Curious to hear from anyone who attended this workshop nenckiopenlab.org/why/
It explored questions like:
What motivates – and demotivates us – in our research?
How our overt motivations – ones that we speak about in public, in grant writing or science communication – relate to the real ones?
It explored questions like:
What motivates – and demotivates us – in our research?
How our overt motivations – ones that we speak about in public, in grant writing or science communication – relate to the real ones?
Reposted by Rui Ponte Costa
High impact, small size.
We welcome papers that address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer.
Find out more: buff.ly/mVtikMw
We welcome papers that address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer.
Find out more: buff.ly/mVtikMw
December 26, 2025 at 2:59 PM
High impact, small size.
We welcome papers that address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer.
Find out more: buff.ly/mVtikMw
We welcome papers that address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer.
Find out more: buff.ly/mVtikMw
Reposted by Rui Ponte Costa
1/X Excited to present this preprint on multi-tasking, with
@david-g-clark.bsky.social and Ashok Litwin-Kumar! Timely too, as “low-D manifold” has been trending again. (If you read thru the end, we escape Flatland and return to the glorious high-D world we deserve.) www.biorxiv.org/content/10.6...
@david-g-clark.bsky.social and Ashok Litwin-Kumar! Timely too, as “low-D manifold” has been trending again. (If you read thru the end, we escape Flatland and return to the glorious high-D world we deserve.) www.biorxiv.org/content/10.6...
A theory of multi-task computation and task selection
Neural activity during the performance of a stereotyped behavioral task is often described as low-dimensional, occupying only a limited region in the space of all firing-rate patterns. This region has...
www.biorxiv.org
December 15, 2025 at 7:41 PM
1/X Excited to present this preprint on multi-tasking, with
@david-g-clark.bsky.social and Ashok Litwin-Kumar! Timely too, as “low-D manifold” has been trending again. (If you read thru the end, we escape Flatland and return to the glorious high-D world we deserve.) www.biorxiv.org/content/10.6...
@david-g-clark.bsky.social and Ashok Litwin-Kumar! Timely too, as “low-D manifold” has been trending again. (If you read thru the end, we escape Flatland and return to the glorious high-D world we deserve.) www.biorxiv.org/content/10.6...
Reposted by Rui Ponte Costa
🔬 We're hiring a Junior Group Leader for Data-Driven Digital Twins/System Models in medicine/life sciences at @uni_goettingen! Perfect opportunity for early-career researchers who want to:
- Lead their own research group
- Work at the intersection of AI, simulation, and biomedicine
- Lead their own research group
- Work at the intersection of AI, simulation, and biomedicine
December 19, 2025 at 8:02 AM
🔬 We're hiring a Junior Group Leader for Data-Driven Digital Twins/System Models in medicine/life sciences at @uni_goettingen! Perfect opportunity for early-career researchers who want to:
- Lead their own research group
- Work at the intersection of AI, simulation, and biomedicine
- Lead their own research group
- Work at the intersection of AI, simulation, and biomedicine
Reposted by Rui Ponte Costa
Bichan Wu (@bichanw.bsky.social) & I wrote a tutorial paper on Reduced Rank Regression (RRR) — the statistical method underlying "communication subspaces" from Semedo et al 2019 — aimed at neuroscientists.
arxiv.org/abs/2512.12467
arxiv.org/abs/2512.12467
Reduced rank regression for neural communication: a tutorial for neuroscientists
Reduced rank regression (RRR) is a statistical method for finding a low-dimensional linear mapping between a set of high-dimensional inputs and outputs. In recent years, RRR has found numerous applica...
arxiv.org
December 17, 2025 at 2:06 AM
Bichan Wu (@bichanw.bsky.social) & I wrote a tutorial paper on Reduced Rank Regression (RRR) — the statistical method underlying "communication subspaces" from Semedo et al 2019 — aimed at neuroscientists.
arxiv.org/abs/2512.12467
arxiv.org/abs/2512.12467
Reposted by Rui Ponte Costa
Spread the word: I'm looking to hire a postdoc to explore the concept of attention (as studied in psych/neuro, not the transformer mechanism) in large Vision-Language Models. More details here: lindsay-lab.github.io/2025/12/08/p...
#MLSky #neurojobs #compneuro
#MLSky #neurojobs #compneuro
Lindsay Lab - Postdoc Position
Artificial neural networks applied to psychology, neuroscience, and climate change
lindsay-lab.github.io
December 8, 2025 at 11:53 PM
Spread the word: I'm looking to hire a postdoc to explore the concept of attention (as studied in psych/neuro, not the transformer mechanism) in large Vision-Language Models. More details here: lindsay-lab.github.io/2025/12/08/p...
#MLSky #neurojobs #compneuro
#MLSky #neurojobs #compneuro
Reposted by Rui Ponte Costa
Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability | Science www.science.org/doi/10.1126/...
Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability
Flexibility and stability of neuronal ensembles are crucial features of brain function. Little is known about how these properties of local circuits are influenced by long-range inputs. We show, in mi...
www.science.org
December 12, 2025 at 7:46 AM
Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability | Science www.science.org/doi/10.1126/...
Reposted by Rui Ponte Costa
It's happening! Canada launched two programs to recruit international researchers.
Canada Impact+ Research Chairs (1 million/yr for 8 yrs +)
Canada Impact+ Emerging Leaders.
I will do my best to facilitate the process for those interested. Hit me up.
www.canada.ca/en/impact-pl...
Canada Impact+ Research Chairs (1 million/yr for 8 yrs +)
Canada Impact+ Emerging Leaders.
I will do my best to facilitate the process for those interested. Hit me up.
www.canada.ca/en/impact-pl...
The Government of Canada introduces new programs for international researchers - Canada.ca
www.canada.ca
December 9, 2025 at 6:06 PM
It's happening! Canada launched two programs to recruit international researchers.
Canada Impact+ Research Chairs (1 million/yr for 8 yrs +)
Canada Impact+ Emerging Leaders.
I will do my best to facilitate the process for those interested. Hit me up.
www.canada.ca/en/impact-pl...
Canada Impact+ Research Chairs (1 million/yr for 8 yrs +)
Canada Impact+ Emerging Leaders.
I will do my best to facilitate the process for those interested. Hit me up.
www.canada.ca/en/impact-pl...
Reposted by Rui Ponte Costa
Impact of demographic change in one image.
December 9, 2025 at 7:58 PM
Impact of demographic change in one image.
Reposted by Rui Ponte Costa
📣We have 2 open faculty positions for senior researchers in Neuroscience at Queen's University!
healthsci.queensu.ca/administrati...
1. a new Director for our Centre for Neuroscience Studies
2. a non-human primate NeuroAI researcher
Please share widely and reach out for questions!
healthsci.queensu.ca/administrati...
1. a new Director for our Centre for Neuroscience Studies
2. a non-human primate NeuroAI researcher
Please share widely and reach out for questions!
Administrative Opportunities
healthsci.queensu.ca
December 9, 2025 at 6:55 PM
📣We have 2 open faculty positions for senior researchers in Neuroscience at Queen's University!
healthsci.queensu.ca/administrati...
1. a new Director for our Centre for Neuroscience Studies
2. a non-human primate NeuroAI researcher
Please share widely and reach out for questions!
healthsci.queensu.ca/administrati...
1. a new Director for our Centre for Neuroscience Studies
2. a non-human primate NeuroAI researcher
Please share widely and reach out for questions!
@natneuro.nature.com wrote a very nice research highlighted of our paper
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Recurrence has it covered - Nature Neuroscience
Nature Neuroscience - Recurrence has it covered
www.nature.com
December 8, 2025 at 10:23 AM
@natneuro.nature.com wrote a very nice research highlighted of our paper
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Rui Ponte Costa
We are opening a FACULTY POSITION (tenure track, permanent) in the University of Cambridge at the interface of control and biology, interpreted broadly. Theorists and wet lab quantitative biologists with backgrounds in control, EE, applied math, ... apply by Jan 28!
www.cam.ac.uk/jobs/univers...
www.cam.ac.uk/jobs/univers...
University Assistant/Associate Professor in Control Theory and Systems Biology
Applications are invited for a University Assistant/Associate Professorship in the broad area of Control Theory and Systems Biology. The successful candidate will join the Control Group
www.cam.ac.uk
December 3, 2025 at 12:19 PM
We are opening a FACULTY POSITION (tenure track, permanent) in the University of Cambridge at the interface of control and biology, interpreted broadly. Theorists and wet lab quantitative biologists with backgrounds in control, EE, applied math, ... apply by Jan 28!
www.cam.ac.uk/jobs/univers...
www.cam.ac.uk/jobs/univers...
Reposted by Rui Ponte Costa
Finally got the job ad—looking for 2 PhD students to start spring next year:
www.gao-unit.com/join-us/
If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply!
I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮
www.gao-unit.com/join-us/
If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply!
I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮
December 3, 2025 at 9:37 AM
Finally got the job ad—looking for 2 PhD students to start spring next year:
www.gao-unit.com/join-us/
If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply!
I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮
www.gao-unit.com/join-us/
If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply!
I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮
Reposted by Rui Ponte Costa
It feels surreal, but my 3+ years at @bristoluni.bsky.social are finished. It was a wonderful experience, and I had great fortune in the students who chose to work with me, the mentors and colleagues (academic and professional services) I had.
December 2, 2025 at 3:59 PM
It feels surreal, but my 3+ years at @bristoluni.bsky.social are finished. It was a wonderful experience, and I had great fortune in the students who chose to work with me, the mentors and colleagues (academic and professional services) I had.
Reposted by Rui Ponte Costa
How I contributed to rejecting one of my favorite papers of all times, Yes, I teach it to students daily, and refer to it in lots of papers. Sorry. open.substack.com/pub/kording/...
How I contributed to rejecting one of my favorite papers of all time
I believe we should talk about the mistakes we make.
open.substack.com
December 2, 2025 at 1:27 AM
How I contributed to rejecting one of my favorite papers of all times, Yes, I teach it to students daily, and refer to it in lots of papers. Sorry. open.substack.com/pub/kording/...
Reposted by Rui Ponte Costa
A remarkable journey of resilience and transformation, from the chaotic corridors of group homes to the halls of Columbia and Stanford, EMERGENCE is a coming-of-age tale where heartbreak and humor meet the scientific wonder of modern artificial intelligence.
🔗 Preorder: tinyurl.com/fzcxb5ea
🔗 Preorder: tinyurl.com/fzcxb5ea
November 17, 2025 at 6:08 PM
A remarkable journey of resilience and transformation, from the chaotic corridors of group homes to the halls of Columbia and Stanford, EMERGENCE is a coming-of-age tale where heartbreak and humor meet the scientific wonder of modern artificial intelligence.
🔗 Preorder: tinyurl.com/fzcxb5ea
🔗 Preorder: tinyurl.com/fzcxb5ea
A beautiful summary of our paper! Thank you @neurosock.bsky.social
The hippocampus is not a library, it is a simulation engine.
HPC is known for storing maps of the environment but not so known for generating planned trajectories.
This paper proposes that recurrence in CA3 is crucial for planning.
A🧵with my toy model and notes:
#neuroskyence #compneuro #NeuroAI
HPC is known for storing maps of the environment but not so known for generating planned trajectories.
This paper proposes that recurrence in CA3 is crucial for planning.
A🧵with my toy model and notes:
#neuroskyence #compneuro #NeuroAI
November 28, 2025 at 7:58 AM
A beautiful summary of our paper! Thank you @neurosock.bsky.social
Reposted by Rui Ponte Costa
Brains have many pathways / subnetworks but which principles underlie their formation?
In our #NeurIPS paper lead by Jack Cook we identify biologically relevant inductive biases that create pathways in brain-like Mixture-of-Experts models🧵
#neuroskyence #compneuro #neuroAI
arxiv.org/abs/2506.02813
In our #NeurIPS paper lead by Jack Cook we identify biologically relevant inductive biases that create pathways in brain-like Mixture-of-Experts models🧵
#neuroskyence #compneuro #neuroAI
arxiv.org/abs/2506.02813
November 21, 2025 at 12:01 PM
Brains have many pathways / subnetworks but which principles underlie their formation?
In our #NeurIPS paper lead by Jack Cook we identify biologically relevant inductive biases that create pathways in brain-like Mixture-of-Experts models🧵
#neuroskyence #compneuro #neuroAI
arxiv.org/abs/2506.02813
In our #NeurIPS paper lead by Jack Cook we identify biologically relevant inductive biases that create pathways in brain-like Mixture-of-Experts models🧵
#neuroskyence #compneuro #neuroAI
arxiv.org/abs/2506.02813
Reposted by Rui Ponte Costa
In next #BrAInWorldsJournalClub, denizkumral.bsky.social presents the work of @dabalpedamonti.bsky.social, @mohintasamia.bsky.social & @somnirons.bsky.social in Nat Commun 2025: doi.org/10.1038/s41467-025-64591-9 ✨Join @ilka-diester.bsky.social & @mschoenauer.bsky.social for an inspiring discussion💡
November 17, 2025 at 1:28 PM
In next #BrAInWorldsJournalClub, denizkumral.bsky.social presents the work of @dabalpedamonti.bsky.social, @mohintasamia.bsky.social & @somnirons.bsky.social in Nat Commun 2025: doi.org/10.1038/s41467-025-64591-9 ✨Join @ilka-diester.bsky.social & @mschoenauer.bsky.social for an inspiring discussion💡
Reposted by Rui Ponte Costa
Are you looking to do independent research related to machine learning and/or data science? Want to get some teaching experience too? Apply to be a faculty fellow at the Center for Data Science at New York University! Positions are for two years. apply.interfolio.com/174686
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 21, 2025 at 2:28 PM
Are you looking to do independent research related to machine learning and/or data science? Want to get some teaching experience too? Apply to be a faculty fellow at the Center for Data Science at New York University! Positions are for two years. apply.interfolio.com/174686
Reposted by Rui Ponte Costa
Delighted to see this finally out: rdcu.be/eO9oW
We tested whether brief striatal dopamine release events influence the vigor of skilled movements. Despite popular belief, we did not find any evidence linking rapid dopamine dynamics to motor vigor on a moment-by-moment basis.
We tested whether brief striatal dopamine release events influence the vigor of skilled movements. Despite popular belief, we did not find any evidence linking rapid dopamine dynamics to motor vigor on a moment-by-moment basis.
Subsecond dopamine fluctuations do not specify the vigor of ongoing actions
Nature Neuroscience - Liu and colleagues show that the vigor (that is, speed and amplitude) of dexterous movements is not controlled by ongoing fluctuations in extracellular dopamine within the...
rdcu.be
November 10, 2025 at 3:43 PM
Delighted to see this finally out: rdcu.be/eO9oW
We tested whether brief striatal dopamine release events influence the vigor of skilled movements. Despite popular belief, we did not find any evidence linking rapid dopamine dynamics to motor vigor on a moment-by-moment basis.
We tested whether brief striatal dopamine release events influence the vigor of skilled movements. Despite popular belief, we did not find any evidence linking rapid dopamine dynamics to motor vigor on a moment-by-moment basis.
Reposted by Rui Ponte Costa
Apply to become a CSHL-Simons Fellow in Neuroscience!
Run your own lab, pursue bold ideas, join a highly collaborative community!
All areas including experimental or computational neuro, including NeuroAI & systems
PhD required; ≤~1 yr postdoc
www.cshl.edu/about-us/car...
Run your own lab, pursue bold ideas, join a highly collaborative community!
All areas including experimental or computational neuro, including NeuroAI & systems
PhD required; ≤~1 yr postdoc
www.cshl.edu/about-us/car...
Fellows Positions | Cold Spring Harbor Laboratory
CSHL Simons Fellow in NEUROSCIENCE Cold Spring Harbor Laboratory (CSHL) is seeking to fill a Cold Spring Harbor Laboratory Fellow position in the area of NEUROSCIENCE (experimental and/or computationa...
www.cshl.edu
October 24, 2025 at 7:16 PM
Apply to become a CSHL-Simons Fellow in Neuroscience!
Run your own lab, pursue bold ideas, join a highly collaborative community!
All areas including experimental or computational neuro, including NeuroAI & systems
PhD required; ≤~1 yr postdoc
www.cshl.edu/about-us/car...
Run your own lab, pursue bold ideas, join a highly collaborative community!
All areas including experimental or computational neuro, including NeuroAI & systems
PhD required; ≤~1 yr postdoc
www.cshl.edu/about-us/car...
Reposted by Rui Ponte Costa
1/N
How do neural dynamics in motor cortex interact with those in subcortical networks to flexibly control movement? I’m beyond thrilled to share our work on this problem, led by Eric Kirk @eric-kirk.bsky.social with help from Kangjia Cai!
www.biorxiv.org/content/10.1...
How do neural dynamics in motor cortex interact with those in subcortical networks to flexibly control movement? I’m beyond thrilled to share our work on this problem, led by Eric Kirk @eric-kirk.bsky.social with help from Kangjia Cai!
www.biorxiv.org/content/10.1...
June 23, 2025 at 12:28 PM
1/N
How do neural dynamics in motor cortex interact with those in subcortical networks to flexibly control movement? I’m beyond thrilled to share our work on this problem, led by Eric Kirk @eric-kirk.bsky.social with help from Kangjia Cai!
www.biorxiv.org/content/10.1...
How do neural dynamics in motor cortex interact with those in subcortical networks to flexibly control movement? I’m beyond thrilled to share our work on this problem, led by Eric Kirk @eric-kirk.bsky.social with help from Kangjia Cai!
www.biorxiv.org/content/10.1...