Sarah Dimeloe
@sarahdimeloe.bsky.social
Immunologist at University of Birmingham, UK. Particular interest in immune cell metabolism. Lister Institute Fellow. Co-Director, MRC AIM doctoral training partnership.
Another great study from @nickjonesimmuno.bsky.social lab and collaborators, highlighting a novel metabolic target to modulate T cell function in context of autoimmunity
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications
α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...
www.nature.com
November 5, 2025 at 7:44 AM
Another great study from @nickjonesimmuno.bsky.social lab and collaborators, highlighting a novel metabolic target to modulate T cell function in context of autoimmunity
Reposted by Sarah Dimeloe
I am so proud to say that our paper is now available at Aging Cell. There is a paucity of data as to how the menopause impacts your immune system, and the aim of this study was to investigate the impact of the menopause on monocyte phenotype and function.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy
Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace....
onlinelibrary.wiley.com
October 9, 2025 at 10:21 AM
I am so proud to say that our paper is now available at Aging Cell. There is a paucity of data as to how the menopause impacts your immune system, and the aim of this study was to investigate the impact of the menopause on monocyte phenotype and function.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Sarah Dimeloe
We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...
Research Associate in in Neuro-Immunology and Extraceullar Matrix Biology (ImmunoMatrix):Oxford Road
Our Glyco-Immunology (Dyer) lab has produced published and preliminary data demonstrating that an under-appreciated structure, the glycocalyx, on endothelial- and immune- cells regulates immune cell recruitment by:
www.jobs.manchester.ac.uk
September 12, 2025 at 3:47 PM
We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by Sarah Dimeloe
This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...
www.nature.com/articles/s42...
The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism
This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
www.nature.com
July 28, 2025 at 3:02 PM
This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Sarah Dimeloe
Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma
Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...
www.biorxiv.org
July 27, 2025 at 12:28 PM
Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
Reposted by Sarah Dimeloe
🦠 New research shows obesity disrupts dendritic cell responses to viruses by impairing cytokine production & metabolism - helping explain higher infection risk.
📖 Read the open-access study: https://bit.ly/40kBiiH
By @andrea-woodcock.bsky.social et al.
##Immunology
📖 Read the open-access study: https://bit.ly/40kBiiH
By @andrea-woodcock.bsky.social et al.
##Immunology
June 27, 2025 at 10:09 AM
🦠 New research shows obesity disrupts dendritic cell responses to viruses by impairing cytokine production & metabolism - helping explain higher infection risk.
📖 Read the open-access study: https://bit.ly/40kBiiH
By @andrea-woodcock.bsky.social et al.
##Immunology
📖 Read the open-access study: https://bit.ly/40kBiiH
By @andrea-woodcock.bsky.social et al.
##Immunology
Reposted by Sarah Dimeloe
'Male CD8+ T cells stimulated with IL-15 exhibited greater bystander activation, including increased NKG2D expression and greater antigen-independent cytotoxicity against tumor cells compared with female CD8+ T cells.'
#immunology #immunosky
onlinelibrary.wiley.com/doi/10.1002/...
#immunology #immunosky
onlinelibrary.wiley.com/doi/10.1002/...
Biological Sex Influences Human Bystander CD8+ T Cell Activation
CD8+ T cells isolated from male donors exhibit greater IL-15–driven bystander activation, NKG2D expression, and cytotoxicity than female CD8+ cells. This study reveals a sex-based difference in innat....
onlinelibrary.wiley.com
June 27, 2025 at 6:18 AM
'Male CD8+ T cells stimulated with IL-15 exhibited greater bystander activation, including increased NKG2D expression and greater antigen-independent cytotoxicity against tumor cells compared with female CD8+ T cells.'
#immunology #immunosky
onlinelibrary.wiley.com/doi/10.1002/...
#immunology #immunosky
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Sarah Dimeloe
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells #immunometabolism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells - Nature Communications
Iron has been shown to be necessary for the activation and differentiation of CD8+ T cells. Here the authors investigate changes in CD8+ T cell metabolism in iron limiting conditions and find that asp...
www.nature.com
June 20, 2025 at 4:46 PM
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells #immunometabolism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sarah Dimeloe
I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.
March 3, 2025 at 8:46 AM
I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.
Reposted by Sarah Dimeloe
First Post on blue-sky. We are hiring! Post-doctoral position available in the neuroimmunology of stroke. Please check out link below and share elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
February 20, 2025 at 3:14 PM
First Post on blue-sky. We are hiring! Post-doctoral position available in the neuroimmunology of stroke. Please check out link below and share elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Reposted by Sarah Dimeloe
🚨 new paper alert!!
Congrats to Andrea Woodcock on delivering this from during the depths of the pandemic! Thanks to @mary-canavan.bsky.social for the collab. Obesity drives dysregulation in DC responses to viral infection
academic.oup.com/discovimmuno...
Congrats to Andrea Woodcock on delivering this from during the depths of the pandemic! Thanks to @mary-canavan.bsky.social for the collab. Obesity drives dysregulation in DC responses to viral infection
academic.oup.com/discovimmuno...
Obesity drives dysregulation in DC responses to viral infection
AbstractIntroduction. Obesity is a worldwide epidemic, with over 1 billion people worldwide living with obesity. It is associated with an increased risk of
academic.oup.com
February 7, 2025 at 8:58 PM
🚨 new paper alert!!
Congrats to Andrea Woodcock on delivering this from during the depths of the pandemic! Thanks to @mary-canavan.bsky.social for the collab. Obesity drives dysregulation in DC responses to viral infection
academic.oup.com/discovimmuno...
Congrats to Andrea Woodcock on delivering this from during the depths of the pandemic! Thanks to @mary-canavan.bsky.social for the collab. Obesity drives dysregulation in DC responses to viral infection
academic.oup.com/discovimmuno...
Online now, our latest manuscript reporting findings on the metabolic basis of cytokine-driven CD4+ T cell expansion, assessed in vitro and during T cell proliferation following autologous stem cell transplantation.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
IL-7 promotes integrated glucose and amino acid sensing during homeostatic CD4+ T cell proliferation
Interleukin (IL)-7 promotes T cell expansion during lymphopenia. We studied the metabolic basis in CD4+ T cells, observing increased glucose usage for…
www.sciencedirect.com
January 20, 2025 at 1:13 PM
Online now, our latest manuscript reporting findings on the metabolic basis of cytokine-driven CD4+ T cell expansion, assessed in vitro and during T cell proliferation following autologous stem cell transplantation.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Sarah Dimeloe
An excellent PhD opportunity available in our team: long-range consequences of parasite infection, gut-lung communication and helminth-viral co-infection. Part of the EastBio training programme. Closing date 17th January. Please get in touch!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
EastBio: Long-range consequences of intestinal helminth infection. at University of Edinburgh on FindAPhD.com
PhD Project - EastBio: Long-range consequences of intestinal helminth infection. at University of Edinburgh, listed on FindAPhD.com
www.findaphd.com
December 12, 2024 at 8:21 AM
An excellent PhD opportunity available in our team: long-range consequences of parasite infection, gut-lung communication and helminth-viral co-infection. Part of the EastBio training programme. Closing date 17th January. Please get in touch!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Great to have past and present lab members together today to celebrate Taylor’s PhD graduation with her. Nancy, Victoria and Isaac even donned their own robes to join the procession… Congrats Taylor and we wish you all the very best!
December 9, 2024 at 6:33 PM
Great to have past and present lab members together today to celebrate Taylor’s PhD graduation with her. Nancy, Victoria and Isaac even donned their own robes to join the procession… Congrats Taylor and we wish you all the very best!
Reposted by Sarah Dimeloe
#EMDS2024 was brilliant. Thx to all the organisers. Planning is well underway for EMDS25: Scotland Edition. We look forward to welcoming you to beautiful Edinburgh next year.
👀 for details in the coming months.
@britsocimm.bsky.social @cytokinesociety.bsky.social @societymucosalimm.bsky.social
👀 for details in the coming months.
@britsocimm.bsky.social @cytokinesociety.bsky.social @societymucosalimm.bsky.social
It was a truly wonderful #EMDS2024 meeting.
Hope to see all of you next year in Edinburgh with a great organizer, @bainlab.bsky.social
Hope to see all of you next year in Edinburgh with a great organizer, @bainlab.bsky.social
November 29, 2024 at 1:54 PM
#EMDS2024 was brilliant. Thx to all the organisers. Planning is well underway for EMDS25: Scotland Edition. We look forward to welcoming you to beautiful Edinburgh next year.
👀 for details in the coming months.
@britsocimm.bsky.social @cytokinesociety.bsky.social @societymucosalimm.bsky.social
👀 for details in the coming months.
@britsocimm.bsky.social @cytokinesociety.bsky.social @societymucosalimm.bsky.social
There’s a really exciting range of PhD projects on offer through the MRC “AIM” doctoral training partnership between the Universities of Birmingham, Leicester and Nottingham. 4-year funded studentships with great training opportunities too. Check out the options: more.bham.ac.uk/mrc-aim/phd-...
PhD Opportunities – MRC AIM
more.bham.ac.uk
November 28, 2024 at 7:21 AM
There’s a really exciting range of PhD projects on offer through the MRC “AIM” doctoral training partnership between the Universities of Birmingham, Leicester and Nottingham. 4-year funded studentships with great training opportunities too. Check out the options: more.bham.ac.uk/mrc-aim/phd-...
Reposted by Sarah Dimeloe
Another PhD opportunity in the team! This time its an exciting collaboration with @halllab.bsky.social and @kimhardie.bsky.social looking at why not all bacteria become resistant! www.findaphd.com/phds/project... Deadline 10th Jan and open to Uk and overseas! Pls repost!
Why does Acinetobacter lwoffii not become resistant to antibiotics? at University of Birmingham on FindAPhD.com
PhD Project - Why does Acinetobacter lwoffii not become resistant to antibiotics? at University of Birmingham, listed on FindAPhD.com
www.findaphd.com
November 27, 2024 at 3:00 PM
Another PhD opportunity in the team! This time its an exciting collaboration with @halllab.bsky.social and @kimhardie.bsky.social looking at why not all bacteria become resistant! www.findaphd.com/phds/project... Deadline 10th Jan and open to Uk and overseas! Pls repost!
We had a great time today at this fantastic event. So many great science presentations, alongside interesting and thought-proving talks on the progressive history of Manchester and how to build and maintain positive and inclusive research culture in the lab. Thanks all for bringing it together!
November 18, 2024 at 9:01 PM
We had a great time today at this fantastic event. So many great science presentations, alongside interesting and thought-proving talks on the progressive history of Manchester and how to build and maintain positive and inclusive research culture in the lab. Thanks all for bringing it together!
It was great to work with Kendle Maslowski’s group @mmimic.bsky.social and others on this project, interrogating the curious question of why T cells aren’t engaged by bacterial cancer therapy, and how to make them so! It’s all down to metabolism of course 😉…
Check it out!!! Our work delineating why T cells aren't needed for Salmonella colorectal cancer therapy, and how to get them on board is out 😅🧪🦠. @cruk-si.bsky.social Collab with @bendinglab.bsky.social @sarahdimeloe.bsky.social #Immunosky #Microsky #metabolism www.embopress.org/doi/full/10....
www.embopress.org
November 18, 2024 at 2:50 PM
It was great to work with Kendle Maslowski’s group @mmimic.bsky.social and others on this project, interrogating the curious question of why T cells aren’t engaged by bacterial cancer therapy, and how to make them so! It’s all down to metabolism of course 😉…
Great opportunity to join our wonderful immunology, infection and inflammation community in Birmingham!
Feels like a salient time to remind that we are now recruiting the very best talent at UoB on our 125th anniversary Fellows and Chairs scheme. Looking for people across the whole remit of our school of Infection, Inflammation, and Immunology. Contact me to discuss
fellowsandchairs.birmingham.ac.uk
fellowsandchairs.birmingham.ac.uk
125th Anniversary Fellows and Chairs | University of Birmingham
This is 125 years of NobelPrize-winning research.This is your opportunity to become one of our 125th Anniversary Fellows and Chairs.
fellowsandchairs.birmingham.ac.uk
November 15, 2024 at 5:29 PM
Great opportunity to join our wonderful immunology, infection and inflammation community in Birmingham!
Reposted by Sarah Dimeloe
To celebrate the 125th anniversary of the University of Birmingham, we are recruiting 100 Anniversary Fellows and 25 Anniversary Chairs fellowsandchairs.birmingham.ac.uk
If you are interested to join our community of researchers in infection, inflammation and immunology, please DM me!
If you are interested to join our community of researchers in infection, inflammation and immunology, please DM me!
125th Anniversary Fellows and Chairs | University of Birmingham
This is 125 years of NobelPrize-winning research.This is your opportunity to become one of our 125th Anniversary Fellows and Chairs.
fellowsandchairs.birmingham.ac.uk
November 13, 2024 at 8:12 PM
To celebrate the 125th anniversary of the University of Birmingham, we are recruiting 100 Anniversary Fellows and 25 Anniversary Chairs fellowsandchairs.birmingham.ac.uk
If you are interested to join our community of researchers in infection, inflammation and immunology, please DM me!
If you are interested to join our community of researchers in infection, inflammation and immunology, please DM me!
Reposted by Sarah Dimeloe
JOB CLAXON!
I am recruiting a post-doctoral researcher on a BBSRC-funded project (36 months) on the genetics and functional genomics of vancomycin resistance in enterococci.
Further details here: edzz.fa.em3.oraclecloud.com/hcmUI/Candid...
Please DM or email me if you want to discuss this post.
I am recruiting a post-doctoral researcher on a BBSRC-funded project (36 months) on the genetics and functional genomics of vancomycin resistance in enterococci.
Further details here: edzz.fa.em3.oraclecloud.com/hcmUI/Candid...
Please DM or email me if you want to discuss this post.
Research Fellow - Department of Microbes, Infections and Microbiomes - 104864 - Grade 7
This exciting BBSRC-funded project aims to mechanistically characterise the fitness costs associated with vancomycin resistance in the Gram-positive opportunistic pathogens Enterococcus faecalis and E...
edzz.fa.em3.oraclecloud.com
November 12, 2024 at 10:41 PM
JOB CLAXON!
I am recruiting a post-doctoral researcher on a BBSRC-funded project (36 months) on the genetics and functional genomics of vancomycin resistance in enterococci.
Further details here: edzz.fa.em3.oraclecloud.com/hcmUI/Candid...
Please DM or email me if you want to discuss this post.
I am recruiting a post-doctoral researcher on a BBSRC-funded project (36 months) on the genetics and functional genomics of vancomycin resistance in enterococci.
Further details here: edzz.fa.em3.oraclecloud.com/hcmUI/Candid...
Please DM or email me if you want to discuss this post.
Great opportunity here in a supportive lab!
Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism?
Then come join me & @juanquintana.bsky.social at the @lydiabeckeriii.bsky.social as a research assistant 🤓 Email to arrange an informal chat 🧪 #ImmunoSky www.jobs.manchester.ac.uk/Job/JobDetai...
Then come join me & @juanquintana.bsky.social at the @lydiabeckeriii.bsky.social as a research assistant 🤓 Email to arrange an informal chat 🧪 #ImmunoSky www.jobs.manchester.ac.uk/Job/JobDetai...
Research Assistant in Tissue Immunology:Oxford Road
www.jobs.manchester.ac.uk
November 12, 2024 at 2:09 PM
Great opportunity here in a supportive lab!