Patrick van der Wel
@pcavanderwel.bsky.social
Solid-state NMR, Zernike Institute, university of Groningen. Posts = personal. Spectroscopy, biochemistry, structural biology, amyloid &
condensates, Huntington disease, membrane biophysics, biomaterials etc
condensates, Huntington disease, membrane biophysics, biomaterials etc
Pinned
Probing photochemically-induced dynamic transitions by magic-angle-spinning NMR combined with in situ irradiation
Light is often the stimulus of choice for dynamically changing structure and function in materials and other contexts, including not only many smart materials and photovoltaics, but also biological an...
doi.org
Now officially published: our new paper “Probing photochemically-induced dynamic transitions by magic-angle-spinning NMR combined with in situ irradiation”. by Alessia Lasorsa and co-workers. In the Journal of Materials Chemistry A @jmaterchem.rsc.org doi.org/10.1039/D5TA...
Reposted by Patrick van der Wel
#compchem 🗳️ I'm making a series of exercices on “molecular simulation of materials”, focusing on classical atomistic methods. Other lecturers cover electronic structure and ab initio MD.
What would be good (simple) systems to study, nice properties to calculate, analysis methods to showcase?
What would be good (simple) systems to study, nice properties to calculate, analysis methods to showcase?
a woman in a suit says okay in front of a nbc sign
ALT: a woman in a suit says okay in front of a nbc sign
media.tenor.com
November 10, 2025 at 4:21 PM
#compchem 🗳️ I'm making a series of exercices on “molecular simulation of materials”, focusing on classical atomistic methods. Other lecturers cover electronic structure and ab initio MD.
What would be good (simple) systems to study, nice properties to calculate, analysis methods to showcase?
What would be good (simple) systems to study, nice properties to calculate, analysis methods to showcase?
Reposted by Patrick van der Wel
Dit zou de kern moeten zijn van de formatie van een 'post-Schoof coalitie'. Hoe Koolmees die in gang zet vanuit de inhoud in plaats vanuit blokkades? #BetrouwbareBronnen tekent de route. omny.fm/shows/betrou...
November 9, 2025 at 10:57 AM
Dit zou de kern moeten zijn van de formatie van een 'post-Schoof coalitie'. Hoe Koolmees die in gang zet vanuit de inhoud in plaats vanuit blokkades? #BetrouwbareBronnen tekent de route. omny.fm/shows/betrou...
Reposted by Patrick van der Wel
Zonder docenten geen universiteit. Maar we zijn ook nergens zonder mensen die de computersystemen draaiende houden, de prullenbakken legen en de inkoop regelen. Wie zijn die stille krachten achter de universiteit? Deel 9: AV-technicus Jasper Veldkamp. ukrant.nl/magazine/de-...
De stille kracht: het moderne onderwijs is nergens zonder Jasper Veldkamp
Wie zijn toch die stille krachten die de universiteit draaiende houden? Deel 9: AV-technicus Jasper Veldkamp.
ukrant.nl
November 5, 2025 at 8:04 AM
Zonder docenten geen universiteit. Maar we zijn ook nergens zonder mensen die de computersystemen draaiende houden, de prullenbakken legen en de inkoop regelen. Wie zijn die stille krachten achter de universiteit? Deel 9: AV-technicus Jasper Veldkamp. ukrant.nl/magazine/de-...
Later today! See the online seminar by Camilla Terenzi ( @w-u-r.bsky.social ) about “NMR and MRI in food science: a journey from lab to real-life conditions” as part of the Leipzig Spin Resonance Colloquium: www.physes.uni-leipzig.de/en/lsr-collo... #nmrchat #mri
Universität Leipzig: Leipzig Spin Resonance Colloquium
www.physes.uni-leipzig.de
November 5, 2025 at 8:25 AM
Later today! See the online seminar by Camilla Terenzi ( @w-u-r.bsky.social ) about “NMR and MRI in food science: a journey from lab to real-life conditions” as part of the Leipzig Spin Resonance Colloquium: www.physes.uni-leipzig.de/en/lsr-collo... #nmrchat #mri
An important investment that is important for the future of (integrative?) structural biology research in the Netherlands.
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 4, 2025 at 11:19 AM
An important investment that is important for the future of (integrative?) structural biology research in the Netherlands.
Reposted by Patrick van der Wel
Ik vind het wel fraai, die nieuwe dark mode op de borden op stations...
November 4, 2025 at 7:03 AM
Ik vind het wel fraai, die nieuwe dark mode op de borden op stations...
New article @hdbuzzfeed.bsky.social about AMT-130: “UniQure and FDA No Longer in Alignment on Approval Pathway for AMT-130” en.hdbuzz.net/uniqure-and-... #huntingtonsdisease #polyQ
UniQure and FDA No Longer in Alignment on Approval Pathway for AMT-130 – HDBuzz
en.hdbuzz.net
November 3, 2025 at 8:25 PM
New article @hdbuzzfeed.bsky.social about AMT-130: “UniQure and FDA No Longer in Alignment on Approval Pathway for AMT-130” en.hdbuzz.net/uniqure-and-... #huntingtonsdisease #polyQ
Reposted by Patrick van der Wel
Chaperone dependency during biogenesis does not correlate with chaperone dependency during refolding
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Chaperone dependency during biogenesis does not correlate with chaperone dependency during refolding | Molecular Systems Biology
imageimageStructural profiling of the E. coli proteome deficient in DnaKJ or trigger factor shows which proteins are chaperone-dependent
in vivo, a surprising temperature effect on DnaKJ dependency, a...
www.embopress.org
November 3, 2025 at 10:13 AM
Chaperone dependency during biogenesis does not correlate with chaperone dependency during refolding
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Patrick van der Wel
I've been getting back into the Hitchhiker's Guide to the Galaxy series after many years, and the most relatable part is how everyday objects like doors and elevators have been imbued with artificial intelligence and it just makes them obnoxious and frustrating to use and everyone hates it.
November 1, 2025 at 8:55 PM
I've been getting back into the Hitchhiker's Guide to the Galaxy series after many years, and the most relatable part is how everyday objects like doors and elevators have been imbued with artificial intelligence and it just makes them obnoxious and frustrating to use and everyone hates it.
Some more #running around #Groningen
November 2, 2025 at 3:48 PM
Some more #running around #Groningen
Reposted by Patrick van der Wel
Am looking for a cloud storage solution that is European / non-US - anyone experience with jottacloud? Other recommendations?
jottacloud.com/en/
jottacloud.com/en/
Jottacloud – Cloud storage made easy
Innovative and secure cloud storage for private and business use. Your files are stored on environmentally friendly servers, protected by Scandinavian privacy laws.
jottacloud.com
November 2, 2025 at 11:33 AM
Am looking for a cloud storage solution that is European / non-US - anyone experience with jottacloud? Other recommendations?
jottacloud.com/en/
jottacloud.com/en/
New review article “Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle” by Esmeralda Villavicencio Gonzalez and Huda Zoghbi in the Journal of Experimental Medicine: doi.org/10.1084/jem.... #polyQ #huntingtonsdisease #ataxia
Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle | Journal of Experimental Medicine | Rockefeller University Press
This comprehensive review by Villavicencio Gonzalez and Zoghbi integrates established and emerging insights into the pathogenic mechanisms of polyglutamine
doi.org
November 2, 2025 at 11:35 AM
New review article “Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle” by Esmeralda Villavicencio Gonzalez and Huda Zoghbi in the Journal of Experimental Medicine: doi.org/10.1084/jem.... #polyQ #huntingtonsdisease #ataxia
Reposted by Patrick van der Wel
Even more excitingly, with the new data added, I am still 'substantially' under the 12 page limit.
That's like almost a brief paragraph worth of space.
I did go to Jimmy John's and get a souped up sammie to reward myself for this morning.
That's like almost a brief paragraph worth of space.
I did go to Jimmy John's and get a souped up sammie to reward myself for this morning.
November 1, 2025 at 8:42 PM
Even more excitingly, with the new data added, I am still 'substantially' under the 12 page limit.
That's like almost a brief paragraph worth of space.
I did go to Jimmy John's and get a souped up sammie to reward myself for this morning.
That's like almost a brief paragraph worth of space.
I did go to Jimmy John's and get a souped up sammie to reward myself for this morning.
Reposted by Patrick van der Wel
Meanwhile Halloween 🎃 #Halloween2025 in #Pittsburgh
November 1, 2025 at 7:50 PM
Meanwhile Halloween 🎃 #Halloween2025 in #Pittsburgh
Reposted by Patrick van der Wel
Der gruseligste Moment des gestrigen Halloween-Abends: …
November 1, 2025 at 10:57 AM
Der gruseligste Moment des gestrigen Halloween-Abends: …
Reposted by Patrick van der Wel
New HD focused article leveraging multi-modal imaging from our long-standing collaboration with @danielebertoglio.bsky.social and colleagues! www.sciencedirect.com/science/arti...
Longitudinal investigation of structural and resting-state effective connectivity alterations in a non-human primate model of Huntington's disease
Huntington's disease (HD) is a genetic neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene which produce a mutant hunting…
www.sciencedirect.com
October 24, 2025 at 12:12 PM
New HD focused article leveraging multi-modal imaging from our long-standing collaboration with @danielebertoglio.bsky.social and colleagues! www.sciencedirect.com/science/arti...
Reposted by Patrick van der Wel
Reposted by Patrick van der Wel
NWO Vidi grant for Evan Zhao for “A new in situ NMR method for understanding lithium-mediated ammonia synthesis”
#radboud #NMR #congrats
www.ru.nl/en/research/...
#radboud #NMR #congrats
www.ru.nl/en/research/...
NWO Vidi grants for research into inequality, ammoniac and the reading life of teens | Radboud University
The Netherlands Organisation for Scientific Research (NWO) has awarded thirteen Nijmegen researchers Vidi funding of up to 850,000 euros. This will allow them to develop their own line of research and...
www.ru.nl
October 31, 2025 at 8:09 AM
NWO Vidi grant for Evan Zhao for “A new in situ NMR method for understanding lithium-mediated ammonia synthesis”
#radboud #NMR #congrats
www.ru.nl/en/research/...
#radboud #NMR #congrats
www.ru.nl/en/research/...
Reposted by Patrick van der Wel
Honest millennial question: what was academia like before emails?
October 31, 2025 at 7:36 AM
Honest millennial question: what was academia like before emails?
Reposted by Patrick van der Wel
“The bad review will come from your list of suggested reviewers”
October 31, 2025 at 7:39 AM
“The bad review will come from your list of suggested reviewers”
Today is the day: the 60th Dutch #NMRDG meeting bringing together the magnetic resonance community of the Netherlands. This time hosted at Radboud University in Nijmegen.
See: sac.kncv.nl/nmr
#nmrchat #epr #ssnmr
Huge thanks to the local organizers at Radboud and to our sponsors.
See: sac.kncv.nl/nmr
#nmrchat #epr #ssnmr
Huge thanks to the local organizers at Radboud and to our sponsors.
The Dutch NMR Discussion Group - SAC
sac.kncv.nl
October 31, 2025 at 7:37 AM
Today is the day: the 60th Dutch #NMRDG meeting bringing together the magnetic resonance community of the Netherlands. This time hosted at Radboud University in Nijmegen.
See: sac.kncv.nl/nmr
#nmrchat #epr #ssnmr
Huge thanks to the local organizers at Radboud and to our sponsors.
See: sac.kncv.nl/nmr
#nmrchat #epr #ssnmr
Huge thanks to the local organizers at Radboud and to our sponsors.
Reposted by Patrick van der Wel
Save the date (for Dutch NMR community and its friends): this year we have the 60th #NMRDG symposium. To recognize it is the 60th, it will be an extra special event, hosted in Nijmegen at Radboud University. More info to follow, but mark the date in your calendars now: Friday Oct 31st 2025
January 17, 2025 at 7:46 PM
Save the date (for Dutch NMR community and its friends): this year we have the 60th #NMRDG symposium. To recognize it is the 60th, it will be an extra special event, hosted in Nijmegen at Radboud University. More info to follow, but mark the date in your calendars now: Friday Oct 31st 2025
Reposted by Patrick van der Wel
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Quick Check Needed
mrc.tal.net
October 29, 2025 at 9:17 AM
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...