Takeshi Irie
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oncoanesthesia.bsky.social
Takeshi Irie
@oncoanesthesia.bsky.social
63 followers 210 following 5 posts
Working at the cancer/anesthesia interface. Opinions my own
Posts Replies Media Videos
Reposted by Takeshi Irie
jama.com
Any daily #alcohol consumption is associated with certain cancers, and the risk of #cancer increases with higher alcohol intake.

📊 This JAMA Insights discusses the evidence related to the
US Surgeon General’s Advisory on alcohol and cancer risk.

ja.ma/41EkKTy
August 16, 2025 at 4:08 AM
Reposted by Takeshi Irie
bjajournals.bsky.social
Intra-arterial #lidocaine may improve survival in hepatocellular carcinoma patients receiving transcatheter arterial chemoembolisation #TACE: is this too good to be true?
www.bjanaesthesia.org
August 12, 2025 at 11:02 AM
Reposted by Takeshi Irie
nature.com
Nature research paper: Design of highly functional genome editors by modelling CRISPR–Cas sequences

go.nature.com/3UAYBBB
Design of highly functional genome editors by modelling CRISPR–Cas sequences - Nature
Gene editors designed using artificial intelligence can undertake precision editing of the human genome.
go.nature.com
July 30, 2025 at 6:50 PM
Reposted by Takeshi Irie
natbiotech.nature.com
Research Highlight: Computationally designed enzymes show potent catalytic activity www.nature.com/articles/s41...
Computationally designed enzymes show potent catalytic activity - Nature Biotechnology
Nature Biotechnology - Computationally designed enzymes show potent catalytic activity
www.nature.com
July 29, 2025 at 6:56 PM
Reposted by Takeshi Irie
anesthesiology.bsky.social
Visual Abstract in #Anesthesiology - Perioperative Nitric Oxide Conditioning Reduces Acute Kidney Injury in Cardiac Surgery Patients with Chronic Kidney Disease (the DEFENDER Trial) 🖌️ ow.ly/Kial50Wqw8a
July 18, 2025 at 5:01 PM
Reposted by Takeshi Irie
erictopol.bsky.social
—Why did you go to sleep?
—My mitochondria made me do it.
www.nature.com/articles/s41...
Mitochondrial origins of the pressure to sleep - Nature
Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
www.nature.com
July 16, 2025 at 10:26 PM
Reposted by Takeshi Irie
erictopol.bsky.social
On the potential risk of gabapentin (Neurontin) for mild cognitive impairment and dementia
rapm.bmj.com/content/earl...
July 11, 2025 at 2:36 PM
Reposted by Takeshi Irie
maitreya.bsky.social
Genome Sciences is looking for a Director of Departmental Computing. This is a rare opportunity for someone interested in leading our excellent IT team, building and maintaining computational infrastructure, and working closely with our faculty and labs uwhires.admin.washington.edu/ENG/candidat...
UW Human Resources
University of Washington Human Resources
uwhires.admin.washington.edu
July 11, 2025 at 9:54 PM
oncoanesthesia.bsky.social
3D-printed biomedical grade peel away nasal trumpets in nasal fiberoptic intubation of manikins. Concave longitudinal tear guides performed faithfully
sciencedirect.com/science/arti...
#PANTs #AFOI #airway #intubation #3D-printing
Peel-away nasal trumpet for fibreoptic tracheal intubation: buckle resistance and geometry of 3D-printed prototypes with high performance in airway manikin simulations
sciencedirect.com
July 1, 2025 at 7:36 PM
Reposted by Takeshi Irie
erictopol.bsky.social
Not just shingles vaccine, but also RSV vaccine reduces the risk of dementia, which highlights the benefit of revving up the immune system in older individuals
www.nature.com/articles/s41...
Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections - npj Vaccines
npj Vaccines - Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections
www.nature.com
June 27, 2025 at 5:48 PM
Reposted by Takeshi Irie
drdavidcanty.bsky.social
The future of mobile healthcare!

#BlueSky #Medsky #BlueSky
May 7, 2025 at 2:34 PM
Reposted by Takeshi Irie
nyutandon.bsky.social
An NYU Tandon research team led by Assistant Prof Nathalie Pinkerton has developed Sequential NanoPrecipitation (SNaP), a breakthrough in drug delivery manufacturing.

#NYUTandonMade @ieeespectrum.bsky.social
It’s a SNaP: New Technique Paves Way for Scalable Therapeutic Nanoparticle Manufacturing
Bridging the gap between lab-scale drug delivery research and large-scale pharmaceutical manufacturing
buff.ly
March 3, 2025 at 5:38 PM
Reposted by Takeshi Irie
natureportfolio.nature.com
Nanoplastics can compromise intestinal integrity in mice by altering the interactions between the gut #microbiome and the host, according to a paper in Nature Communications. go.nature.com/4jLgF6u #medsky 🧪
This is figure 6, which shows the pathways of nanoplastics-induced gut microbiota changes.
June 10, 2025 at 10:34 PM
Reposted by Takeshi Irie
natchembio.nature.com
A programmable RNA acetylation system using dCas13-eNAT10 is developed to install N4-acetylcytidine on target RNAs in cells and in vivo, enabling functional studies of RNA acetylation and revealing the unique role of RNA acetylation in transcript localization

www.nature.com/articles/s41...
Programmable RNA acetylation with CRISPR–Cas13 - Nature Chemical Biology
Yu et al. developed a programmable RNA acetylation system using dCas13–eNAT10 to specifically install N4-acetylcytidine on target RNAs in cells and in vivo, enabling functional studies of RNA acetylat...
www.nature.com
June 3, 2025 at 8:29 PM
Reposted by Takeshi Irie
elowitzlab.bsky.social
Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches.
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 3, 2025 at 12:11 AM
Reposted by Takeshi Irie
brittlundgren.bsky.social
Are you a PI of a federal grant cancelled by the Trump administration?

Please share your info with the Democratic Staff of the House Committee on Science, Space, and Technology, who launched this portal yesterday to track funding cancellations 🔭🧪

forms.office.com/pages/respon...
Grant Cancellation Web Form WAS YOUR GRANT CANCELED BY PRESIDENT TRUMP? The Committee on Science, Space, and Technology, Democratic Staff, is surveying the impact of the Trump Administration’s cancelation of federal research awards. If your award was terminated since January 20, 2025, please fill out this brief survey. If you had multiple awards terminated, please fill out a separate form for each award. While anonymous submissions will be helpful to the Committee’s efforts, we encourage you to leave your contact information if you are open to having a confidential conversation with Committee staff. Please find our confidentiality policies at the following link – any information you share will be treated with these protections, regardless of your current affiliation with any current or former funding agency: https://democrats-science.house.gov/contact/whistleblower
May 29, 2025 at 1:46 PM
Reposted by Takeshi Irie
science.org
Many with sleep apnea aren’t adequately treated because they find continuous positive airway pressure machines too burdensome. A new pill may offer an alternative.
Sleep apnea pill shows striking success in large clinical trial
Drug combination targeting lax airways is nearing an FDA submission
scim.ag
May 24, 2025 at 2:07 PM
Reposted by Takeshi Irie
jama.com
The initiation of vasopressin following recommendations by a reinforcement learning model was associated with decreased mortality in patients with septic shock already receiving norepinephrine.

ja.ma/4jaZE5d
May 21, 2025 at 8:08 PM
Reposted by Takeshi Irie
ludwigcancer.bsky.social
A team co-led by Ludwig @unil.bsky.social’s Helen Carrasco Hope & Nicola Vannini reports that age-related metabolic decline impairs CAR-T cell function. Replenishing NAD+, a key metabolic molecule, in the cells restores their efficacy in preclinical models of cancer. bit.ly/4kspK4H

#CanSky #OncoSky
May 21, 2025 at 9:02 PM
Reposted by Takeshi Irie
mclem.org
They're terminating OPT.

Today the nominee to head USCIS stated directly: he will end Optional Practical Training, the single largest channel for high-skill immigrants to work in the US.

6 weeks ago I warned about this & summarized the research on impacts of this drastic action—> @piie.com
Skilled immigration on the chopping block? Effects of eliminating "Optional Practical Training" in the US
The White House has taken numerous steps to sharply reduce the number of immigrant workers, with or without legal status, in the US economy. These policies, so far, typically target immigrants with le...
www.piie.com
May 21, 2025 at 9:04 PM
Reposted by Takeshi Irie
nature.com
The CRISPR family’s most versatile member has made its medical debut: a cutting-edge gene-editing technique known as prime editing has been used to treat a person for the first time

https://go.nature.com/3YNta9V
World first: ultra-powerful CRISPR treatment trialled in a person
Immune-cell function improved in a teenager whose DNA was altered using prime editing.
go.nature.com
May 19, 2025 at 1:58 PM
Reposted by Takeshi Irie
scinews.bsky.social
Personalized Gene Editing to Treat an Inborn Error of Metabolism. #NEJM #TIC2025

www.nejm.org/doi/full/10....
May 17, 2025 at 10:24 AM
Reposted by Takeshi Irie
davidsinclairphd.bsky.social
All NIH grants supporting my lab's trainees and medical research have been terminated. I am not alone. We scientists work hard to make the world a better place & we will not go down without a fight 🥊
May 16, 2025 at 1:17 AM
Reposted by Takeshi Irie
ucsanfrancisco.bsky.social
New study from @ucsfmedicine.bsky.social shows estrogen and progesterone signal T-regs in the meninges to produce opioids, stopping pain before it reaches the brain. tiny.ucsf.edu/pG5MU9
Estrogen and Progesterone Stimulate the Body to Make Opioids
A new study found that female hormones can suppress pain signals before they reach the brain by making immune cells near the spinal cord produce opioids.
tiny.ucsf.edu
April 7, 2025 at 6:09 PM
Reposted by Takeshi Irie
bjajournals.bsky.social
#Remimazolam is increasingly used as an induction agent for general anaesthesia. The optimal bolus induction dose for children is estimated to be 0.45-0.60mg/kg for age 1-6 years and 0.35-0.45mg/kg in 6-12 years
www.bjanaesthesia.org
May 9, 2025 at 11:02 AM