Patrick van der Wel
@pcavanderwel.bsky.social
Solid-state NMR, Zernike Institute, university of Groningen. Posts = personal. Spectroscopy, biochemistry, structural biology, amyloid &
condensates, Huntington disease, membrane biophysics, biomaterials etc
condensates, Huntington disease, membrane biophysics, biomaterials etc
Reposted by Patrick van der Wel
Josef Zwanziger, @aaronrossini.bsky.social, and I published a rebuttal of a recent Nature Commun. paper claiming that enantiomers produce large differences in J coupling constants.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
DFT calculations and theory do not support enantiospecificity in NMR J-coupling constants - Nature Communications
Nature Communications - DFT calculations and theory do not support enantiospecificity in NMR J-coupling constants
doi.org
November 14, 2025 at 5:13 PM
Josef Zwanziger, @aaronrossini.bsky.social, and I published a rebuttal of a recent Nature Commun. paper claiming that enantiomers produce large differences in J coupling constants.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Patrick van der Wel
SMASH 2026 Small Molecule NMR Conference, First announcement ! Sunday 13.09.2026 – Wednesday 16.09.2026, Hotel Alpenrock, Breckenridge, CO, USA, Program Chairs Sarah Robinson (Genentech) & Gennady Khirich (Merck) smashnmr.org #NMRchat #NMRevents 🧲
SMASH - Small molecule NMR conference
Small molecule NMR conference.
smashnmr.org
November 13, 2025 at 8:36 PM
SMASH 2026 Small Molecule NMR Conference, First announcement ! Sunday 13.09.2026 – Wednesday 16.09.2026, Hotel Alpenrock, Breckenridge, CO, USA, Program Chairs Sarah Robinson (Genentech) & Gennady Khirich (Merck) smashnmr.org #NMRchat #NMRevents 🧲
Reposted by Patrick van der Wel
Moss: Private Investigator
Due to their unique traits, mosses have been used as forensic evidence to determine how a crime occurred, sometimes even linking a person to a very specific location. 🧵⬇️
Due to their unique traits, mosses have been used as forensic evidence to determine how a crime occurred, sometimes even linking a person to a very specific location. 🧵⬇️
November 13, 2025 at 6:04 PM
Moss: Private Investigator
Due to their unique traits, mosses have been used as forensic evidence to determine how a crime occurred, sometimes even linking a person to a very specific location. 🧵⬇️
Due to their unique traits, mosses have been used as forensic evidence to determine how a crime occurred, sometimes even linking a person to a very specific location. 🧵⬇️
Reposted by Patrick van der Wel
A newly revealed structure of the MutSβ molecular machine offers fresh insight into how CAG repeats expand, and how we might one day stop them.
en.hdbuzz.net/unzipping-th...
en.hdbuzz.net/unzipping-th...
Unzipping the Secrets of DNA Repair – HDBuzz
en.hdbuzz.net
November 13, 2025 at 2:42 PM
A newly revealed structure of the MutSβ molecular machine offers fresh insight into how CAG repeats expand, and how we might one day stop them.
en.hdbuzz.net/unzipping-th...
en.hdbuzz.net/unzipping-th...
Reposted by Patrick van der Wel
Wide ranging discussion about my correspondence with Director Bhattacharya and other topics ending with how I am dealing with my discovery that the major interpretation of my PhD thesis work is wrong.
Our interview with @jeremymberg.bsky.social about “Fifty Shades of Jay,” hirings at the NIH, and the importance of the NLM.
www.the-geyser.com/interview-je...
www.the-geyser.com/interview-je...
Interview — Jeremy Berg
How "Fifty Shades of Jay" came to be, and why the NLM is so vital to science
www.the-geyser.com
November 12, 2025 at 10:54 AM
Wide ranging discussion about my correspondence with Director Bhattacharya and other topics ending with how I am dealing with my discovery that the major interpretation of my PhD thesis work is wrong.
Vanavond mooie presentatie gezien van Petra Rudolf , georganiseerd door de Koninklijke Natuurkundige Gemeenschap KNG in het Forum gebouw
November 11, 2025 at 9:15 PM
Vanavond mooie presentatie gezien van Petra Rudolf , georganiseerd door de Koninklijke Natuurkundige Gemeenschap KNG in het Forum gebouw
Reposted by Patrick van der Wel
#compchem 🗳️ I'm making a series of exercices on “molecular simulation of materials”, focusing on classical atomistic methods. Other lecturers cover electronic structure and ab initio MD.
What would be good (simple) systems to study, nice properties to calculate, analysis methods to showcase?
What would be good (simple) systems to study, nice properties to calculate, analysis methods to showcase?
a woman in a suit says okay in front of a nbc sign
ALT: a woman in a suit says okay in front of a nbc sign
media.tenor.com
November 10, 2025 at 4:21 PM
#compchem 🗳️ I'm making a series of exercices on “molecular simulation of materials”, focusing on classical atomistic methods. Other lecturers cover electronic structure and ab initio MD.
What would be good (simple) systems to study, nice properties to calculate, analysis methods to showcase?
What would be good (simple) systems to study, nice properties to calculate, analysis methods to showcase?
Reposted by Patrick van der Wel
Dit zou de kern moeten zijn van de formatie van een 'post-Schoof coalitie'. Hoe Koolmees die in gang zet vanuit de inhoud in plaats vanuit blokkades? #BetrouwbareBronnen tekent de route. omny.fm/shows/betrou...
November 9, 2025 at 10:57 AM
Dit zou de kern moeten zijn van de formatie van een 'post-Schoof coalitie'. Hoe Koolmees die in gang zet vanuit de inhoud in plaats vanuit blokkades? #BetrouwbareBronnen tekent de route. omny.fm/shows/betrou...
Reposted by Patrick van der Wel
Zonder docenten geen universiteit. Maar we zijn ook nergens zonder mensen die de computersystemen draaiende houden, de prullenbakken legen en de inkoop regelen. Wie zijn die stille krachten achter de universiteit? Deel 9: AV-technicus Jasper Veldkamp. ukrant.nl/magazine/de-...
De stille kracht: het moderne onderwijs is nergens zonder Jasper Veldkamp
Wie zijn toch die stille krachten die de universiteit draaiende houden? Deel 9: AV-technicus Jasper Veldkamp.
ukrant.nl
November 5, 2025 at 8:04 AM
Zonder docenten geen universiteit. Maar we zijn ook nergens zonder mensen die de computersystemen draaiende houden, de prullenbakken legen en de inkoop regelen. Wie zijn die stille krachten achter de universiteit? Deel 9: AV-technicus Jasper Veldkamp. ukrant.nl/magazine/de-...
Later today! See the online seminar by Camilla Terenzi ( @w-u-r.bsky.social ) about “NMR and MRI in food science: a journey from lab to real-life conditions” as part of the Leipzig Spin Resonance Colloquium: www.physes.uni-leipzig.de/en/lsr-collo... #nmrchat #mri
Universität Leipzig: Leipzig Spin Resonance Colloquium
www.physes.uni-leipzig.de
November 5, 2025 at 8:25 AM
Later today! See the online seminar by Camilla Terenzi ( @w-u-r.bsky.social ) about “NMR and MRI in food science: a journey from lab to real-life conditions” as part of the Leipzig Spin Resonance Colloquium: www.physes.uni-leipzig.de/en/lsr-collo... #nmrchat #mri
An important investment that is important for the future of (integrative?) structural biology research in the Netherlands.
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 4, 2025 at 11:19 AM
An important investment that is important for the future of (integrative?) structural biology research in the Netherlands.
Reposted by Patrick van der Wel
Ik vind het wel fraai, die nieuwe dark mode op de borden op stations...
November 4, 2025 at 7:03 AM
Ik vind het wel fraai, die nieuwe dark mode op de borden op stations...
New article @hdbuzzfeed.bsky.social about AMT-130: “UniQure and FDA No Longer in Alignment on Approval Pathway for AMT-130” en.hdbuzz.net/uniqure-and-... #huntingtonsdisease #polyQ
UniQure and FDA No Longer in Alignment on Approval Pathway for AMT-130 – HDBuzz
en.hdbuzz.net
November 3, 2025 at 8:25 PM
New article @hdbuzzfeed.bsky.social about AMT-130: “UniQure and FDA No Longer in Alignment on Approval Pathway for AMT-130” en.hdbuzz.net/uniqure-and-... #huntingtonsdisease #polyQ
Reposted by Patrick van der Wel
Chaperone dependency during biogenesis does not correlate with chaperone dependency during refolding
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Chaperone dependency during biogenesis does not correlate with chaperone dependency during refolding | Molecular Systems Biology
imageimageStructural profiling of the E. coli proteome deficient in DnaKJ or trigger factor shows which proteins are chaperone-dependent
in vivo, a surprising temperature effect on DnaKJ dependency, a...
www.embopress.org
November 3, 2025 at 10:13 AM
Chaperone dependency during biogenesis does not correlate with chaperone dependency during refolding
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Patrick van der Wel
I've been getting back into the Hitchhiker's Guide to the Galaxy series after many years, and the most relatable part is how everyday objects like doors and elevators have been imbued with artificial intelligence and it just makes them obnoxious and frustrating to use and everyone hates it.
November 1, 2025 at 8:55 PM
I've been getting back into the Hitchhiker's Guide to the Galaxy series after many years, and the most relatable part is how everyday objects like doors and elevators have been imbued with artificial intelligence and it just makes them obnoxious and frustrating to use and everyone hates it.
Some more #running around #Groningen
November 2, 2025 at 3:48 PM
Some more #running around #Groningen
Reposted by Patrick van der Wel
Am looking for a cloud storage solution that is European / non-US - anyone experience with jottacloud? Other recommendations?
jottacloud.com/en/
jottacloud.com/en/
Jottacloud – Cloud storage made easy
Innovative and secure cloud storage for private and business use. Your files are stored on environmentally friendly servers, protected by Scandinavian privacy laws.
jottacloud.com
November 2, 2025 at 11:33 AM
Am looking for a cloud storage solution that is European / non-US - anyone experience with jottacloud? Other recommendations?
jottacloud.com/en/
jottacloud.com/en/
New review article “Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle” by Esmeralda Villavicencio Gonzalez and Huda Zoghbi in the Journal of Experimental Medicine: doi.org/10.1084/jem.... #polyQ #huntingtonsdisease #ataxia
Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle | Journal of Experimental Medicine | Rockefeller University Press
This comprehensive review by Villavicencio Gonzalez and Zoghbi integrates established and emerging insights into the pathogenic mechanisms of polyglutamine
doi.org
November 2, 2025 at 11:35 AM
New review article “Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle” by Esmeralda Villavicencio Gonzalez and Huda Zoghbi in the Journal of Experimental Medicine: doi.org/10.1084/jem.... #polyQ #huntingtonsdisease #ataxia
Reposted by Patrick van der Wel
Even more excitingly, with the new data added, I am still 'substantially' under the 12 page limit.
That's like almost a brief paragraph worth of space.
I did go to Jimmy John's and get a souped up sammie to reward myself for this morning.
That's like almost a brief paragraph worth of space.
I did go to Jimmy John's and get a souped up sammie to reward myself for this morning.
November 1, 2025 at 8:42 PM
Even more excitingly, with the new data added, I am still 'substantially' under the 12 page limit.
That's like almost a brief paragraph worth of space.
I did go to Jimmy John's and get a souped up sammie to reward myself for this morning.
That's like almost a brief paragraph worth of space.
I did go to Jimmy John's and get a souped up sammie to reward myself for this morning.
Reposted by Patrick van der Wel
Meanwhile Halloween 🎃 #Halloween2025 in #Pittsburgh
November 1, 2025 at 7:50 PM
Meanwhile Halloween 🎃 #Halloween2025 in #Pittsburgh
Reposted by Patrick van der Wel
Der gruseligste Moment des gestrigen Halloween-Abends: …
November 1, 2025 at 10:57 AM
Der gruseligste Moment des gestrigen Halloween-Abends: …
Reposted by Patrick van der Wel
New HD focused article leveraging multi-modal imaging from our long-standing collaboration with @danielebertoglio.bsky.social and colleagues! www.sciencedirect.com/science/arti...
Longitudinal investigation of structural and resting-state effective connectivity alterations in a non-human primate model of Huntington's disease
Huntington's disease (HD) is a genetic neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene which produce a mutant hunting…
www.sciencedirect.com
October 24, 2025 at 12:12 PM
New HD focused article leveraging multi-modal imaging from our long-standing collaboration with @danielebertoglio.bsky.social and colleagues! www.sciencedirect.com/science/arti...
Reposted by Patrick van der Wel
