Almost there... It's a bad day to be a supplementary table. 360 pages 😮‍💨 #PhAlmostDone

In 3 large longitudinal adolescent cohorts (@CO90s, @theabcdstudy MCS @CLScohorts) we found that temperature decreased across adolescence, meaning symptoms became more aligned and stable with age 📉🧊 ...

We applied this to depression symptoms:

In a high temperature network, symptoms are less stable and fluctuate 🔥
In a low temperature network, symptoms are stable and harder to shift 🧊 ...

A fantastic week at #WCPG2024 in Singapore! Grateful to work and travel with many wonderful people 🔬🦀🇸🇬

Hello from Singapore #wcpg2024!🌏 I am presenting an update on the current results of the *Adolescent-Onset Depression GWAS* on Friday at 3pm in the symposium on Genomics and Life Course Data. Come and watch!

🚨🌡️New pre-print on PsyArXiv!
We conceptualise and investigate *network temperature* as a measure of longitudinal stability in depression symptom networks across adolescence.

[Replication in 3 cohorts with >35k adolescents!]
osf.io/preprints/ps...

Lastly, we leveraged data from multiancestry depression GWAS to test MDD-PRS association with trajectories in the diverse #ABCDstudy. Weak evidence underscores the need for better-powered GWAS in non-European ancestries AND well-phenotyped cohort data from across the globe...

We then computed PRS and looked at single trait PRS associations, followed by multivariate PRSs of each model factor. We found remarkably consistent results across the cohorts with many PRS x trajectories replicating...

Second, we used multivariate genomic structural equation modelling (GSEM) to derive multitrait models of genetic psychopathology from 7 major and correlated conditions. The hierarchical factor model (c) provided the best fit of shared covariance...

First, we derived trajectories of depression symptoms using growth mixture modelling. We replicated 4 trajectories in both cohorts: persistent, increasing, decreasing and stable low. These trajectories were validated against common exposures and outcomes...

I am delighted to announce my first first-author paper has just been published in
@JAMAPsych! 🥳🧬📈 ‘Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts’. Link to paper: ja.ma/4bkGsPj and a 🧵 of our key findings below…