Andy Hogan
@andyhogan82.bsky.social
Immunologist interested in all things MAIT cells, Obesity, NK cells & Cancer. Professor at Maynooth University
Reposted by Andy Hogan
Studies of T cell acute lymphoblastic leukemia reveal that canagliflozin possesses potent anti-leukaemic effects underpinned by proliferative defects, cell cycle disruption and apoptosis, actions synergized by restriction of serine and glycine www.sciencedirect.com/science/arti...
Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…
www.sciencedirect.com
October 20, 2025 at 7:40 PM
Studies of T cell acute lymphoblastic leukemia reveal that canagliflozin possesses potent anti-leukaemic effects underpinned by proliferative defects, cell cycle disruption and apoptosis, actions synergized by restriction of serine and glycine www.sciencedirect.com/science/arti...
Reposted by Andy Hogan
Compelling metabolic benefits of semaglutide over 30 weeks in patients with schizophrenia Rxed with second-generation antipsychotic agents jamanetwork.com/journals/jam...
Semaglutide Treatment of Antipsychotic-Treated Patients With Schizophrenia, Prediabetes, and Obesity
This multicenter randomized clinical trial assesses the effect of once-weekly administration of the glucagon-like peptide-1 receptor agonist semaglutide in adults treated with second-generation antips...
jamanetwork.com
September 3, 2025 at 9:18 PM
Compelling metabolic benefits of semaglutide over 30 weeks in patients with schizophrenia Rxed with second-generation antipsychotic agents jamanetwork.com/journals/jam...
Reposted by Andy Hogan
MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines
www.science.org/doi/10.1126/... @sciimmunology.bsky.social @aliamini419.bsky.social @thelucygarner.bsky.social @nprovine.bsky.social
www.science.org/doi/10.1126/... @sciimmunology.bsky.social @aliamini419.bsky.social @thelucygarner.bsky.social @nprovine.bsky.social
August 29, 2025 at 9:16 PM
MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines
www.science.org/doi/10.1126/... @sciimmunology.bsky.social @aliamini419.bsky.social @thelucygarner.bsky.social @nprovine.bsky.social
www.science.org/doi/10.1126/... @sciimmunology.bsky.social @aliamini419.bsky.social @thelucygarner.bsky.social @nprovine.bsky.social
Reposted by Andy Hogan
Delighted to share our new review in @cp-trendsendomet.bsky.social on Repurposing metabolic drugs (GLP-1s & SGLT2s) as anti-inflammatory agents! Thanks to @nickjonesimmuno.bsky.social for this joint effort
doi.org/10.1016/j.te...
doi.org/10.1016/j.te...
August 13, 2025 at 9:21 PM
Delighted to share our new review in @cp-trendsendomet.bsky.social on Repurposing metabolic drugs (GLP-1s & SGLT2s) as anti-inflammatory agents! Thanks to @nickjonesimmuno.bsky.social for this joint effort
doi.org/10.1016/j.te...
doi.org/10.1016/j.te...
Reposted by Andy Hogan
Delighted to have our latest paper now online in Stem Cell Research & Therapy rdcu.be/ezDs3
Congrats to lead co-first authors @courteney.bsky.social @laurabitterlich.bsky.social and collaborators @james Ankrum @andyhogan82.bsky.social @maynoothuniversity.ie
Congrats to lead co-first authors @courteney.bsky.social @laurabitterlich.bsky.social and collaborators @james Ankrum @andyhogan82.bsky.social @maynoothuniversity.ie
Palmitate enhances MSC immunomodulation of human macrophages via the ceramide/CCL2 axis in vitro
rdcu.be
August 7, 2025 at 4:43 AM
Delighted to have our latest paper now online in Stem Cell Research & Therapy rdcu.be/ezDs3
Congrats to lead co-first authors @courteney.bsky.social @laurabitterlich.bsky.social and collaborators @james Ankrum @andyhogan82.bsky.social @maynoothuniversity.ie
Congrats to lead co-first authors @courteney.bsky.social @laurabitterlich.bsky.social and collaborators @james Ankrum @andyhogan82.bsky.social @maynoothuniversity.ie
Reposted by Andy Hogan
This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...
www.nature.com/articles/s42...
The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism
This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
www.nature.com
July 28, 2025 at 3:02 PM
This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Andy Hogan
🦠 New research shows obesity disrupts dendritic cell responses to viruses by impairing cytokine production & metabolism - helping explain higher infection risk.
📖 Read the open-access study: https://bit.ly/40kBiiH
By @andrea-woodcock.bsky.social et al.
##Immunology
📖 Read the open-access study: https://bit.ly/40kBiiH
By @andrea-woodcock.bsky.social et al.
##Immunology
June 27, 2025 at 10:09 AM
🦠 New research shows obesity disrupts dendritic cell responses to viruses by impairing cytokine production & metabolism - helping explain higher infection risk.
📖 Read the open-access study: https://bit.ly/40kBiiH
By @andrea-woodcock.bsky.social et al.
##Immunology
📖 Read the open-access study: https://bit.ly/40kBiiH
By @andrea-woodcock.bsky.social et al.
##Immunology
Couple of months into our new social media experiment and we are blown away by the engagement - over 2.6 million views on TikTok alone and the daily feedback both online and in person has been so positive and supportive! A whole new way of spreading research based info
vm.tiktok.com/ZNdSrMT71/
vm.tiktok.com/ZNdSrMT71/
TikTok - Make Your Day
vm.tiktok.com
June 5, 2025 at 8:36 PM
Couple of months into our new social media experiment and we are blown away by the engagement - over 2.6 million views on TikTok alone and the daily feedback both online and in person has been so positive and supportive! A whole new way of spreading research based info
vm.tiktok.com/ZNdSrMT71/
vm.tiktok.com/ZNdSrMT71/
Our lab @obesityimmunology.bsky.social is looking to support a stellar scientist in their application to the Marie-Sklodowska-Curie European or Global Fellowship to join us to unravel the impact of obesity on the immune system - DM or email andrew.e.hogan@mu.ie for details europa.eu/!B8hjh3
Choose Europe: advance your research career in the EU
Move to the EU as a researcher or scientist. Discover how to relocate, find jobs and funding, and enjoy Europe's excellent quality of life.
europa.eu
May 20, 2025 at 7:58 PM
Our lab @obesityimmunology.bsky.social is looking to support a stellar scientist in their application to the Marie-Sklodowska-Curie European or Global Fellowship to join us to unravel the impact of obesity on the immune system - DM or email andrew.e.hogan@mu.ie for details europa.eu/!B8hjh3
En route home from @kingscollegelondon.bsky.social after 2 days of fantastic science chats! Huge thanks to @peruchalab.bsky.social for the invite and hospitality. Hopefully lots of new collaborations
March 26, 2025 at 4:43 PM
En route home from @kingscollegelondon.bsky.social after 2 days of fantastic science chats! Huge thanks to @peruchalab.bsky.social for the invite and hospitality. Hopefully lots of new collaborations
Reposted by Andy Hogan
Obesity is associated with increased susceptibility to infection, which may be due to obesity-induced immune dysregulation. The latest article exchange highlight from @discovimmunol.bsky.social looks at dendritic cell responses to Sendai Virus in a mouse model of diet-induced obesity.
February 20, 2025 at 6:14 AM
Obesity is associated with increased susceptibility to infection, which may be due to obesity-induced immune dysregulation. The latest article exchange highlight from @discovimmunol.bsky.social looks at dendritic cell responses to Sendai Virus in a mouse model of diet-induced obesity.
Reposted by Andy Hogan
More evidence for GLP-1 medications in limiting rates of cancer. "The findings of this cohort study suggest that GLP-1RAs are associated with reduced risk of developing several hematologic cancers in patients with T2D"
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Hematologic Cancers Among Patients With Type 2 Diabetes Prescribed GLP-1RAs
This cohort study compares the risks of developing different hematologic cancers in patients with type 2 diabetes treated with glucagon-like peptide–1 receptor agonists (GLP-1RAs) compared with metfor...
jamanetwork.com
March 6, 2025 at 8:00 PM
More evidence for GLP-1 medications in limiting rates of cancer. "The findings of this cohort study suggest that GLP-1RAs are associated with reduced risk of developing several hematologic cancers in patients with T2D"
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
At the Irish Coalition for People living with Obesity's (ICPO) book launch - a child friendly non-stigmatizing introduction to what is Obesity - great initiative
March 3, 2025 at 7:45 PM
At the Irish Coalition for People living with Obesity's (ICPO) book launch - a child friendly non-stigmatizing introduction to what is Obesity - great initiative
Reposted by Andy Hogan
For my immunology followers, the cantrell lab is on bluesky. Applied proteomics, immunometabolism, T cells, protein degradation, signalling what more could you ask for?
Give them a follow: @cantrell-lab.bsky.social
Give them a follow: @cantrell-lab.bsky.social
March 2, 2025 at 7:29 PM
For my immunology followers, the cantrell lab is on bluesky. Applied proteomics, immunometabolism, T cells, protein degradation, signalling what more could you ask for?
Give them a follow: @cantrell-lab.bsky.social
Give them a follow: @cantrell-lab.bsky.social
Very latest work from @lindavsinclair.bsky.social out today in Nature Immunology www.nature.com/articles/s41...
Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology
Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...
www.nature.com
February 27, 2025 at 4:46 PM
Very latest work from @lindavsinclair.bsky.social out today in Nature Immunology www.nature.com/articles/s41...
Reposted by Andy Hogan
Changes in body composition following tirzepatide treatment in a substudy of participants from the SURMOUNT-1 trial; the change in body weight, fat mass and lean mass from baseline to Week 72 was −21.3%, −33.9% and −10.9%, consistent across subgroups dom-pubs.onlinelibrary.wiley.com/doi/full/10....
February 25, 2025 at 8:48 PM
Changes in body composition following tirzepatide treatment in a substudy of participants from the SURMOUNT-1 trial; the change in body weight, fat mass and lean mass from baseline to Week 72 was −21.3%, −33.9% and −10.9%, consistent across subgroups dom-pubs.onlinelibrary.wiley.com/doi/full/10....
🚨 new paper alert!!
Congrats to Andrea Woodcock on delivering this from during the depths of the pandemic! Thanks to @mary-canavan.bsky.social for the collab. Obesity drives dysregulation in DC responses to viral infection
academic.oup.com/discovimmuno...
Congrats to Andrea Woodcock on delivering this from during the depths of the pandemic! Thanks to @mary-canavan.bsky.social for the collab. Obesity drives dysregulation in DC responses to viral infection
academic.oup.com/discovimmuno...
Obesity drives dysregulation in DC responses to viral infection
AbstractIntroduction. Obesity is a worldwide epidemic, with over 1 billion people worldwide living with obesity. It is associated with an increased risk of
academic.oup.com
February 7, 2025 at 8:58 PM
🚨 new paper alert!!
Congrats to Andrea Woodcock on delivering this from during the depths of the pandemic! Thanks to @mary-canavan.bsky.social for the collab. Obesity drives dysregulation in DC responses to viral infection
academic.oup.com/discovimmuno...
Congrats to Andrea Woodcock on delivering this from during the depths of the pandemic! Thanks to @mary-canavan.bsky.social for the collab. Obesity drives dysregulation in DC responses to viral infection
academic.oup.com/discovimmuno...
Great new paper from Sandberg group @ki.se in @pnas.org showing IL-10 producing MAIT cells - a population negatively regulated by IL-18
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
February 4, 2025 at 8:43 PM
Great new paper from Sandberg group @ki.se in @pnas.org showing IL-10 producing MAIT cells - a population negatively regulated by IL-18
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Brilliant presentation from @ArdenaBeirsha from our lab today at #IGCT25 conference @maynoothuni.bsky.social
January 31, 2025 at 10:13 AM
Brilliant presentation from @ArdenaBeirsha from our lab today at #IGCT25 conference @maynoothuni.bsky.social
Reposted by Andy Hogan
Our second webinar hosted from USA, will be by Laurent Gapin and Antonia Rotolo.
Thursday, February 6th at 16:00 GMT (8:00 Pacific, 11:00 Eastern, 1:00 Friday Tokyo)
If you haven't join, get updates and link here: www.cd1mr1.com/cd1-mr1-soci...
Thursday, February 6th at 16:00 GMT (8:00 Pacific, 11:00 Eastern, 1:00 Friday Tokyo)
If you haven't join, get updates and link here: www.cd1mr1.com/cd1-mr1-soci...
January 26, 2025 at 4:15 PM
Our second webinar hosted from USA, will be by Laurent Gapin and Antonia Rotolo.
Thursday, February 6th at 16:00 GMT (8:00 Pacific, 11:00 Eastern, 1:00 Friday Tokyo)
If you haven't join, get updates and link here: www.cd1mr1.com/cd1-mr1-soci...
Thursday, February 6th at 16:00 GMT (8:00 Pacific, 11:00 Eastern, 1:00 Friday Tokyo)
If you haven't join, get updates and link here: www.cd1mr1.com/cd1-mr1-soci...
Reposted by Andy Hogan
New arrivals from X so thought we'd share our most recent paper where we show GLP-1 analogue therapy in people with obesity increases metabolic activity but only in those who loose weight - adding increased energy burn to increased satiety as a mechanism of action
doi.org/10.1002/oby....
doi.org/10.1002/oby....
January 23, 2025 at 2:53 PM
New arrivals from X so thought we'd share our most recent paper where we show GLP-1 analogue therapy in people with obesity increases metabolic activity but only in those who loose weight - adding increased energy burn to increased satiety as a mechanism of action
doi.org/10.1002/oby....
doi.org/10.1002/oby....
Delighted to say I have been promoted to Professor - huge thanks to all my lab members present and past - its their hard work and talent that made this happen
January 11, 2025 at 7:03 PM
Delighted to say I have been promoted to Professor - huge thanks to all my lab members present and past - its their hard work and talent that made this happen