Rui Benedito
@ruibenedito.bsky.social
Functional Genetics in Biomedicine
Pinned
Rui Benedito
@ruibenedito.bsky.social
· Jun 26
The new Department of Functional Genetics at the Max Planck Institute for Molecular Biomedicine is looking for scientists at any level. 👉 mpi-muenster.mpg.de/780013/profil
Reposted by Rui Benedito
Yet another great reason to live in Europe!!
Multilingualism protects against accelerated aging 😀
An analysis of aging in >86,000 participants across 27 European countries
Amoruso et al, Nature Aging 🧪⏳
www.nature.com/articles/s43...
Multilingualism protects against accelerated aging 😀
An analysis of aging in >86,000 participants across 27 European countries
Amoruso et al, Nature Aging 🧪⏳
www.nature.com/articles/s43...
November 10, 2025 at 7:51 PM
Yet another great reason to live in Europe!!
Multilingualism protects against accelerated aging 😀
An analysis of aging in >86,000 participants across 27 European countries
Amoruso et al, Nature Aging 🧪⏳
www.nature.com/articles/s43...
Multilingualism protects against accelerated aging 😀
An analysis of aging in >86,000 participants across 27 European countries
Amoruso et al, Nature Aging 🧪⏳
www.nature.com/articles/s43...
Reposted by Rui Benedito
Excited to embark on this scientific journey with Ewa Paluch and Daniel StJohnston to understand fundamentals of epithelial tissue and cell shapes! Thank you to @erc.europa.eu for the support!
🚀 Exciting news! ERC Synergy Grant of €8.5 million to Sara Wickström @sarawickstrom.bsky.social, Daniel St Jonston @gurdoninstitute.bsky.social and Ewa Paluch @universitypress.cambridge.org! This highly interdisciplinary project will boost our understanding of tissue biology. #ERCSyG @erc.europa.eu
November 6, 2025 at 12:14 PM
Excited to embark on this scientific journey with Ewa Paluch and Daniel StJohnston to understand fundamentals of epithelial tissue and cell shapes! Thank you to @erc.europa.eu for the support!
Reposted by Rui Benedito
🚀 Exciting news! ERC Synergy Grant of €8.5 million to Sara Wickström @sarawickstrom.bsky.social, Daniel St Jonston @gurdoninstitute.bsky.social and Ewa Paluch @universitypress.cambridge.org! This highly interdisciplinary project will boost our understanding of tissue biology. #ERCSyG @erc.europa.eu
November 6, 2025 at 11:21 AM
🚀 Exciting news! ERC Synergy Grant of €8.5 million to Sara Wickström @sarawickstrom.bsky.social, Daniel St Jonston @gurdoninstitute.bsky.social and Ewa Paluch @universitypress.cambridge.org! This highly interdisciplinary project will boost our understanding of tissue biology. #ERCSyG @erc.europa.eu
Reposted by Rui Benedito
Pls spread the word! We have a postdoc position available in the Rocha Lab @mpi-muenster.bsky.social. Join our team to study mechanisms underlying robust organ development using zebrafish embryos and human organoids.
mpi-muenster.mpg.de/career
mpi-muenster.mpg.de/career
We are looking for a #Postdoc with a great interest in biological robustness to lead a project investigating the self-correction capabilities of the developing nervous system. Join us at the @rocha-lab.bsky.social Rocha lab @mpi-muenster.bsky.social!
jobs.mpi-muenster.mpg.de/jobposting/0...
jobs.mpi-muenster.mpg.de/jobposting/0...
July 10, 2025 at 12:10 PM
Pls spread the word! We have a postdoc position available in the Rocha Lab @mpi-muenster.bsky.social. Join our team to study mechanisms underlying robust organ development using zebrafish embryos and human organoids.
mpi-muenster.mpg.de/career
mpi-muenster.mpg.de/career
Reposted by Rui Benedito
We are looking for postdoctoral researchers to join us at the MPI for Molecular Biomedicine 👇 postdocprogram.mpg.de/all-postdoc-...
September 12, 2025 at 6:48 AM
We are looking for postdoctoral researchers to join us at the MPI for Molecular Biomedicine 👇 postdocprogram.mpg.de/all-postdoc-...
We are looking for postdoctoral researchers to join us at the MPI for Molecular Biomedicine 👇 postdocprogram.mpg.de/all-postdoc-...
September 12, 2025 at 6:48 AM
We are looking for postdoctoral researchers to join us at the MPI for Molecular Biomedicine 👇 postdocprogram.mpg.de/all-postdoc-...
Reposted by Rui Benedito
Double the discovery, double the momentum 🚀
Europe doubles down on research competitiveness with a major boost to #HorizonEurope:
€95.5 billion foreseen for 2021-2027
💰💰💰💰💰💰💰💰💰
€175 billion proposed for 2028-2034
💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰
Europe doubles down on research competitiveness with a major boost to #HorizonEurope:
€95.5 billion foreseen for 2021-2027
💰💰💰💰💰💰💰💰💰
€175 billion proposed for 2028-2034
💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰
August 5, 2025 at 6:55 AM
Double the discovery, double the momentum 🚀
Europe doubles down on research competitiveness with a major boost to #HorizonEurope:
€95.5 billion foreseen for 2021-2027
💰💰💰💰💰💰💰💰💰
€175 billion proposed for 2028-2034
💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰
Europe doubles down on research competitiveness with a major boost to #HorizonEurope:
€95.5 billion foreseen for 2021-2027
💰💰💰💰💰💰💰💰💰
€175 billion proposed for 2028-2034
💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰
Reposted by Rui Benedito
Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...
August 18, 2025 at 7:45 AM
Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...
Reposted by Rui Benedito
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Group Leader - Genome Biology Unit
Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...
embl.wd103.myworkdayjobs.com
July 30, 2025 at 1:41 PM
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Many Congrats !
I am honoured to be elected as a Member of EMBO and look forward to contributing to its mission and community!
Welcome and congratulations to the 60 new members and 9 associate members who have been elected to the EMBO Membership! This honour celebrates #research excellence and outstanding achievements in the #LifeSciences. 🧪
Learn more here:
www.embo.org/press-releas... #EMBOMembers2025
Learn more here:
www.embo.org/press-releas... #EMBOMembers2025
July 2, 2025 at 2:08 PM
Many Congrats !
Reposted by Rui Benedito
We have an open postdoc position to work on PTEN and vascular Malformations. If you are intersted, apply: careers.carrerasresearch.org/jobs/6107690...
VAC_53_2025 - POSTDOCTORAL RESEARCH - Institut de Recerca contra la Leucèmia Josep Carreras
Join the Josep Carreras Leukaemia Research Institute and contribute to our mission of innovating and advancing the fight against leukaemia and other hematologic diseases.
careers.carrerasresearch.org
June 27, 2025 at 3:22 PM
We have an open postdoc position to work on PTEN and vascular Malformations. If you are intersted, apply: careers.carrerasresearch.org/jobs/6107690...
We generated the mice back in 2017, but this movie below from the latest paper of Taija Makinen lab by Hans Schoofs shows the best tissue volume imaging ever done with iMb2-Mosaic mice. The Puzzle shape lymphatic cells | @Nature share.google/sez4ForrNsCE...
This work would not have been possible without our many collaborators who provided reagents, lines and much needed support! @ruibenedito.bsky.social, M. Jeansson, @brittae.bsky.social, D. Vestweber, K. Gängel, O. Friedrich, J. van Buul, P. Saharinen, R. Smith and M. Majda and many others!
June 26, 2025 at 8:26 PM
We generated the mice back in 2017, but this movie below from the latest paper of Taija Makinen lab by Hans Schoofs shows the best tissue volume imaging ever done with iMb2-Mosaic mice. The Puzzle shape lymphatic cells | @Nature share.google/sez4ForrNsCE...
The new Department of Functional Genetics at the Max Planck Institute for Molecular Biomedicine is looking for scientists at any level. 👉 mpi-muenster.mpg.de/780013/profil
June 26, 2025 at 8:15 AM
The new Department of Functional Genetics at the Max Planck Institute for Molecular Biomedicine is looking for scientists at any level. 👉 mpi-muenster.mpg.de/780013/profil
Reposted by Rui Benedito
Reposted by Rui Benedito
We want to connect:
To link model builders with data generators.
To bring together scientists asking why cells behave the way they do, and others figuring out how to model that behavior.
If you're working on AI in biology, consider joining!
https://tinyurl.com/y35m6khy
To link model builders with data generators.
To bring together scientists asking why cells behave the way they do, and others figuring out how to model that behavior.
If you're working on AI in biology, consider joining!
https://tinyurl.com/y35m6khy
June 4, 2025 at 7:12 AM
We want to connect:
To link model builders with data generators.
To bring together scientists asking why cells behave the way they do, and others figuring out how to model that behavior.
If you're working on AI in biology, consider joining!
https://tinyurl.com/y35m6khy
To link model builders with data generators.
To bring together scientists asking why cells behave the way they do, and others figuring out how to model that behavior.
If you're working on AI in biology, consider joining!
https://tinyurl.com/y35m6khy
Reposted by Rui Benedito
Here we study the origin of the cardiac cell lineages in the mouse embryo. Separate but coordinated lineages independently specified at gastrulation generate the myocardium and endocardium. Credits: Miquel Sendra & coll: Jorge Dominguez, K. McDole and L. Guinard
authors.elsevier.com/sd/article/S...
authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
May 27, 2025 at 3:18 PM
Here we study the origin of the cardiac cell lineages in the mouse embryo. Separate but coordinated lineages independently specified at gastrulation generate the myocardium and endocardium. Credits: Miquel Sendra & coll: Jorge Dominguez, K. McDole and L. Guinard
authors.elsevier.com/sd/article/S...
authors.elsevier.com/sd/article/S...
Reposted by Rui Benedito
Research | Kraft et al. identify TIE2 activation as a key driver of PI3KCA-related venous malformations and demonstrate that inhibiting TIE2 signalling can suppress the growth of advanced lesions.
rdcu.be/en0hU
rdcu.be/en0hU
Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations - Nature Cardiovascular Research
Kraft et al. identify TIE2 activation as a key driver of PIK3CA-related venous malformations and demonstrate that inhibiting TIE2 signaling can suppress the growth of advanced lesions.
doi.org
May 27, 2025 at 4:35 PM
Research | Kraft et al. identify TIE2 activation as a key driver of PI3KCA-related venous malformations and demonstrate that inhibiting TIE2 signalling can suppress the growth of advanced lesions.
rdcu.be/en0hU
rdcu.be/en0hU
Reposted by Rui Benedito
We hope these findings bring us closer to better treatments for this challenging condition. #vascularbiology #PIK3CA #venousmalformation
Huge thanks to our fantastic collaborators Michael Potente, René Hägerling, Friedrich Kapp, @mvikkula.bsky.social, Laurence Boon, @ruibenedito.bsky.social
Huge thanks to our fantastic collaborators Michael Potente, René Hägerling, Friedrich Kapp, @mvikkula.bsky.social, Laurence Boon, @ruibenedito.bsky.social
May 25, 2025 at 2:35 PM
We hope these findings bring us closer to better treatments for this challenging condition. #vascularbiology #PIK3CA #venousmalformation
Huge thanks to our fantastic collaborators Michael Potente, René Hägerling, Friedrich Kapp, @mvikkula.bsky.social, Laurence Boon, @ruibenedito.bsky.social
Huge thanks to our fantastic collaborators Michael Potente, René Hägerling, Friedrich Kapp, @mvikkula.bsky.social, Laurence Boon, @ruibenedito.bsky.social
Reposted by Rui Benedito
One of the reasons I love #DevelopmentalBiology is that it's so visually engaging. I had the pleasure of organising an image competition at the GRC last March, and share this passion. You can now check out these images on @the-node.bsky.social: thenode.biologists.com/grs-developm...
GRS Developmental Biology 2025 Image gallery - the Node
The 2025 Developmental Biology Gordon Research Seminar (GRS) was held on March 29-30 2025. This year, the GRS co-chairs Ana R. Hernandez Rodriguez and
thenode.biologists.com
May 15, 2025 at 8:02 AM
One of the reasons I love #DevelopmentalBiology is that it's so visually engaging. I had the pleasure of organising an image competition at the GRC last March, and share this passion. You can now check out these images on @the-node.bsky.social: thenode.biologists.com/grs-developm...
Reposted by Rui Benedito
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Interphase cell morphology defines the mode, symmetry, and outcome of mitosis
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
www.science.org
May 6, 2025 at 8:39 PM
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Reposted by Rui Benedito
If you are interested in vascular malformations you may want to check our new work published today in Cancer Discovery, where we discover a somatic genetic event causing vascular malformations in PTEN hamartoma tumor syndrome (PHTS) aacrjournals.org/cancerdiscov...
Somatic uniparental disomy of PTEN in endothelial cells causes vascular malformations in patients with PTEN Hamartoma Tumor Syndrome
Abstract. PTEN Hamartoma Tumor Syndrome (PHTS) is a rare tumor risk disorder caused by germline loss-of-function mutations in PTEN. Half of these patients develop vascular malformations, a hamartoma c...
aacrjournals.org
March 28, 2025 at 3:12 PM
If you are interested in vascular malformations you may want to check our new work published today in Cancer Discovery, where we discover a somatic genetic event causing vascular malformations in PTEN hamartoma tumor syndrome (PHTS) aacrjournals.org/cancerdiscov...
Lets move to Heart Insufficiency instead. More accurate and less dramatic.
The frequently used medical term "heart failure" is awful and needs to be replaced
www.nejm.org/doi/full/10.... @nejm.org
www.nejm.org/doi/full/10.... @nejm.org
March 27, 2025 at 1:05 PM
Lets move to Heart Insufficiency instead. More accurate and less dramatic.
Reposted by Rui Benedito
—What are these 12 companies that purport to promote longevity and healthspan missing?
—Evidence.
erictopol.substack.com/p/the-busine...
—Evidence.
erictopol.substack.com/p/the-busine...
March 25, 2025 at 5:07 PM
—What are these 12 companies that purport to promote longevity and healthspan missing?
—Evidence.
erictopol.substack.com/p/the-busine...
—Evidence.
erictopol.substack.com/p/the-busine...
Reposted by Rui Benedito
This work would not have been possible without our many collaborators who provided reagents, lines and much needed support! @ruibenedito.bsky.social, M. Jeansson, @brittae.bsky.social, D. Vestweber, K. Gängel, O. Friedrich, J. van Buul, P. Saharinen, R. Smith and M. Majda and many others!
March 20, 2025 at 2:05 PM
This work would not have been possible without our many collaborators who provided reagents, lines and much needed support! @ruibenedito.bsky.social, M. Jeansson, @brittae.bsky.social, D. Vestweber, K. Gängel, O. Friedrich, J. van Buul, P. Saharinen, R. Smith and M. Majda and many others!
Amazing work from Hans Schoofs and colleagues in Taija Makinen lab. Also a good example how intravital imaging of cellular mosaics can be very informative.
• Happy to announce that our paper in @nature.com is finally out! Thanks to the perseverance of @taijamakinenlab.bsky.social and our many collaborators we finally pulled it off! A small 🧵
www.nature.com/articles/s41...
Laymen video:
www.nature.com/articles/d41...
www.nature.com/articles/s41...
Laymen video:
www.nature.com/articles/d41...
Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium - Nature
Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous...
www.nature.com
March 20, 2025 at 6:31 PM
Amazing work from Hans Schoofs and colleagues in Taija Makinen lab. Also a good example how intravital imaging of cellular mosaics can be very informative.