Poppy Zenzi Grimes
@pzg.bsky.social
Final yr PhD @ UoEdinburgh; Genetic epidemiology ~ adolescent depression. Trajectories📈genomics🧬networks🕸️dynamic systems🌀
Almost there... It's a bad day to be a supplementary table. 360 pages 😮💨 #PhAlmostDone
November 27, 2025 at 12:32 PM
Almost there... It's a bad day to be a supplementary table. 360 pages 😮💨 #PhAlmostDone
Reposted by Poppy Zenzi Grimes
@hakha.bsky.social and I wrote a Research Briefing (with a lay summary + "behind the scenes") of our paper on how genes are prioritized by GWAS and rare variant burden tests. 🧬🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
How do genetic association studies rank genes?
Genome-wide association studies and rare-variant burden tests reveal complementary aspects of trait biology.
www.nature.com
November 19, 2025 at 6:43 PM
@hakha.bsky.social and I wrote a Research Briefing (with a lay summary + "behind the scenes") of our paper on how genes are prioritized by GWAS and rare variant burden tests. 🧬🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Poppy Zenzi Grimes
Brilliant paper by Visscher et al.
Populations differ in traits/disease burden. Are these differences due to genetics?
Comparing single variants or polygenic scores between populations is biased due to environmental confounders correlated with the variants.
1/3
www.medrxiv.org/content/10.1...
Populations differ in traits/disease burden. Are these differences due to genetics?
Comparing single variants or polygenic scores between populations is biased due to environmental confounders correlated with the variants.
1/3
www.medrxiv.org/content/10.1...
Direct effect of genetic ancestry on complex traits in a Mexican population
Human populations differ in disease prevalences and in average values of phenotypes, but the extent to which differences are caused by genetic or environmental factors is unknown for most complex trai...
www.medrxiv.org
September 11, 2025 at 5:57 AM
Brilliant paper by Visscher et al.
Populations differ in traits/disease burden. Are these differences due to genetics?
Comparing single variants or polygenic scores between populations is biased due to environmental confounders correlated with the variants.
1/3
www.medrxiv.org/content/10.1...
Populations differ in traits/disease burden. Are these differences due to genetics?
Comparing single variants or polygenic scores between populations is biased due to environmental confounders correlated with the variants.
1/3
www.medrxiv.org/content/10.1...
Reposted by Poppy Zenzi Grimes
A few thoughts on Herasight, the new embryo selection company. First, their whitepaper (drive.google.com/file/d/1EpFi...) implies that competitors like Nucleus have been marketing and selling grossly erroneous risk estimates. This is shocking if true! 🧵
August 2, 2025 at 2:38 PM
A few thoughts on Herasight, the new embryo selection company. First, their whitepaper (drive.google.com/file/d/1EpFi...) implies that competitors like Nucleus have been marketing and selling grossly erroneous risk estimates. This is shocking if true! 🧵
Reposted by Poppy Zenzi Grimes
What's going on in psychiatric genetics? The @pgcgenetics.bsky.social have now published our latest progress review in @thelancetpsych.bsky.social, highlighting discovery, and laying out a map for moving forwards!
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
The Psychiatric Genomics Consortium: discoveries and directions
Research by the Psychiatric Genomics Consortium (PGC) has advanced the discovery of
common and rare genetic variations that contribute to the susceptibility to many psychiatric
disorders and neurodeve...
www.thelancet.com
June 27, 2025 at 10:52 AM
What's going on in psychiatric genetics? The @pgcgenetics.bsky.social have now published our latest progress review in @thelancetpsych.bsky.social, highlighting discovery, and laying out a map for moving forwards!
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Poppy Zenzi Grimes
You don’t need more ideas.
You need a better question.
A thread on clarity, chaos, & what a Nobel Prize winner, a mosquito net & a PhD meltdown taught me about writing (+ thinking) better.
🪨 Here’s my new Respect the Marble post: catherineeunicedevries.substack.com/p/you-dont-n...
🧵
You need a better question.
A thread on clarity, chaos, & what a Nobel Prize winner, a mosquito net & a PhD meltdown taught me about writing (+ thinking) better.
🪨 Here’s my new Respect the Marble post: catherineeunicedevries.substack.com/p/you-dont-n...
🧵
You Don’t Need More Ideas. You Need a Better Question
What Michelangelo, a Nobel Laureate, and a PhD Meltdown Taught Me about Research Questions
catherineeunicedevries.substack.com
June 4, 2025 at 7:54 AM
You don’t need more ideas.
You need a better question.
A thread on clarity, chaos, & what a Nobel Prize winner, a mosquito net & a PhD meltdown taught me about writing (+ thinking) better.
🪨 Here’s my new Respect the Marble post: catherineeunicedevries.substack.com/p/you-dont-n...
🧵
You need a better question.
A thread on clarity, chaos, & what a Nobel Prize winner, a mosquito net & a PhD meltdown taught me about writing (+ thinking) better.
🪨 Here’s my new Respect the Marble post: catherineeunicedevries.substack.com/p/you-dont-n...
🧵
Excited to share that the second paper from my PhD has just been published in @NatMentHealth!🧠🧵
We modelled depression symptom networks in >35k teenagers to derive their 'network temperature' and found evidence symptom stabilisation across adolescence...
www.nature.com/articles/s44...
We modelled depression symptom networks in >35k teenagers to derive their 'network temperature' and found evidence symptom stabilisation across adolescence...
www.nature.com/articles/s44...
Network temperature as a metric of stability in depression symptoms across adolescence - Nature Mental Health
This study explores the dynamics of adolescent depression through the lens of network temperature, a novel concept in psychological symptom networks. Researchers observed a decrease in network tempera...
www.nature.com
April 29, 2025 at 2:36 PM
Excited to share that the second paper from my PhD has just been published in @NatMentHealth!🧠🧵
We modelled depression symptom networks in >35k teenagers to derive their 'network temperature' and found evidence symptom stabilisation across adolescence...
www.nature.com/articles/s44...
We modelled depression symptom networks in >35k teenagers to derive their 'network temperature' and found evidence symptom stabilisation across adolescence...
www.nature.com/articles/s44...
Reposted by Poppy Zenzi Grimes
Dissertation by Dr Rachel Los not only includes acknowledgements, but also .. anti-acknowledgements.
delta.tudelft.nl/en/article/a...
delta.tudelft.nl/en/article/a...
March 13, 2025 at 3:45 PM
Dissertation by Dr Rachel Los not only includes acknowledgements, but also .. anti-acknowledgements.
delta.tudelft.nl/en/article/a...
delta.tudelft.nl/en/article/a...
Reposted by Poppy Zenzi Grimes
You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Genomic network analysis characterizes genetic architecture and identifies trait-specific biology
Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...
www.medrxiv.org
December 6, 2024 at 3:56 PM
You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Poppy Zenzi Grimes
New large study (n ~ 6 million) in @JAMApsych tracking mental disorder trends in Denmark showing increases in mood disorders in recent birth cohorts tinyurl.com/c5nyfd8k
November 27, 2024 at 9:08 PM
New large study (n ~ 6 million) in @JAMApsych tracking mental disorder trends in Denmark showing increases in mood disorders in recent birth cohorts tinyurl.com/c5nyfd8k
Reposted by Poppy Zenzi Grimes
The terrific @pgcgenetics.bsky.social Major Depressive Disorder Working Group in Singapore
October 23, 2024 at 1:20 PM
The terrific @pgcgenetics.bsky.social Major Depressive Disorder Working Group in Singapore
Hello from Singapore #wcpg2024!🌏 I am presenting an update on the current results of the *Adolescent-Onset Depression GWAS* on Friday at 3pm in the symposium on Genomics and Life Course Data. Come and watch!
October 17, 2024 at 7:16 AM
Hello from Singapore #wcpg2024!🌏 I am presenting an update on the current results of the *Adolescent-Onset Depression GWAS* on Friday at 3pm in the symposium on Genomics and Life Course Data. Come and watch!
I’m presenting three different projects at these upcoming conferences over the next month! Looking forward to meeting fellow MH researchers 🌏
· World Congress of Psychiatric Genetics 🇸🇬
· International Congress of Neuropsychiatry 🇦🇺
· Society for Mental Health Research Conference 🇦🇺
· World Congress of Psychiatric Genetics 🇸🇬
· International Congress of Neuropsychiatry 🇦🇺
· Society for Mental Health Research Conference 🇦🇺
October 9, 2024 at 9:43 AM
I’m presenting three different projects at these upcoming conferences over the next month! Looking forward to meeting fellow MH researchers 🌏
· World Congress of Psychiatric Genetics 🇸🇬
· International Congress of Neuropsychiatry 🇦🇺
· Society for Mental Health Research Conference 🇦🇺
· World Congress of Psychiatric Genetics 🇸🇬
· International Congress of Neuropsychiatry 🇦🇺
· Society for Mental Health Research Conference 🇦🇺
🚨🌡️New pre-print on PsyArXiv!
We conceptualise and investigate *network temperature* as a measure of longitudinal stability in depression symptom networks across adolescence.
[Replication in 3 cohorts with >35k adolescents!]
osf.io/preprints/ps...
We conceptualise and investigate *network temperature* as a measure of longitudinal stability in depression symptom networks across adolescence.
[Replication in 3 cohorts with >35k adolescents!]
osf.io/preprints/ps...
August 2, 2024 at 8:32 AM
🚨🌡️New pre-print on PsyArXiv!
We conceptualise and investigate *network temperature* as a measure of longitudinal stability in depression symptom networks across adolescence.
[Replication in 3 cohorts with >35k adolescents!]
osf.io/preprints/ps...
We conceptualise and investigate *network temperature* as a measure of longitudinal stability in depression symptom networks across adolescence.
[Replication in 3 cohorts with >35k adolescents!]
osf.io/preprints/ps...
Reposted by Poppy Zenzi Grimes
Network Temperature as a Metric of Stability in Depression Symptoms Across Adolescence: http://osf.io/9zmge/
August 1, 2024 at 10:32 AM
Network Temperature as a Metric of Stability in Depression Symptoms Across Adolescence: http://osf.io/9zmge/
Reposted by Poppy Zenzi Grimes
This is the recording of my June 2024 keynote at the DPK congress, entitled "Embracing complexity: studying mental health problems as systems, not syndromes".
They made a nice recording & allowed me to share it.
Thanks a ton, DPK organizers 🖤.
🧪 #stats #psychscisky
www.youtube.com/watch?v=B1cR...
They made a nice recording & allowed me to share it.
Thanks a ton, DPK organizers 🖤.
🧪 #stats #psychscisky
www.youtube.com/watch?v=B1cR...
Studying mental health problems as systems, not syndromes
This is a keynote I gave at the DPK congress in Berlin 2024, a large conference primarily attended by psychotherapists. I want to thank them—and especially T...
www.youtube.com
July 11, 2024 at 9:30 AM
This is the recording of my June 2024 keynote at the DPK congress, entitled "Embracing complexity: studying mental health problems as systems, not syndromes".
They made a nice recording & allowed me to share it.
Thanks a ton, DPK organizers 🖤.
🧪 #stats #psychscisky
www.youtube.com/watch?v=B1cR...
They made a nice recording & allowed me to share it.
Thanks a ton, DPK organizers 🖤.
🧪 #stats #psychscisky
www.youtube.com/watch?v=B1cR...
Missing data, longitudinal binary symptoms for multi-group Ising model estimation. HELP!!!! Impute? If so, how to pool estimates? Don't think it's right to avg. over networks? Use maximum likelihood estimator instead? 😵💫
May 22, 2024 at 3:59 PM
Missing data, longitudinal binary symptoms for multi-group Ising model estimation. HELP!!!! Impute? If so, how to pool estimates? Don't think it's right to avg. over networks? Use maximum likelihood estimator instead? 😵💫
I am delighted to announce my first first-author paper has just been published in
@JAMAPsych! 🥳🧬📈 ‘Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts’. Link to paper: ja.ma/4bkGsPj and a 🧵 of our key findings below…
@JAMAPsych! 🥳🧬📈 ‘Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts’. Link to paper: ja.ma/4bkGsPj and a 🧵 of our key findings below…
May 17, 2024 at 10:23 AM
I am delighted to announce my first first-author paper has just been published in
@JAMAPsych! 🥳🧬📈 ‘Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts’. Link to paper: ja.ma/4bkGsPj and a 🧵 of our key findings below…
@JAMAPsych! 🥳🧬📈 ‘Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts’. Link to paper: ja.ma/4bkGsPj and a 🧵 of our key findings below…
Reposted by Poppy Zenzi Grimes
Great job students and faculty of the International Statistical Genetics Workshop 2024 in Boulder, what an amazing week it was, as always 🧬❤️🍻
Next year it's GWAS and sequence data analysis again, see you then: colorado.edu/ibg/workshop
Next year it's GWAS and sequence data analysis again, see you then: colorado.edu/ibg/workshop
March 10, 2024 at 2:17 AM
Great job students and faculty of the International Statistical Genetics Workshop 2024 in Boulder, what an amazing week it was, as always 🧬❤️🍻
Next year it's GWAS and sequence data analysis again, see you then: colorado.edu/ibg/workshop
Next year it's GWAS and sequence data analysis again, see you then: colorado.edu/ibg/workshop