WASHINGTON—Praising the process as yet another miracle of biology that modern medicine chooses to ignore, a gray-lipped Robert F. Kennedy Jr. spoke at a press conference Wednesday during which he tout...

Regioisomeric control is presented as a precise strategy to resolve the energy-stability conflict in trifunctionalized 1,2,4-triazole energetic materials. By positioning a stabilizing amino group adjacent to a highly energetic trinitromethyl group, a new molecule, 1-trinitromethyl-3-nitro-5-amino-1,2,4-triazole (TN-ANTA), was designed and synthesized. Compared to its reported isomer, TN-ANTA exhibits a superior combination of high density (1.905 g/cm3 vs 1.878 g/cm3), enhanced thermal stability (Tdec = 128 °C vs 119 °C), and markedly improved impact sensitivity (7 J vs 1 J). Mechanistic studies reveal that this enhancement stems from a combination of more compact crystal packing, driven by stronger intermolecular interactions, and a higher bond dissociation energy of the weakest C-NO2 bond due to intramolecular stabilization. The superiority of this design principle was further validated as the energetic salts of TN-ANTA also consistently displayed higher densities and thermal stabilities than their corresponding isomers. This work establishes regioisomeric placement of functional groups as a powerful approach for the rational design of advanced energetic materials.