Nick Jones
@nickjonesimmuno.bsky.social
T-cell aficionado at Swansea University. Interested in metabolism of T-cell mediated disorders from autoimmunity to T-ALL.
Reposted by Nick Jones
📢Interested in #CancerMetabolism and #leukemia using mouse models in vivo? Come join us!! We're looking for a #postdoc to help us drive one of our multiple currently funded projects! Friends & colleagues, please RT!
👇👇👇
jobs.rutgers.edu/postings/260...
👇👇👇
jobs.rutgers.edu/postings/260...
Postdoctoral Associate
Rutgers, The State University of New Jersey is seeking a Postdoctoral Associate within the Cancer Pharmacology Department at the Rutgers Cancer Institute. In this role, the Postdoctoral Associate will...
jobs.rutgers.edu
October 30, 2025 at 7:23 PM
📢Interested in #CancerMetabolism and #leukemia using mouse models in vivo? Come join us!! We're looking for a #postdoc to help us drive one of our multiple currently funded projects! Friends & colleagues, please RT!
👇👇👇
jobs.rutgers.edu/postings/260...
👇👇👇
jobs.rutgers.edu/postings/260...
Reposted by Nick Jones
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function
->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai
->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function
Given that reduced expression of ABHD11 within CD4+ T-cells is associated with remission in RA21, we sought to better understand the role of ABHD11 in T-cell biology. Firstly, we established the degree of ABHD11 protein expression in human CD4+ T-cells,...
www.nature.com
November 5, 2025 at 9:03 AM
Reposted by Nick Jones
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function @natcomms.nature.com @nickjonesimmuno.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 3, 2025 at 11:18 PM
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function @natcomms.nature.com @nickjonesimmuno.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nick Jones
Targeting the mitochondrial protein ABHD11 in T-cells may help reduce inflammation and delay autoimmune disease progression by regulating immune cell metabolism. doi.org/g983xc
Mitochondrial protein represents promising target for autoimmune disease treatment
A new study led by Swansea University has revealed a new way to potentially treat certain autoimmune diseases by targeting a protein that helps regulate energy production in immune cells.
medicalxpress.com
November 3, 2025 at 7:35 PM
Targeting the mitochondrial protein ABHD11 in T-cells may help reduce inflammation and delay autoimmune disease progression by regulating immune cell metabolism. doi.org/g983xc
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications
α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...
www.nature.com
November 3, 2025 at 10:20 AM
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nick Jones
T-ALL exploits a neural proinflammatory pathway to colonize the meninges @jci.org
www.jci.org/articles/vie...
www.jci.org/articles/vie...
October 23, 2025 at 5:22 PM
T-ALL exploits a neural proinflammatory pathway to colonize the meninges @jci.org
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Really thrilled to have been involved in this project. It’s an absolute mammoth of a paper looking at the way T-cell leukaemia exploits inflammation to colonise the meninges. Congratulations to Nitesh and @kseniam.bsky.social 🍸
Please give it a read!
www.jci.org/articles/vie...
Please give it a read!
www.jci.org/articles/vie...
JCI -
T-cell acute lymphoblastic leukemia exploits a neural proinflammatory pathway to colonize the meninges
www.jci.org
October 23, 2025 at 5:37 PM
Really thrilled to have been involved in this project. It’s an absolute mammoth of a paper looking at the way T-cell leukaemia exploits inflammation to colonise the meninges. Congratulations to Nitesh and @kseniam.bsky.social 🍸
Please give it a read!
www.jci.org/articles/vie...
Please give it a read!
www.jci.org/articles/vie...
Reposted by Nick Jones
We hiring! Please share this post with your talented ECRs
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
October 21, 2025 at 3:57 PM
We hiring! Please share this post with your talented ECRs
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…
www.sciencedirect.com
October 21, 2025 at 9:37 AM
Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Nick Jones
Studies of T cell acute lymphoblastic leukemia reveal that canagliflozin possesses potent anti-leukaemic effects underpinned by proliferative defects, cell cycle disruption and apoptosis, actions synergized by restriction of serine and glycine www.sciencedirect.com/science/arti...
Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…
www.sciencedirect.com
October 20, 2025 at 7:40 PM
Studies of T cell acute lymphoblastic leukemia reveal that canagliflozin possesses potent anti-leukaemic effects underpinned by proliferative defects, cell cycle disruption and apoptosis, actions synergized by restriction of serine and glycine www.sciencedirect.com/science/arti...
Reposted by Nick Jones
Reposted by Nick Jones
I am so proud to say that our paper is now available at Aging Cell. There is a paucity of data as to how the menopause impacts your immune system, and the aim of this study was to investigate the impact of the menopause on monocyte phenotype and function.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy
Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace....
onlinelibrary.wiley.com
October 9, 2025 at 10:21 AM
I am so proud to say that our paper is now available at Aging Cell. There is a paucity of data as to how the menopause impacts your immune system, and the aim of this study was to investigate the impact of the menopause on monocyte phenotype and function.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Really pleased to share two review articles the lab has been involved in lately 👇🏻
Thanks for the involvement!
Thanks for the involvement!
August 14, 2025 at 7:26 PM
Really pleased to share two review articles the lab has been involved in lately 👇🏻
Thanks for the involvement!
Thanks for the involvement!
Reposted by Nick Jones
Delighted to share our new review in @cp-trendsendomet.bsky.social on Repurposing metabolic drugs (GLP-1s & SGLT2s) as anti-inflammatory agents! Thanks to @nickjonesimmuno.bsky.social for this joint effort
doi.org/10.1016/j.te...
doi.org/10.1016/j.te...
August 13, 2025 at 9:21 PM
Delighted to share our new review in @cp-trendsendomet.bsky.social on Repurposing metabolic drugs (GLP-1s & SGLT2s) as anti-inflammatory agents! Thanks to @nickjonesimmuno.bsky.social for this joint effort
doi.org/10.1016/j.te...
doi.org/10.1016/j.te...
Reposted by Nick Jones
We have a PhD position open for a talented & enthusiastic grad student interested in Neuro-Immune communication in the context of dementia. Come and join myself and @nickjonesimmuno.bsky.social click 👇 or contact me for more info
www.swansea.ac.uk/postgraduate...
www.swansea.ac.uk/postgraduate...
Medicine: Fully Funded BRACE PhD in Alzheimer’s Research (RS855) - Swansea University
We offer a wide range of funded and fully funded research scholarships in all subject areas. Explore your options and apply now.
www.swansea.ac.uk
July 2, 2025 at 9:21 AM
We have a PhD position open for a talented & enthusiastic grad student interested in Neuro-Immune communication in the context of dementia. Come and join myself and @nickjonesimmuno.bsky.social click 👇 or contact me for more info
www.swansea.ac.uk/postgraduate...
www.swansea.ac.uk/postgraduate...
Reposted by Nick Jones
Preprint: Characterization of the dual roles of senescent-like T cells that arise during healthy and unhealthy ageing
www.biorxiv.org/content/10.1...
@drsianh.bsky.social
www.biorxiv.org/content/10.1...
@drsianh.bsky.social
June 20, 2025 at 2:23 AM
Preprint: Characterization of the dual roles of senescent-like T cells that arise during healthy and unhealthy ageing
www.biorxiv.org/content/10.1...
@drsianh.bsky.social
www.biorxiv.org/content/10.1...
@drsianh.bsky.social
Reposted by Nick Jones
Join me + Dr David Palmer, Haematology Clinician at UHS NHS @bsmsmedschool.bsky.social, for a 3.5yr School of Life Sci funded PhD (UK fees only) studying RUNX1 mutations in myeloid leukaemia here at @sussex.ac.uk @sussexbcr.bsky.social @sussexcancer.org
Details 👇
www.sussex.ac.uk/study/fees-f...
Details 👇
www.sussex.ac.uk/study/fees-f...
School of Life Sciences Studentship : University of Sussex
www.sussex.ac.uk
June 6, 2025 at 1:51 PM
Join me + Dr David Palmer, Haematology Clinician at UHS NHS @bsmsmedschool.bsky.social, for a 3.5yr School of Life Sci funded PhD (UK fees only) studying RUNX1 mutations in myeloid leukaemia here at @sussex.ac.uk @sussexbcr.bsky.social @sussexcancer.org
Details 👇
www.sussex.ac.uk/study/fees-f...
Details 👇
www.sussex.ac.uk/study/fees-f...
Very cool post doc position for someone with immunology and metabolism background. Looking at a ketogenic diet in a RCT setting with Dr Emma Vincent’s group at the University of Bristol. Please reshare! 👇🏻 www.linkedin.com/jobs/view/42...
University of Bristol hiring Senior Research Associate in Molecular Metabolism in City Of Bristol, England, United Kingdom | LinkedIn
Posted 7:56:20 AM. The roleWe are looking for an enthusiastic and skilled researcher to work as part of a team running…See this and similar jobs on LinkedIn.
www.linkedin.com
May 21, 2025 at 10:09 AM
Very cool post doc position for someone with immunology and metabolism background. Looking at a ketogenic diet in a RCT setting with Dr Emma Vincent’s group at the University of Bristol. Please reshare! 👇🏻 www.linkedin.com/jobs/view/42...
Reposted by Nick Jones
Great collaboration with @inespinedatorra.bsky.social @georgearobinson.bsky.social @anisurrahman.bsky.social @arrdept-ucldom.bsky.social
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Subclinical Atherosclerosis Risk Can Be Predicted in Female Patients With Systemic Lupus Erythematosus Using Metabolomic Signatures: An Observational Study | Journal of the American Heart Association
www.ahajournals.org
April 9, 2025 at 3:52 PM
Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures www.cell.com/cell/abstrac...
www.cell.com
April 8, 2025 at 8:03 PM
Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures www.cell.com/cell/abstrac...
Reposted by Nick Jones
Happy to share the copy-edited version of our story uncovering an ACLY-MYC feedforward loop in T-ALL! @bloodneoplasia.bsky.social @rutgerscancer.bsky.social @dasilva-diz.bsky.social
doi.org/10.1016/j.bn...
doi.org/10.1016/j.bn...
March 26, 2025 at 4:50 PM
Happy to share the copy-edited version of our story uncovering an ACLY-MYC feedforward loop in T-ALL! @bloodneoplasia.bsky.social @rutgerscancer.bsky.social @dasilva-diz.bsky.social
doi.org/10.1016/j.bn...
doi.org/10.1016/j.bn...
Reposted by Nick Jones
So excited to see this out please read the paper, article and listen to us on the radio! Big thanks to @uclnews.bsky.social, our superstar postdoc @hlpeks.bsky.social, co-senior author Prof Coziana Ciurtin and collaborators @emmaschambers.bsky.social
Until menopause women have more key immune cells, which may explain why they're less prone to some infections than men, finds a @jem.org study from @arrdept-ucldom.bsky.social including Dr Hannah Peckham @hlpeks.bsky.social & Dr Lizzy Rosser @bcellsrosser.bsky.social
www.ucl.ac.uk/news/2025/ma...
www.ucl.ac.uk/news/2025/ma...
Abundance of key immune cells may be influenced by oestrogen and XX chromosomes
Women have a higher proportion of key immune cells between puberty and menopause, which may be linked to the sex hormone oestrogen and explain why they are less susceptible to certain infectious disea...
www.ucl.ac.uk
March 25, 2025 at 2:38 PM
So excited to see this out please read the paper, article and listen to us on the radio! Big thanks to @uclnews.bsky.social, our superstar postdoc @hlpeks.bsky.social, co-senior author Prof Coziana Ciurtin and collaborators @emmaschambers.bsky.social
Reposted by Nick Jones
Happy to share our In Focus comment on targeting metabolism in T-ALL in #BloodCancerDiscovery, single-handedly written by @dasilva-diz.bsky.social! Thanks for the invitation to write on such an exciting topic @tanyabondar.bsky.social! @rutgerscancer.bsky.social aacrjournals.org/bloodcancerd...
March 21, 2025 at 3:49 PM
Happy to share our In Focus comment on targeting metabolism in T-ALL in #BloodCancerDiscovery, single-handedly written by @dasilva-diz.bsky.social! Thanks for the invitation to write on such an exciting topic @tanyabondar.bsky.social! @rutgerscancer.bsky.social aacrjournals.org/bloodcancerd...
Reposted by Nick Jones
ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity https://www.biorxiv.org/content/10.1101/2025.03.19.643996v1
March 19, 2025 at 10:16 PM
ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity https://www.biorxiv.org/content/10.1101/2025.03.19.643996v1
First preprint from the lab! Massive effort from @ben-j-jenkins.bsky.social and Yasmin. Thanks always to great collaborators and co-leads James and Emma. Any feedback greatly appreciated:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity
Chronic inflammation in autoimmunity is driven by T cell hyperactivation. This unregulated response to self is fuelled by heightened metabolic programmes, which offers a promising new direction to unc...
www.biorxiv.org
March 20, 2025 at 8:46 AM
First preprint from the lab! Massive effort from @ben-j-jenkins.bsky.social and Yasmin. Thanks always to great collaborators and co-leads James and Emma. Any feedback greatly appreciated:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...