Sophie de Carné (she/her)
@sdecarne.bsky.social
Cancer Biologist • Junior Professor and Group Leader at Gustave Roussy • Franco-British Young Leader 2025 🇨🇵🇬🇧
@univparissaclay.bsky.social
@gustaveroussy.fr
@crick.ac.uk alumna
@univparissaclay.bsky.social
@gustaveroussy.fr
@crick.ac.uk alumna
Reposted by Sophie de Carné (she/her)
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
October 31, 2025 at 8:45 AM
Paul Nurse describing the main job of a PI
(From ‘The Thinking Game’, 2024)
(From ‘The Thinking Game’, 2024)
Cell plasticity as a mechanism to evade KRAS inhibition in colorectal cancer.
#KRAS #CellPlasticity #CancerStemCell 🧪
#KRAS #CellPlasticity #CancerStemCell 🧪
A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer
Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...
aacrjournals.org
October 29, 2025 at 6:48 AM
Cell plasticity as a mechanism to evade KRAS inhibition in colorectal cancer.
#KRAS #CellPlasticity #CancerStemCell 🧪
#KRAS #CellPlasticity #CancerStemCell 🧪
Reposted by Sophie de Carné (she/her)
#ESMO25
Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine
Translational work showing mechanism of increased INF-alpha leading to immune priming
Phase III in development… @oncoalert.bsky.social
Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine
Translational work showing mechanism of increased INF-alpha leading to immune priming
Phase III in development… @oncoalert.bsky.social
October 19, 2025 at 1:22 PM
#ESMO25
Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine
Translational work showing mechanism of increased INF-alpha leading to immune priming
Phase III in development… @oncoalert.bsky.social
Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine
Translational work showing mechanism of increased INF-alpha leading to immune priming
Phase III in development… @oncoalert.bsky.social
Reposted by Sophie de Carné (she/her)
📰 « Quels progrès dans la lutte contre le cancer ? »
@humanite.fr publie la tribune du Pr Fabrice André qui appelle à renforcer la prévention et la recherche sur les causes environnementales et comportementales des cancers, chez les 20-40 ans.↩️
www.humanite.fr/en-debat/can...
@humanite.fr publie la tribune du Pr Fabrice André qui appelle à renforcer la prévention et la recherche sur les causes environnementales et comportementales des cancers, chez les 20-40 ans.↩️
www.humanite.fr/en-debat/can...
Quels progrès dans la lutte contre le cancer ? (2/2) - L'Humanité
Les pathologies cancéreuses sont mieux combattues. Les récentes découvertes liées à l’immunothérapie viennent s’ajouter aux thérapies ciblées et géniques. Mais des questions se...
www.humanite.fr
October 16, 2025 at 9:31 AM
📰 « Quels progrès dans la lutte contre le cancer ? »
@humanite.fr publie la tribune du Pr Fabrice André qui appelle à renforcer la prévention et la recherche sur les causes environnementales et comportementales des cancers, chez les 20-40 ans.↩️
www.humanite.fr/en-debat/can...
@humanite.fr publie la tribune du Pr Fabrice André qui appelle à renforcer la prévention et la recherche sur les causes environnementales et comportementales des cancers, chez les 20-40 ans.↩️
www.humanite.fr/en-debat/can...
Reposted by Sophie de Carné (she/her)
Yet another example of negative commercial determinants of health
Sunbeds are known to be especially harmful for young population, increasing the risk of skin cancer by 59%, according to the cancer research agency
And again yet, some governemnts prioritise (commercial) profir over (public) health
Sunbeds are known to be especially harmful for young population, increasing the risk of skin cancer by 59%, according to the cancer research agency
And again yet, some governemnts prioritise (commercial) profir over (public) health
Despite regulation, commercial sunbeds remain popular with young people and indoor tanning is experiencing a boom in popularity.
An outright ban of sunbeds is likely to be cost effective for the NHS, says this Analysis
www.bmj.com/content/391/...
An outright ban of sunbeds is likely to be cost effective for the NHS, says this Analysis
www.bmj.com/content/391/...
October 2, 2025 at 8:03 AM
Yet another example of negative commercial determinants of health
Sunbeds are known to be especially harmful for young population, increasing the risk of skin cancer by 59%, according to the cancer research agency
And again yet, some governemnts prioritise (commercial) profir over (public) health
Sunbeds are known to be especially harmful for young population, increasing the risk of skin cancer by 59%, according to the cancer research agency
And again yet, some governemnts prioritise (commercial) profir over (public) health
If you are looking for a postdoc position in a great lab with a fantastic PI, the Caswell Lab at UCL is recruiting 🙂
Our lab is hiring!
This is for a postdoctoral position @ucl.ac.uk in Respiratory Medicine.
Please check out the link for more details:
www.ucl.ac.uk/work-at-ucl/...
This is for a postdoctoral position @ucl.ac.uk in Respiratory Medicine.
Please check out the link for more details:
www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
September 25, 2025 at 4:32 PM
If you are looking for a postdoc position in a great lab with a fantastic PI, the Caswell Lab at UCL is recruiting 🙂
Reposted by Sophie de Carné (she/her)
Increases in wildfires are expected to cause a notable increase in premature deaths, according to two studies in Nature.
go.nature.com/4mynauQ
go.nature.com/4nJoxI5
#medsky ⚒️ 🧪
go.nature.com/4mynauQ
go.nature.com/4nJoxI5
#medsky ⚒️ 🧪
September 19, 2025 at 7:49 PM
Increases in wildfires are expected to cause a notable increase in premature deaths, according to two studies in Nature.
go.nature.com/4mynauQ
go.nature.com/4nJoxI5
#medsky ⚒️ 🧪
go.nature.com/4mynauQ
go.nature.com/4nJoxI5
#medsky ⚒️ 🧪
Reposted by Sophie de Carné (she/her)
📰 @gustaveroussy.fr toujours 1er centre français et 1er centre européen en #oncologie.
En savoir plus ⤵
En savoir plus ⤵
Gustave Roussy toujours 1er centre français et 1er centre européen en oncologie
L’excellence de Gustave Roussy est une nouvelle fois reconnue par le magazine américain Newsweek, qui a classé l’Institut 1er centre de lutte contre le cancer en France et en Europe, et parmi les meil...
www.gustaveroussy.fr
September 15, 2025 at 1:21 PM
📰 @gustaveroussy.fr toujours 1er centre français et 1er centre européen en #oncologie.
En savoir plus ⤵
En savoir plus ⤵
Reposted by Sophie de Carné (she/her)
📰 La chercheuse Sophie de Carné nommée Young Leader par le Conseil franco-britannique.
⬇
⬇
August 29, 2025 at 10:30 AM
📰 La chercheuse Sophie de Carné nommée Young Leader par le Conseil franco-britannique.
⬇
⬇
Congrats @inigolanda.bsky.social and Stephanie Corgnac 👏
🏆 Félicitations aux lauréats du concours de l’@inserm.fr !
Chaque année, les principaux organismes de #recherche publique français recrutent leurs nouveaux chargés de recherche titulaires. Cette année, deux chercheurs de @gustaveroussy.fr figurent parmi les lauréats du concours. ⤵
Chaque année, les principaux organismes de #recherche publique français recrutent leurs nouveaux chargés de recherche titulaires. Cette année, deux chercheurs de @gustaveroussy.fr figurent parmi les lauréats du concours. ⤵
Félicitations aux lauréats du concours de l’INSERM
Chaque année, les principaux organismes de recherche publique français recrutent leurs nouveaux chargés de recherche titulaires via un système de concours très sélectif.
www.gustaveroussy.fr
August 27, 2025 at 8:27 AM
Congrats @inigolanda.bsky.social and Stephanie Corgnac 👏
Reposted by Sophie de Carné (she/her)
I am excited to announce that my laboratory @ucl.ac.uk is now open!
We are hiring so please contact us if you are interested.
www.caswelllaboratory.com
We are hiring so please contact us if you are interested.
www.caswelllaboratory.com
Lung Cancer Prevention Laboratory
Pioneering research in lung cancer to improve diagnosis, treatment and prevention
www.caswelllaboratory.com
April 7, 2025 at 7:34 PM
I am excited to announce that my laboratory @ucl.ac.uk is now open!
We are hiring so please contact us if you are interested.
www.caswelllaboratory.com
We are hiring so please contact us if you are interested.
www.caswelllaboratory.com
Reposted by Sophie de Carné (she/her)
Join Caetano Reis e Sousa (@reisesousalab.bsky.social) as he describes how our immune systems work and his team’s research into better understanding dendritic cell receptors. www.youtube.com/watch?v=nBC9...
The Past, Present and Future of Immunology Research – with Caetano Reis e Sousa
YouTube video by Francis Crick Institute
www.youtube.com
July 16, 2025 at 4:16 PM
Join Caetano Reis e Sousa (@reisesousalab.bsky.social) as he describes how our immune systems work and his team’s research into better understanding dendritic cell receptors. www.youtube.com/watch?v=nBC9...
Writing is thinking. A reminder on why scientists write, and why we should continue writing in the era of large-language models by Nature Review Bioengineering
@natureportfolio.nature.com
www.nature.com/articles/s44...
#AI #LLM 🧪
@natureportfolio.nature.com
www.nature.com/articles/s44...
#AI #LLM 🧪
Writing is thinking - Nature Reviews Bioengineering
On the value of human-generated scientific writing in the age of large-language models.
www.nature.com
July 22, 2025 at 8:07 AM
Writing is thinking. A reminder on why scientists write, and why we should continue writing in the era of large-language models by Nature Review Bioengineering
@natureportfolio.nature.com
www.nature.com/articles/s44...
#AI #LLM 🧪
@natureportfolio.nature.com
www.nature.com/articles/s44...
#AI #LLM 🧪
Reposted by Sophie de Carné (she/her)
How exercise during pregnancy can improve metabolic health of offspring: a key mediator (Serpina3c) from mother's white adipose tissue gets into fetal circulation, suppresses inflammation, as demonstrated in the mouse model
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
January 31, 2025 at 2:29 PM
How exercise during pregnancy can improve metabolic health of offspring: a key mediator (Serpina3c) from mother's white adipose tissue gets into fetal circulation, suppresses inflammation, as demonstrated in the mouse model
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Sophie de Carné (she/her)
Thrilled to announce I'm moving to Manchester to lead the Cancer Origins group! If you're interested in how mutations and exposures drive tumourigenesis — come join the adventure
We are recruiting two exciting #Postdoctoral roles:
🧪 Work with @clausjorgensen.bsky.social on targeting the tumour #microenvironment in #PancreaticCancer
🥼 Join @drwilliamhill.bsky.social to study air pollution & #LungCancer
Full details of both positions at:
www.cruk.manchester.ac.uk/careers/
🧪 Work with @clausjorgensen.bsky.social on targeting the tumour #microenvironment in #PancreaticCancer
🥼 Join @drwilliamhill.bsky.social to study air pollution & #LungCancer
Full details of both positions at:
www.cruk.manchester.ac.uk/careers/
June 6, 2025 at 3:32 PM
Thrilled to announce I'm moving to Manchester to lead the Cancer Origins group! If you're interested in how mutations and exposures drive tumourigenesis — come join the adventure
Reposted by Sophie de Carné (she/her)
Very important and timely statement from @miriammerad.bsky.social, president of IUIS.
A statement from our President, Miriam Merad, to the #IUIScommunity. We invite you to read, reflect, and share this within the #GlobalImmunology network.
👉 https://loom.ly/iZseYbQ
@miriammerad.bsky.social
#VaccinesWork #ImmunologyWithoutBorders
👉 https://loom.ly/iZseYbQ
@miriammerad.bsky.social
#VaccinesWork #ImmunologyWithoutBorders
July 3, 2025 at 9:08 AM
Very important and timely statement from @miriammerad.bsky.social, president of IUIS.
Reposted by Sophie de Carné (she/her)
This has been the most productive 🇬🇧🇫🇷 Summit since Lancaster House 2010. With next week’s 🇬🇧🇩🇪Summit and Defence Treaty, it marks the final laying of the Brexit ghost, at least in terms of bilateral links with EU countries. The combination of Putin and Trump has made this essential. A 🧵
July 11, 2025 at 12:06 PM
This has been the most productive 🇬🇧🇫🇷 Summit since Lancaster House 2010. With next week’s 🇬🇧🇩🇪Summit and Defence Treaty, it marks the final laying of the Brexit ghost, at least in terms of bilateral links with EU countries. The combination of Putin and Trump has made this essential. A 🧵
Reposted by Sophie de Carné (she/her)
🚨New Article Alert from Nature Cancer !
'Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer'
✏️ By Michael Karin and colleagues
🔗 www.nature.com/articles/s43...
'Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer'
✏️ By Michael Karin and colleagues
🔗 www.nature.com/articles/s43...
Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer - Nature Cancer
Using pancreatic organoids and genetic mouse models, Antonucci et al. show that cellular stress activates an NRF2–EZH2 epigenetic axis leading to metabolic reprogramming and subsequent malignant trans...
www.nature.com
July 4, 2025 at 10:41 AM
🚨New Article Alert from Nature Cancer !
'Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer'
✏️ By Michael Karin and colleagues
🔗 www.nature.com/articles/s43...
'Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer'
✏️ By Michael Karin and colleagues
🔗 www.nature.com/articles/s43...
Reposted by Sophie de Carné (she/her)
Clinicogenomic landscape of #PDAC identifies KRAS mutant dosage as prognostic of overall survival
@NatureMedicine
doi.org/10.1038/s415...
👉Very comprehensive analysis on the impact of KRAS
👉Key for understanding de novo and acquired resistance to RAS 💊
@myESMO
@NatureMedicine
doi.org/10.1038/s415...
👉Very comprehensive analysis on the impact of KRAS
👉Key for understanding de novo and acquired resistance to RAS 💊
@myESMO
February 20, 2025 at 2:02 PM
Clinicogenomic landscape of #PDAC identifies KRAS mutant dosage as prognostic of overall survival
@NatureMedicine
doi.org/10.1038/s415...
👉Very comprehensive analysis on the impact of KRAS
👉Key for understanding de novo and acquired resistance to RAS 💊
@myESMO
@NatureMedicine
doi.org/10.1038/s415...
👉Very comprehensive analysis on the impact of KRAS
👉Key for understanding de novo and acquired resistance to RAS 💊
@myESMO
So climate change is causing people to become allergic to one of the very things that contribute to it? How very fascinating 🤓
#Gaia #ClimateChange
#Gaia #ClimateChange
Not only is climate change causing ticks to expand their territory, it's also causing an explosion in alpha-gal syndrome, which makes people allergic to eating red meat or using products that come from those animals. A dozen cases in '09 to over 450,000 now. 🧪
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
‘Explosive increase’ of ticks that cause meat allergy in US due to climate crisis
Unusually aggressive lone star ticks, common in the south-east, are spreading to areas previously too cold for them
www.theguardian.com
June 30, 2025 at 9:17 PM
So climate change is causing people to become allergic to one of the very things that contribute to it? How very fascinating 🤓
#Gaia #ClimateChange
#Gaia #ClimateChange
Diversity is a driver for discovery 💡
Thank you, Pasteur et al., for promoting diversity in science 🏳️🌈🏳️⚧️💪🧪
#DiversityInScience
Thank you, Pasteur et al., for promoting diversity in science 🏳️🌈🏳️⚧️💪🧪
#DiversityInScience
🌈 United for diversity in science 🌈
Researchers from Institut Pasteur joined the 2025 Pride March alongside @institutcurie.bsky.social, Les Cordeliers Research Center, @institutcochin.bsky.social @institutimagine.bsky.social
👩🔬 Because diverse labs make better science.
#DiversityInScience
Researchers from Institut Pasteur joined the 2025 Pride March alongside @institutcurie.bsky.social, Les Cordeliers Research Center, @institutcochin.bsky.social @institutimagine.bsky.social
👩🔬 Because diverse labs make better science.
#DiversityInScience
June 30, 2025 at 8:48 PM
Diversity is a driver for discovery 💡
Thank you, Pasteur et al., for promoting diversity in science 🏳️🌈🏳️⚧️💪🧪
#DiversityInScience
Thank you, Pasteur et al., for promoting diversity in science 🏳️🌈🏳️⚧️💪🧪
#DiversityInScience
Reposted by Sophie de Carné (she/her)
Calling all early-career RAS biology scientists!
🧬 Want to showcase your research? Submit your abstract for #TargetingRAS2025 by July 15th for a chance to take part in Short Talks.
Connect, get feedback, and shine among experts! Ready to step up? 🌟 More info: https://targetingras.com/registration/
🧬 Want to showcase your research? Submit your abstract for #TargetingRAS2025 by July 15th for a chance to take part in Short Talks.
Connect, get feedback, and shine among experts! Ready to step up? 🌟 More info: https://targetingras.com/registration/
June 27, 2025 at 8:32 AM
Calling all early-career RAS biology scientists!
🧬 Want to showcase your research? Submit your abstract for #TargetingRAS2025 by July 15th for a chance to take part in Short Talks.
Connect, get feedback, and shine among experts! Ready to step up? 🌟 More info: https://targetingras.com/registration/
🧬 Want to showcase your research? Submit your abstract for #TargetingRAS2025 by July 15th for a chance to take part in Short Talks.
Connect, get feedback, and shine among experts! Ready to step up? 🌟 More info: https://targetingras.com/registration/
Reposted by Sophie de Carné (she/her)
Members of the MILI Trial team are attending the 2025 CRUK Cancer Prevention Research Conference this week.
@cancerresearchuk.org @oxfordcancer.bsky.social
#CRUK #LFS
@cancerresearchuk.org @oxfordcancer.bsky.social
#CRUK #LFS
June 25, 2025 at 9:36 AM
Members of the MILI Trial team are attending the 2025 CRUK Cancer Prevention Research Conference this week.
@cancerresearchuk.org @oxfordcancer.bsky.social
#CRUK #LFS
@cancerresearchuk.org @oxfordcancer.bsky.social
#CRUK #LFS
Thrilled to announce that I’m joining the 2025 Franco-British Young Leaders Programme!
Looking forward to building bridges between science, society, and institutions across my two countries 🇫🇷🇬🇧
2025 Young Leaders announced francobritish.org/en/2025-youn...
Looking forward to building bridges between science, society, and institutions across my two countries 🇫🇷🇬🇧
2025 Young Leaders announced francobritish.org/en/2025-youn...
2025 Young Leaders announced / L’annonce de la cohorte des Young Leaders 2025 – Franco-British Council
francobritish.org
June 10, 2025 at 5:17 PM
Thrilled to announce that I’m joining the 2025 Franco-British Young Leaders Programme!
Looking forward to building bridges between science, society, and institutions across my two countries 🇫🇷🇬🇧
2025 Young Leaders announced francobritish.org/en/2025-youn...
Looking forward to building bridges between science, society, and institutions across my two countries 🇫🇷🇬🇧
2025 Young Leaders announced francobritish.org/en/2025-youn...
Reposted by Sophie de Carné (she/her)
We are recruiting! We're searching for a postdoctoral research fellow to study patient-specific regulators of plasticity in primary and metastatic CRC. Please reach out if you have any questions! www.ucl.ac.uk/work-at-ucl/...
May 23, 2025 at 3:32 PM
We are recruiting! We're searching for a postdoctoral research fellow to study patient-specific regulators of plasticity in primary and metastatic CRC. Please reach out if you have any questions! www.ucl.ac.uk/work-at-ucl/...