Merve Yigit
@merveyigit.bsky.social
PhD student in Sendoel Lab | eIF2A | skin cancer | RNA biology | Translation
Pinned
Merve Yigit
@merveyigit.bsky.social
· Jun 29
The summer of defenses continues, huge congratulations Dr. Yigit for a superbly delivered talk and an excellent defense!
PhDone 🥳🎓
The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A
The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A
Check out the latest work from our lab! Amazing job @dadita.bsky.social 👏🏻👏🏻💯
How can we identify novel regulators of germ layer differentiation and body patterning? I am happy to announce that my preprint using single-cell CRISPR screens in gastruloids to answer this question is now online! Thank you to the rest of the @sendoellab.bsky.social and all coauthors!
Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids https://www.biorxiv.org/content/10.1101/2025.07.22.666114v1
July 26, 2025 at 1:09 PM
Check out the latest work from our lab! Amazing job @dadita.bsky.social 👏🏻👏🏻💯
PhDone 🥳🎓
The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A
The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A
The summer of defenses continues, huge congratulations Dr. Yigit for a superbly delivered talk and an excellent defense!
June 29, 2025 at 8:52 PM
PhDone 🥳🎓
The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A
The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A
Reposted by Merve Yigit
Preprint by the Sendoel Lab ( @sendoellab.bsky.social ) with first author Merve Yigit ( @merveyigit.bsky.social "The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control"
@biorxivpreprint.bsky.social
buff.ly/hP9Iani
@anupamd.bsky.social
@biorxivpreprint.bsky.social
buff.ly/hP9Iani
@anupamd.bsky.social
May 27, 2025 at 7:01 AM
Preprint by the Sendoel Lab ( @sendoellab.bsky.social ) with first author Merve Yigit ( @merveyigit.bsky.social "The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control"
@biorxivpreprint.bsky.social
buff.ly/hP9Iani
@anupamd.bsky.social
@biorxivpreprint.bsky.social
buff.ly/hP9Iani
@anupamd.bsky.social
I’m thrilled to share my very first first-author preprint and our lab’s latest work💫 We discovered a novel role for eIF2A in ribosome-associated quality control (RQC), challenging decades-old assumptions about its enigmatic function in translation initiation.
Check it out to learn more! ⭐️
#RNA
Check it out to learn more! ⭐️
#RNA
Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control
The noncanonical translation initiation factor eIF2A plays critical roles in diverse cellular processes, including the integrated stress response, neurodegeneration and tumorigenesis. However, the pre...
www.biorxiv.org
May 26, 2025 at 10:23 PM
I’m thrilled to share my very first first-author preprint and our lab’s latest work💫 We discovered a novel role for eIF2A in ribosome-associated quality control (RQC), challenging decades-old assumptions about its enigmatic function in translation initiation.
Check it out to learn more! ⭐️
#RNA
Check it out to learn more! ⭐️
#RNA
Oh, the weather outside is frightful
But the paper submission is so delightful
And since we've no results yet
Let it pipette, let it pipette, let it pipette
But the paper submission is so delightful
And since we've no results yet
Let it pipette, let it pipette, let it pipette
It‘s beginning to look a lot like Christmas🎄 when you suddenly need two additional pairs of helping hands 🐙 🧪
@merveyigit.bsky.social @fabiolavaldiviaf.bsky.social
@merveyigit.bsky.social @fabiolavaldiviaf.bsky.social
December 12, 2024 at 8:29 PM
Oh, the weather outside is frightful
But the paper submission is so delightful
And since we've no results yet
Let it pipette, let it pipette, let it pipette
But the paper submission is so delightful
And since we've no results yet
Let it pipette, let it pipette, let it pipette
Reposted by Merve Yigit
How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse epidermis 1/6
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 18, 2024 at 3:35 PM
How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse epidermis 1/6
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...