Dr Mathew Wilson
@mathewgwilson.bsky.social
Clinical Research Fellow at The Royal Marsden Hospital, London. Medical Oncology. Work focus on #Melanoma and Lung Cancer. Native Scotsman 🏴, adopted New Zealander 🇳🇿. #medsky #oncsky #oncology #lcsm
Pinned
I think today is going to be a good day.
Costco has nicely laid out produce & most folks go knowing what food they need for the week
Health insurance is a deliberately confusing marketplace, and most people can’t be reasonably expected to know what they need
Universal healthcare is the answer to this in every other wealthy country
Health insurance is a deliberately confusing marketplace, and most people can’t be reasonably expected to know what they need
Universal healthcare is the answer to this in every other wealthy country
Encouraging people to “be entrepreneurs” and negotiate their own health insurance with a multi-billion-dollar for-profit industry is like telling someone to take their Costco membership fee and go negotiate directly with food manufacturers.
November 14, 2025 at 5:58 PM
Costco has nicely laid out produce & most folks go knowing what food they need for the week
Health insurance is a deliberately confusing marketplace, and most people can’t be reasonably expected to know what they need
Universal healthcare is the answer to this in every other wealthy country
Health insurance is a deliberately confusing marketplace, and most people can’t be reasonably expected to know what they need
Universal healthcare is the answer to this in every other wealthy country
$1Trillion is enough wealth for a million people to each become a millionaire
It’s enough for 10million people to buy a small apartment and live in it
It’s enough for 20million people to get a university education
Nobody benefits from this much concentration of wealth
Malignant capitalism
It’s enough for 10million people to buy a small apartment and live in it
It’s enough for 20million people to get a university education
Nobody benefits from this much concentration of wealth
Malignant capitalism
Elon Musk's $1tn pay deal approved by Tesla shareholders
The richest man in the world will get hundreds of millions of new shares if he hits his targets.
www.bbc.com
November 7, 2025 at 1:50 PM
$1Trillion is enough wealth for a million people to each become a millionaire
It’s enough for 10million people to buy a small apartment and live in it
It’s enough for 20million people to get a university education
Nobody benefits from this much concentration of wealth
Malignant capitalism
It’s enough for 10million people to buy a small apartment and live in it
It’s enough for 20million people to get a university education
Nobody benefits from this much concentration of wealth
Malignant capitalism
Happy Monday all, it’s Day4 of #ESMO25
My hot picks for today:
✅Updated data on #SWOG1801 & #NADINA
✅#SafeStopTrial (early discontinuation of CPI in CR/PR)
✅#STAMP (adj pembro in Merkel Cell)
✅Phase1 #IMA203 for 👁️Uveal Melanoma in Presidential session
@oncoalert.bsky.social @myesmo.bsky.social
My hot picks for today:
✅Updated data on #SWOG1801 & #NADINA
✅#SafeStopTrial (early discontinuation of CPI in CR/PR)
✅#STAMP (adj pembro in Merkel Cell)
✅Phase1 #IMA203 for 👁️Uveal Melanoma in Presidential session
@oncoalert.bsky.social @myesmo.bsky.social
October 20, 2025 at 5:04 AM
Happy Monday all, it’s Day4 of #ESMO25
My hot picks for today:
✅Updated data on #SWOG1801 & #NADINA
✅#SafeStopTrial (early discontinuation of CPI in CR/PR)
✅#STAMP (adj pembro in Merkel Cell)
✅Phase1 #IMA203 for 👁️Uveal Melanoma in Presidential session
@oncoalert.bsky.social @myesmo.bsky.social
My hot picks for today:
✅Updated data on #SWOG1801 & #NADINA
✅#SafeStopTrial (early discontinuation of CPI in CR/PR)
✅#STAMP (adj pembro in Merkel Cell)
✅Phase1 #IMA203 for 👁️Uveal Melanoma in Presidential session
@oncoalert.bsky.social @myesmo.bsky.social
#HARMONi-6 & #OptiTROP-Lung04 both large phase-3 RCT in a china🇨🇳 only population. Both given Presidentials #ESMO25
Discussants commented re confirmatory trials in worldwide setting
Is this necessary in 2025? Why don’t we consistently raise this question to EU/US trials?🇪🇺🇺🇸
#oncology #LCSM #oncsky
Discussants commented re confirmatory trials in worldwide setting
Is this necessary in 2025? Why don’t we consistently raise this question to EU/US trials?🇪🇺🇺🇸
#oncology #LCSM #oncsky
October 19, 2025 at 4:59 PM
#HARMONi-6 & #OptiTROP-Lung04 both large phase-3 RCT in a china🇨🇳 only population. Both given Presidentials #ESMO25
Discussants commented re confirmatory trials in worldwide setting
Is this necessary in 2025? Why don’t we consistently raise this question to EU/US trials?🇪🇺🇺🇸
#oncology #LCSM #oncsky
Discussants commented re confirmatory trials in worldwide setting
Is this necessary in 2025? Why don’t we consistently raise this question to EU/US trials?🇪🇺🇺🇸
#oncology #LCSM #oncsky
#OptiTROP-Lung04
🫁Sac-TMT (Trop2 ADC) vs Pt doublet in EGFR mutant #NSCLC 2nd line after targeted therapy
mPFS 8.3 vs 4.3months
mOS Not Reached vs 17.4months
No ILD/pneumonitis. G3 Tox similar in both arms
Exciting option, in a challenging setting
#ESMO25 @oncoalert.bsky.social #LCSM
🫁Sac-TMT (Trop2 ADC) vs Pt doublet in EGFR mutant #NSCLC 2nd line after targeted therapy
mPFS 8.3 vs 4.3months
mOS Not Reached vs 17.4months
No ILD/pneumonitis. G3 Tox similar in both arms
Exciting option, in a challenging setting
#ESMO25 @oncoalert.bsky.social #LCSM
October 19, 2025 at 3:05 PM
#OptiTROP-Lung04
🫁Sac-TMT (Trop2 ADC) vs Pt doublet in EGFR mutant #NSCLC 2nd line after targeted therapy
mPFS 8.3 vs 4.3months
mOS Not Reached vs 17.4months
No ILD/pneumonitis. G3 Tox similar in both arms
Exciting option, in a challenging setting
#ESMO25 @oncoalert.bsky.social #LCSM
🫁Sac-TMT (Trop2 ADC) vs Pt doublet in EGFR mutant #NSCLC 2nd line after targeted therapy
mPFS 8.3 vs 4.3months
mOS Not Reached vs 17.4months
No ILD/pneumonitis. G3 Tox similar in both arms
Exciting option, in a challenging setting
#ESMO25 @oncoalert.bsky.social #LCSM
#HARMOMi-6
🫁Compared Ivonescimab (PD-1 + VEGF bispecific) vs Tizlelizumab (PD1) in combo ŵ Chemo in 1st line setting for squamous #NSCLC
mPFS = 11.1 vs 6.9 months
Benefit preserved across subgroups including PD-L1<1%
OSdata awaited…
No increase in tox
This data is exciting #ESMO25 @OncoAlert
🫁Compared Ivonescimab (PD-1 + VEGF bispecific) vs Tizlelizumab (PD1) in combo ŵ Chemo in 1st line setting for squamous #NSCLC
mPFS = 11.1 vs 6.9 months
Benefit preserved across subgroups including PD-L1<1%
OSdata awaited…
No increase in tox
This data is exciting #ESMO25 @OncoAlert
October 19, 2025 at 2:43 PM
#HARMOMi-6
🫁Compared Ivonescimab (PD-1 + VEGF bispecific) vs Tizlelizumab (PD1) in combo ŵ Chemo in 1st line setting for squamous #NSCLC
mPFS = 11.1 vs 6.9 months
Benefit preserved across subgroups including PD-L1<1%
OSdata awaited…
No increase in tox
This data is exciting #ESMO25 @OncoAlert
🫁Compared Ivonescimab (PD-1 + VEGF bispecific) vs Tizlelizumab (PD1) in combo ŵ Chemo in 1st line setting for squamous #NSCLC
mPFS = 11.1 vs 6.9 months
Benefit preserved across subgroups including PD-L1<1%
OSdata awaited…
No increase in tox
This data is exciting #ESMO25 @OncoAlert
#ESMO25
Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine
Translational work showing mechanism of increased INF-alpha leading to immune priming
Phase III in development… @oncoalert.bsky.social
Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine
Translational work showing mechanism of increased INF-alpha leading to immune priming
Phase III in development… @oncoalert.bsky.social
October 19, 2025 at 1:22 PM
#ESMO25
Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine
Translational work showing mechanism of increased INF-alpha leading to immune priming
Phase III in development… @oncoalert.bsky.social
Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine
Translational work showing mechanism of increased INF-alpha leading to immune priming
Phase III in development… @oncoalert.bsky.social
Good Morning Berlin! it’s day 3 of #ESMO25
My top picks today are:
🫁 HARMONi6 - Ivonescimab vs PD1 1st line in #NSCLC
🫁OptiTROP-Lung04 - sac-TMT in EGFR
mutant NSCLC post TKI
🩻DREAM3R - Durva+CT 1st line in #Mesothelioma
🏌️ENZARAD (ANZUP 1303) - ADT + RT
#LCSM @oncoalert.bsky.social
My top picks today are:
🫁 HARMONi6 - Ivonescimab vs PD1 1st line in #NSCLC
🫁OptiTROP-Lung04 - sac-TMT in EGFR
mutant NSCLC post TKI
🩻DREAM3R - Durva+CT 1st line in #Mesothelioma
🏌️ENZARAD (ANZUP 1303) - ADT + RT
#LCSM @oncoalert.bsky.social
October 19, 2025 at 5:46 AM
Good Morning Berlin! it’s day 3 of #ESMO25
My top picks today are:
🫁 HARMONi6 - Ivonescimab vs PD1 1st line in #NSCLC
🫁OptiTROP-Lung04 - sac-TMT in EGFR
mutant NSCLC post TKI
🩻DREAM3R - Durva+CT 1st line in #Mesothelioma
🏌️ENZARAD (ANZUP 1303) - ADT + RT
#LCSM @oncoalert.bsky.social
My top picks today are:
🫁 HARMONi6 - Ivonescimab vs PD1 1st line in #NSCLC
🫁OptiTROP-Lung04 - sac-TMT in EGFR
mutant NSCLC post TKI
🩻DREAM3R - Durva+CT 1st line in #Mesothelioma
🏌️ENZARAD (ANZUP 1303) - ADT + RT
#LCSM @oncoalert.bsky.social
#RAMPART demonstrated improved disease free suvivival at three years in resectable Renal Cell Carcinoma with addition of adjuvant #Durvalumab and #Tremelimumab
3year DFS 81% vs 73% for surveillance
Nb increased tox, including myocarditis
#ESMO25 @oncoalert.bsky.social
3year DFS 81% vs 73% for surveillance
Nb increased tox, including myocarditis
#ESMO25 @oncoalert.bsky.social
October 18, 2025 at 7:31 AM
#RAMPART demonstrated improved disease free suvivival at three years in resectable Renal Cell Carcinoma with addition of adjuvant #Durvalumab and #Tremelimumab
3year DFS 81% vs 73% for surveillance
Nb increased tox, including myocarditis
#ESMO25 @oncoalert.bsky.social
3year DFS 81% vs 73% for surveillance
Nb increased tox, including myocarditis
#ESMO25 @oncoalert.bsky.social
ts Day 2 #ESMO25!
Today I am looking forward to:
🫁#DeLLphi-303 1st line Tatlatamab in SCLC
🫘#RAMPART from James Larkin on adjuvant IO in RCC
👁️#PLUME Len/Pem in uveal melanoma
⭐️Special Session on PeriOperative strategies from Sapna Patel & others
@myesmo.bsky.social @oncoalert.bsky.social #LCSM
Today I am looking forward to:
🫁#DeLLphi-303 1st line Tatlatamab in SCLC
🫘#RAMPART from James Larkin on adjuvant IO in RCC
👁️#PLUME Len/Pem in uveal melanoma
⭐️Special Session on PeriOperative strategies from Sapna Patel & others
@myesmo.bsky.social @oncoalert.bsky.social #LCSM
October 18, 2025 at 4:46 AM
ts Day 2 #ESMO25!
Today I am looking forward to:
🫁#DeLLphi-303 1st line Tatlatamab in SCLC
🫘#RAMPART from James Larkin on adjuvant IO in RCC
👁️#PLUME Len/Pem in uveal melanoma
⭐️Special Session on PeriOperative strategies from Sapna Patel & others
@myesmo.bsky.social @oncoalert.bsky.social #LCSM
Today I am looking forward to:
🫁#DeLLphi-303 1st line Tatlatamab in SCLC
🫘#RAMPART from James Larkin on adjuvant IO in RCC
👁️#PLUME Len/Pem in uveal melanoma
⭐️Special Session on PeriOperative strategies from Sapna Patel & others
@myesmo.bsky.social @oncoalert.bsky.social #LCSM
#ALEX study shows 81.1 month median OS in final report of study from Tong Mok
Amongst the longest overall survivals reported in lung cancer. Further trials of 3rd and 4th gen TKI ongoing. Much work to do, but valuable to reflect on how far things have com
#ESMO25 #LCSM #Alk #NSCLC
Amongst the longest overall survivals reported in lung cancer. Further trials of 3rd and 4th gen TKI ongoing. Much work to do, but valuable to reflect on how far things have com
#ESMO25 #LCSM #Alk #NSCLC
October 17, 2025 at 3:29 PM
Phase 2 #NORTHSTAR presented by @YYElamin: improved PFS ŵ addition of local consolidative therapy (Sx or RT) after initiation of Osimertinib for #NSCLC. Acceptable safety profile. Benefit in Oligo & poly metastatic disease. Exciting pathway to explore further... #ESMO25 #LCSM #Oncsky #Medsky
October 17, 2025 at 2:24 PM
@ESMO day1 #ESMO25
Today looking forward to:
-Session on optimising peri-operative IO from @MartinReck2
-ReCIPE-M1 study from Jacob Orme
-session on emerging options beyond CPI chsired. Y Ines Pires de Silva
-Final ALEX data from Tony Mok and Beamion data from Sanjay Popat
@myesmo.bsky.social
Today looking forward to:
-Session on optimising peri-operative IO from @MartinReck2
-ReCIPE-M1 study from Jacob Orme
-session on emerging options beyond CPI chsired. Y Ines Pires de Silva
-Final ALEX data from Tony Mok and Beamion data from Sanjay Popat
@myesmo.bsky.social
October 17, 2025 at 11:15 AM
@ESMO day1 #ESMO25
Today looking forward to:
-Session on optimising peri-operative IO from @MartinReck2
-ReCIPE-M1 study from Jacob Orme
-session on emerging options beyond CPI chsired. Y Ines Pires de Silva
-Final ALEX data from Tony Mok and Beamion data from Sanjay Popat
@myesmo.bsky.social
Today looking forward to:
-Session on optimising peri-operative IO from @MartinReck2
-ReCIPE-M1 study from Jacob Orme
-session on emerging options beyond CPI chsired. Y Ines Pires de Silva
-Final ALEX data from Tony Mok and Beamion data from Sanjay Popat
@myesmo.bsky.social
Reposted by Dr Mathew Wilson
For those of you wondering why newer antibodies are now called -tugs -barts -migs and -ments not -mabs, this is the official @who.int INN explainer
tinyurl.com/49bxfn4t
tinyurl.com/49bxfn4t
September 5, 2025 at 3:52 AM
For those of you wondering why newer antibodies are now called -tugs -barts -migs and -ments not -mabs, this is the official @who.int INN explainer
tinyurl.com/49bxfn4t
tinyurl.com/49bxfn4t
Highly recommend this event. I had the opportunity to go last year - excellent for learning and great networking
#LCSM #Oncsky #MedSky 🫁🫁
#LCSM #Oncsky #MedSky 🫁🫁
📣 Calling early-career clinicians!
TOGA’s 2025 Lung Cancer Preceptorship is your chance to deepen your knowledge of thoracic cancers and learn from top experts in a hands-on setting.
📅 Dates: November 28-29
📍 Location: Melbourne
Expressions of interest close 30 September 2025.
TOGA’s 2025 Lung Cancer Preceptorship is your chance to deepen your knowledge of thoracic cancers and learn from top experts in a hands-on setting.
📅 Dates: November 28-29
📍 Location: Melbourne
Expressions of interest close 30 September 2025.
September 1, 2025 at 3:00 AM
🫁Reduced smoking rates have prevented 3.8million lung cancer deaths in USA alone since 1970
Not all lung cancer is caused by smoking, but a large portion of it is. Public policy can be very effective. All countries should move towards net zero tobacco
#LCMS #medsky #Oncsky
doi.org/10.3322/caac...
Not all lung cancer is caused by smoking, but a large portion of it is. Public policy can be very effective. All countries should move towards net zero tobacco
#LCMS #medsky #Oncsky
doi.org/10.3322/caac...
Averted lung cancer deaths due to reductions in cigarette smoking in the United States, 1970–2022
Lung cancer mortality rates in the United States have declined steeply in recent decades, largely because of substantial reductions in smoking prevalence, as approximately 85% of lung cancer deaths a....
doi.org
August 14, 2025 at 10:08 AM
🫁Reduced smoking rates have prevented 3.8million lung cancer deaths in USA alone since 1970
Not all lung cancer is caused by smoking, but a large portion of it is. Public policy can be very effective. All countries should move towards net zero tobacco
#LCMS #medsky #Oncsky
doi.org/10.3322/caac...
Not all lung cancer is caused by smoking, but a large portion of it is. Public policy can be very effective. All countries should move towards net zero tobacco
#LCMS #medsky #Oncsky
doi.org/10.3322/caac...
60y/o man with bromide induced psychosis after consulting with ChatGPT on how to improve his diet 🧂🥦.
***For anyone in doubt, do not ask AI for medical advice. Even the best tools are dangerous when used for the wrong job***
#medsky #AI #ChatGPT #Bromide
www.acpjournals.org/doi/epdf/10....
***For anyone in doubt, do not ask AI for medical advice. Even the best tools are dangerous when used for the wrong job***
#medsky #AI #ChatGPT #Bromide
www.acpjournals.org/doi/epdf/10....
A Case of Bromism Influenced by Use of Artificial Intelligence
www.acpjournals.org
August 12, 2025 at 4:55 PM
60y/o man with bromide induced psychosis after consulting with ChatGPT on how to improve his diet 🧂🥦.
***For anyone in doubt, do not ask AI for medical advice. Even the best tools are dangerous when used for the wrong job***
#medsky #AI #ChatGPT #Bromide
www.acpjournals.org/doi/epdf/10....
***For anyone in doubt, do not ask AI for medical advice. Even the best tools are dangerous when used for the wrong job***
#medsky #AI #ChatGPT #Bromide
www.acpjournals.org/doi/epdf/10....
Phase I/II of an oncolytic immunotherapy + Nivo for anti-PD1-Refactoy melanoma
👉Stage 4 Cutaneous
🦠ORR 32.9%
🦠 median DOR 33.7months
🦠Response in injected + non-injected lesions
🦠G3/4 tox 12.9%
Exciting prospect in difficult setting
Phase III already underway…
#oncsky #medsky #melanoma #IO #virus
👉Stage 4 Cutaneous
🦠ORR 32.9%
🦠 median DOR 33.7months
🦠Response in injected + non-injected lesions
🦠G3/4 tox 12.9%
Exciting prospect in difficult setting
Phase III already underway…
#oncsky #medsky #melanoma #IO #virus
RP1 Combined With Nivolumab in Advanced Anti–PD-1–Failed Melanoma (IGNYTE)
PURPOSEEffective treatment options for melanoma after immune checkpoint blockade failure
are limited. RP1 (vusolimogene oderparepvec) is an HSV-1–based oncolytic immunotherapy,
here evaluated in combi...
ascopubs.org
July 16, 2025 at 10:03 PM
A careful version of this (exemptions for children, elderly, pregnancy etc) is not necessarily all bad
Many GP practices are basically local small businesses owned by the doctors who work there
In Australia & New Zealand patients pay a small fee to see GP, both have great public healthcare systems
Many GP practices are basically local small businesses owned by the doctors who work there
In Australia & New Zealand patients pay a small fee to see GP, both have great public healthcare systems
Patients should pay £20 for a GP appointment as part of an insurance-based NHS, says former Tory Minister Sajid Javid.
It is a plan for mass democide of low/middle income families, sick, old and disabled to enable corporations/rich to profiteer.
Defend your rights or lose them.
archive.ph/lJHUh
It is a plan for mass democide of low/middle income families, sick, old and disabled to enable corporations/rich to profiteer.
Defend your rights or lose them.
archive.ph/lJHUh
Charge £20 for GP appointments, says think tank
Sajid Javid, who backs report by Policy Exchange, says Britain is ‘long overdue’ a ‘serious conversation’ about how the NHS is funded
www.telegraph.co.uk
July 16, 2025 at 8:21 PM
A careful version of this (exemptions for children, elderly, pregnancy etc) is not necessarily all bad
Many GP practices are basically local small businesses owned by the doctors who work there
In Australia & New Zealand patients pay a small fee to see GP, both have great public healthcare systems
Many GP practices are basically local small businesses owned by the doctors who work there
In Australia & New Zealand patients pay a small fee to see GP, both have great public healthcare systems
Bills in progress indicate your elected representatives are voting for this batshit madness
Soo many politicians have a legal or economic skillset, but very few are scientifically or medically literate
One way to get politics out of science would be for more scientists to get elected into politics
Soo many politicians have a legal or economic skillset, but very few are scientifically or medically literate
One way to get politics out of science would be for more scientists to get elected into politics
Rolling back vaccine access while expanding unwarranted access to over the counter ivermectin is proof that we are living in a most idiotic timeline.
July 11, 2025 at 5:46 PM
Bills in progress indicate your elected representatives are voting for this batshit madness
Soo many politicians have a legal or economic skillset, but very few are scientifically or medically literate
One way to get politics out of science would be for more scientists to get elected into politics
Soo many politicians have a legal or economic skillset, but very few are scientifically or medically literate
One way to get politics out of science would be for more scientists to get elected into politics