Sébastien Pfeffer
@sebpfeffer.bsky.social
RNA biologist / Virologist / Principal Investigator / CNRS / Strasbourg / https://ibmc.cnrs.fr/en/laboratoire/arn-en/equipes/rna-regulation-in-viral-infections/
Working on #RNA and #virus. Mostly interested in #RNAi #microRNAs #innateimmunity #arboviruses
Working on #RNA and #virus. Mostly interested in #RNAi #microRNAs #innateimmunity #arboviruses
Reposted by Sébastien Pfeffer
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by Sébastien Pfeffer
Are bats tolerant of all viruses? With a comparative -omics approach, we show that Egyptian fruit bat cells show both antiviral and pro-inflammatory immune responses to infection with Zika virus while our Jamaican fruit bat cells are not susceptible.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 28, 2025 at 4:23 PM
Are bats tolerant of all viruses? With a comparative -omics approach, we show that Egyptian fruit bat cells show both antiviral and pro-inflammatory immune responses to infection with Zika virus while our Jamaican fruit bat cells are not susceptible.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sébastien Pfeffer
Reposted by Sébastien Pfeffer
BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:
October 11, 2025 at 2:10 AM
BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:
Reposted by Sébastien Pfeffer
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
nyti.ms
October 8, 2025 at 11:29 PM
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
Reposted by Sébastien Pfeffer
Reposted by Sébastien Pfeffer
After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs | PNAS
Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza
A virus (IAV) transcription/replication process. Herein,...
www.pnas.org
October 7, 2025 at 6:26 PM
After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Sébastien Pfeffer
Macron s'inspire de Groland au premier degré en fait.
Cet extrait vient de Groland. Mais quand tu compares avec la réalité, tu ne vois presque plus de différence sur ces histoires de remaniement et de nouveau gouvernement.
October 6, 2025 at 6:09 PM
Macron s'inspire de Groland au premier degré en fait.
Reposted by Sébastien Pfeffer
Want to connect with researchers in #GeneRegulation, small RNAs, #StructuralBiology and more? Sign up for EMBO Workshop "RNA-guided genome protection" in Caux, Switzerland, 16–20 June 2026!
Deadline: 15 March
meetings.embo.org/event/26-gen...
#DNAsky #RNAsky #EMBORNAGenomeProtection #EMBOevents 🧪
Deadline: 15 March
meetings.embo.org/event/26-gen...
#DNAsky #RNAsky #EMBORNAGenomeProtection #EMBOevents 🧪
RNA-guided genome protection
The genome carries information across generations, ensuring species survival. To preserve faithful transmission of genetic information, RNA-directed mechanisms safeguard the genome integrity in diver…
meetings.embo.org
October 6, 2025 at 3:06 PM
Want to connect with researchers in #GeneRegulation, small RNAs, #StructuralBiology and more? Sign up for EMBO Workshop "RNA-guided genome protection" in Caux, Switzerland, 16–20 June 2026!
Deadline: 15 March
meetings.embo.org/event/26-gen...
#DNAsky #RNAsky #EMBORNAGenomeProtection #EMBOevents 🧪
Deadline: 15 March
meetings.embo.org/event/26-gen...
#DNAsky #RNAsky #EMBORNAGenomeProtection #EMBOevents 🧪
Today was a great day for Charline Pasquier, who successfully defended her PhD thesis in front of the jury composed of @annemarthe.bsky.social @ericci-aeruginosa.bsky.social, Stefania Millevoi and Jean-Luc Imler. Congratulations to her for a brilliant defense! 🍾
September 16, 2025 at 5:25 PM
Today was a great day for Charline Pasquier, who successfully defended her PhD thesis in front of the jury composed of @annemarthe.bsky.social @ericci-aeruginosa.bsky.social, Stefania Millevoi and Jean-Luc Imler. Congratulations to her for a brilliant defense! 🍾
Reposted by Sébastien Pfeffer
September 10, 2025 at 3:26 PM
Reposted by Sébastien Pfeffer
Genome-wide mapping of RNA-protein associations through sequencing go.nature.com/4gmf1Ii
Genome-wide mapping of RNA-protein associations through sequencing - Nature Biotechnology
A resource of human RNA-protein associations is produced using a sequencing-based method.
go.nature.com
September 10, 2025 at 3:42 PM
Genome-wide mapping of RNA-protein associations through sequencing go.nature.com/4gmf1Ii
Reposted by Sébastien Pfeffer
Phages, viruses that infect bacteria, could help fight antibiotic resistance, but phage–host interactions are not yet sufficiently understood. Researchers from #HIRI, JMU & HZI now successfully interfered with phage reproduction using ASOs.
Just out in @nature.com:
www.nature.com/articles/s41...
Just out in @nature.com:
www.nature.com/articles/s41...
www.nature.com
September 10, 2025 at 3:38 PM
Phages, viruses that infect bacteria, could help fight antibiotic resistance, but phage–host interactions are not yet sufficiently understood. Researchers from #HIRI, JMU & HZI now successfully interfered with phage reproduction using ASOs.
Just out in @nature.com:
www.nature.com/articles/s41...
Just out in @nature.com:
www.nature.com/articles/s41...
Reposted by Sébastien Pfeffer
Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...
An ancient and essential miRNA family controls cellular interaction pathways in C. elegans
A microRNA that arose at the origin of eumetazoans regulates cell adhesion and signaling in C. elegans through conserved targets.
www.science.org
September 3, 2025 at 6:16 PM
Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...
Reposted by Sébastien Pfeffer
New paper from Bin Cao, showing that placenta-specific KO of ADAR1 is embryonic lethal.
ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface
This study reveals that ADAR1, an RNA-editing enzyme, fine-tunes immune responses in the placenta by preventing the accumulation of immunogenic double-stranded RNAs (dsRNAs) from interferon-stimulate...
advanced.onlinelibrary.wiley.com
August 22, 2025 at 11:28 AM
New paper from Bin Cao, showing that placenta-specific KO of ADAR1 is embryonic lethal.
Reposted by Sébastien Pfeffer
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
August 21, 2025 at 3:20 PM
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
Reposted by Sébastien Pfeffer
I've seen this on Bluesky and had to try it myself. The image below was the response to the prompt: "Show me a diagram of the US presidents since Herbert Hoover, with their names and years in office under their photos" Bravo, OpenAI, bravo.
August 8, 2025 at 7:08 PM
I've seen this on Bluesky and had to try it myself. The image below was the response to the prompt: "Show me a diagram of the US presidents since Herbert Hoover, with their names and years in office under their photos" Bravo, OpenAI, bravo.
Reposted by Sébastien Pfeffer
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
August 6, 2025 at 3:36 PM
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
Reposted by Sébastien Pfeffer
bioRxiv bat signal going up. We have a big backlog of submissions. If any affiliates have time to do some screening, we (and all the authors) would be immensely grateful! 🙏
July 31, 2025 at 12:32 PM
bioRxiv bat signal going up. We have a big backlog of submissions. If any affiliates have time to do some screening, we (and all the authors) would be immensely grateful! 🙏
Reposted by Sébastien Pfeffer
last call!
submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!
submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!
⏰ Abstract deadline for 'The mobile genome' is 29 July!
👉 https://s.embl.org/mge25-01-bl
Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍
⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out!
#EMBOMobileGenome
👉 https://s.embl.org/mge25-01-bl
Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍
⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out!
#EMBOMobileGenome
July 29, 2025 at 8:41 AM
last call!
submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!
submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!
Reposted by Sébastien Pfeffer
Une protéine humaine héritée des bactéries révèle un pan méconnu de notre immunité.
Lire le communiqué : presse.inserm.fr/une-proteine...
Lire le communiqué : presse.inserm.fr/une-proteine...
Une protéine humaine héritée des bactéries révèle un pan méconnu de notre immunité - Salle de presse de l'Inserm
Depuis quelques années, certains scientifiques explorent les liens inattendus entre les protéines humaines impliquées dans la défense de l’organisme et certains mécanismes immunitaires bactériens. C’e...
presse.inserm.fr
July 29, 2025 at 1:01 PM
Une protéine humaine héritée des bactéries révèle un pan méconnu de notre immunité.
Lire le communiqué : presse.inserm.fr/une-proteine...
Lire le communiqué : presse.inserm.fr/une-proteine...
🚨Preprint alert! Kind of a late notice, but here is our latest work on bat Dicer and viral infection. Work led by @leagaucherand.bsky.social and Hugo Marie in the lab. @cnrsbiologie.bsky.social @unistra.fr @frm-officiel.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Dicer accumulates in cytoplasmic foci upon alphavirus infection and plays a proviral role in Myotis myotis bat cells
Bats are reservoirs for many viruses that frequently cause epidemics in humans and animals. It is thus critical to better understand their immune system and mechanisms of antiviral immunity. Despite a...
www.biorxiv.org
July 28, 2025 at 2:08 PM
🚨Preprint alert! Kind of a late notice, but here is our latest work on bat Dicer and viral infection. Work led by @leagaucherand.bsky.social and Hugo Marie in the lab. @cnrsbiologie.bsky.social @unistra.fr @frm-officiel.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sébastien Pfeffer
I am happy to share our last preprint, where we identified FASN as an endogenous dsRNA-associated factor and demonstrated that its depletion triggers endodsRNA accumulation and a stronger antiviral response to exogenous dsRNAs,#RNA, #interferon,#immunometabolism
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Fatty Acid Synthase binds endogenous dsRNAs and dampens the innate immune response to exogenous dsRNAs by limiting their accumulation.
In mammalian cells, the presence of double-stranded RNA (dsRNA) in the cytoplasm is a danger signal indicative of viral infection. Cells establish and maintain an antiviral state via the production of...
www.biorxiv.org
July 18, 2025 at 8:37 PM
I am happy to share our last preprint, where we identified FASN as an endogenous dsRNA-associated factor and demonstrated that its depletion triggers endodsRNA accumulation and a stronger antiviral response to exogenous dsRNAs,#RNA, #interferon,#immunometabolism
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Sébastien Pfeffer
Hot off the press, our latest review of RNA-lipid interactions -> The secret life of RNA and lipids: "There is no life without RNA or lipids. But could there be life with only RNA and lipids?" @tcjea.bsky.social @bcube-tud.bsky.social be-tud.bsky.social
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
The secret life of RNA and lipids
There is no life without RNA or lipids. But could there be life with only RNA and lipids? The discovery that RNA can catalyse reactions in addition to encoding information opened new directions for...
www.tandfonline.com
July 4, 2025 at 1:54 PM
Hot off the press, our latest review of RNA-lipid interactions -> The secret life of RNA and lipids: "There is no life without RNA or lipids. But could there be life with only RNA and lipids?" @tcjea.bsky.social @bcube-tud.bsky.social be-tud.bsky.social
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Reposted by Sébastien Pfeffer
Corey Allard et al asks how “solar-powered” slugs maintain stolen chloroplasts from their diet for photosynthesis and starvation resistance. @cellpress.bsky.social, @harvardmcb.bsky.social, @harvardmed.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
June 25, 2025 at 4:21 PM
Corey Allard et al asks how “solar-powered” slugs maintain stolen chloroplasts from their diet for photosynthesis and starvation resistance. @cellpress.bsky.social, @harvardmcb.bsky.social, @harvardmed.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...