Dr Mathew Wilson
@mathewgwilson.bsky.social
Clinical Research Fellow at The Royal Marsden Hospital, London. Medical Oncology. Work focus on #Melanoma and Lung Cancer. Native Scotsman 🏴, adopted New Zealander 🇳🇿. #medsky #oncsky #oncology #lcsm
Pinned
I think today is going to be a good day.
Happy New Year!
I think this year is going to be a good year
I think this year is going to be a good year
January 1, 2026 at 12:58 AM
Happy New Year!
I think this year is going to be a good year
I think this year is going to be a good year
Got a sandwich today from Britains iconic bakery chain:
Greggs lady “did you ken there’s a Greggs Diet now?”
Me “oh aye? Does it work?”
Greggs lady “I’d have tae say No. Not if you’re wanting tae lose weight”
#greggs #bakery #Diet #weightloss #healthyeating #newyear #resolution #scotland
Greggs lady “did you ken there’s a Greggs Diet now?”
Me “oh aye? Does it work?”
Greggs lady “I’d have tae say No. Not if you’re wanting tae lose weight”
#greggs #bakery #Diet #weightloss #healthyeating #newyear #resolution #scotland
December 31, 2025 at 3:56 PM
Got a sandwich today from Britains iconic bakery chain:
Greggs lady “did you ken there’s a Greggs Diet now?”
Me “oh aye? Does it work?”
Greggs lady “I’d have tae say No. Not if you’re wanting tae lose weight”
#greggs #bakery #Diet #weightloss #healthyeating #newyear #resolution #scotland
Greggs lady “did you ken there’s a Greggs Diet now?”
Me “oh aye? Does it work?”
Greggs lady “I’d have tae say No. Not if you’re wanting tae lose weight”
#greggs #bakery #Diet #weightloss #healthyeating #newyear #resolution #scotland
‘Specialist of your choice’ is an odd criteria for hospital healthcare. People often don’t know which exactly which spcialist they need. A well run public system can triage anyone to the right place equitably
Do you expect to pick your own pilot when you fly? (To be fair, @mcuban.bsky.social might)
Do you expect to pick your own pilot when you fly? (To be fair, @mcuban.bsky.social might)
The UK is very different from Medicare. In Medicare you can mostly go to a specialist of your choice. Not in the UK
This is how most UHC works. Will Americans be ok with this change to Medicare ?
Referrals for specialist care - NHS share.google/X84C9oCy1rE1...
This is how most UHC works. Will Americans be ok with this change to Medicare ?
Referrals for specialist care - NHS share.google/X84C9oCy1rE1...
December 29, 2025 at 1:55 AM
‘Specialist of your choice’ is an odd criteria for hospital healthcare. People often don’t know which exactly which spcialist they need. A well run public system can triage anyone to the right place equitably
Do you expect to pick your own pilot when you fly? (To be fair, @mcuban.bsky.social might)
Do you expect to pick your own pilot when you fly? (To be fair, @mcuban.bsky.social might)
Are you rich & don’t like paying taxes? Buy land!!
Keir Starmer has decided to only charge inheritance tax to agricultural landowners on estates over £2.5million
However if your only asset is a family home, you start paying inheritance tax at £325,000
What’s the point of this labour government?
Keir Starmer has decided to only charge inheritance tax to agricultural landowners on estates over £2.5million
However if your only asset is a family home, you start paying inheritance tax at £325,000
What’s the point of this labour government?
Government waters down farm inheritance tax plan
The government has now said it will lift the intended threshold from £1m to £2.5m.
www.bbc.com
December 23, 2025 at 7:45 PM
Are you rich & don’t like paying taxes? Buy land!!
Keir Starmer has decided to only charge inheritance tax to agricultural landowners on estates over £2.5million
However if your only asset is a family home, you start paying inheritance tax at £325,000
What’s the point of this labour government?
Keir Starmer has decided to only charge inheritance tax to agricultural landowners on estates over £2.5million
However if your only asset is a family home, you start paying inheritance tax at £325,000
What’s the point of this labour government?
It comes to my attention that Americans don’t use the word ‘tortoise’ & call #tortoises (ie the slow moving guys who sleep all winter) #turtles (ie the ocean dwelling dudes) and sometimes call them ‘land turtles’ 🐢
All tortoises are turtles. But not all turtles are tortoises. Tortoises are real
All tortoises are turtles. But not all turtles are tortoises. Tortoises are real
December 15, 2025 at 12:19 AM
It comes to my attention that Americans don’t use the word ‘tortoise’ & call #tortoises (ie the slow moving guys who sleep all winter) #turtles (ie the ocean dwelling dudes) and sometimes call them ‘land turtles’ 🐢
All tortoises are turtles. But not all turtles are tortoises. Tortoises are real
All tortoises are turtles. But not all turtles are tortoises. Tortoises are real
Remember to get your winter vaccine folks - it’s literally a potion that gives you more hit points.
I am currently on ID consult service. I saw my first severe case of post influenza staphylococcal pneumonia of the season today - very sick patient admitted to the ICU.
Every patient I have seen so far admitted with influenza this week is unvaccinated.
The vaccines keep you out of hospital!
Get 💉💉💉
Every patient I have seen so far admitted with influenza this week is unvaccinated.
The vaccines keep you out of hospital!
Get 💉💉💉
December 11, 2025 at 12:06 AM
Remember to get your winter vaccine folks - it’s literally a potion that gives you more hit points.
In the long term a world with good, caring, benevolent AI will generate domesticated people and a comfortable stagnant era without innovation
A world with antagonistic AI will generate inequality and injustice and strife and response and progress to the next thing beyond AI
A world with antagonistic AI will generate inequality and injustice and strife and response and progress to the next thing beyond AI
Yes. We have to worry about AI and robotics.
Some questions:
Some questions:
December 8, 2025 at 10:30 PM
In the long term a world with good, caring, benevolent AI will generate domesticated people and a comfortable stagnant era without innovation
A world with antagonistic AI will generate inequality and injustice and strife and response and progress to the next thing beyond AI
A world with antagonistic AI will generate inequality and injustice and strife and response and progress to the next thing beyond AI
Do other men have this problem? Sometimes I wear a suit that I think looks decent, and then realise I look like a mafia boss from the 1930s
#fashionformen #strongmidsection #mob
#fashionformen #strongmidsection #mob
November 28, 2025 at 12:10 AM
Do other men have this problem? Sometimes I wear a suit that I think looks decent, and then realise I look like a mafia boss from the 1930s
#fashionformen #strongmidsection #mob
#fashionformen #strongmidsection #mob
Costco has nicely laid out produce & most folks go knowing what food they need for the week
Health insurance is a deliberately confusing marketplace, and most people can’t be reasonably expected to know what they need
Universal healthcare is the answer to this in every other wealthy country
Health insurance is a deliberately confusing marketplace, and most people can’t be reasonably expected to know what they need
Universal healthcare is the answer to this in every other wealthy country
Encouraging people to “be entrepreneurs” and negotiate their own health insurance with a multi-billion-dollar for-profit industry is like telling someone to take their Costco membership fee and go negotiate directly with food manufacturers.
November 14, 2025 at 5:58 PM
Costco has nicely laid out produce & most folks go knowing what food they need for the week
Health insurance is a deliberately confusing marketplace, and most people can’t be reasonably expected to know what they need
Universal healthcare is the answer to this in every other wealthy country
Health insurance is a deliberately confusing marketplace, and most people can’t be reasonably expected to know what they need
Universal healthcare is the answer to this in every other wealthy country
$1Trillion is enough wealth for a million people to each become a millionaire
It’s enough for 10million people to buy a small apartment and live in it
It’s enough for 20million people to get a university education
Nobody benefits from this much concentration of wealth
Malignant capitalism
It’s enough for 10million people to buy a small apartment and live in it
It’s enough for 20million people to get a university education
Nobody benefits from this much concentration of wealth
Malignant capitalism
Elon Musk's $1tn pay deal approved by Tesla shareholders
The richest man in the world will get hundreds of millions of new shares if he hits his targets.
www.bbc.com
November 7, 2025 at 1:50 PM
$1Trillion is enough wealth for a million people to each become a millionaire
It’s enough for 10million people to buy a small apartment and live in it
It’s enough for 20million people to get a university education
Nobody benefits from this much concentration of wealth
Malignant capitalism
It’s enough for 10million people to buy a small apartment and live in it
It’s enough for 20million people to get a university education
Nobody benefits from this much concentration of wealth
Malignant capitalism
Happy Monday all, it’s Day4 of #ESMO25
My hot picks for today:
✅Updated data on #SWOG1801 & #NADINA
✅#SafeStopTrial (early discontinuation of CPI in CR/PR)
✅#STAMP (adj pembro in Merkel Cell)
✅Phase1 #IMA203 for 👁️Uveal Melanoma in Presidential session
@oncoalert.bsky.social @myesmo.bsky.social
My hot picks for today:
✅Updated data on #SWOG1801 & #NADINA
✅#SafeStopTrial (early discontinuation of CPI in CR/PR)
✅#STAMP (adj pembro in Merkel Cell)
✅Phase1 #IMA203 for 👁️Uveal Melanoma in Presidential session
@oncoalert.bsky.social @myesmo.bsky.social
October 20, 2025 at 5:04 AM
Happy Monday all, it’s Day4 of #ESMO25
My hot picks for today:
✅Updated data on #SWOG1801 & #NADINA
✅#SafeStopTrial (early discontinuation of CPI in CR/PR)
✅#STAMP (adj pembro in Merkel Cell)
✅Phase1 #IMA203 for 👁️Uveal Melanoma in Presidential session
@oncoalert.bsky.social @myesmo.bsky.social
My hot picks for today:
✅Updated data on #SWOG1801 & #NADINA
✅#SafeStopTrial (early discontinuation of CPI in CR/PR)
✅#STAMP (adj pembro in Merkel Cell)
✅Phase1 #IMA203 for 👁️Uveal Melanoma in Presidential session
@oncoalert.bsky.social @myesmo.bsky.social
#HARMONi-6 & #OptiTROP-Lung04 both large phase-3 RCT in a china🇨🇳 only population. Both given Presidentials #ESMO25
Discussants commented re confirmatory trials in worldwide setting
Is this necessary in 2025? Why don’t we consistently raise this question to EU/US trials?🇪🇺🇺🇸
#oncology #LCSM #oncsky
Discussants commented re confirmatory trials in worldwide setting
Is this necessary in 2025? Why don’t we consistently raise this question to EU/US trials?🇪🇺🇺🇸
#oncology #LCSM #oncsky
October 19, 2025 at 4:59 PM
#HARMONi-6 & #OptiTROP-Lung04 both large phase-3 RCT in a china🇨🇳 only population. Both given Presidentials #ESMO25
Discussants commented re confirmatory trials in worldwide setting
Is this necessary in 2025? Why don’t we consistently raise this question to EU/US trials?🇪🇺🇺🇸
#oncology #LCSM #oncsky
Discussants commented re confirmatory trials in worldwide setting
Is this necessary in 2025? Why don’t we consistently raise this question to EU/US trials?🇪🇺🇺🇸
#oncology #LCSM #oncsky
#OptiTROP-Lung04
🫁Sac-TMT (Trop2 ADC) vs Pt doublet in EGFR mutant #NSCLC 2nd line after targeted therapy
mPFS 8.3 vs 4.3months
mOS Not Reached vs 17.4months
No ILD/pneumonitis. G3 Tox similar in both arms
Exciting option, in a challenging setting
#ESMO25 @oncoalert.bsky.social #LCSM
🫁Sac-TMT (Trop2 ADC) vs Pt doublet in EGFR mutant #NSCLC 2nd line after targeted therapy
mPFS 8.3 vs 4.3months
mOS Not Reached vs 17.4months
No ILD/pneumonitis. G3 Tox similar in both arms
Exciting option, in a challenging setting
#ESMO25 @oncoalert.bsky.social #LCSM
October 19, 2025 at 3:05 PM
#OptiTROP-Lung04
🫁Sac-TMT (Trop2 ADC) vs Pt doublet in EGFR mutant #NSCLC 2nd line after targeted therapy
mPFS 8.3 vs 4.3months
mOS Not Reached vs 17.4months
No ILD/pneumonitis. G3 Tox similar in both arms
Exciting option, in a challenging setting
#ESMO25 @oncoalert.bsky.social #LCSM
🫁Sac-TMT (Trop2 ADC) vs Pt doublet in EGFR mutant #NSCLC 2nd line after targeted therapy
mPFS 8.3 vs 4.3months
mOS Not Reached vs 17.4months
No ILD/pneumonitis. G3 Tox similar in both arms
Exciting option, in a challenging setting
#ESMO25 @oncoalert.bsky.social #LCSM
#HARMOMi-6
🫁Compared Ivonescimab (PD-1 + VEGF bispecific) vs Tizlelizumab (PD1) in combo ŵ Chemo in 1st line setting for squamous #NSCLC
mPFS = 11.1 vs 6.9 months
Benefit preserved across subgroups including PD-L1<1%
OSdata awaited…
No increase in tox
This data is exciting #ESMO25 @OncoAlert
🫁Compared Ivonescimab (PD-1 + VEGF bispecific) vs Tizlelizumab (PD1) in combo ŵ Chemo in 1st line setting for squamous #NSCLC
mPFS = 11.1 vs 6.9 months
Benefit preserved across subgroups including PD-L1<1%
OSdata awaited…
No increase in tox
This data is exciting #ESMO25 @OncoAlert
October 19, 2025 at 2:43 PM
#HARMOMi-6
🫁Compared Ivonescimab (PD-1 + VEGF bispecific) vs Tizlelizumab (PD1) in combo ŵ Chemo in 1st line setting for squamous #NSCLC
mPFS = 11.1 vs 6.9 months
Benefit preserved across subgroups including PD-L1<1%
OSdata awaited…
No increase in tox
This data is exciting #ESMO25 @OncoAlert
🫁Compared Ivonescimab (PD-1 + VEGF bispecific) vs Tizlelizumab (PD1) in combo ŵ Chemo in 1st line setting for squamous #NSCLC
mPFS = 11.1 vs 6.9 months
Benefit preserved across subgroups including PD-L1<1%
OSdata awaited…
No increase in tox
This data is exciting #ESMO25 @OncoAlert
#ESMO25
Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine
Translational work showing mechanism of increased INF-alpha leading to immune priming
Phase III in development… @oncoalert.bsky.social
Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine
Translational work showing mechanism of increased INF-alpha leading to immune priming
Phase III in development… @oncoalert.bsky.social
October 19, 2025 at 1:22 PM
#ESMO25
Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine
Translational work showing mechanism of increased INF-alpha leading to immune priming
Phase III in development… @oncoalert.bsky.social
Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine
Translational work showing mechanism of increased INF-alpha leading to immune priming
Phase III in development… @oncoalert.bsky.social
Good Morning Berlin! it’s day 3 of #ESMO25
My top picks today are:
🫁 HARMONi6 - Ivonescimab vs PD1 1st line in #NSCLC
🫁OptiTROP-Lung04 - sac-TMT in EGFR
mutant NSCLC post TKI
🩻DREAM3R - Durva+CT 1st line in #Mesothelioma
🏌️ENZARAD (ANZUP 1303) - ADT + RT
#LCSM @oncoalert.bsky.social
My top picks today are:
🫁 HARMONi6 - Ivonescimab vs PD1 1st line in #NSCLC
🫁OptiTROP-Lung04 - sac-TMT in EGFR
mutant NSCLC post TKI
🩻DREAM3R - Durva+CT 1st line in #Mesothelioma
🏌️ENZARAD (ANZUP 1303) - ADT + RT
#LCSM @oncoalert.bsky.social
October 19, 2025 at 5:46 AM
Good Morning Berlin! it’s day 3 of #ESMO25
My top picks today are:
🫁 HARMONi6 - Ivonescimab vs PD1 1st line in #NSCLC
🫁OptiTROP-Lung04 - sac-TMT in EGFR
mutant NSCLC post TKI
🩻DREAM3R - Durva+CT 1st line in #Mesothelioma
🏌️ENZARAD (ANZUP 1303) - ADT + RT
#LCSM @oncoalert.bsky.social
My top picks today are:
🫁 HARMONi6 - Ivonescimab vs PD1 1st line in #NSCLC
🫁OptiTROP-Lung04 - sac-TMT in EGFR
mutant NSCLC post TKI
🩻DREAM3R - Durva+CT 1st line in #Mesothelioma
🏌️ENZARAD (ANZUP 1303) - ADT + RT
#LCSM @oncoalert.bsky.social
#RAMPART demonstrated improved disease free suvivival at three years in resectable Renal Cell Carcinoma with addition of adjuvant #Durvalumab and #Tremelimumab
3year DFS 81% vs 73% for surveillance
Nb increased tox, including myocarditis
#ESMO25 @oncoalert.bsky.social
3year DFS 81% vs 73% for surveillance
Nb increased tox, including myocarditis
#ESMO25 @oncoalert.bsky.social
October 18, 2025 at 7:31 AM
#RAMPART demonstrated improved disease free suvivival at three years in resectable Renal Cell Carcinoma with addition of adjuvant #Durvalumab and #Tremelimumab
3year DFS 81% vs 73% for surveillance
Nb increased tox, including myocarditis
#ESMO25 @oncoalert.bsky.social
3year DFS 81% vs 73% for surveillance
Nb increased tox, including myocarditis
#ESMO25 @oncoalert.bsky.social
ts Day 2 #ESMO25!
Today I am looking forward to:
🫁#DeLLphi-303 1st line Tatlatamab in SCLC
🫘#RAMPART from James Larkin on adjuvant IO in RCC
👁️#PLUME Len/Pem in uveal melanoma
⭐️Special Session on PeriOperative strategies from Sapna Patel & others
@myesmo.bsky.social @oncoalert.bsky.social #LCSM
Today I am looking forward to:
🫁#DeLLphi-303 1st line Tatlatamab in SCLC
🫘#RAMPART from James Larkin on adjuvant IO in RCC
👁️#PLUME Len/Pem in uveal melanoma
⭐️Special Session on PeriOperative strategies from Sapna Patel & others
@myesmo.bsky.social @oncoalert.bsky.social #LCSM
October 18, 2025 at 4:46 AM
ts Day 2 #ESMO25!
Today I am looking forward to:
🫁#DeLLphi-303 1st line Tatlatamab in SCLC
🫘#RAMPART from James Larkin on adjuvant IO in RCC
👁️#PLUME Len/Pem in uveal melanoma
⭐️Special Session on PeriOperative strategies from Sapna Patel & others
@myesmo.bsky.social @oncoalert.bsky.social #LCSM
Today I am looking forward to:
🫁#DeLLphi-303 1st line Tatlatamab in SCLC
🫘#RAMPART from James Larkin on adjuvant IO in RCC
👁️#PLUME Len/Pem in uveal melanoma
⭐️Special Session on PeriOperative strategies from Sapna Patel & others
@myesmo.bsky.social @oncoalert.bsky.social #LCSM
#ALEX study shows 81.1 month median OS in final report of study from Tong Mok
Amongst the longest overall survivals reported in lung cancer. Further trials of 3rd and 4th gen TKI ongoing. Much work to do, but valuable to reflect on how far things have com
#ESMO25 #LCSM #Alk #NSCLC
Amongst the longest overall survivals reported in lung cancer. Further trials of 3rd and 4th gen TKI ongoing. Much work to do, but valuable to reflect on how far things have com
#ESMO25 #LCSM #Alk #NSCLC
October 17, 2025 at 3:29 PM
Phase 2 #NORTHSTAR presented by @YYElamin: improved PFS ŵ addition of local consolidative therapy (Sx or RT) after initiation of Osimertinib for #NSCLC. Acceptable safety profile. Benefit in Oligo & poly metastatic disease. Exciting pathway to explore further... #ESMO25 #LCSM #Oncsky #Medsky
October 17, 2025 at 2:24 PM
@ESMO day1 #ESMO25
Today looking forward to:
-Session on optimising peri-operative IO from @MartinReck2
-ReCIPE-M1 study from Jacob Orme
-session on emerging options beyond CPI chsired. Y Ines Pires de Silva
-Final ALEX data from Tony Mok and Beamion data from Sanjay Popat
@myesmo.bsky.social
Today looking forward to:
-Session on optimising peri-operative IO from @MartinReck2
-ReCIPE-M1 study from Jacob Orme
-session on emerging options beyond CPI chsired. Y Ines Pires de Silva
-Final ALEX data from Tony Mok and Beamion data from Sanjay Popat
@myesmo.bsky.social
October 17, 2025 at 11:15 AM
@ESMO day1 #ESMO25
Today looking forward to:
-Session on optimising peri-operative IO from @MartinReck2
-ReCIPE-M1 study from Jacob Orme
-session on emerging options beyond CPI chsired. Y Ines Pires de Silva
-Final ALEX data from Tony Mok and Beamion data from Sanjay Popat
@myesmo.bsky.social
Today looking forward to:
-Session on optimising peri-operative IO from @MartinReck2
-ReCIPE-M1 study from Jacob Orme
-session on emerging options beyond CPI chsired. Y Ines Pires de Silva
-Final ALEX data from Tony Mok and Beamion data from Sanjay Popat
@myesmo.bsky.social