Oliver Stone
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oliverastone.bsky.social
Oliver Stone
@oliverastone.bsky.social
Developmental biologist interested in cell specification and vascular biology.

Sir Henry Dale Fellow and Group Leader at the University of Oxford.

@idrm.ox.ac.uk | @oxforddpag.bsky.social | @ox.ac.uk
Pinned
Very happy to share our work on lymphatic endothelial cell specification, which was published in Nature Cardiovascular Research this week.
Reposted by Oliver Stone
I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting!

Registration and abstract submission is now open - join us!

bsdb.org/meetings/

March 23-26, 2026 - UK
October 23, 2025 at 5:25 PM
Reposted by Oliver Stone
The new Department of Functional Genetics at the Max Planck Institute for Molecular Biomedicine is looking for scientists at any level. 👉 mpi-muenster.mpg.de/780013/profil
June 26, 2025 at 8:15 AM
Reposted by Oliver Stone
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Interphase cell morphology defines the mode, symmetry, and outcome of mitosis
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
www.science.org
May 6, 2025 at 8:39 PM
Reposted by Oliver Stone
Very excited to see the first Beisaw lab publication out in its final form 🥳🥳 rdcu.be/ei1I7 if you’re interested in zebrafish heart regeneration and how cardiomyocytes replace the fibrotic injured tissue (spoiler alert: macrophages play an important role), then read it here 👇
Border-zone cardiomyocytes and macrophages regulate extracellular matrix remodeling to promote cardiomyocyte protrusion during cardiac regeneration
Nature Communications - Adult zebrafish are capable of heart regeneration, but how the collagenous injury site is replaced remains unclear. Here they provide an in-depth analysis of cardiomyocyte...
rdcu.be
April 23, 2025 at 5:53 PM
Reposted by Oliver Stone
Excited to see our work describing an external immune organ in the #zebrafish published in JEM! Big thanks to Aurora Kraus and @zebrafishmk.bsky.social and all of our other amazing collaborators including @edanfoley.bsky.social @biomarina-vg.bsky.social #WeinsteinLab rupress.org/jem/article-... 🧪
April 1, 2025 at 11:38 PM
Reposted by Oliver Stone
#onlywithHCR: @degrainger.bsky.social, @oliverastone.bsky.social, and their team reveal that lymphatic endothelial cells arise from specialized progenitors. #HCRimaging helped them to visualize endothelial progenitors in whole-mount mouse embryos.

Learn more: www.nature.com/articles/s44...
March 28, 2025 at 4:30 PM
Reposted by Oliver Stone
Vascular Development: What determines whether an endothelial cell becomes part of an artery, a vein or a capillary?
elifesciences.org/articles/106...
March 20, 2025 at 4:21 AM
Reposted by Oliver Stone
Excited to share this paper that is a long time coming from the lab on epigenetic/transcriptional regulation of organotypic endothelial specialization out today @naturecvr.bsky.social go.nature.com/4krSJqh
Mapping the transcriptional and epigenetic landscape of organotypic endothelial diversity in the developing and adult mouse
Nature Cardiovascular Research - Cantu Gutierrez et al. identify the common and unique transcriptional regulatory networks in the endothelium of six different organs throughout development, and...
go.nature.com
March 17, 2025 at 5:24 PM
Reposted by Oliver Stone
Some great images in this years @the-node.bsky.social image competition. Including my own "Thymus in the Spotlight" image taken in the @idrm.ox.ac.uk Zeiss CoE.

Vote for your favorite here: thenode.biologists.com/vote-for-you...
March 11, 2025 at 10:56 AM
Reposted by Oliver Stone
My first blue update! Sharing my most recent illustration in a scientific journal.Thank you to @oliverastone.bsky.social who contacted me to adapt his concept as the cover for his paper in @naturecvr.bsky.social. These are the original design and the journal version!
February 26, 2025 at 1:12 PM
Reposted by Oliver Stone
We are excited to share our work on Context-dependent response of endothelial cells to PIK3CA mutation. A tour the force of many; thank you all for your invaluable contribution. @aangulou.bsky.social @ruibenedito.bsky.social @debocklab.bsky.social @sandradcastillo.bsky.social
bit.ly/4blKSqa
Context-dependent response of endothelial cells to PIK3CA mutation
Cancer mutations in the PIK3CA gene cause congenital disorders. The endothelium is among the most frequently affected tissues in these disorders, displaying aberrant vascular overgrowth in the form of...
bit.ly
February 26, 2025 at 12:19 PM
Reposted by Oliver Stone
We have a postdoc position available in the lab! Come and work on lymphatic vascular development and regeneration. We use zebrafish, mouse, cells, tumour models and love imaging, genetics and genomics🔬
Come join us in Melbourne!

www.seek.com.au/job/82157187...
Postdoctoral Fellow Job in Melbourne at Peter MacCallum Cancer Centre - SEEK
The Hogan laboratory is offering work for a highly motivated and skilled postdoctoral fellow in the area of lymphatic development and regeneration.
www.seek.com.au
February 19, 2025 at 6:16 AM
Reposted by Oliver Stone
Paper alert! Congrats to Lara, @cmdooley.bsky.social , @douglasadamoski.bsky.social and Thomas Juan for their great work on identifying the first example of Transcriptional Adaption in humans!🎉
1/? 🧬 New Breakthrough in Duchenne Muscular Dystrophy (DMD)!
Our new paper in
@Nature
reveals how utrophin—a dystrophin “backup”—is upregulated in DMD. The key? Transcriptional adaptation (TA), triggered by mutant mRNA decay, not protein loss.
[🔗 Link: www.nature.com/articles/s41...
https://www.nature.com/articles/s41586-024-08539-x]
February 13, 2025 at 12:29 PM
Reposted by Oliver Stone
Same same but different? How blood and lymphatic vessels induce cell contact inhibition - Our new short review is out @BiochemSoc @PPPublishing #BST #vascularbiology #contactinhibition #CIP #endothelial #junctions @dzhk_germany @UKEHamburg portlandpress.com/biochemsoctr...
February 7, 2025 at 7:57 PM
Reposted by Oliver Stone
iFlpMosaics are now published @naturemethods. A compendium of novel genetic tools and related methods for inducing and analysing genetic mosaics in a high-throughput manner.Tweetorial 👇

nature.com/articles/s4159…
February 11, 2025 at 7:38 AM
Reposted by Oliver Stone
February 10, 2025 at 10:31 AM
Reposted by Oliver Stone
If you're a non-UK scientist who wants to come to the UK for a postdoc, this year's Newton Fellowships are now open. You'll need a lab to host you (which could be me, but truly, could be any PI, so get in touch with someone you'd like to work with!)

royalsociety.org/grants/newto...
Newton International Fellowships | Royal Society
This fellowship is for non-UK scientists who are at an early stage of their research career and wish to conduct research in the UK.
royalsociety.org
January 29, 2025 at 5:27 PM
Reposted by Oliver Stone
DPAG's Stone Group publishes new research in
@naturecvr.bsky.social on the cellular mechanisms underpinning the formation of lymphatic endothelial cells
@oliverastone.bsky.social @degrainger.bsky.social
Read the paper here www.nature.com/articles/s44...
Direct specification of lymphatic endothelium from mesenchymal progenitors - Nature Cardiovascular Research
Lupu, Grainger, Kirschnick et al. show that, contrary to prevailing belief, the initial specification of mammalian lymphatic endothelial cells primarily occurs from previously unidentified mesenchymal...
www.nature.com
January 23, 2025 at 9:30 AM
Very happy to share our work on lymphatic endothelial cell specification, which was published in Nature Cardiovascular Research this week.
January 22, 2025 at 4:14 PM
Reposted by Oliver Stone
✨Excited to share our work revisiting the developmental origins of mammalian lymphatic endothelial cells.✨

A summary of our key findings using scRNA-seq, snMultiome-seq and imaging to show the direct specification of mesenchymal progenitors to LECs🧵 #blutorial #blabstract

tinyurl.com/LECspec
Direct specification of lymphatic endothelium from mesenchymal progenitors - Nature Cardiovascular Research
Lupu, Grainger, Kirschnick et al. show that, contrary to prevailing belief, the initial specification of mammalian lymphatic endothelial cells primarily occurs from previously unidentified mesenchymal...
tinyurl.com
January 13, 2025 at 2:31 PM
Reposted by Oliver Stone
Finally, out in print: "Mesodermal fibronectin controls cell shape, polarity, and mechanotransduction in the second heart field during cardiac outflow tract development."
www.cell.com/developmenta...
January 9, 2025 at 9:54 PM
Thank you for highlighting the paper, Tim!
January 7, 2025 at 4:20 PM
Reposted by Oliver Stone
Where did our neck muscles come from?🧪
Here's our #evodevo #devbio deep dive feat. #zebrafish, mouse, axolotls, & more!

Led by Eglantine Heude & Tajbakhsh lab at Pasteur, the team at National Museum of Natural History France, & lab alumni Karin Prummel & Rob Lalonde.
www.nature.com/articles/s41...
Co-option of neck muscles supported the vertebrate water-to-land transition - Nature Communications
The evolutionary water-to-land transition involved the separation of the skull from the pectoral girdle, though these musculoskeletal changes have not been deeply characterised. Here they show that th...
www.nature.com
December 5, 2024 at 12:02 AM