🔗 Aggregation dynamics of a 150 kDa Aβ42 oligomer: Insights from cryo electron microscopy and multimodal analysis. Computational and Structural Biotechnology Journal, doi.org/10.1016/j.cs...
📚 CSBJ: www.csbj.org
#CryoEM #ProteinAggregation #Biophysics #StructuralBiology #Alzheimers #Neuroscience
📚 CSBJ: www.csbj.org
#CryoEM #ProteinAggregation #Biophysics #StructuralBiology #Alzheimers #Neuroscience
October 21, 2025 at 3:09 PM
🔗 Aggregation dynamics of a 150 kDa Aβ42 oligomer: Insights from cryo electron microscopy and multimodal analysis. Computational and Structural Biotechnology Journal, doi.org/10.1016/j.cs...
📚 CSBJ: www.csbj.org
#CryoEM #ProteinAggregation #Biophysics #StructuralBiology #Alzheimers #Neuroscience
📚 CSBJ: www.csbj.org
#CryoEM #ProteinAggregation #Biophysics #StructuralBiology #Alzheimers #Neuroscience
Research Article: Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis -Protein Science
#proteinaggregation #misfolding #proteinfolding #proinsulin #disulfidebonds #betacells #Diabetes
onlinelibrary.wiley.com/doi/full/10....
#proteinaggregation #misfolding #proteinfolding #proinsulin #disulfidebonds #betacells #Diabetes
onlinelibrary.wiley.com/doi/full/10....
April 7, 2024 at 12:33 AM
Research Article: Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis -Protein Science
#proteinaggregation #misfolding #proteinfolding #proinsulin #disulfidebonds #betacells #Diabetes
onlinelibrary.wiley.com/doi/full/10....
#proteinaggregation #misfolding #proteinfolding #proinsulin #disulfidebonds #betacells #Diabetes
onlinelibrary.wiley.com/doi/full/10....
Hello #bluesky community. I am an Assistant Professor working in the field of Parkinson's disease biology. Looking to connect with other researchers in the field of #neurodegeneration #movementdisorders #parkinson #proteinaggregation. #HiSciSky #AcademicSky
October 18, 2023 at 4:20 PM
Hello #bluesky community. I am an Assistant Professor working in the field of Parkinson's disease biology. Looking to connect with other researchers in the field of #neurodegeneration #movementdisorders #parkinson #proteinaggregation. #HiSciSky #AcademicSky
Our first article on proinsulin proteostasis from ETSU. 😊
www.frontiersin.org/journals/mol...
Testament to great efforts by undergraduate students in my lab! 🙋🏻♂️
#proteinfolding #diabetes #proteinaggregation #insulin #proinsulin #ERqualitycontrol #proteostasis
www.frontiersin.org/journals/mol...
Testament to great efforts by undergraduate students in my lab! 🙋🏻♂️
#proteinfolding #diabetes #proteinaggregation #insulin #proinsulin #ERqualitycontrol #proteostasis
Frontiers | Exploring proinsulin proteostasis: insights into beta cell health and diabetes
www.frontiersin.org
March 5, 2025 at 1:47 PM
Our first article on proinsulin proteostasis from ETSU. 😊
www.frontiersin.org/journals/mol...
Testament to great efforts by undergraduate students in my lab! 🙋🏻♂️
#proteinfolding #diabetes #proteinaggregation #insulin #proinsulin #ERqualitycontrol #proteostasis
www.frontiersin.org/journals/mol...
Testament to great efforts by undergraduate students in my lab! 🙋🏻♂️
#proteinfolding #diabetes #proteinaggregation #insulin #proinsulin #ERqualitycontrol #proteostasis
Scientists at #UniMainz and @imbmainz propose a concept of a #ProteinAggregation clock to measure #ageing and #health / Potential new way for detecting the risk of getting #AgeRelatedDiseases...
December 12, 2024 at 10:49 AM
Scientists at #UniMainz and @imbmainz propose a concept of a #ProteinAggregation clock to measure #ageing and #health / Potential new way for detecting the risk of getting #AgeRelatedDiseases...
#ProteinAggregation is a hallmark of #neurodegeneration. This study shows that HAPLN2 aggregates in the aging brain, triggering #inflammation; microglial clearance regulates HAPLN2 buildup. This links protein accumulation to immune activation in healthy #aging @plosbiology.org 🧪 plos.io/4fJy7YG
August 18, 2025 at 8:02 AM
#ProteinAggregation is a hallmark of #neurodegeneration. This study shows that HAPLN2 aggregates in the aging brain, triggering #inflammation; microglial clearance regulates HAPLN2 buildup. This links protein accumulation to immune activation in healthy #aging @plosbiology.org 🧪 plos.io/4fJy7YG
Rice University created AnapTh, a fluorescent amino acid probe that detects micro‑environment shifts in live cells, showing early aggregation hotspots (Sept 10 2025). Read more: https://getnews.me/fluorescent-zoom-lens-detects-early-protein-changes-linked-to-disease/ #proteinaggregation #nanoprobes
September 13, 2025 at 7:23 PM
Rice University created AnapTh, a fluorescent amino acid probe that detects micro‑environment shifts in live cells, showing early aggregation hotspots (Sept 10 2025). Read more: https://getnews.me/fluorescent-zoom-lens-detects-early-protein-changes-linked-to-disease/ #proteinaggregation #nanoprobes
So excited to have finally made it to a FENS-Hertie Winter School in Austria! Arrived to see everyone in post-dinner working group mode. The learning never stops!🥳🧠
#FENSSchool on #proteinaggregation and its consequences in #neurodegenerativedisorders
#Hertie
@lucbuee.bsky.social & Susanne Wegmann
#FENSSchool on #proteinaggregation and its consequences in #neurodegenerativedisorders
#Hertie
@lucbuee.bsky.social & Susanne Wegmann
December 1, 2024 at 8:15 PM
So excited to have finally made it to a FENS-Hertie Winter School in Austria! Arrived to see everyone in post-dinner working group mode. The learning never stops!🥳🧠
#FENSSchool on #proteinaggregation and its consequences in #neurodegenerativedisorders
#Hertie
@lucbuee.bsky.social & Susanne Wegmann
#FENSSchool on #proteinaggregation and its consequences in #neurodegenerativedisorders
#Hertie
@lucbuee.bsky.social & Susanne Wegmann
Available online - the Review "PARPs and ADP-ribosylation-mediated #biomolecularcondensates: determinants, dynamics, and disease implications" from @leunglab.bsky.social and colleagues.
#phaseseparation #proteincondensation #proteinaggregation
Free access at: authors.elsevier.com/a/1kZlO3S6Gf...
#phaseseparation #proteincondensation #proteinaggregation
Free access at: authors.elsevier.com/a/1kZlO3S6Gf...
February 10, 2025 at 8:31 PM
Available online - the Review "PARPs and ADP-ribosylation-mediated #biomolecularcondensates: determinants, dynamics, and disease implications" from @leunglab.bsky.social and colleagues.
#phaseseparation #proteincondensation #proteinaggregation
Free access at: authors.elsevier.com/a/1kZlO3S6Gf...
#phaseseparation #proteincondensation #proteinaggregation
Free access at: authors.elsevier.com/a/1kZlO3S6Gf...
Diese Erkrankungen sind schwer zu modellieren, aber erste Ansätze mit 3D-Kultursystemen zeigen Potenzial – insbesondere zur Erforschung von Proteinaggregation und Neurotoxizität.
May 15, 2025 at 11:48 AM
Diese Erkrankungen sind schwer zu modellieren, aber erste Ansätze mit 3D-Kultursystemen zeigen Potenzial – insbesondere zur Erforschung von Proteinaggregation und Neurotoxizität.
#ProteinAggregation is a hallmark of #neurodegeneration. This study shows that HAPLN2 aggregates in the aging brain, triggering #inflammation; microglial clearance regulates HAPLN2 buildup. This links protein accumulation to immune activation in healthy #aging @plosbiology.org 🧪 plos.io/4fJy7YG
August 15, 2025 at 4:26 PM
#ProteinAggregation is a hallmark of #neurodegeneration. This study shows that HAPLN2 aggregates in the aging brain, triggering #inflammation; microglial clearance regulates HAPLN2 buildup. This links protein accumulation to immune activation in healthy #aging @plosbiology.org 🧪 plos.io/4fJy7YG
🌀 Prionenerkrankungen
Schwierig zu modellieren, aber es gibt erste Ansätze, Prionenpathologie mit Hilfe von 3D-Systemen nachzustellen – inkl. Beobachtung von Proteinaggregation und Neurotoxizität in realistischeren Kontexten.
Schwierig zu modellieren, aber es gibt erste Ansätze, Prionenpathologie mit Hilfe von 3D-Systemen nachzustellen – inkl. Beobachtung von Proteinaggregation und Neurotoxizität in realistischeren Kontexten.
May 15, 2025 at 11:38 AM
🌀 Prionenerkrankungen
Schwierig zu modellieren, aber es gibt erste Ansätze, Prionenpathologie mit Hilfe von 3D-Systemen nachzustellen – inkl. Beobachtung von Proteinaggregation und Neurotoxizität in realistischeren Kontexten.
Schwierig zu modellieren, aber es gibt erste Ansätze, Prionenpathologie mit Hilfe von 3D-Systemen nachzustellen – inkl. Beobachtung von Proteinaggregation und Neurotoxizität in realistischeren Kontexten.
Ambroxol displaces α-synuclein from the membrane and inhibits the formation of early protein-lipid coaggregates
Carles, E., Dreier, J. E. et al.
Paper
Details
#AmbroxolResearch #NeurodegenerativeDiseases #ProteinAggregation
Carles, E., Dreier, J. E. et al.
Paper
Details
#AmbroxolResearch #NeurodegenerativeDiseases #ProteinAggregation
August 21, 2025 at 4:01 PM
Ambroxol displaces α-synuclein from the membrane and inhibits the formation of early protein-lipid coaggregates
Carles, E., Dreier, J. E. et al.
Paper
Details
#AmbroxolResearch #NeurodegenerativeDiseases #ProteinAggregation
Carles, E., Dreier, J. E. et al.
Paper
Details
#AmbroxolResearch #NeurodegenerativeDiseases #ProteinAggregation
It was a pleasure to host Prof. Dr. Paolo Arosio from @ethzurich.bsky.social, who gave a fascinating talk on "Engineering Enzymatic Reactions and Protein Aggregation with Biomolecular Condensates." #BiomolecularCondensates #PhaseSeparation #EnzymaticReactions #ProteinAggregation
March 21, 2025 at 5:21 PM
It was a pleasure to host Prof. Dr. Paolo Arosio from @ethzurich.bsky.social, who gave a fascinating talk on "Engineering Enzymatic Reactions and Protein Aggregation with Biomolecular Condensates." #BiomolecularCondensates #PhaseSeparation #EnzymaticReactions #ProteinAggregation
Das Team zeigte, dass das Protein EPS8 mit dem Altern zusammenhängt und zu toxischer Proteinaggregation führt.
Durch die Reduzierung der EPS8-Aktivität konnte die Bildung toxischer Proteinaggregate verhindert und neuronale Funktionen im Modellorganismus C.elegans erhalten werden
Durch die Reduzierung der EPS8-Aktivität konnte die Bildung toxischer Proteinaggregate verhindert und neuronale Funktionen im Modellorganismus C.elegans erhalten werden
September 3, 2025 at 3:17 PM
Das Team zeigte, dass das Protein EPS8 mit dem Altern zusammenhängt und zu toxischer Proteinaggregation führt.
Durch die Reduzierung der EPS8-Aktivität konnte die Bildung toxischer Proteinaggregate verhindert und neuronale Funktionen im Modellorganismus C.elegans erhalten werden
Durch die Reduzierung der EPS8-Aktivität konnte die Bildung toxischer Proteinaggregate verhindert und neuronale Funktionen im Modellorganismus C.elegans erhalten werden
🙌 Huge thanks to all authors, and to Phospho Biomedical Animation for the stunning cover!
📚 Full issue: pubs.acs.org/toc/jacsat/1...
📄 Paper: pubs.acs.org/doi/10.1021/...
@radford-lab.bsky.social @naranson.bsky.social
#amyloid #chemsky #diabetes #proteinaggregation
(6/6)
📚 Full issue: pubs.acs.org/toc/jacsat/1...
📄 Paper: pubs.acs.org/doi/10.1021/...
@radford-lab.bsky.social @naranson.bsky.social
#amyloid #chemsky #diabetes #proteinaggregation
(6/6)
April 10, 2025 at 3:17 PM
🙌 Huge thanks to all authors, and to Phospho Biomedical Animation for the stunning cover!
📚 Full issue: pubs.acs.org/toc/jacsat/1...
📄 Paper: pubs.acs.org/doi/10.1021/...
@radford-lab.bsky.social @naranson.bsky.social
#amyloid #chemsky #diabetes #proteinaggregation
(6/6)
📚 Full issue: pubs.acs.org/toc/jacsat/1...
📄 Paper: pubs.acs.org/doi/10.1021/...
@radford-lab.bsky.social @naranson.bsky.social
#amyloid #chemsky #diabetes #proteinaggregation
(6/6)
Online now - the Spotlight "Balancing act: lipid-to-protein ratios steer the aggregation fate of #αsynuclein" from Christian Blum and Mireille Claessens.
#LipidMembranes #ProteinAggregation #Amyloid
authors.elsevier.com/a/1kgCK3S6Gf...
#LipidMembranes #ProteinAggregation #Amyloid
authors.elsevier.com/a/1kgCK3S6Gf...
authors.elsevier.com
February 27, 2025 at 2:05 AM
Online now - the Spotlight "Balancing act: lipid-to-protein ratios steer the aggregation fate of #αsynuclein" from Christian Blum and Mireille Claessens.
#LipidMembranes #ProteinAggregation #Amyloid
authors.elsevier.com/a/1kgCK3S6Gf...
#LipidMembranes #ProteinAggregation #Amyloid
authors.elsevier.com/a/1kgCK3S6Gf...
Forschende von #UniMainz u @imbmainz schlagen Konzept einer #Proteinaggregation|suhr zur Messung von #Alterung u #Gesundheit vor / Neue Möglichkeit zur Bestimmung des Risikos altersbedingter Krankheiten...
December 21, 2024 at 6:36 PM
Forschende von #UniMainz u @imbmainz schlagen Konzept einer #Proteinaggregation|suhr zur Messung von #Alterung u #Gesundheit vor / Neue Möglichkeit zur Bestimmung des Risikos altersbedingter Krankheiten...
Hello #neuroscience community. I am an Assistant Professor at IISER-Thiruvananthapuram working on Parkinson's disease biology. Looking to connect with other researchers in the field of #neurodegeneration
#movementdisorders #parkinson #proteinaggregation #HiSciSky #AcademicSky
#movementdisorders #parkinson #proteinaggregation #HiSciSky #AcademicSky
November 9, 2024 at 5:37 PM
Hello #neuroscience community. I am an Assistant Professor at IISER-Thiruvananthapuram working on Parkinson's disease biology. Looking to connect with other researchers in the field of #neurodegeneration
#movementdisorders #parkinson #proteinaggregation #HiSciSky #AcademicSky
#movementdisorders #parkinson #proteinaggregation #HiSciSky #AcademicSky
Recombinant proteins are commonly used to investigate #proteinaggregation--but can purification tags themselves affect aggregation? 🤔 A new study published in @febsletters.bsky.social suggests this may be the case ➡️ tinyurl.com/yhecdb3j
July 30, 2025 at 8:00 AM
Recombinant proteins are commonly used to investigate #proteinaggregation--but can purification tags themselves affect aggregation? 🤔 A new study published in @febsletters.bsky.social suggests this may be the case ➡️ tinyurl.com/yhecdb3j
What separates harmless from harmful protein aggregates? A recent study in The FASEB Journal links changes in PABPN1 structure to muscle cell dysfunction in OPMD—highlighting key differences between wild-type and expanded variants.
🔗 buff.ly/i34Ot9v
#MuscleBiology #ProteinAggregation #FASEBJournal
🔗 buff.ly/i34Ot9v
#MuscleBiology #ProteinAggregation #FASEBJournal
August 5, 2025 at 3:03 PM
What separates harmless from harmful protein aggregates? A recent study in The FASEB Journal links changes in PABPN1 structure to muscle cell dysfunction in OPMD—highlighting key differences between wild-type and expanded variants.
🔗 buff.ly/i34Ot9v
#MuscleBiology #ProteinAggregation #FASEBJournal
🔗 buff.ly/i34Ot9v
#MuscleBiology #ProteinAggregation #FASEBJournal
AI learns the language of sticky proteins. A breakthrough for Alzheimer’s, biotech, and beyond. #AIinBiotech #ProteinAggregation #Neurodegeneration
CANYA AI Decodes the Language of Sticky Proteins
A groundbreaking AI model trained on 100,000 synthetic protein sequences reveals new insights into what makes proteins clump, opening the door to better drugs and deeper understanding of diseases like Alzheimer’s.
geekoo.news
May 5, 2025 at 5:01 AM
AI learns the language of sticky proteins. A breakthrough for Alzheimer’s, biotech, and beyond. #AIinBiotech #ProteinAggregation #Neurodegeneration