Sendoel Lab
@sendoellab.bsky.social
Sendoel lab at the University of Zurich, alumnus of the The Rockefeller University, NYC.
We are excited about mRNA translation, stem cells and cancer.
www.sendoellab.org
We are excited about mRNA translation, stem cells and cancer.
www.sendoellab.org
Reposted by Sendoel Lab
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Recent discoveries on the acquisition of the highest levels of human performance
Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...
www.science.org
December 20, 2025 at 11:49 PM
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Sendoel Lab
"This promise of an AI future, is really just a collective anxiety that wealthy people have about how well they're gonna be able to control us in the future."
- @tressiemcphd.bsky.social with an absolute mic drop moment about AI bullshit.
Incredible words.
Listen to all of it!
- @tressiemcphd.bsky.social with an absolute mic drop moment about AI bullshit.
Incredible words.
Listen to all of it!
December 19, 2025 at 12:24 PM
"This promise of an AI future, is really just a collective anxiety that wealthy people have about how well they're gonna be able to control us in the future."
- @tressiemcphd.bsky.social with an absolute mic drop moment about AI bullshit.
Incredible words.
Listen to all of it!
- @tressiemcphd.bsky.social with an absolute mic drop moment about AI bullshit.
Incredible words.
Listen to all of it!
Interesting.
"We find that while TAD boundaries pair more frequently than non-boundary regions, these interactions are infrequent and are uncorrelated with transcriptional activity of genes within the TAD. (...) These results suggest that TAD boundary architecture and gene activity are largely uncoupled"
TAD boundary architecture and gene activity are uncoupled
Topologically associating domains (TADs) are prominent features of genome organization. A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD...
www.biorxiv.org
December 19, 2025 at 9:19 AM
Interesting.
Reposted by Sendoel Lab
We wrote two reviews on cell migration, published today in Nature Methods.
They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data
Review 1: nature.com/articles/s41...
Review 2: nature.com/articles/s41...
They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data
Review 1: nature.com/articles/s41...
Review 2: nature.com/articles/s41...
December 18, 2025 at 1:03 PM
We wrote two reviews on cell migration, published today in Nature Methods.
They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data
Review 1: nature.com/articles/s41...
Review 2: nature.com/articles/s41...
They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data
Review 1: nature.com/articles/s41...
Review 2: nature.com/articles/s41...
Validate using RT-qPCR.
December 16, 2025 at 3:34 PM
Validate using RT-qPCR.
Thank you @erc.europa.eu and the panel for supporting our project RIBOSCOPE! Above all, thank you to all past & present lab members whose dedication made this possible. We are excited to push single-cell technologies to map the translational landscape of cancer.
#ERCCoG
#ERCCoG
The results of the ERC Consolidator Grant call have been announced! 📣
349 researchers have been selected for funding. Congratulations to all! #ERCCogG!
👉 buff.ly/uu62uFV
#FrontierResearch #EUfunded #HorizonEurope
@scienceinnovation.ec.europa.eu
349 researchers have been selected for funding. Congratulations to all! #ERCCogG!
👉 buff.ly/uu62uFV
#FrontierResearch #EUfunded #HorizonEurope
@scienceinnovation.ec.europa.eu
December 10, 2025 at 9:08 AM
Thank you @erc.europa.eu and the panel for supporting our project RIBOSCOPE! Above all, thank you to all past & present lab members whose dedication made this possible. We are excited to push single-cell technologies to map the translational landscape of cancer.
#ERCCoG
#ERCCoG
The summer of defenses comes to an end! Huge congratulations to David (@dadita.bsky.social ) on a brillant PhD and thank you for everything you have done to shape our lab community from day 1 on. We’re thrilled you’re staying in Zurich and wish you all the best in your next chapter!
October 31, 2025 at 9:52 AM
The summer of defenses comes to an end! Huge congratulations to David (@dadita.bsky.social ) on a brillant PhD and thank you for everything you have done to shape our lab community from day 1 on. We’re thrilled you’re staying in Zurich and wish you all the best in your next chapter!
Our first PhD generation is flying out of the nest. Thank you Merve and Clara for shaping our lab from day one on.
Wishing you all the best in your next chapters, we’re excited to see what comes next for you!
Wishing you all the best in your next chapters, we’re excited to see what comes next for you!
September 2, 2025 at 3:55 PM
Our first PhD generation is flying out of the nest. Thank you Merve and Clara for shaping our lab from day one on.
Wishing you all the best in your next chapters, we’re excited to see what comes next for you!
Wishing you all the best in your next chapters, we’re excited to see what comes next for you!
Reposted by Sendoel Lab
🔬✨ Join us this Saturday (September 6) | 16:00-23:00 at Nacht der Forschung 2025 at the University of Bern ✨ Come and check out our booth "RNA – Master of Versatility" 👩🔬
Meet our researchers & enjoy pipetted cocktails at the reproduzierBAR!
www.nachtderforschung.unibe.ch
#ndfunibern @unibe.ch
Meet our researchers & enjoy pipetted cocktails at the reproduzierBAR!
www.nachtderforschung.unibe.ch
#ndfunibern @unibe.ch
September 1, 2025 at 9:08 AM
🔬✨ Join us this Saturday (September 6) | 16:00-23:00 at Nacht der Forschung 2025 at the University of Bern ✨ Come and check out our booth "RNA – Master of Versatility" 👩🔬
Meet our researchers & enjoy pipetted cocktails at the reproduzierBAR!
www.nachtderforschung.unibe.ch
#ndfunibern @unibe.ch
Meet our researchers & enjoy pipetted cocktails at the reproduzierBAR!
www.nachtderforschung.unibe.ch
#ndfunibern @unibe.ch
Reposted by Sendoel Lab
If you are interested in #DevBio, #organoids, #gastruloids or #CRISPR, check out the tweetorial to our new preprint on uncovering novel regulators of body plan formation in gastruloids using single cell CRISPR screens!
A big thank you to all co-authors that made this paper possible!
A big thank you to all co-authors that made this paper possible!
The establishment of the body plan during gastrulation is a hallmark of animal life, yet much of its regulation remains unclear. Here, we combine gastruloids and single-cell CRISPR screenings to uncover new regulators of the body plan.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 6, 2025 at 4:47 PM
If you are interested in #DevBio, #organoids, #gastruloids or #CRISPR, check out the tweetorial to our new preprint on uncovering novel regulators of body plan formation in gastruloids using single cell CRISPR screens!
A big thank you to all co-authors that made this paper possible!
A big thank you to all co-authors that made this paper possible!
Reposted by Sendoel Lab
The authors report that all seven tested deep learning models failed to outperform simple baselines in predicting transcriptome changes after single or double perturbations.
I will duck for cover.
I will duck for cover.
August 7, 2025 at 1:54 AM
The authors report that all seven tested deep learning models failed to outperform simple baselines in predicting transcriptome changes after single or double perturbations.
I will duck for cover.
I will duck for cover.
Reposted by Sendoel Lab
Genome-wide chromatin recording resolves dynamic cell state changes https://www.biorxiv.org/content/10.1101/2025.08.05.668773v1
August 7, 2025 at 6:32 AM
Genome-wide chromatin recording resolves dynamic cell state changes https://www.biorxiv.org/content/10.1101/2025.08.05.668773v1
The establishment of the body plan during gastrulation is a hallmark of animal life, yet much of its regulation remains unclear. Here, we combine gastruloids and single-cell CRISPR screenings to uncover new regulators of the body plan.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 6, 2025 at 4:14 PM
The establishment of the body plan during gastrulation is a hallmark of animal life, yet much of its regulation remains unclear. Here, we combine gastruloids and single-cell CRISPR screenings to uncover new regulators of the body plan.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Third defense this summer officially in the books. Huge congrats to Fabiola for a brilliant presentation and defense! #Summerofdefenses
August 4, 2025 at 3:03 PM
Third defense this summer officially in the books. Huge congrats to Fabiola for a brilliant presentation and defense! #Summerofdefenses
Reposted by Sendoel Lab
….and more #gastruloid preprint with proof of how to use their robustness and scalabiliy in high throughput screens to learn about #posttranscriptional regulation of gene expression @ Sendoel and Lutolf labs www.biorxiv.org/content/10.1...
July 23, 2025 at 3:20 PM
….and more #gastruloid preprint with proof of how to use their robustness and scalabiliy in high throughput screens to learn about #posttranscriptional regulation of gene expression @ Sendoel and Lutolf labs www.biorxiv.org/content/10.1...
Reposted by Sendoel Lab
Preprint by the @sendoellab.bsky.social in collab w/ the Lutolf & Zavolan labs w/1st author David Taborsky "Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids" @biorxivpreprint.bsky.social
buff.ly/mL3a71T
@dadita.bsky.socia
@mihaelazavolan.bsky.social
buff.ly/mL3a71T
@dadita.bsky.socia
@mihaelazavolan.bsky.social
July 25, 2025 at 7:01 AM
Preprint by the @sendoellab.bsky.social in collab w/ the Lutolf & Zavolan labs w/1st author David Taborsky "Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids" @biorxivpreprint.bsky.social
buff.ly/mL3a71T
@dadita.bsky.socia
@mihaelazavolan.bsky.social
buff.ly/mL3a71T
@dadita.bsky.socia
@mihaelazavolan.bsky.social
Reposted by Sendoel Lab
How can we identify novel regulators of germ layer differentiation and body patterning? I am happy to announce that my preprint using single-cell CRISPR screens in gastruloids to answer this question is now online! Thank you to the rest of the @sendoellab.bsky.social and all coauthors!
Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids https://www.biorxiv.org/content/10.1101/2025.07.22.666114v1
July 25, 2025 at 2:59 PM
How can we identify novel regulators of germ layer differentiation and body patterning? I am happy to announce that my preprint using single-cell CRISPR screens in gastruloids to answer this question is now online! Thank you to the rest of the @sendoellab.bsky.social and all coauthors!
Reposted by Sendoel Lab
PhDone 🥳🎓
The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A
The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A
The summer of defenses continues, huge congratulations Dr. Yigit for a superbly delivered talk and an excellent defense!
June 29, 2025 at 8:52 PM
PhDone 🥳🎓
The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A
The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A
The summer of defenses continues, huge congratulations Dr. Yigit for a superbly delivered talk and an excellent defense!
June 27, 2025 at 5:07 PM
The summer of defenses continues, huge congratulations Dr. Yigit for a superbly delivered talk and an excellent defense!
Reposted by Sendoel Lab
new out in Nature today www.nature.com/articles/s41...
Cross-tissue multicellular coordination and its rewiring in cancer - Nature
Comprehensive single-cell transcriptomic analysis of 35 human tissues reveals 12 cross-tissue coordinated cellular modules that exhibit intramodule communication and dynamic changes with ageing, and w...
www.nature.com
May 28, 2025 at 4:10 PM
new out in Nature today www.nature.com/articles/s41...
The very first PhD graduate of our lab! Great science, fantastic presentation and expertly defended. Huge congratulations on this well-earned milestone Dr. Duré!
May 28, 2025 at 2:37 PM
The very first PhD graduate of our lab! Great science, fantastic presentation and expertly defended. Huge congratulations on this well-earned milestone Dr. Duré!
Reposted by Sendoel Lab
Preprint by the Sendoel Lab ( @sendoellab.bsky.social ) with first author Merve Yigit ( @merveyigit.bsky.social "The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control"
@biorxivpreprint.bsky.social
buff.ly/hP9Iani
@anupamd.bsky.social
@biorxivpreprint.bsky.social
buff.ly/hP9Iani
@anupamd.bsky.social
May 27, 2025 at 7:01 AM
Preprint by the Sendoel Lab ( @sendoellab.bsky.social ) with first author Merve Yigit ( @merveyigit.bsky.social "The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control"
@biorxivpreprint.bsky.social
buff.ly/hP9Iani
@anupamd.bsky.social
@biorxivpreprint.bsky.social
buff.ly/hP9Iani
@anupamd.bsky.social
Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control
The noncanonical translation initiation factor eIF2A plays critical roles in diverse cellular processes, including the integrated stress response, neurodegeneration and tumorigenesis. However, the pre...
www.biorxiv.org
May 26, 2025 at 9:35 PM
Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The former GRC Stem Cells & Cancer has found its new home in beautiful Malta, fantastic meeting ahead!
🛫You won’t want to miss us in stunning Malta!🌴🏖️ Get ready to be inspired at the STEM CELLS & CANCER conference. INCREDIBLE LINE-UP of speakers!
🎙️Cedric Blanpain @cedric-blanpain.bsky.social
🎙️Peter Dirks
🎙️Catriona Jamieson… and more 🧵
📅 September 28, 2025
🔗 bit.ly/49sCfJp
@fusionconf.bsky.social
🎙️Cedric Blanpain @cedric-blanpain.bsky.social
🎙️Peter Dirks
🎙️Catriona Jamieson… and more 🧵
📅 September 28, 2025
🔗 bit.ly/49sCfJp
@fusionconf.bsky.social
✈️Join us in paradise!
The stunning Malta will be the perfect setting to stimulate great discussions on Stem Cell and Cancer Biology 🔬
World-leading experts will share their exciting science.
🗓️Fusion Conference Stem Cells & Cancer! September 28, 2025
bit.ly/49sCfJp
The stunning Malta will be the perfect setting to stimulate great discussions on Stem Cell and Cancer Biology 🔬
World-leading experts will share their exciting science.
🗓️Fusion Conference Stem Cells & Cancer! September 28, 2025
bit.ly/49sCfJp
March 27, 2025 at 9:34 PM
The former GRC Stem Cells & Cancer has found its new home in beautiful Malta, fantastic meeting ahead!
Reposted by Sendoel Lab
New Night Science Podcast episode! David Baker was awarded the 2024 Nobel Prize in Chemistry. He explains how he socially engineers his lab’s "communal brain", where all individuals function like neurons, densely interconnected to maximize idea generation.
nightscience.buzzsprout.com/1744020/epis...
nightscience.buzzsprout.com/1744020/epis...
March 25, 2025 at 7:30 AM
New Night Science Podcast episode! David Baker was awarded the 2024 Nobel Prize in Chemistry. He explains how he socially engineers his lab’s "communal brain", where all individuals function like neurons, densely interconnected to maximize idea generation.
nightscience.buzzsprout.com/1744020/epis...
nightscience.buzzsprout.com/1744020/epis...