Qandeel Soomro
@qandeelsoomro.bsky.social
Assistant Professor, Nephrologist at NYU
Research interest: CVD, Autonomic dysfunction in CKD/ESKD. JAE at JASN. Opinions are mine. #Nephsky
Research interest: CVD, Autonomic dysfunction in CKD/ESKD. JAE at JASN. Opinions are mine. #Nephsky
A lot of funny opinions about the fish oil RCT. People have spent their entire careers trying to understand the complex pathophysiology of high cardiovascular mortality in those with CKD. Here all we were waiting for is fish oil!
The editorial of this paper is kind of funny. They don't recommend use given "outsized results of early trials have failed to be replicated". Given the effect size is ginormous, the likelihood that any meta-analysis would not show that this is beneficial is very small.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis | NEJM
Cardiovascular disease is the leading cause of death in patients receiving hemodialysis,
yet effective preventive therapies remain limited. Supplementation with n−3 polyunsaturated
fatty acids, esp...
www.nejm.org
November 12, 2025 at 3:10 PM
A lot of funny opinions about the fish oil RCT. People have spent their entire careers trying to understand the complex pathophysiology of high cardiovascular mortality in those with CKD. Here all we were waiting for is fish oil!
Reposted by Qandeel Soomro
No no no begs every archivist. You are never going to be able to find anything. Please don’t start using emojis in file names. Who asked for this? What fresh hell is next?
November 12, 2025 at 10:38 AM
No no no begs every archivist. You are never going to be able to find anything. Please don’t start using emojis in file names. Who asked for this? What fresh hell is next?
“Pause before accepting such remarkable results as gospel” hmm probably good advice from my mentor
Editorial: Fish Oil for Patients Receiving Hemodialysis — Red Herring or Great Catch? nej.md/49zWAOM
November 7, 2025 at 9:03 PM
“Pause before accepting such remarkable results as gospel” hmm probably good advice from my mentor
Reposted by Qandeel Soomro
Just a call out to smart women helping the entire world.
This is Lotte Bjerre Knudsen.
She invented liraglutide and co-invented semaglutide.
She is one of the biggest reasons we have effective anti obesity medications. And her sense of style for this talk is 🤌
This is Lotte Bjerre Knudsen.
She invented liraglutide and co-invented semaglutide.
She is one of the biggest reasons we have effective anti obesity medications. And her sense of style for this talk is 🤌
November 5, 2025 at 2:23 PM
Just a call out to smart women helping the entire world.
This is Lotte Bjerre Knudsen.
She invented liraglutide and co-invented semaglutide.
She is one of the biggest reasons we have effective anti obesity medications. And her sense of style for this talk is 🤌
This is Lotte Bjerre Knudsen.
She invented liraglutide and co-invented semaglutide.
She is one of the biggest reasons we have effective anti obesity medications. And her sense of style for this talk is 🤌
Reposted by Qandeel Soomro
(1/3) Paying close attention to morphologic detail can sometimes suggest etiologic clues in cases of severe chronic renal injury. The glomerulus in this image, for example, shows near complete global glomerulosclerosis.
#TeachingPoints #kidneypath #nephsky #pathsky #renal
#TeachingPoints #kidneypath #nephsky #pathsky #renal
October 28, 2025 at 1:02 PM
(1/3) Paying close attention to morphologic detail can sometimes suggest etiologic clues in cases of severe chronic renal injury. The glomerulus in this image, for example, shows near complete global glomerulosclerosis.
#TeachingPoints #kidneypath #nephsky #pathsky #renal
#TeachingPoints #kidneypath #nephsky #pathsky #renal
Reposted by Qandeel Soomro
It has been 2 years since Rajnish Mehrotra stepped up to become the inaugural senior editor-in-chief of the ASN Publications portfolio. Read the interview with #ASNKidneyNews here to learn more about the portfolio structure and what's next here: kidney.pub/KN1710-17
@rajmehrotra.bsky.social
@rajmehrotra.bsky.social
October 28, 2025 at 3:00 PM
It has been 2 years since Rajnish Mehrotra stepped up to become the inaugural senior editor-in-chief of the ASN Publications portfolio. Read the interview with #ASNKidneyNews here to learn more about the portfolio structure and what's next here: kidney.pub/KN1710-17
@rajmehrotra.bsky.social
@rajmehrotra.bsky.social
Reposted by Qandeel Soomro
How about instead:
October 28, 2025 at 11:33 AM
How about instead:
Reposted by Qandeel Soomro
If people knew how many medical guidelines are based on change scores getting predicted from baseline severity, everyone would be really scared
October 27, 2025 at 12:48 PM
If people knew how many medical guidelines are based on change scores getting predicted from baseline severity, everyone would be really scared
Reposted by Qandeel Soomro
This paper’s been popping as “evidence” that you can’t do real #causalinference w/ obs data. To me it shows you need rigorous pre-specified design (in addition to the willingness to fold when your hypothesis is not possible to answer with the data at hand). #EpiSky, #CausalSky, #AcademicSky
October 22, 2025 at 2:59 PM
This paper’s been popping as “evidence” that you can’t do real #causalinference w/ obs data. To me it shows you need rigorous pre-specified design (in addition to the willingness to fold when your hypothesis is not possible to answer with the data at hand). #EpiSky, #CausalSky, #AcademicSky
Reposted by Qandeel Soomro
One of the adaptive designs we are seeing more frequently is the Sequential Multiple Assignment Randomised Trial (or SMART trial) 1/7
#MethodologyMonday #126
#MethodologyMonday #126
October 20, 2025 at 6:39 AM
One of the adaptive designs we are seeing more frequently is the Sequential Multiple Assignment Randomised Trial (or SMART trial) 1/7
#MethodologyMonday #126
#MethodologyMonday #126
Reposted by Qandeel Soomro
The opening plenary at #KidneyWk looks phenomenal
Renal RCT Renaissance is upon us
(LBCT list drops tomorrow)
www.asn-online.org/education/ki...
Renal RCT Renaissance is upon us
(LBCT list drops tomorrow)
www.asn-online.org/education/ki...
October 16, 2025 at 1:10 PM
The opening plenary at #KidneyWk looks phenomenal
Renal RCT Renaissance is upon us
(LBCT list drops tomorrow)
www.asn-online.org/education/ki...
Renal RCT Renaissance is upon us
(LBCT list drops tomorrow)
www.asn-online.org/education/ki...
Reposted by Qandeel Soomro
I read and write, I explore and I question, I design and script and analyse, I interpret and communicate. I do this to train my mind in the hopes of one day generating new knowledge. New knowledge that might even be useful, and that no algorithm can yet be trained on.
Y'all. I just got ChatGPT to do everything in R for this manuscript. I mean EVERYTHING. And it's all legit and reproducible. I'm shook.
How are we mentoring our trainees in statistics now? Who needs to learn coding in R line by line, and who doesn't?
scienceforeveryone.science/statistics-i...
How are we mentoring our trainees in statistics now? Who needs to learn coding in R line by line, and who doesn't?
scienceforeveryone.science/statistics-i...
Statistics in the era of AI
How do we mentor, teach, and do stats when AI can do so much of the work?
scienceforeveryone.science
October 12, 2025 at 8:07 AM
I read and write, I explore and I question, I design and script and analyse, I interpret and communicate. I do this to train my mind in the hopes of one day generating new knowledge. New knowledge that might even be useful, and that no algorithm can yet be trained on.
Reposted by Qandeel Soomro
This is a nice paper. It faces down a common problem: in order to explain to why a common approach cannot work even in theory, we first need to teach a framework in which regression is not magic that tells us which variables on right cause the variable on left. It's exhausting.
Anyway great paper!
Anyway great paper!
October 7, 2025 at 11:38 AM
This is a nice paper. It faces down a common problem: in order to explain to why a common approach cannot work even in theory, we first need to teach a framework in which regression is not magic that tells us which variables on right cause the variable on left. It's exhausting.
Anyway great paper!
Anyway great paper!
Reposted by Qandeel Soomro
"Uncooperative statistician": the term used (typically by a senior clinician) to describe a well-trained and knowledgeable statistician who refuses to conduct flawed or fraudulent research.
October 3, 2025 at 12:59 PM
"Uncooperative statistician": the term used (typically by a senior clinician) to describe a well-trained and knowledgeable statistician who refuses to conduct flawed or fraudulent research.
Reposted by Qandeel Soomro
What worries me? Statements like "searching for biological causes is bound to be unproductive" and studying exposures "diverts funding from more important issues."
That's a false dichotomy! We can tackle overdiagnosis AND investigate why more young people are getting cancer. 10/
That's a false dichotomy! We can tackle overdiagnosis AND investigate why more young people are getting cancer. 10/
October 1, 2025 at 10:16 PM
What worries me? Statements like "searching for biological causes is bound to be unproductive" and studying exposures "diverts funding from more important issues."
That's a false dichotomy! We can tackle overdiagnosis AND investigate why more young people are getting cancer. 10/
That's a false dichotomy! We can tackle overdiagnosis AND investigate why more young people are getting cancer. 10/
Reposted by Qandeel Soomro
Researcher: "I've been funded to study how <bollocks variable>* is a risk factor for <bollocks variable>* in cross sectional data"
(*bonus points if these are different versions of the same damn variable!)
Me: "Can you give the money back?"
(*bonus points if these are different versions of the same damn variable!)
Me: "Can you give the money back?"
October 1, 2025 at 4:04 PM
Researcher: "I've been funded to study how <bollocks variable>* is a risk factor for <bollocks variable>* in cross sectional data"
(*bonus points if these are different versions of the same damn variable!)
Me: "Can you give the money back?"
(*bonus points if these are different versions of the same damn variable!)
Me: "Can you give the money back?"
Reposted by Qandeel Soomro
Science is grounded in observation. Measurement is a tool for observation. Measurements should be evaluated for validity and reliability/uncertainty. Scientists who use measurements without understanding their properties are not really scientists at all.
Can large language models stand in for human participants?
Many social scientists seem to think so, and are already using "silicon samples" in research.
One problem: depending on the analytic decisions made, you can basically get these samples to show any effect you want.
THREAD 🧵
Many social scientists seem to think so, and are already using "silicon samples" in research.
One problem: depending on the analytic decisions made, you can basically get these samples to show any effect you want.
THREAD 🧵
The threat of analytic flexibility in using large language models to simulate human data: A call to attention
Social scientists are now using large language models to create "silicon samples" - synthetic datasets intended to stand in for human respondents, aimed at revolutionising human subjects research. How...
arxiv.org
October 1, 2025 at 5:39 AM
Science is grounded in observation. Measurement is a tool for observation. Measurements should be evaluated for validity and reliability/uncertainty. Scientists who use measurements without understanding their properties are not really scientists at all.
Reposted by Qandeel Soomro
This year commemorates the 75th anniversary of the @NIDDKgov. Check out this review to celebrate the achievements and impact of the NIDDK in improving health and well-being of people living with kidney disease, simultaneously published across #ASNJASN #ASNCJASN #ASNKidney360
kidney.pub/JASN0898
kidney.pub/JASN0898
September 30, 2025 at 6:00 PM
This year commemorates the 75th anniversary of the @NIDDKgov. Check out this review to celebrate the achievements and impact of the NIDDK in improving health and well-being of people living with kidney disease, simultaneously published across #ASNJASN #ASNCJASN #ASNKidney360
kidney.pub/JASN0898
kidney.pub/JASN0898
Sure sure… who is going to teach the clinicians though. They “very much” don’t understand probabilities let alone odds ratios, ARR, RR, HR
Clinicians can enhance patient understanding by using numerical data instead of verbal probabilities, consistent denominators, absolute risk comparisons, and clear context for unfamiliar data types.
ja.ma/4pAC3zi
ja.ma/4pAC3zi
September 26, 2025 at 4:42 PM
Sure sure… who is going to teach the clinicians though. They “very much” don’t understand probabilities let alone odds ratios, ARR, RR, HR
Reposted by Qandeel Soomro
Randomized controlled trials are a key tool to study cause and effect. Why do they matter and how do they work?
September 24, 2025 at 2:15 PM
Randomized controlled trials are a key tool to study cause and effect. Why do they matter and how do they work?
Reposted by Qandeel Soomro
Whoa—my book is up for pre-order!
𝐌𝐨𝐝𝐞𝐥 𝐭𝐨 𝐌𝐞𝐚𝐧𝐢𝐧𝐠: 𝐇𝐨𝐰 𝐭𝐨 𝐈𝐧𝐭𝐞𝐫𝐩𝐫𝐞𝐭 𝐒𝐭𝐚𝐭 & 𝐌𝐋 𝐌𝐨𝐝𝐞𝐥𝐬 𝐢𝐧 #Rstats 𝐚𝐧𝐝 #PyData
The book presents an ultra-simple and powerful workflow to make sense of ± any model you fit
The web version will stay free forever and my proceeds go to charity.
tinyurl.com/4fk56fc8
𝐌𝐨𝐝𝐞𝐥 𝐭𝐨 𝐌𝐞𝐚𝐧𝐢𝐧𝐠: 𝐇𝐨𝐰 𝐭𝐨 𝐈𝐧𝐭𝐞𝐫𝐩𝐫𝐞𝐭 𝐒𝐭𝐚𝐭 & 𝐌𝐋 𝐌𝐨𝐝𝐞𝐥𝐬 𝐢𝐧 #Rstats 𝐚𝐧𝐝 #PyData
The book presents an ultra-simple and powerful workflow to make sense of ± any model you fit
The web version will stay free forever and my proceeds go to charity.
tinyurl.com/4fk56fc8
September 17, 2025 at 7:49 PM
Whoa—my book is up for pre-order!
𝐌𝐨𝐝𝐞𝐥 𝐭𝐨 𝐌𝐞𝐚𝐧𝐢𝐧𝐠: 𝐇𝐨𝐰 𝐭𝐨 𝐈𝐧𝐭𝐞𝐫𝐩𝐫𝐞𝐭 𝐒𝐭𝐚𝐭 & 𝐌𝐋 𝐌𝐨𝐝𝐞𝐥𝐬 𝐢𝐧 #Rstats 𝐚𝐧𝐝 #PyData
The book presents an ultra-simple and powerful workflow to make sense of ± any model you fit
The web version will stay free forever and my proceeds go to charity.
tinyurl.com/4fk56fc8
𝐌𝐨𝐝𝐞𝐥 𝐭𝐨 𝐌𝐞𝐚𝐧𝐢𝐧𝐠: 𝐇𝐨𝐰 𝐭𝐨 𝐈𝐧𝐭𝐞𝐫𝐩𝐫𝐞𝐭 𝐒𝐭𝐚𝐭 & 𝐌𝐋 𝐌𝐨𝐝𝐞𝐥𝐬 𝐢𝐧 #Rstats 𝐚𝐧𝐝 #PyData
The book presents an ultra-simple and powerful workflow to make sense of ± any model you fit
The web version will stay free forever and my proceeds go to charity.
tinyurl.com/4fk56fc8
Reposted by Qandeel Soomro
Peer review is vital to publishing high-quality, valid research. JASN wants to recognize the top reviewers of 2025: Drs. Dennis Brown, Ladan Golestaneh, Monica Suet Ying Ng, Navdeep Tangri, and Nicola M. Thomas. Over the next few weeks, we'll share their thoughts on peer review. #PeerReviewWeek
September 15, 2025 at 3:00 PM
Peer review is vital to publishing high-quality, valid research. JASN wants to recognize the top reviewers of 2025: Drs. Dennis Brown, Ladan Golestaneh, Monica Suet Ying Ng, Navdeep Tangri, and Nicola M. Thomas. Over the next few weeks, we'll share their thoughts on peer review. #PeerReviewWeek
Reposted by Qandeel Soomro
So I decided to take the histamine / #SARSCOV2 / #COVID19 literature for a ride after the astelazine nasal spray randomized trial that showed that application of the spray for 3 times a day may cut the risk of COVID19 PCR confirmed infection by 71%
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
September 8, 2025 at 4:56 AM
So I decided to take the histamine / #SARSCOV2 / #COVID19 literature for a ride after the astelazine nasal spray randomized trial that showed that application of the spray for 3 times a day may cut the risk of COVID19 PCR confirmed infection by 71%
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Most overused word heard on rounds around the hospital- “trend”. Physicians love it and is an excuse to bypass all thinking and decision making for the day moving along folks…on to the next trend I mean patient
The serum creatinine level is a concentration, amount per volume.
If you quickly expand plasma volume by 20%, the Cr will decrease by ~20%, saying nothing of GFR.
Same goes for ALT, WBC, CRP, and other values that we trend and sometimes overinterpret small fluctuations of.
If you quickly expand plasma volume by 20%, the Cr will decrease by ~20%, saying nothing of GFR.
Same goes for ALT, WBC, CRP, and other values that we trend and sometimes overinterpret small fluctuations of.
September 7, 2025 at 6:01 PM
Most overused word heard on rounds around the hospital- “trend”. Physicians love it and is an excuse to bypass all thinking and decision making for the day moving along folks…on to the next trend I mean patient