Nick Jones
@nickjonesimmuno.bsky.social
T-cell aficionado at Swansea University. Interested in metabolism of T-cell mediated disorders from autoimmunity to T-ALL.
Reposted by Nick Jones
🧬 Have you submitted your abstract for #UKimmunomet26? The deadline is approaching in 3 weeks!
Join the UK’s leading immunometabolism meeting in NCL for cutting edge research, international speakers & sessions for ECRs.
Find out more & register 🔗 https://bit.ly/493uE45
Join the UK’s leading immunometabolism meeting in NCL for cutting edge research, international speakers & sessions for ECRs.
Find out more & register 🔗 https://bit.ly/493uE45
February 12, 2026 at 10:00 AM
🧬 Have you submitted your abstract for #UKimmunomet26? The deadline is approaching in 3 weeks!
Join the UK’s leading immunometabolism meeting in NCL for cutting edge research, international speakers & sessions for ECRs.
Find out more & register 🔗 https://bit.ly/493uE45
Join the UK’s leading immunometabolism meeting in NCL for cutting edge research, international speakers & sessions for ECRs.
Find out more & register 🔗 https://bit.ly/493uE45
Reposted by Nick Jones
What are the immune system changes in refractory Myasthenia Gravis? Read our publication today in Med 🌟 @ncaresearchnhs.bsky.social @fbmh-uom.bsky.social @dns-uom.bsky.social @lydiabeckeriii.bsky.social @neuromuscularmanc.bsky.social @madhvimenon.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Lymphocyte alterations and elevated complement signaling are key features of refractory myasthenia gravis
A significant proportion of patients with myasthenia gravis (MG) remain refractory to standard immunosuppressive therapy, and biomarkers to help guide…
www.sciencedirect.com
February 6, 2026 at 8:51 PM
What are the immune system changes in refractory Myasthenia Gravis? Read our publication today in Med 🌟 @ncaresearchnhs.bsky.social @fbmh-uom.bsky.social @dns-uom.bsky.social @lydiabeckeriii.bsky.social @neuromuscularmanc.bsky.social @madhvimenon.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Nick Jones
Very proud that our investigating uveitis pathogenesis in young people living with arthritis is out today @natcomms.nature.com. A real team science effort made possible by collaborations across hospital & researchers with support of patients. Check it out 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Altered B cell activation contributes to the immunopathogenesis of childhood arthritis-associated uveitis - Nature Communications
Juvenile idiopathic arthritis (JIA) associated uveitis can cause vision loss in children, but mechanisms remain unclear. The authors here identify elevated CD19+IgD-CD27- double negative type 1 B cell...
www.nature.com
February 3, 2026 at 12:47 PM
Very proud that our investigating uveitis pathogenesis in young people living with arthritis is out today @natcomms.nature.com. A real team science effort made possible by collaborations across hospital & researchers with support of patients. Check it out 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nick Jones
****2-NBDG does not measure glucose uptake****
Just your regular reminder of this fact 😁.
See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.
This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄
pmc.ncbi.nlm.nih.gov/articles/PMC...
Just your regular reminder of this fact 😁.
See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.
This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄
pmc.ncbi.nlm.nih.gov/articles/PMC...
Single Cell Glucose Uptake Assays: A Cautionary Tale
Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose ...
pmc.ncbi.nlm.nih.gov
January 30, 2026 at 1:57 AM
****2-NBDG does not measure glucose uptake****
Just your regular reminder of this fact 😁.
See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.
This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄
pmc.ncbi.nlm.nih.gov/articles/PMC...
Just your regular reminder of this fact 😁.
See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.
This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by Nick Jones
Ksenia Matlawska-Wasowska @kseniam.bsky.social and team show T-cell leukemia exploits an inflammatory pathway to invade the brain's protective layers: doi.org/10.1172/JCI1...
The image features GFP⁺ T-ALL leukemic infiltrates within whole-mount murine meningeal tissue.
The image features GFP⁺ T-ALL leukemic infiltrates within whole-mount murine meningeal tissue.
January 22, 2026 at 5:06 PM
Ksenia Matlawska-Wasowska @kseniam.bsky.social and team show T-cell leukemia exploits an inflammatory pathway to invade the brain's protective layers: doi.org/10.1172/JCI1...
The image features GFP⁺ T-ALL leukemic infiltrates within whole-mount murine meningeal tissue.
The image features GFP⁺ T-ALL leukemic infiltrates within whole-mount murine meningeal tissue.
Reposted by Nick Jones
Immunometabolism researchers are meeting in Newcastle on 16-17 April!
Join us for 2 days of fantastic immunometabolism research, Bright Sparks sessions & networking with the community. #UKimmunomet26
Submit your abstract by 5 March and register now 👉 https://bit.ly/493uE45
Join us for 2 days of fantastic immunometabolism research, Bright Sparks sessions & networking with the community. #UKimmunomet26
Submit your abstract by 5 March and register now 👉 https://bit.ly/493uE45
January 15, 2026 at 11:00 AM
Immunometabolism researchers are meeting in Newcastle on 16-17 April!
Join us for 2 days of fantastic immunometabolism research, Bright Sparks sessions & networking with the community. #UKimmunomet26
Submit your abstract by 5 March and register now 👉 https://bit.ly/493uE45
Join us for 2 days of fantastic immunometabolism research, Bright Sparks sessions & networking with the community. #UKimmunomet26
Submit your abstract by 5 March and register now 👉 https://bit.ly/493uE45
Reposted by Nick Jones
Don't miss out on your chance to attend "Fuelling the immune response IV: #UKimmunometabolismMeeting2026"
Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science
📆16-17th April
www.immunology.org/events/fuell...
Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science
📆16-17th April
www.immunology.org/events/fuell...
Fuelling the immune response IV: UK immunometabolism meeting 2026 | British Society for Immunology
www.immunology.org
January 6, 2026 at 3:02 PM
Don't miss out on your chance to attend "Fuelling the immune response IV: #UKimmunometabolismMeeting2026"
Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science
📆16-17th April
www.immunology.org/events/fuell...
Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science
📆16-17th April
www.immunology.org/events/fuell...
Reposted by Nick Jones
🚨 📣 NEW PAPER ALERT 🚨📣
Probably, our most exciting discovery yet!!
We performed the first-ever dietary pan-amino acid dropout screen in cancer in vivo using T-ALL as a model, and surprisingly found histidine as critically needed for T-ALL progression
www.biorxiv.org/content/10.6...
Probably, our most exciting discovery yet!!
We performed the first-ever dietary pan-amino acid dropout screen in cancer in vivo using T-ALL as a model, and surprisingly found histidine as critically needed for T-ALL progression
www.biorxiv.org/content/10.6...
A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL
Dietary interventions show therapeutic potential in cancer, but systematic comparisons are lacking. We performed a dietary pan-amino acid dropout screen in an orthotopic model of NOTCH1-driven T-cell ...
www.biorxiv.org
December 24, 2025 at 2:26 AM
🚨 📣 NEW PAPER ALERT 🚨📣
Probably, our most exciting discovery yet!!
We performed the first-ever dietary pan-amino acid dropout screen in cancer in vivo using T-ALL as a model, and surprisingly found histidine as critically needed for T-ALL progression
www.biorxiv.org/content/10.6...
Probably, our most exciting discovery yet!!
We performed the first-ever dietary pan-amino acid dropout screen in cancer in vivo using T-ALL as a model, and surprisingly found histidine as critically needed for T-ALL progression
www.biorxiv.org/content/10.6...
Reposted by Nick Jones
Registrations are now open for 'Fuelling the immune response', the 4th UK immunometabolism meeting, led by the BSI Immunometabolism Affinity Group.
Join us in Newcastle on 16 and 17 April 2026 for cutting edge immune metabolism research #UKimmunomet26
Register here: https://bit.ly/493uE45
Join us in Newcastle on 16 and 17 April 2026 for cutting edge immune metabolism research #UKimmunomet26
Register here: https://bit.ly/493uE45
December 18, 2025 at 9:25 AM
Registrations are now open for 'Fuelling the immune response', the 4th UK immunometabolism meeting, led by the BSI Immunometabolism Affinity Group.
Join us in Newcastle on 16 and 17 April 2026 for cutting edge immune metabolism research #UKimmunomet26
Register here: https://bit.ly/493uE45
Join us in Newcastle on 16 and 17 April 2026 for cutting edge immune metabolism research #UKimmunomet26
Register here: https://bit.ly/493uE45
Reposted by Nick Jones
📣🚨📣 NEW PAPER ALERT!! Did you ever struggle to differentiate very similar populations in #scRNA? Struggle no more with CANTAO! Really enjoyable collaboration between our lab and the Khiabanian lab @rutgerscancer.bsky.social!!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
CANTAO: guiding clustering and annotation in single-cell RNA sequencing using average overlap - Molecular Systems Biology
Single-cell RNA sequencing allows defining cellular identities based on transcriptional similarity using unsupervised clustering. However, a single clustering resolution may not yield groups of cells ...
link.springer.com
December 8, 2025 at 4:11 PM
📣🚨📣 NEW PAPER ALERT!! Did you ever struggle to differentiate very similar populations in #scRNA? Struggle no more with CANTAO! Really enjoyable collaboration between our lab and the Khiabanian lab @rutgerscancer.bsky.social!!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Nick Jones
Great to see our recent hepatic TRM review as the inspiration behind the @natrevgastrohep.nature.com December issue cover!
#ScienceWin ❤️
#ScienceWin ❤️
Our DECEMBER ISSUE is live! Hepatic T cells, microbiome and pancreatic cancer, portal hypertension and cirrhosis, metabolic and alcohol-related liver disease and much more!
www.nature.com/nrgastro/vol...
www.nature.com/nrgastro/vol...
December 7, 2025 at 9:19 PM
Great to see our recent hepatic TRM review as the inspiration behind the @natrevgastrohep.nature.com December issue cover!
#ScienceWin ❤️
#ScienceWin ❤️
Reposted by Nick Jones
Discover how systemic factors shape immune function in Metabolism meets immunity at #BSI25.
Hear top insights from Prof Thekla Cordes and Prof Christoph Hess on the latest in immunometabolism. Don’t miss it!
Learn more about the programme: https://bit.ly/4a5iBp1
Hear top insights from Prof Thekla Cordes and Prof Christoph Hess on the latest in immunometabolism. Don’t miss it!
Learn more about the programme: https://bit.ly/4a5iBp1
November 25, 2025 at 3:28 PM
Discover how systemic factors shape immune function in Metabolism meets immunity at #BSI25.
Hear top insights from Prof Thekla Cordes and Prof Christoph Hess on the latest in immunometabolism. Don’t miss it!
Learn more about the programme: https://bit.ly/4a5iBp1
Hear top insights from Prof Thekla Cordes and Prof Christoph Hess on the latest in immunometabolism. Don’t miss it!
Learn more about the programme: https://bit.ly/4a5iBp1
Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus
Congrats to Laurence Morel and team!
www.cell.com/cell-reports...
Congrats to Laurence Morel and team!
www.cell.com/cell-reports...
Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus
Choi et al. show that pharmacologically restricting glycolysis improves the cellular,
transcriptional, and metabolic machinery in murine lupus TFH cells. Transcript overlaps
between TFH cells from lup...
www.cell.com
November 25, 2025 at 9:02 PM
Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus
Congrats to Laurence Morel and team!
www.cell.com/cell-reports...
Congrats to Laurence Morel and team!
www.cell.com/cell-reports...
Interesting paper examining the role of dietary fructose and its implications in pathogenic Th17-mediated inflammatory disease 👇🏻
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Fructose intake driven glycolysis-ROS-EGFR axis specifically promotes the generation and pathogenicity of Th17 cells - Nature Communications
Th17 cells play roles in maintaining immune homeostasis but also potentially harmful inflammatory processes. Here, authors show that homeostatic and pathological Th17 cells are distinct subtypes, resp...
www.nature.com
November 25, 2025 at 9:00 PM
Interesting paper examining the role of dietary fructose and its implications in pathogenic Th17-mediated inflammatory disease 👇🏻
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nick Jones
📢Interested in #CancerMetabolism and #leukemia using mouse models in vivo? Come join us!! We're looking for a #postdoc to help us drive one of our multiple currently funded projects! Friends & colleagues, please RT!
👇👇👇
jobs.rutgers.edu/postings/260...
👇👇👇
jobs.rutgers.edu/postings/260...
Postdoctoral Associate
Rutgers, The State University of New Jersey is seeking a Postdoctoral Associate within the Cancer Pharmacology Department at the Rutgers Cancer Institute. In this role, the Postdoctoral Associate will...
jobs.rutgers.edu
October 30, 2025 at 7:23 PM
📢Interested in #CancerMetabolism and #leukemia using mouse models in vivo? Come join us!! We're looking for a #postdoc to help us drive one of our multiple currently funded projects! Friends & colleagues, please RT!
👇👇👇
jobs.rutgers.edu/postings/260...
👇👇👇
jobs.rutgers.edu/postings/260...
Reposted by Nick Jones
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function
->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai
->Nature | More from Lil Dr Glen EcoChat at BigEarthData.ai
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function
Given that reduced expression of ABHD11 within CD4+ T-cells is associated with remission in RA21, we sought to better understand the role of ABHD11 in T-cell biology. Firstly, we established the degree of ABHD11 protein expression in human CD4+ T-cells,...
www.nature.com
November 5, 2025 at 9:03 AM
Reposted by Nick Jones
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function @natcomms.nature.com @nickjonesimmuno.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 3, 2025 at 11:18 PM
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function @natcomms.nature.com @nickjonesimmuno.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nick Jones
Targeting the mitochondrial protein ABHD11 in T-cells may help reduce inflammation and delay autoimmune disease progression by regulating immune cell metabolism. doi.org/g983xc
Mitochondrial protein represents promising target for autoimmune disease treatment
A new study led by Swansea University has revealed a new way to potentially treat certain autoimmune diseases by targeting a protein that helps regulate energy production in immune cells.
medicalxpress.com
November 3, 2025 at 7:35 PM
Targeting the mitochondrial protein ABHD11 in T-cells may help reduce inflammation and delay autoimmune disease progression by regulating immune cell metabolism. doi.org/g983xc
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications
α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...
www.nature.com
November 3, 2025 at 10:20 AM
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nick Jones
T-ALL exploits a neural proinflammatory pathway to colonize the meninges @jci.org
www.jci.org/articles/vie...
www.jci.org/articles/vie...
October 23, 2025 at 5:22 PM
T-ALL exploits a neural proinflammatory pathway to colonize the meninges @jci.org
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Really thrilled to have been involved in this project. It’s an absolute mammoth of a paper looking at the way T-cell leukaemia exploits inflammation to colonise the meninges. Congratulations to Nitesh and @kseniam.bsky.social 🍸
Please give it a read!
www.jci.org/articles/vie...
Please give it a read!
www.jci.org/articles/vie...
JCI -
T-cell acute lymphoblastic leukemia exploits a neural proinflammatory pathway to colonize the meninges
www.jci.org
October 23, 2025 at 5:37 PM
Really thrilled to have been involved in this project. It’s an absolute mammoth of a paper looking at the way T-cell leukaemia exploits inflammation to colonise the meninges. Congratulations to Nitesh and @kseniam.bsky.social 🍸
Please give it a read!
www.jci.org/articles/vie...
Please give it a read!
www.jci.org/articles/vie...
Reposted by Nick Jones
We hiring! Please share this post with your talented ECRs
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
October 21, 2025 at 3:57 PM
We hiring! Please share this post with your talented ECRs
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…
www.sciencedirect.com
October 21, 2025 at 9:37 AM
Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Nick Jones
Studies of T cell acute lymphoblastic leukemia reveal that canagliflozin possesses potent anti-leukaemic effects underpinned by proliferative defects, cell cycle disruption and apoptosis, actions synergized by restriction of serine and glycine www.sciencedirect.com/science/arti...
Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…
www.sciencedirect.com
October 20, 2025 at 7:40 PM
Studies of T cell acute lymphoblastic leukemia reveal that canagliflozin possesses potent anti-leukaemic effects underpinned by proliferative defects, cell cycle disruption and apoptosis, actions synergized by restriction of serine and glycine www.sciencedirect.com/science/arti...
Reposted by Nick Jones
