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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 3d

RIP James D. Watson, co-discoverer of DNAs double helix🥇Jim was a kind, generous mentor to me, who never hesitated to meet, give feedback, or share stories from the early days of molecular biology. His signed double helix hangs in my office as a reminder how one discovery can change the world 🙏

Jim Watson and me at his office at Cold spring Harbor

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 8d

Thrilled to have David Guyer join the @lifebiosciences.bsky.social board, maker of the first anti-VEGF eye drug, two successful biotech IPOs, the largest ever ex-US pharma deal, and sale of his latest company, EyeBio, for ~$3B to Merck in 2024. Midas touch 🙏✨🥇
www.lifebiosciences.com/life-bioscie...

Life Biosciences Appoints Industry Veteran David Guyer, M.D. to Board of Directors

Life Bio adds accomplished biotech leader to its Board as the company prepares for an early 2026 initiation of human trials BOSTON, November 3, 2025 – Life Biosciences (“Life Bio”), a biotechnology co...

www.lifebiosciences.com

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 27d

Grateful for the leadership of President. Jeffrey Tsai at Asia University and so excited for what’s ahead 🚀
Press release:
tinyurl.com/fdn8ckd9

Asia University Partners with NucleicAI to Build a Sovereign AI Life Science Data Platform

/PRNewswire/ -- Asia University will partner with NucleicAI LLC, a next-generation platform and data company specializing in AI-driven genomics, precision...

tinyurl.com

David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 27d

Dr. Haghighi is Chief Executive and Director, Harvard Medical School International Center for Genetic Disease, Principal Investigator and Director, Bahrain National Genome Program at Harvard and Assistant Professor of Medicine, Harvard Medical School, and Brigham and Women's Hospital

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 27d

This is more than a regional milestone. It reflects our broader commitment to working with governments, academia, and industry worldwide to responsibly unlock the full potential of genomics and AI

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 27d

Dr. Alireza Haghighi, my cofounder and I, are proud to announce an exciting partnership with Asia University to develop a "Sovereign AI Life Science Data Platform for Taiwan", a national system for secure health data sharing, AI-powered analytics, and collaborative research

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 27d

The AI-powered bioanalytics company NucleicAI.com, founded by Harvard geneticists Alireza Haghighi & David Sinclair, takes another big step forward towards their goal of building a global AI infrastructure to advance longevity science & affordable healthcare for all
tinyurl.com/fdn8ckd9

Asia University Partners with NucleicAI to Build a Sovereign AI Life Science Data Platform

/PRNewswire/ -- Asia University will partner with NucleicAI LLC, a next-generation platform and data company specializing in AI-driven genomics, precision...

tinyurl.com

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Sep 13

Centenarians don’t just live longer, they get sick later, and their diseases progress more slowly. Longevity isn’t just about living longer, it’s avoiding illnesses that kill you

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Sep 12

We’re the first generation to understand aging at the molecular level. That knowledge changes everything

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Sep 11

1 in 10,000 humans lives past 100. In some villages, it’s 1 in 10. Lifestyle matters

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Sep 10

Every healthy habit you choose is a vote for your future self

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Sep 9

Computers in the future may weigh no more than 1.5 tons @popmech, 1949

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Sep 8

Loneliness is as dangerous as smoking. Put your phone down and get out there

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Sep 7

Aging is not inevitable, it’s biology. And biology can be changed

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Aug 26

With ER-100 on track for human trials in Q1 2026, this program is moving quickly 💉👁️ Jerry McLaughlin, our CEO, and I are so grateful for the creativity, dedication, and persistence the board & entire R&D team led by Dr. Sharon Rosenzweig-Lipson

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Aug 26

This adds to earlier data showing clear functional benefits in the eye. They also beautifully match the mouse data we published in Nature (2020), in fact they are even more dramatic in their reversal of DNA methylation 😲 www.nature.com/articles/s41...

Reprogramming to recover youthful epigenetic information and restore vision - Nature

Expression of three Yamanaka transcription factors in mouse retinal ganglion cells restores youthful DNA methylation patterns, promotes axon regeneration after injury, and reverses vision loss in a mo...

www.nature.com

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Aug 26

These results add to the weight of evidence that reprogramming is not just for age-reversal, it can be used to treat diseases that affect millions worldwide and with few effective treatments

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Aug 26

In liver disease (MASH), ER-300, an AAV-delivered package of reprogramming genes, improved multiple key liver health biomarkers in an animal model, from ALT/AST to cholesterol and steatosis (fat content) scores

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Aug 26

Said presenter and CSO, Sharon Rosenzweig-Lipson, "These results bring us closer to pioneering a new class of epigenetic therapies that can modify the biology of aging itself and, in doing so, transform how age-related diseases, such as optic neuropathies and MASH, are addressed”

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Aug 26

Life Biosciences presented this new data
the ARDD conference in Copenhagen this week

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Aug 26

This news is strong evidence that the original vision to develop therapies that reversal of aging to prevent and cure diseases of aging and injuries isn’t just a fanciful idea

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Aug 26

NEWS: @lifebiosciences.bsky.social reports new drug candidate ER-300 improves liver health while ER-100 reverses age & restores healthy DNA methylation patterns in the monkey eye, with clear functional improvements in vision. Human trials set for January, 26. It’s happening...
🧵 tinyurl.com/4dysm7bv

Life Biosciences Presents New Data at ARDD 2025 on the Company’s Partial Epigenetic Reprogramming Platform in Liver and Ocular Diseases

ER-300 improves key biomarkers of liver health in an animal model of MASH These data, along with additional ER-100 preclinical data from a nonhuman primate model of NAION demonstrating clear restorati...

tinyurl.com

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · Jun 5

Career award among casualties of ‘terrifying’ cuts affecting lab of David Sinclair news.harvard.edu/gazette/stor...

Young researcher’s ALS attack plan is now a no-go — Harvard Gazette

Career award among the casualties of "terrifying" cuts affecting lab of David Sinclair, which studies aging and disease.

news.harvard.edu

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · May 16

All NIH grants supporting my lab's trainees and medical research have been terminated. I am not alone. We scientists work hard to make the world a better place & we will not go down without a fight 🥊

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · May 6

Just posted our manuscript on "mPhenoAge," the first composite biological age measure for mice 🐭🧵 Proud of Alice and the entire team! 👏
@biorxivpreprint.bsky.social @volofoundation.bsky.social
tinyurl.com/544kzccz

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